National Health Research Institutes (NHRI) Division of Cancer Research Taiwan Cooperative Oncology Group (TCOG) 11529 128 No. 128, Yen-Chiu-Yuan Road, Sec. 2, NanKang, Taipei 11529, Taiwan, R.O.C. TEL886-2-26534401 FAX886-2-27823755 http//www.nhri.org.tw
1982 20 (http//www.nhri.org.tw)
50% 30% NHRI/TCOG87.10 1 NHRI/TCOG 87.10
1. 20.50 16.14 6.43 9.27 5.79 7.23( 86 9 ) (1) (2) (3) (1) (2) (3) (4) (5) (4) (5) 2. 1. ( ) / 2. NHRI/TCOG87.10 3 NHRI/TCOG 87.10
1. (screening) (surveillance) (population) 2. 3. 4. 2 4 3 6 50 % 1997 (American Cancer Society) ( ) A. 50 B. (a) (1 ) (b) (1 ) (c) NHRI/TCOG87.10 5 NHRI/TCOG 87.10
(d) () 60 40 (e) ( d ) 50 () C. (a) 12 ~ 15 (b) 35 65% 45 90% 10 ~ 12 1 ~ 2 (c) (d) ( ) 50 45 80% 21 5. ( 1 ) NHRI/TCOG87.10 7 NHRI/TCOG 87.10
6. 0.2 1. 2. X NHRI/TCOG87.10 9 NHRI/TCOG 87.10
3. (rigid) (flexible sigmoidoscope) 25 60 ( ) 4. (barium enema) (double contrast barium enema) 5. (colonoscopy) TNM (1997 TNM ) 1. A. [T] Tx T0 Tis (lamina propria) T1 T2 T3 T4 / (visceral peritoneam) * Tis (Muscularis mucosae) **T4 B. [N] Nx N0 NHRI/TCOG87.10 11 NHRI/TCOG 87.10
N1 1 3 N2 4 C. [M] Mx M0 M1 2. (AJCC /UICC ) Tis N0 M0 T1-2 N0 M0 T3-4 N0 M0 Tis-4 N1-2 M0 Tis-4 N0-2 M1 (TNM, 1997) (sarcomas) (carcinoid tumor) 1. (Adenocarcinoma in situ) (Adenocarcinoma) (Mucinous carcinoma) colloid type (50%) (Signet ring cell carcinoma) (50% ) (Squamous cell carcinoma) (Adenosquamous carcinoma) (Undifferentiated carcinoma) 2. (G) Gx G1 G2 G3 G4 3. TNM NHRI/TCOG87.10 13 NHRI/TCOG 87.10
1. A. B. C. D. E. F. G. H. I. 2. A. 5-FU Leucovorin 15~40% CPT-11Oxaliplatin NHRI/TCOG87.10 15 NHRI/TCOG 87.10
Tomudex UFT CapecitabineS-1 B. (a) () (b) () 5-FU Leucovorin ( ) (c) () 5-FU Levamisole 40% 5-FU Levamisole 5-FU Leucovorin 5-FU Levamisole 5-FU Levamisole 5-FU Leucovorin NHRI/TCOG87.10 17 NHRI/TCOG 87.10
3. (1) A. (a) (T3-4N0 T1-4N1-2) GITSGNCCTGNSABP 45 50 60 (scarring) (sphincter sparing procedure) (b) (endocavitary radiotherapy) X (interstitial implantation) B. (a) 1.8 2 45 50 (b) (intraoperative radiotherapy) NHRI/TCOG87.10 19 NHRI/TCOG 87.10
(c) (2) (3) ( ) () NHRI/TCOG87.10 21 NHRI/TCOG 87.10
TCOG TCOG NHRI/TCOG87.10 23 NHRI/TCOG 87.10