Chin J Blood Transfusion Feb 2014 Vol. 27 No. 2 lung injury TRALI transfusion-associated circulatory overload TACO International Haemo

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2014 2 27 2 Chin J Blood Transfusion Feb 2014 Vol. 27 No. 2 郭永建 219 褚晓凌王洪燕郭永建 350004 R457.

1 Chin J Blood Transfusion Feb 2014 Vol. 27 No. 2 郭永建 219 褚晓凌王洪燕郭永建 R C X Introduction of BCSH guideline on the investigation and management of acute transfusion reactions CHU Xiaoling WANG Hongyan GUO Yongjian. Corresponding author GUO Yongjian. Department of Transfusion Medicine Fujian Medical University Fujian Blood Center Fuzhou China Key words acute transfusion reaction investigation management guideline The British Committee for Standards in Haematology BCSH 1 acute transfusion reaction ATR 20 ATR MEDLINE 1950 EMBASE 1980 CINAHL 1982 Cochrane DARE CRD 1 1 GRADE ATR 1 ATR recommended ATR 2 suggested ATR A 2 ATR B C 2. 4 Serious Hazards of Transfusion SHOT ATR < 24 h doi /j. cjbt. issn x ~ director@ fjxyzx. org transfusion-related acute 24 Lehrer RI Ganz T. Cathelicidins a family of endogenous antimicro- 37-kilodalton cationic granule protein of human neutrophil granulo- bial peptides. Curr Opin Hematol Cocchi F DeVico AL Garzino-Demo A et al. Identification of RANTES MIP-1 alpha and MIP-1 beta as the major HIV-suppressive factors produced by CD8 + T cells. Science Brandt E Petersen F Ludwig A et al. The beta-thromboglobulins and platelet factor 4 blood platelet-derived CXC chemokines with divergent roles in early neutrophil regulation. J Leukoc Biol Shafer WM Martin LE Spitznagel Jk. Late intraphagosomal hydrogen ion concentration favors the in vitro antimicrobial capacity of a Oxford Systematic Reviews Initiative SRI SRI cytes. Infect Immun Renee-Claude M Dietz RM Mazzola JL et al. Beneficial influence of platelets on antibiotic efficacy in an in vitro model of staphylococcus aureus-induced endocarditis. Antimicrob Agents Chemother Baboldashti NZ Poulsen RC Franklin SL et al. Platelet-rich plasma protects tenocytes from adverse side effects of dexamethasone and ciprofloxacin. Am J Sports Med

2 Chin J Blood Transfusion Feb 2014 Vol. 27 No. 2 lung injury TRALI transfusion-associated circulatory overload TACO International Haemovigilance Network IHN ATR International Society Blood Transfusion ISBT ATR ATR 1 2 ATR 3 24 h 2 ATR ~ 2 2 B 7 ATR 8 UKRC 1 A ~ mg IgA IgA IgA ATR 14 ATR 1 B h IgA FFP - FFP 2 B 18 IgA IgA IgA IgA < g /L IgA 5 ATR 20 MHRA SHOT 2. 5 ATR ATR fe- brile non-haemolytic transfusion reactions FNHTR

3 Chin J Blood Transfusion Feb 2014 Vol. 27 No ATR ATR 0. 5% ~ 3% 5 SHOT FNHTR ATR 14 / / / ATR 1C 7 ATR ATR ATR ATR ATR Airway Breathing TRALI TACO Circulation ABC transfusionassociated dyspnoea TAD ATR 1 ATR 1C 2 ATR 1 2 2C h 2C h A ATR 2 2 IHN /ISBT 1 2 T 38 T 39 2 / 1 ~ 2 / 3 T 2 / T 39 / / / 1 1 < 1 h mmhg

4 Chin J Blood Transfusion Feb 2014 Vol. 27 No. 2 4 h 1 h 1 ATR 5 1C ~ 2 2B A ATR ATR 1C 1 2 > ml 0. 5 mg 1 /3 6 ~ ml 0. 3 mg < ml mg β 2

5 Chin J Blood Transfusion Feb 2014 Vol. 27 No min TAD ~ ml 2 10 mg mg ABO 39 2 disseminated intravascular coagulation DIC ISBT /IHN 1C TRALI ABO 3 ABO Ⅳ β 2 3 TRALI TACO TRALI TACO 500 ~ mg > 70 2C < 6 h 1 < 6 h 2 h 38 1 ~ X TRALI TACO TAD ATR X- TRALI TACO TRALI 4 TRALI TACO 3 TRALI TACO SHOT TAD IHN ATR TAD 24 h TRALI TACO 3

6 Chin J Blood Transfusion Feb 2014 Vol. 27 No. 2 1C IgA IgA 2C IgA ATR 2C IgA * 2 39 DAT LDH DAT IgA EDTA < g /L IgA X- IgA 3 h 24 h 30 mmhg 80 mmhg IgA DAT Ig LDH HLA - FNHRT HPA -HNA 2 FNHRT 14 FNHRT 1 h ATR -HLA -HPA -HNA 1B 4 ATR ~ FNHTR 15 Azuma h Heddle C ~ 650 mg FNHTR 2C 12 ~ ~ ~ 60 min ~ 18 Heddle 19 Vo 20

7 Chin J Blood Transfusion Feb 2014 Vol. 27 No IgA 17 IgA HLA -HPA -HNA HLA HPA HNA C C fresh frozen plasma FFP ATR ATR ATR - FFP 2B 18 1C FFP 20 Medicines and Healthcare - FFP Products Regulatory Agency MHRA SHOT IgA 19 IgA 1C IgA IgA ATR 1C http / /www. opsi. gov. uk /si / si2005 / htm 1C IgA < g /L IgA SHOT /IHN /IS- BT 2 SHOT 1 IgA IgA IgA TRALI ATR -IgA 2 IgA IgA IgA IgA -IgA IgA IgA ATR IgA MHRA SHOT ATR IgA ATR IgA ATR IgA 3 IgA

8 Chin J Blood Transfusion Feb 2014 Vol. 27 No. 2 bjh /pdf International Haemovigilance Network / International Society for Blood transfusion. Proposed standard definitions for surveillance of ISBT /IHN ATR non-infectious adverse transfusion reactions ATR http / /www. isbtweb. org /fileadmin /user_upload /WP_on_Haemovigilance / ISBT_definitions_final_2011 4_. pdf 1 2 ATR FNHTR 4 Paglino J Pomper G Fisch G et al. Reduction of febrile but not allergic reactions to RBCs and platelets after conversion to universal prestorage leukoreduction. Transfusion ATR 5 Fry J Arnold D Clase C et al. Transfusion premedication to prevent acute transfusion reactions a retrospective observational study to assess current practices. Transfusion Knowles S Ed. and Cohen H on behalf of the Serious Hazards of 2. Transfusion SHOT Steering Group. The 2010 Annual SHOT Report http / /www. shotuk. org /wpcontent / uploads /2011 /10 / SHOT-2010-Report1. pdf 7 Heddle N. Febrile nonhemolytic transfusion reactions / /Popovsky M. Transfusion reactions. 3rd edition. Bethesda. AABB Press Tobian A Savage W Tisch D et al. Prevention of allergic transfusion reactions to platelets and red blood cells through plasma reduc- 2. ABO Rh D tion. Transfusion ABO Rh D 9 Sandler S Vassallo R. Anaphylactic transfusion reactions. Transfusion Savage W Tobian A Fuller A et al. Allergic transfusion reactions 4. to platelets are associated more with recipient and donor factors than with product attributes. Transfusion Kim S Cho H Hwang Y et al. Non-steroidal anti-inflammatory 5. drugs for the common cold. Cochrane Database of Systematic Reviews CD ~ 7 12 Heddle N Klama L Roberts R et al. A prospective study to identify the risk factors associated with acute reactions to platelet and red cell transfusions. Transfusion British Committee for Standards in Haematology. Guideline on the investigation and management of acute transfusion reactions Prepared by the BCSH Blood Transfusion Task Force http / /onlinelibrary. wiley. com /doi / / 13 Heddle N Blajchman M Meyer R et al. A randomized controlled trial comparing the frequency of acute reactions to plasma-removed platelets and presorage WBC-reduced platelets. Transfusion Ezidiegwu C Lauenstein K Rosales L et al. febrile Nonhemolytic transfusion reactions. Management by premedication and cost implications in adult patients Arch Pathol Lab Med ATR Kennedy L Case D Hurd D et al. A prospective randomized double-blind controlled trial of acetominaphen and diphenhydra- ATR ATR mine pretransfusion medication versus placebo for the prevention of transfusion reactions. Transfusion Patterson B Freedman J Blanchette V et al. Effect of premedication guidelines and leucoreduction on the rate of febrile nonhaemolytic transfusion reactions. Transfus Med Sanders R Maddirala S Geiger T et al. Premedication with acetaminophen or diphenhydramine for transfusion with leucoreduced blood products in children. Br J Haematol

9 Chin J Blood Transfusion Feb 2014 Vol. 27 No Wang S Lara P Lee-Ow A et al. Acetaminophen and diphenhydramine as premedication for platelet transfusions A prospective randomized double-blind placebo-controlled trial. Am J Hematol Heddle N Klama L Meyer R et al. A randomized controlled trial comparing plasma removal with white cell reduction to prevent reactions to platelets. Transfusion Vo T Cowles J Heal J et al. Platelet washing to prevent recurrent febrile reactions to leucocyte-reduced transfusions. Transfus Med Azuma H Hirayama J Akino M et al. Reduction in adverse reactions to platelets by the removal of plasma supernatant and resuspension in a new additive solution M-sol Transfusion A ATR A1 ATR A1. 1 A mmhg TRA- FNHTR TRALI LI transfusion transmitted infection TTI FNHTR ABO A1. 7 TRALI DIC TTI ABO TTI 2 TTI 2005 ~ 2010 SHOT A1. 8 TTI A1. 9 ABO A1. 2 A1. 10 TTI 1 A1. 3 A2 ATR A2. 1 A X A2. 2 TRALI TACO TAD TACO 1 TTI TACO TRALI 2 A1. 5

Chin J Blood Transfusion Nov 2013 Vol. 26 No LIMS electronic issue EI and Healthcare Products Regulatory Agency MHRA 2. 1

2013 11 26 11 Chin J Blood Transfusion Nov 2013 Vol. 26 No. 11 郭永建 1161 BCSH 英国血液学标准委员会 2012 年赵国华赵维齐 100021 BCSH R457. 1 A 1004-549X 2013 11-1161-12 British Committee for Standards in Haematology BCSH