(ROS) (hs-crp C) ( ) () () ()
(ROS): vs. (ROS) 1 10% 6 48 (ROS)20.7% (ROS)25.9% 2.20 ROS 20.7% 2.20 ROS 25.9% 2.00 1. 2.00 1. 1. 1. 1. 1. 1.20 1.20 1.00 1.00 Day 1 Day 1 RESTING ROS 1 HOUR ROS DURING EXERCISE 1 HOUR Resting Control Day 1 Average 1.71 1.51 1.35 1.33 < 0.001 % Change -11.6% -20.7% -21.8% Exercise Control Day 1 Average 1.94 1.74 1.44 1.43 < 0.001 % Change -10.2% -25.9% -26.3%
: vs. 0. ROS 42.6% 0. ROS 44.9% 0.35 0.35 0.30 0.25 0.20 0.15 0.30 0.25 0.20 0.15 0.10 0.10 0.05 0.05 0.00 0.00 Day 1 Day 1 RESTING ROS 1 HOUR ROS DURING EXERCISE 1 HOUR Resting Control Day 1 Average 0.32 0.18 0.18 0.14 < 0.001 % Change -45.2% -42.6% -55.9% Exercise Control Day 1 Average 0. 0.26 0.22 0.20 < 0.001 % Change -36.1% -44.9% -50.4%
: 35.8% : hs-crp (C) 12 hs-crp 34.1% 28.7% 21.3% 34.1% 0.45 0. 0.35 0.30 0.25 0.20 0.15 0.10 0.05 0.00 Day 1 2. 2.20 2.00 1. 1. 1. 1.20 1.00 hs-crp 6.00 5.50 5.00 4.50 4.00 3.50 3.00 2.50 2.00 1.50 1.00 hs-crp (>3.0) RESISTANCE TO INDUCED INFLAMMATION Resistance Control Day 1 Average 0.02 0.03 0.03 0.03 < 0.001 % Change 35.8% 28.7% 22.1% hs-crp Average 1.79 1.53 1.41 t-test ns 0.024 % Change -14.6% -21.3% hs-crp Elevated >3.0 Control Average 5.25 3.82 3.46 t-test ns 0.002 % Change -27.2% -34.1%
: 487.5% 8.5% : HDL HDL()HDL 18.3% 7.5% 8.5% 7.1% 18.3% 250 2 230 220 210 200 190 1 170 TOTAL CHOLESTEROL TOTAL CHOLESTEROL HDL CHOLESTEROL 250 2 90 85 90 85 230 75 75 220 70 70 210 200 65 65 190 55 55 50 50 1 170 45 45 HDL CHOLESTEROL TOTAL CHOLESTEROL TOTAL CHOLESTEROL HDL CHOLESTEROL HDL CHOLESTEROL Average 211.3 195.5 195.3 % Change -7.5% -7.6% Elevated Control Average 235.2 215.2 213.4 % Change -8.5% -9.3% Average 63.1 67.6 68.8 t-test 0.0027 0.0026 % Change 7.1% 9.1% Low Control Average 50.3 59.5 63.1 t-test 0.0027 0.0026 % Change 18.3% 25.6%
: 48 6 8.8% 23.3% 1 1 120 100 TRIGLYCERIDES 8.8% 220 200 1 1 1 120 100 TRIGLYCERIDES 23.3% TRIGLYCERIDES Average 113.3 103.3 92.3 t-test 0.0266 0.0045 % Change -8.8% -18.5% TRIGLYCERIDES Elevated Control Average 202.5 155.3 116.2 t-test 0.001 0.002 % Change -23.3% -42.6%
: LDL 48 LDL ( )6.7% LDL LDL 11.3% : VLDL VLDL ( ) VLDL VLDLVLDL 6.7% 11.3% 27.4% 34.3% 65.3% 170 LDL CHOLESTEROL 170 LDL CHOLESTEROL VLDL CHOLESTEROL VLDL CHOLESTEROL 1 1 35 35 150 1 130 120 110 150 1 130 120 110 30 25 20 15 10 30 25 20 15 10 100 100 5 5 LDL CHOLESTEROL LDL CHOLESTEROL VLDL CHOLESTEROL VLDL CHOLESTEROL Average 128.2 119.6 117.8 % Change -6.7% -8.1% Elevated Control Average 1.3 142.2 141.5 % Change -11.3% -11.8% Average 15.1 10.9 8.8 % Change -27.4% -41.6% Elevated Control Average 34.1 22.4 11.9 t-test 0.005 < 0.001 % Change -34.3% -65.3%
: 48 65.2% 5.9% : 48 65.0% 6.9% 5.2% 5.9% 5.0% 6.9% 131 SYSTOLIC BLOOD PRESSURE 131 SYSTOLIC BLOOD PRESSURE 90 DIASTOLIC BLOOD PRESSURE 90 DIASTOLIC BLOOD PRESSURE 128 125 122 119 116 128 125 122 119 116 85 75 70 85 75 70 113 113 65 65 110 110 SYSTOLIC BLOOD PRESSURE SYSTOLIC BLOOD PRESSURE DIASTOLIC BLOOD PRESSURE DIASTOLIC BLOOD PRESSURE Average 124.5 118.0 116.6 % Change -5.2% -6.3% Elevated Control Average 129.3 121.6 118.8 % Change -5.9% -8.1% Average.2 76.2 75.4 % Change -5.0% -6.0% Elevated Control Average 87.3 81.3 79.7 t-test < 0.001 0.001 % Change -6.9 % -8.6%
: 48 121 : 1 56 48 812 9 1 6 12 135.3% 5 BEATS/MIN 8 BEATS/MIN 9 BEATS/MIN HEART RATE AFTER 1 HOUR Day 1 NITRIC OXIDE HEART RATE AFTER 1 HOUR Average 59.1 98.3 139.0 SEM 6.6 6.6 12.7 % Change 66.4% 135.3% Everyone Control Day 1 Average 128.5 123.7 120.8 119.2 < 0.001 Beats/min -4.8-7.8-9.4
: 1 27.4% 637.2% 12 44.3% : HbA1c HbA1c 90 1 27.4% BLOOD GLUCOSE 6 37.2% BLOOD GLUCOSE 12 44.3% BLOOD GLUCOSE 4.2% 5.2%.0 50.0.0 30.0 20.0 10.0 0.0 POST-MEAL BLOOD SUGAR SPIKE IN 1 HOUR EVERYONE AFTER TAKING SUPPLEMENT Day 1 39 38 37 36 35 34 33 32 31 30 HbA1c 39 38 37 36 35 34 33 32 31 30 HbA1c POST-MEAL BLOOD SUGAR SPIKE Exercise Control Day 1 Average 47.8 34.7 30.0 26.6 < 0.001-27.4% -37.2% -44.3% HbA1c Average 35.8 34.9 34.3 % Change -2.4% -4.2% HbA1c Elevated Control Average 38.0 36.7 36.0 % Change -3.3-5.2
: HOMA 12 (HOMA)28% HOMA 9.2% 18.9% 13.8% 28.0% 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0.0 HOMA (INSULIN SENSITIVITY) 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0.0 HOMA (INSULIN SENSITIVITY) HOMA Average 3.0 2.7 2.4 t-test ns 0.02 % Change -9.2% -18.9% HOMA Elevated Control Average 4.1 3.5 3.0 t-test ns 0.01 % Change -13.8% -28.0%