... 1... 2... 3... 4... 5... 6... 7... 8 2... 9... 10... 11... 12... 13... 14... 15... 16... 17...
1995 1996~2000 << >><<>> <<>> mgdl(7.0mmoll)110mg/dl(6.1mmol/l)126mg/dl(7.0mmol/l <<>> <<>> 1
2
3
7.0 6.1
4
5
6
7
8 2
9
10
10-1
* 10-2 * HbA1c LDL-C HDL-C
46 1 HbA1c 1 / * 11
2 11-1 11-1 - 2 mmol/l 4.46.1 7.0 >7.0 4.48.0 10.0 >10.0 HbA1c% <6.5 6.57.5 >7.5 mmhg <130/80 >130/80 140/90 <140/90 BMIkg/m 2 <25 <27 27 <24 <26 26 TCmmol/L <4.5 4.5 6.0 HDL-Cmmol/L >1.1 1.10.9 <0.9 TGmmol/L <1.5 1.52.2 >2.2 LDL-Cmmol/L* <2.6 2.63.3 >3.3 * 2003 1 1 2 3 1 2
4 20%30% 1/3 100mg/dl2 6mmol/L 10%<300 mg/d 100mg/dl26mmol/L<200 mg/d 5 55%65% 6 15% 0.81.0g/kg 0.8g/kg 7 8 9 6g/d 10 1000 1500mg/d 1 30 11-2 2 1 >15mmol/L 1 2 1 >35 2 >10 1 >15
2 3 4 5 11-2 %* <35 3554 5569 7889 >90 100 *=220 1 12 14 1 34 20mmol/L(>360mg/dl) 2 / 10%15%
2 3 HbA1C 120 120 A1C HbA1C HbA1C HbA1C DCCT UKPDS HbA1C HbA1C HbA1C 2 HbA1C 3 1 HbA1C 4 1420 12 5 180mg/dl 2 1 16.7mmol/L(300mg/dl) - - 1 - - 5 2 1 2
- 2 2 11-1 2-3 2 11-1 2 - - 2 / () 23 - - +- +- + +- /+ 12 11-1 2 1 1 2
2 UKPDS 2 6 2 40%50% 11 1 12 1 0.51.0U/kg 1 11-3 22 11-12 2 2 2 1 11-3 1U/kg - 11-3 1 10pm 1 RI IA +NPH RI IA RI IA NPH 2 RI IA +NPH RI IA +NPH 3 * RI IA + RI IA RI IA Glargine PZI RI=IA =NPH=PZI= *RI IA Glargine PZI
12 1 2 1 2 3 4 5 6 7 3 1 2 3 4 <130/80mmHgACEI 5 70100mg/dl 90140 mg/dl 6 7 8 112 2 3 46 70100mg/dl 2 90140 mg/dlhba1c >105 mg/dl 2 >140 mg/dl 4 5 3 6 7 8 1
2 1 1 2 3 [3mg/dl(2.65mmol/L),<50ml/min] 4 5 1 2 1 1 0.6/10 1 1 1 2 3 4 20%40% 2 1 1 1 2 3 1 4 5 23 2
1 C 2 2 2 1 2 1 2 2 3 2 2 3 1 4 1 5 1 >60 >65 60 60 1 2 2 2 IGT 65 10%20% 1996 60 2 10 3 4 2 3
13
14
14-5
2
PTCA 2 3 1 23 2 4 9 3 CT,MRI 6 23 1 2 3 4 5 6 36 L- rt-pa
7 8 9 13 10 1 2 65% 3: 4 99% 1 60% 2 20 10 NPDR NPDR NPDR NPDR PDR 1
2 14-7 14-7 030 31 3 14-8 14-8 NPDR PDR 9 6 4 24 23 3 5 0.025 50% 1 500m 500m 2 50% 4 5 NPDR PDR NPDR PDR 6 Mongensen 1 5 5 2
2 1 34 2 5 1 GFRGFR 2 UAER<20g/min <30mg/d GFR GBM 3 UAER 20200g/min 30300mg/d GFR GBM 4 >3.5g/d GFR 5 610 UAER 20200g/min 30300mg/d GBM Kimmelstiel-Wilson 1 <6.1mmol/L(110mg/dl) <8.0mmol/L(144mg/dl)<6.5% 2ACEI II ARB ACEI ARB 12 3 30%50% 4>265mol/L(3mg/dl) 3
<1.0g/d <130/80mmHg>1.0g/d <125/75mmHg 4 TC<4.5mmol/L,LDL-C<2.6mmol/L,HDL-C>1.1mmol/L,TG<1.5mmol/L. TC LDL-C 1 1 2040kD706 25 45kD 2 3 400ml/d 3g/d 2 1 ACEI ARB 0.6g/kg- 125146kJ/kg(30 35kcal/kg) 2 3 D3 4 : >530 mol/l(6mg/dl),<1520ml/min 1 2 1 5% 2 3
4 5 2% 10 60%90% 30%40% 40 1 2 1 6 2 3 3 1 >90 / QT 2 3 4
5 6: 1 1 EC 2 B1B12 B12 3 E2 2 1 2 100IU/d 2 1/3 23 2 5mg/d 3 4 5 6 7 3/4 1 2 3 8%22%1 23 1 23 4 60% 5
1 2 3 123 45 4 1234 2 3 4 5 1 2 3%0.05% 3 2 6.6mmol/L 2 8.8mmol/L 3 23 4
2 Charcot 0.1%0.4% 20 79 5059 1/3 73% 10 1 10% 2 () : 31.5%27.4%(21.8%)(10.2%) (9.1%) X. Charcot X 3,,, 5%10% 1% 15 1992 12.4%, 7.3% 80%
Wagner 14-9 14-9 Wagner 0 1 2 cellulitis 3 4 5 10g 14-10 14-10 Charcot X Biothesiometer TcPO2 1 2 3
4 5 6 7 13 3 1 2 90% 3 4 NIH 1993 impotence (erectile dysfunction,ed)
ED ED ED ED ED 1 100% ED 2 ED 3 ED 4 ED 5 ED ED II EF-5 6 14-11 14-11 0 1 2 3 4 5 1 2 3 4 5 21 21 EDII EF-5 ED 98% 88%II EF-5
1 ED 2 ED 3 i. sidenafil-5pde5 ii. trazodoneapomorphine 4 E1PGE1 PGE1 5 6 ED 35 1%3% 1997 16.1% 88% 4.4%18.2%, 19.3%24.1%,,, 66.5% 99.2% X X 75% 12 CT
1.52 6 B6 X 15 30%50% / / /
15-1 15-1 1123 212 3 31/23/ 4123 5123 6123 7 6 5 4 3 2 1 1self-rating depression scale,sds 2 (self-rating anxiety scale,sas) 123 45 67 123 456 1/5
1 2 15-2 16 25 / TGF- 1 ICAM-1 1
1 2 MRFIT 2 2 1 2 1 2 47 nicotine replacement therapy NRT 1 40%60% 4mg 2mg NHANESI 2 1 21 2 3
17 4 4 <10% MODY 0.5 3
1 2 2 1