: : : : 27372181-8444 52 : 252 / 100 1-100 3 Off- label Use Carbamazepine (Stevene Johnson syndrome) Off- label Use Off-label Use..
. 13 8 Off-label use 39 26 75 Off-lable Use.
Off-label Use. Offlabel Use. Off-label Use? Off-label Use 81 12 1
0910014830 1 ( ) 2 ( ) 3 4 5 Off-label Use 13 8 4/19 3 1 2 3 Off-label Use
1. 2. 3. 4. 5. (Off-label use) 6. (Off-label use)- FDA 2010,Vol.53,No.5:45-48.
(Tourette syndrome) (Tourette syndrome TS) 1000 4-6 (4-6 ) Striatal-Thalamic-Cortical (mesolimbic) Spinal System (Dopamine) (Serotonin) (Attention-deficit Hyperactivity disorder ADHD) (Obsessive-compulsive disorder OCD) (ADHD) (ADHD) (Motor tics) (Vocal tics)
1. (simple motor tic) 2. (complex motor tic) (steretoyped) (echopraxia) (obsence gesture) (compulsive) 1. (simple vocal tic) 2. (complex vocal tic) ( 3:1) 2~13 4-6 13~21 ( )
30-40% 30% 30% M.H. Bloch, J.F. Leckman / Journal of Psychosomatic Research 67 (2009) 497 501 EEG ( ) CAT ( ) DSM-IV1994 1. (motor tics) (vocal tics) 2. 3. 18 4. ( ) ( Huntington )
Haloperidol (Binin-U 5mg/tab) Pimozide Haloperidol Pimozide (D2 receptor blocker) 60~80% 70~80% Tetrabenazine (monoamine depleter) (dopamine) (serotonin) (norepinephrine) ( ) Risperidone (Risperdal ) Aripiprazole (Abilify ) ( ) α2-andrenergic agonist Clonidine (Catapres ) Guanfacine (ADHD) α2-andrenergic agonist Guanfacine Clonidine Topiramate (Topamax ) α2-andrenergic agonist
(Botulinum Toxin) 3~6 (mg) ( ) α agonist Clonidine 0.05-0.5 Guanfacine 0.5-4 ( )Antipsychotic agent (Dopamin receptor Antagonist) Haloperidol 0.5-20 Fluphenazine 0.5-20 Pimozide 0.5-10 clonidine ECG QT Risperidone 0.5-16 ( )Dopamine depletyer Tetrabenazine 12.5-100.0 CYP2D6 1. Tourete s syndrome. Roger Kurlan The New England Journal of Medicine 2010,24,2332-2338 2. Clinical course of Tourette syndrome. Michael H. Bloch, James F. Leckman Journal of Psychosomatic Research 2009,67,497 501
(Estrogen) (Progestin) (Estrogen) (Progestin) ( ) 1989 FDA (1) 35 (2) 40 1989 1930 (Estrogen) (Progesterone) 1. 0.05mg (Venous thrombosis) 2. 0.025~0.035 mg Norethindrone ( Levonorgestrel Norgestimate ) 3. 0.02mg Desogestrel Gestodene
Ethinyl estradiol Ethinyl estradiol 0.02mg (Drospirenone) ( ) (1) (2) Levonorgestrel 6 ++ - - Cyproterone 4 - +++ - Drospirenone 4 - ++ + Norgestimate 4 + - - Gestodene 9 + - - Desogesterl 8 + - -
3 (1) 21 21 7 7 8 (2) 28 2 3 ( ) 21 21+7 24+4 21+7 21 7 7 24+4 2~3 (1) / ( : ) (2) ( ) (3) (4) (5) (6) (7) ( ) (8)
1. 2. 3. 7 4. Bayer HealthCare. Online.
1. 2. Micromedex 3. UpTodate 4. Medscape 5. Bayer HealthCare. Online. http://www.yaz-hk.com/scripts/pages/cn/homepage/index.php. 18 Jun 2011
100 1-100 3 ( ) ( ) Rongifene 50mg (Buclizine 2HCl) (ORON) Lonzumin 25mg (Buclizine 2HCl) (OLONZ) 1. Allopurinol 100mg (Allopurinol) (OALL) Cefazolin 1g/vial (Cefazolin) (ICEFA) Zovirax oph oint 4.5g (Acyclovir) (TZOE) Tonsaric 100mg (Allopurinol) (OTONS) Winzolin 1g/vial (Cefazolin) (IWIN) Devirus Oph Oint 4.5gm (Acyclovir) (TDEV) 1. 2. 1. 2. 1. 2. 單 純 疱 疹 性 角 膜 炎 ( ) ( ) Fosamax Plus 70mg (Alendronate Na, colecalciferol) (OFOSA-P) Alendronate 70mg (Alendronate Na) (OALE) 1. colecalciferol Ostelin 250mg (Glucosamine sulfate) (OOST) Serophene 50mg (Clomiphene) (OSERO) Pharmorubicin 10mg/5ml/vial (Epirubicin) (IPHA) Axol 30mg (Ambroxol) Kudona Cap. 250mg (Glucosamine sulfate) (OKUDO) Clomiphene 50mg (Clomiphene) (OCLOM) Epicin 50mg/25ml/vial (Epirubicin) (IEPIC) Musco 30 mg (Ambroxol) 1. 1. 2. 1. 2. 1.
(OAXO) Losec 40mg/vial (Omeprazole) (ILOS) Chemix (Sulfamethoxazole, trimethoprim) (OCHE) Augmentin 375mg (Amoxicillin/ clavulanate) (OAUG) Trimerin syrup 60ml (Trimethoprim/sulfam ethoxazle) (LTRI) (OMUSC) NEXIUM INJ.40mg (Esomeprazole Sodium) (INEUX) Morcasin Tab. (Sulfamethoxazole, trimethoprim) (OMORC) Curam F.C. 1g (Amoxicillin/ clavulanate) (OCUR) SulfacoTrim 60ml (Trimethoprim/sulfa methoxazle) (LSUL) 1. / NSAID 2. Grade A B 4 4 3. 1. Sulfamethoxazole 400mg, trimethoprim 80mg 1. Augmentin 375mg(Amoxicillin 250mg / clavulanate 125mg) Curam F.C. 1g (Amoxicillin 825mg / clavulanate 125mg) 1. 2. ( ) Acetamol INJ. 1g 1. (Propacetamol HCl) (IACET) 2. 3. " ",, ( :8432) " Lidopat Patch 5% 3 / 1. (Lidocaine) (TLIDP) 2. (1) NSAIDs (2) 3
2 (3) Gabapentin 3. (1) 24 3 12 (2) 4. " ",, ( :8432) " Requip PD 1. " ",, (Ropinirole) (OREQ2) ( :8432) " 2. Requip 0.25mg (OREQ- 0.25)& Requip 1mg (OREQ) SynflorixTM (1. " ",, ) ( :8432) " (ISYNF) 2. ISYNF1 ISYNF2 ISYNF3 ISYNF4 Durogesic D- TRANS 12mcg/hr 1. (1) (Fentanyl) (2) (TDU12) (3) 2. Fentanyl 25mcgTransdermal Patch (TFE25) DUROGESIC mcg/hr (TDU50-D) Vimax Foaming Sol'n 1. (Clobetasol propionate) (TVIM) 2. " ",, ( :8432) " 3. & 4. Clobetasol 10gm/tube (TCLOB) ( ) Lexapro F.C. 10mg 1. (Escitalopram Oxalate) (OLEXA) 2. " ",, ( :8432) " LABedin F.C. Tab 200mg 1. (Labetalol) 2. " ",, (OLABE) ( :8432) " Dormicum F.C. 7.5mg 1.
(Midazolam) (ODORM) Finibax 0.25g/vial (Doripenem Hydrate) (IFIN) Omnitrope 5mg(15 Units)/1.5ml (Somatropine) (IOMNIT) SEROquel (Quetiapine) (OSEQ25) Durogesic D- TRANS 12mcg/hr (Fentanyl) (TDU12) 2. " ",, ( :8432) " 1. Doripenem Hydrate ( ) 2. " ",, ( :8432) " 1. ; TURNER'S SYNDROME ;PRADER-WILLI SYNDROME ; ; Small for Gestational Age(SGA) ; 1. 2. Seroquel 100mg (OSEQ) 3. " ",, ( :8432) " 1. (1) (2) (3) 2. Fentanyl 25mcgTransdermal Patch (TFE25) DUROGESIC mcg/hr (TDU50-D) ( ) ( ) Apo-Haloperidol 5mg Binin-U.5mg 1. ( ) (Haloperidol) (Haloperidol) (OHAL5) (OBIN) Vancomycin 500mg Vanco INJ. 500mg 1. (Vancomycin HCl) (Vancomycin HCl) 2. (IVAN2) (IVAN3) Combizym (Pancreatin, Protase EC Cap 1. Lipase, Protase, (Amylase, Protease, Amylase) Lipase) (OCOMB) (OPROT) 2. 3.
( ) ( ) Indocin I.V 1mg/vial Pedea IV 1. (Indomethacin) 10mg/2ml/amp (IIND) (Ibuprofen) 2. (IPEDE) 3. Merpurine 50mg (Mercaptopurine) (OMERP) Mitomycin C 2mg (Mitomycin) (IMIT) Merkaptopurin 50mg (Mercaptopurine) (OMERK) Mitomycin C 10mg (Mitomycin) (IMIT10) 1. 2. 1. ( ) 2. ( ) Rasilez F.C. Tab 150mg 1. (Aliskiren Hemifumarate) 2. (ORASI) A.. 1. 2. >= 18 3. ACEI/ ARB B. a. b. GFR < 30 ml/min C. :