: K B 12
12 Pre-K Ka HMWK PL PF 3
heparin 5 30ku T 1/2
1. AT-? AT-? a a a a Ka AT-? 1000
?????
2. VLDL HDL 3.
1. 2. 3. DIC 4.
1. 2. 3.
LMWH low-molecular-weight heparins 5-6ku a 1) 5ku 16-20 X a AT? X a
2) t 1/2 3) 4 enoxaparin tedelparin fraxiparin
coumarins warfarin dicoumarol acenocoumarol 99% t 1/2 40h
1. 2. Vit.K???? VK g VK VK VK VK
Vit.K
1. 2. 3. 1. 1) Vit.K 2) 3)
sodium citrate Ca 2+ Ca 2+ 2.5% 10ml 100ml
1. aspirin [ ]:, TXA 2,., TXA 2,., PGI 2,.
2.TXA 2 TXA 2 ridogrel picotamide 3. dipyridamole persantin :1), camp? 2) PGI 2??? 3) TXA 2?,????????,??????.
ticlopidine ADP α - ADP clopidogrel
argatroban hirudin lepirudin
b b/ a b / a GP b / a GP b / a
GP b / a abciximab c7e3fab ReoPro c7e3fab GP b / a lamifiban tirofiban xemilofiban fradafiban sibrafiban
fibrinolytics thrombolytics streptokinase
i.v. A V urokinase i.v. A V urokinase
anistreplase 1:1
staphylokinase DNA
t-pa t-pa - scu-pa
K K 1 K 2 K 3 K 4 Ca 2+
K 3 K 3 VK thrombin
1 iron deficiency anemia 2 megaloblastic anemia VB 12 3 aplastic anemia
iron preparations 1g folic acid
DNA VB 12
VB 12 VB12 VB 12
erythropoietin EPO EPO? [Ca 2+ ] (epoetin-a)
GM-CSF
dextran 7.5 70 2 4 20,40 1 10
1. 2. 3.