01 Vol.14 No.1, ScienceDirect * ** ** 100700 510405 100700 CBM R R Microsoft Access Microsoft SQL Server D doi: 10.6/j.issn.1674-4.01.01.00 Osteoporosis, OP 000 050 1.% [1] * ** 011-05-10 011-06-14 05047 00IM00400 00IM0000 Tel 010-64014411 E-mail: zhouqi7005@16.com E-mail: lap64067611@16.com 1
OP OP 1. Cytoscape.7 (Chinese BioMedical Literature Database CBM OP 1 011 6 1.. OP TXT ANSI 061 010SR0740 Access Microsoft SQL Server. [] [~5] 1 1 DN_pairs DN_pairs_frqcy 5. DN_pairs_frqcy 4. DN_pairs_frqcy 1
01 Vol.14 No.1 11. OP 41 1. [] 4 OP 7 14 1 OP 4 OP 5 17 OP 17 16 16 11 6 4. 5 5 5 D 5 5 Selective Estrogen Receptor Modulators, SERM 4 6 5. [7~] 0 4 6 10 1 14 16 1 1 1 4 16 74 7 70 7 5 6 7 56 6 4 6 46 5 4 5 41 5 0 4 1 0 1 [6] 16 10
OP OP OP 1 1 [10] 4 1 1 17 1 [11] 10 10 7 1 10 7 10 OP 1 14 7 5 7 1 0 17 7 7 1 11 11 7 1 1 [1] 4 D 7 17 D 0 D 1 700 OP 1 7 60 OP 70% [1] OP OP 4 1 1 OP OP [1] 5 17 11
01 Vol.14 No.1 OP OP D 161 D 74 74 706 54 0 [14] SERM 4 6 60 0 00 4 00 600 00 1000 100 14 00 1600 7 6 60 4 4 1. 00. 010 5(7) 55~555. Andrea C,Rasmus P.Finding associations and computing similarity via biased pair sampling. 00 Ninth IEEE International Conference on Data Mining. Florida, 00 61~70. Jeffrey WS. Data mining: An overview. CRS Report RL17. 004. 4 Brigitte M, Silke E. Five steps to text mining in biomedical literature. In Proceedings of the Second European Workshop on Data Mining and Text Mining for Bioinformatics. Pisa. 004 47~50. 5 Zheng G, Jiang M, Xu YS, et al. Discrete Derivative Algorithm of Frequency Analysis in Data Mining for Commonly -existed Biological Networks, CNMT 010. Wuhan. 010 5~10. 6.. 010 1 4 100-10. 7.. 006 6(11) ~1. Li S, Zhang ZQ, Wu LJ, et al. Understanding ZHENG in traditional Chinese medicine in the context of neuro-endocrine-immune network. 1
IET Systems Biology, 007,1(1) 51~60. Engineering Research, 00,1(11) 11~15. Tari L, Anwar S, Liang S, et al. Discovering drug-drug interactions: a text -mining and reasoning approach based on properties of drug metabolism. Bioinformatics, 010,6(1) 1547~155. 1.. 006 6(4) 1~. 1 Verit FF, Oguz H, Ozkul Y, et a1. Long -term effects of tibolone on 10.. ocularfunetions in postmenopausal women. Arch Gynecol Obstet, 007, 75 005 (1) 0~05. 11 Shou ZX, Shen L, Yang YP, et al. Effects of epimedium total flavonoids on bone mineral density and bone metabolism -related indices in (4) 55~61. 14.. 010 0(10) 1017~100. primary osteoporosis. Journal of Clinical Rehabilitative Tissue Exploring Rules of Chinese Medicine and Western Medicine Used in the Treatment of Osteoporosis by Text Mining Zhou Qi 1, Chen Weini, Jiang Miao 1, Zheng Guang 1, Guo Hongtao 1, Lu Aiping 1 (1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China;. The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, China) Abstract: This study was aimed to explore rules of Chinese patent medicine, western medicine, together with their combination rules used in the treatment of osteoporosis by text mining. Data on osteoporosis was queried and down- R loaded from SinoMed on March, 011. After transferring semi-structured data into Microsoft SQL Server, the algorithm of data slicing based on frequency analysis was applied. Some simple and meaningful networks were achieved. Data of these networks were imported into Cytoscape and visualized. The results showed that in the treatment of osteoporosis, Chinese patent medicine, such as Zuogui pills, Liuwei Dihuang pills, Gusongbao granules, Yougui pills, and Shengu capsule, are widely used in the clinical practice. Chinese herbal medicine, such as Herba Epimedii, Radix Rehmannia, Radix Astragali, Rhizoma Drynariae, Salvia Miltiorrhiza, Fructus Psoraleae, Radix Puerariae, Radix Angelica, and Cortex Eucommiae, are frequently shown in articles on osteoporosis. Herba Epimedii and Radix Rehmannia are major herbal medicine and most frequently used in the herbal combination. The most important treatment method of osteoporosis is to strengthen the kidney and spleen together with activate and nourish blood. A- mong all western medicine, estrogen agents, Vitamin D, calcium, and thyrocalcitonin are most frequently used in the treatment of osteoporosis. In this paper, rules of Chinese patent medicine and western medicine used in the treatment of osteoporosis were concluded. The combination between Chinese patent medicine and western medicine was also calculated for the clinical application and basic research reference. Keywords: Osteoporosis, text mining, Chinese patent medicine, Chinese herbal medicine, western medicine 1