2003PT ,,

Size: px

Start display at page:

Download "2003PT ,,"

头内郭
5 years ago
Views:

1 A ( ) ( )

2 2003PT ,,

3 / / NMR/MRI 2 / / BECIA 4 / / / / ADC * 2 * 3 *

4 1., 2. (, )

5 2004 1) , 1 1) imqc 4 2) NMR J. Am. Chem. Soc. NMR imqc 2 2 J. Am. Chem. Soc. Chem. Phys. 3) 1 Magnetic Resonance Imaging 1 Magnetic Resonance in Medicine 4) 2. 1) Spiral Spiral Spiral 4

6 (< 20 ms) (Interleaved) Spiral IL-Spiral k- Spiral Spiral-MRI 2D-FFT Spiral-MRI k 2D-FFT PC Spiral TIF GIF JPG BM Spiral-MRI 32 T 2 -MRI T 2 -MRI 8 (Appl Magn Reson 2003, 25: ) 2) Chin Sci Bull 2004, 49: fmri fmri (a) Brodmann (b) (c) (d) fmri 5

7 3. (HR-MAS) 1) HR-MAS PCA SIMCA Cho Gly Tau Lip Ala 2) (HR-MAS) 1 H HR-MAS 1 H 0 10ppm,, 13 C, 13 C, DEPT NOE (CP) 13 C NMR CP,, ; J DEPT, NOE,, NOE CPMG, DEPT,, DEPT (Magn. Reson. Med. Submitted) ) (SM) (PC) -N + (CH 3 ) 3 (-COO - ) -N + (CH 3 ) 3 (Anal. Biochem. 2004, 324, ) 6

8 PC MS + 10 mg IBP + 5 mg IBP O O CH 2 CH= (CH 2 ) n CH 3 Control + N(CH 3 ) 3 =CHCH 2 CH= ppm ppm (T 2 ) (Anal Chem. in preparation) 2 : A B P a b NMR PA + B PB + A c d A B K db K da A B A-B-P (HSA) (SAL) (TOL) 500 MHz NMR R 1 R 1 SAL 32±4 TOL 28±2 17±5 ( J Pharm. Biomed. Anal. revised) 5 1 C 50 Cl C-NMR C 50 Cl (C) C50 D 5h Science 2004, 304 (5671): H-NMR 129 Xe Overhauser SPINOE Spin Polarization-Induced Nuclear Overhauser Effect (NMR, Nuclear Magnetic Resonance) HCl 1 H-NMR 6 N Cs D Xe-NMR (Phys Rev B, 2004, 70: ; Appl Magn Reson 2004, 26(3): ; Prog. Nat Sci. 2004, 14(5): ) 7

9 3 Minnesota Rochester NMR Rochester ms NMR NMR/MRI 2 / ( ) / / ) ) / ( ) 6.0 3) / / 3.0 8

10 4) / 2.0 5) ) Cui YF, Bai GY, Li CG, Ye CH, Liu ML, Analysis of the competitive binding of ligands to human serum albumin using NMR relaxation measurements. Journal of Pharmaceutical and Biomedical Analysis, 2004, 34: Zheng AM, Yang MH, Yue Y, Ye CH, Deng F, 13 C NMR shielding tensors of carboxyl carbon in amino acids calculated by ONIOM method. Chemical Physics Letters, 2004, 399: Chen F, Zhang MJ, Han Y, Xiao FS, Yue Y, Ye CH, Deng F, Characterization of microporosity in ordered mesoporous material MAS-7 by Xe-129 NMR spectroscopy. Journal of Physical Chemistry B, 2004, 108: Zhou X, Luo J, Sun X, Zeng X, Zhan M, Ding S, Liu M, Experiment and dynamic simulations of radiation damping of laser-polarized liquid Xe-129 at low magnetic field in a flow system. Applied Magnetic Resonance, 2004, 26: Yang YH, Bai GY, Zhang X, Ye CH, Liu ML, 1 H NMR spectroscopic evidences of interaction between ibuprofen and lipoproteins in human blood plasma. Analytical Biochemistry, 2004, 324: Chen Z, Chen ZW, Zhong JH, High resolution NMR spectra in inhomogeneous fields via IDEAL (intermolecular dipolar-interaction enhanced all lines) method. Journal of the American Chemical Society, 2004, 126: Yu XY, Cai SH, Chen Z, Interactions between bioactive diperoxovanadate complexes and imidazole: insights into their solution structures by NMR and ESI-MS. Chinese Journal of Structure Chemistry, 2004, 23: Hou T, Chen Z, Hwang DW, Zhong JH, Hwang LP, Intermolecular double-quantum coherence MR microimaging of pig tail with unique image contrast. Magnetic Resonance Imaging, 2004, 22: Chen Z, Zhong JH, Kennedy SD, Intra- and inter-molecular multiple-quantum coherences in liquid nuclear magnetic resonance. Recent Research Developments in Chemical Physics, 2004, 4:In Press. 10. Zhu XQ, Cai CB, Chen Z, Zhong JH, Multiplet patterns of inter-molecular double quantum coherences from dipolar and scalar couplings in solution nuclear magnetic resonance. Chinese Physics, 2004, Accepted. 11. Chen F, Chen CL, Ding SW, Yue Y, Ye CH, Deng F, A new approach to determination of micropore size by 129Xe NMR spectroscopy. Chemical Physics Letters, 2004, 383:

11 12. Chen L, Zhang MJ, Yue Y, Ye CH, Deng F, NMR and theoretical studies of boron-modified mordenite. Microporous and Mesoporous Materials, 2004, 76: ,,,,, NMR., 2004, 62: ,,,,, NMR SPINOE., 2004, 14: Chen Z, Hou T, Chen ZW, Hwang DW, Hwang LP, Selective intermolecular zero-quantum coherence in high-resolution NMR under inhomogeneous fields. Chemical Physics Letters, 2004, 386: Chen Z, Chen ZW, Hwang DW, Zhong JH, Hwang LP, Separation and characterization of different signals from intermolecular three-spin orders in solution NMR. Journal of Magnetic Resonance, 2004, 171: Cai CB, Chen Z, Cai SH, Zhong JH, A simulation algorithm based on Bloch equations and product operator matrix: application to dipolar and scalar couplings. Journal of Magnetic Resonance, 2004, 172: Yu XY, Cai SH, Chen Z, Spectroscopic studies on the interactions between a bioactive diperoxovanadate complex and pyridine. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2004, 60: ,,, Spiral MRI., 2004, 21: Lin QL, Cai SH, Chen Z, Cai CB, Theoretical expression and computer simulation of diffusion behaviors in multiple-quantum coherence NMR. Chinese Journal of Chemical Physics, 2004, 17: Fang K, Li YX, Liu H, Liao WJ, Lei H, Tracing neuronal tracts in the olfactory system of rat and detecting ischemia core in a rat model of focal ischemia using manganese enhanced magnetic resonance imaging. Chinese Science Bulletin, 2004, 49: ,,., 2004, 20: ,,,., 2004, 20: ,,,,., 2004, 53: ,, Gore J, MRI ph., 2004, 23: ,,,,,., 2004, 49: ,,,,., 2004? ,, ICA., 2004, 32: ,,,,., 2004, 23: ,,,, Mn 2+., 2004, 1: ,,,., 2004, 43: ,,,,, 10

12 ., 2004, 14:

<4D F736F F D20B8BDBCFEA3BAB9ABCABEC4DAC8DD2DB9FDB6C9BDF0CAF4D1F5BBAFCEEFC4C9C3D7BDE1B9B9D0C2D3B1B5C4CDE2B3A1D7F7D3C3CFECD3A6CCD8D0D4BCB0BBFAC0EDD1D0BEBF2E646F6378>

<4D F736F F D20B8BDBCFEA3BAB9ABCABEC4DAC8DD2DB9FDB6C9BDF0CAF4D1F5BBAFCEEFC4C9C3D7BDE1B9B9D0C2D3B1B5C4CDE2B3A1D7F7D3C3CFECD3A6CCD8D0D4BCB0BBFAC0EDD1D0BEBF2E646F6378> / 20 SCI 1210 817 8 SCI 854 548 384 219 2018 1 NO 2 Adv MaterChem Soc RevJ Am Chem SocEnergy & Environmental ScienceAdv Funct MaterNano LettElectrochemistry Communications 8 854 384 2018 2 8 Adv MaterChem