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1 4 1 Vol. 4 No Journal of Food Safety and Quality Feb., 2013 陆建平, 张 * 静, 张艳贞 (, ) 摘要 :,,, 关键词 : ; ; The functional activities and application of polygonatum sibiricum polysaccharides LU Jian-Ping, ZHANG Jing, ZHANG Yan-Zhen * (Department of Food Science, College of Art and Application, Beijing Union University, Beijing , China) ABSTRACT: Polyonatum sibiricum polysaccharide (PSP) is an important functional ingredient. It shows various functions such as antioxidation, immunological regulation, antifatigue, antiviral, regulation of blood glucose and lipid, antibacterial and anti-inflammatory. So it has a good future in the fields of food and medicine. In this paper, the biological activities and the applications of PSB in medical prevention and treatment and the prospect of functional food were systematically summarized. KEY WORDS: polygonatum sibiricum polysaccharides; functional activity; application,,, [1,2] [3], (Polygonatum sibiricum polysaccharide, PSP), 1 黄精多糖的化学组成,, -,,,, [2] (thin-layer chromatography, TLC) (nuclear magnetic resonance, NMR) 基金项目 : ( ) (BPHR2012C01) Fund: Supported by Cooperation Project with Jiuhua Mountain Institute of Polygonatum ( ) and Funding Project for Academic Human Resources Development in Beijing Union University (BPHR2012C01) * 通讯作者 :,,, yanzhen@ygi.edu.cn *Corresponding author: ZHANG Yan-Zhen, Associate Professor, Department of Food Science, College of Art and Application, Beijing Union University, No.197, Beitucheng West Road, Haidian District, Beijing , China. yanzhen@ygi.edu.cn

2 274 4 (infrared spectroscopy, IR), α β, 2-6, 13 C-NMR 135DEPT-NMR : Ⅰ 4, β-(1 2), α, ; Ⅱ, 1 6, Ⅲ [1], [4] 2 黄精多糖的功能活性 2.1 抗氧化与抗衰老,,, [5-13] 抗脂质过氧化 (malondialchehyche, MDA), PSP MDA, [7] [8] 抗自由基 DNA,,, [9] 调节氧化防御相关酶活性, (superoxide dismutase, SOD), (glutathione peroxidase, GSH-Px),,, SOD GSH-Px Na + -K + - ATP Ca 2+ -ATP SOD GSH-Px, Na + -K + -ATP Ca 2+ -ATP, Ca 2+ [10], PSP SOD GSH-Px, (lipid peroxide, LPO) (lipofuscin, LF) B (B-type monoamine oxidase, MAO-B) [7, 11] DNA(mtDNA), DNA Ⅰ Ⅱ+ Ⅲ DNA γmrna,, DNA γmrna, Ⅰ Ⅱ+ Ⅲ [12],,,, [13] 2.2 免疫调节 T, (Cy), (DTH), Cy DTH, [14] PSW3A-1( ) PSW4A PSW5B( ) [4] 2.3 抗肿瘤, H 22 S 180 (MCF-27) Heps Eac, - [15,16],,

3 1, : 275 [16] 2.4 调节血糖和血脂 (TG) (TC), [17] (ALX),, NO NOS, TG TC, NO NOS [18] (STZ) STZ,,, Caspase3 [19] 2.5 抗疲劳,,,, [20] [21] 2.6 抗病毒,, Vero, 1 (Stoker ) 2 (333 Sav ), MTT, Vero,,, [22] 2.7 抑菌和抗炎,, (P<0.01), [3] 3 黄精多糖的应用前景,,,,, 3.1 黄精多糖在疾病预防与辅助治疗方面的应用前景预防和治疗动脉粥样硬化, (AS), AS AS AS, AS LDL-C HDL-C [23] AS, C- (CRP), CRP AS AS IL- 6 CRP,, AS AS [24] 预防和治疗老年性痴呆 (Alzheimer's disease, AD), AD, AD,, APP CA1,, [9] ; Morris AD, AD [25]

4 治疗帕金森病 (Parkinson disease, PD),, 6- PD PD, -γ (peroxisome proliferator-activated receptor-γ, PPAR-γ), PD,, ( AD PD ) [26] 改善抑郁, 5- (5-hydroxytryptamine, 5- HT) (dopamine, DA) (norepinephrine, NE) - 2(interleukin-2, IL-2),,,, (5-HT DA) IL-2,, [27] 3.2 黄精多糖在功能食品中的应用前景,, ;,, ;, ;,, [5-13],, [28],,, ;,, [29],,,,,,,, [30], [31],,, ( : );, ( : ) [30] ( ) ( : ) [32],,,, ( : ),,,,,,,,,,,,, 参考文献 [1]. [D]., Fang Y. Separation and structural analysis of Polygonatum polysaccharides and oligosaccharides [D]. Jiangnan University, 2011.

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第 33 卷第 2 期 2010 年 4 月 - 149 - 脱蛋白较好的方法是 Sevag 法, 它是根据蛋白质在氯仿等有机溶剂中变性的特点, 使蛋白质变性成胶状, 此法条件温和, 可避免多糖的降解

第 33 卷第 2 期 2010 年 4 月 - 149 - 脱蛋白较好的方法是 Sevag 法, 它是根据蛋白质在氯仿等有机溶剂中变性的特点, 使蛋白质变性成胶状, 此法条件温和, 可避免多糖的降解 - 148 - Drug Evaluation Research Vol.33 No.2 April 2010 植物多糖的研究进展陶遵威 1, 郑夺 1, 邸明磊 2, 单晓菊 1 天津市医药科学研究所, 天津 300020; 2 天津中医药大学, 天津 300073 2 摘要多糖是由单糖连接而成的多聚物,