UMA UE Anapenil (Clemizole Penicillin and Benzylpenicillin) Grossman, Mexico Biconcilina C Life, Ecuador ClemizolPenicilina Infarmasa, Peru Magnacilin

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UMA UE Anapenil (Clemizole Penicillin and Benzylpenicillin) Grossman, Mexico Biconcilina C Life, Ecuador ClemizolPenicilina Infarmasa, Peru Magnacilina Terbol, Peru Medicilina Medifarma, Peru

2 UMA UE Anapenil (Clemizole Penicillin and Benzylpenicillin) Grossman, Mexico Biconcilina C Life, Ecuador ClemizolPenicilina Infarmasa, Peru Magnacilina Terbol, Peru Medicilina Medifarma, Peru Megacilina Forte (ClemizolePenicillin and Benzylpenicillin) Grünenthal, Peru Megacilina Grünenthal, Peru VETERIARY UE PEICILLI G CLEMIZ Target Animals : espo (Partocillina - Ceva) espo, Peru Topkim (Clemipen trep) Topkim, Turkey Woogene B&G Co., Ltd. Woogene B&G Co., Ltd., Korea ertape (Partomicina) ertape, Brazil EVULTI A Via Pioda 12, 6901 Lugano (witzerland). Tel. +41 (0) , Fax. +41 (0) mail: info@evultisgroup.com ERVICE trategic sourcing of A.P.I.s and intermediates The activity of Evultis A started with the trading of pharmaceutical tudy and development of formulation in bulk according to raw materials, APIs and intermediates, for human and veterinary customer request. uses. Evultis Group is a private company active in the ealthcare InThe constant development of the company, along with the evolution dustry. of the markets, has brought Evultis A to grow year after year and diversify its marketing approaches to face the changes in the require- Evultis Group employs in its controlled companies around 30 people and has a turn-over of more than 45 millions UD. ments as products and customer s requirements. Evultis A has been established in Today Evultis A can be considered the best partner for the small API manufacturing companies which doesn t have the necessary skills to reach the regulated markets and the best partner for the Finished Products marketing companies which need rapidity and flexibility in the operation. Evultis Group is considered as one of the best partner in the human and animal ealthcare Industry. Through the integrated activity of its controlled companies and the worldwide network of partenership and links, Evulris Group can offer a 360 range of services and give a fast and concrete answer to all the present and future needs of the ealthcare Industry. 3

Evultis/Friulchem China Joint Venture Evultis/Friulchem 合资公司 - Activities: Identify reliable manufacturers in China for regulated markets as EU and UA. Coordinate DMF preparation and on-site audits.

3 Evultis/Friulchem China Joint Venture Evultis/Friulchem 合资公司 - Activities: Identify reliable manufacturers in China for regulated markets as EU and UA. Coordinate DMF preparation and on-site audits. Facilitate business operations as solution provider. Partner with local pharmaceutical giants for leading and pioneer APIs and FDFs. - 主要活动 : 为欧洲和美国法规市场在中国大陆寻找可靠的生产商 ; 协调 DMF 文件编写和现场检查 ; 为业务开展提供解决方案 ; 与本土制药企业建立长期稳定的伙伴关系并合作开展前沿原料药和制剂市场开发 ffer to China: - Pidobenzone to be registered in both China and. Korea. - FC products and services - ome pioneer APIs and dosage forms for China (drugs for respiratory contract infections and anti-cancer and tumor drugs). Collaborative research and development is preferred. - K-5 series 针对中国市场, 开展以下工作 : - 在中国和韩国注册化妆品原料匹度苯宗 - 在中国大陆市场推广和销售 FC 产品与服务 - 在中国大陆开展前沿原料药与制剂的联合研发 ( 呼吸系统药物, 抗癌和抗肿瘤药物优先 ) - K-5 系列产品的注册与市场开发 5

4 PRDUCT 7

5 APIs PEICILLI G CLEMIZLE o. Product ame CA. o. pecification 1 Cefprozil UP36 2 Ceftibuten ydrate JP16 3 Cefcapene Pivoxil ydrochloride ydrate JP16 4 Cefditoren Pivoxil JP16 5 Cefozopran ydrochloride JP16 6 Cefpodoxime Proxetil JP16 7 Carumonam odium JP16 8 Tolnaftate EP7.5 9 Tulobuterol hydrochloride In ouse β-lactam antibiotic intermediates, main nucleus, precursor o. Product ame CA. o. Remarks 1 7-APRA For Cefprozil 2 AM For Ceftibuten 3 7-ATCA For Cefditoren Pivoxil 4 BC For Cefcapene Pivoxil 5 PIVA For Cefcapene Pivoxil 6 3-ydroxy Cephem For Ceftizoxime sodium 7 7-AMCA For Cefpodoxime Proxetil 8 7-AVCA For Cefixime/ Cefdinir 9 Ceftezole Acid Ceftezole Acid 10 7-ACP Main nucleus of Cefozopran 11 AMA Main nucleus of Aztreonam 12 Flomoexf Main nucleus of Flomoexf 13 main nucleus of carumonam main nucleus of carumonam ide Chains of cephalosporin o. Product ame CA PE 2-Pentenedioic acid,2-[2[[(phenylmethoxy) carbonyl]-amino]-4-thiazolyl]-,5-(3-methyl-2-buten- 1-yl) ester MFTA 4-Methyl-5-formylthiazole BAPA (Z)-2-(2-t-Butoxycarbonylaminothiazol-4-yl)-2-pentenoic acid MBTA Methyl 2-(2-benzyloxycarbonylaminothiazol-4-yl) acetate ATAA 2-(2-Aminothiazol-4-yl) acetic acid EATA Ethyl 2-(2-aminothiazol-4-yl) acetate EBTA Ethyl 2-(2-benzyloxycarbonylaminothiazol-4-yl) acetate ATA 2-(2-Aminothiazol-4-yl) acetic acid hydrochloride DAEM -2-Benzothiazolyl (Z)-2-(2-aminothiazol-4-yl)-2-acetylox-yiminothioacetate BAEM -2-Benzothiazolyl (Z)-2-(2-aminothiazol-4-yl)-2-trityloxy-iminothioacet ate ATA (Z)-2-(2-aminothiazol-4-yl)-2-trityloxyiminoacetic acid MIM 3-ydroxy-5-mercapto-4-isothiazolecarboxylic acid monosodium salt

6 o. Product ame CA.. PEICILLI G CLEMIZLE MIT 3-ydroxy-5-mercapto-4-isothiazolecarboxylic acid trisodium salt ATDE (Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetica acid EFTG Ethyl 2-(2-formylaminothiazol-4-yl) glyoxylate AIBA 2-Aminooxy-e-methylpropanoic acid hydrochloride EAT Ethyl ( Z )-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate ATA ( Z )-2-(2-Aminothiazol-4-yl)-2-hydroxyiminoacetic acid Mercapto-4-(4-pyridinyl) thiazole ATDA ( Z )-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetic acid ZAEM -2-Benzothiazolyl ( Z )-2-(5-amino-1,2,4-thiadiazol-3-yl)-2- methoxyiminothioacetate MIA ( Z )-2-Methoxyimino-2-furylacetic acid ammonium salt TBCA ( Z )-2-(2-Aminothiazol-4-yl)-2-(t-butoxycarbonylmethoxyimino) acetic acid FATA 2-(2-Formylaminothiazol-4-yl) acetic acid EATG Ethyl 2-(2-aminothiazol-4-yl) glyoxylate ther intermediates o. Product ame CA. o. Abbreviation Remarks Benzyl(3-fluoro-4-morpholinohenyl) carbamate Linezolid nucleus Linezolid intermediate ()-(2,6,7,8-four-1-hydrogen Indeno[5,4-b] ILinezolid side chain Ramelteon intermediates furan-8-based) acetic acid ()-(2,6,7,8-four-1-hydrogen Indeno[5,4-b] Indeno furan acetic Ramelteon intermediates furan-8-based) acetic acid acid Intermediate for pharmaceuticals and agrochemicals o. Product ame CA. o. pecification 1 -Methylhydroxylamine hydrochloride In house 2,-Dimethylhydroxylamine hydrochloride In house DMTD In house 2,5-Dimercapto-1,3,4-thiadiazole 双 DMTD In house Bis(2-mercapto-1,3,4-thiadiazol)-5,5 -disulfane AMTD In house 2-Amino-5-mercapto-1,3,4-thiadiazole 10 11

PEICILLI G CLEMIZLE Product CA r Usage para hydroxy phenyl glycine methyl ester cl 57591-61-4 Cefalexin para hydroxy pheny glycine methyl potassium dane salt 69416-61-1 Cefalexin d-para hydroxy

7 PEICILLI G CLEMIZLE Product CA r Usage para hydroxy phenyl glycine methyl ester cl Cefalexin para hydroxy pheny glycine methyl potassium dane salt Cefalexin d-para hydroxy phenyl glycine methyl ester Cefadroxil D-dihydrophenylglycine sodium dane salt (DG a) idechain for cefradine Amoxicillin trihydrant D-Alpha Phenylglycine Dane alt (ethyl potassium) For Cefalexin TAC(2-thiopheneacetylchloride) Intermediate for Cefaxitin MMTD For Cefazolan/cefazolin/ cefazedone 7-TDA - For Cefazolin or Cefazedone TAA(1-tetrazole-1-YL-Acetic acid) For Cefazoline MMTZ(1-methyl-5-mercapto-tetrazole For Cefoperazone ulbactam acid ulbactam sodium D-Dihydrophenyl glycine base (DG) idechain for cefradine (enzymatic) 12 13

8 PEICILLI G CLEMIZLE 原料药 (APIs) 部分一口服头孢菌素类 (ral cephalosprins) 原料药 PRDUCT LIT 序号药品名称 CA 登记号分分执行标准 1 头孢丙烯 Cefprozil (6R,7R)-3- 丙烯基 -7-[(R)-2- 氨基 -2-(4- 羟基苯基 ) 乙酰氨基 ] -8- 氧代 -5- 硫杂 -1- 氮杂双环 [4.2.0] 辛 -2- 烯 -2- 甲酸一水合物 (6R,7R)-7-[[(2R)-Amino-2-(4-hydroxyphenyl)acetyll]amino]-8-oxo-3-(1-propenyl)- 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate C Cefpodoxime proxetil CGMP. 2 UP32 CP2010 CGMP 4 头孢妥仑匹酯 Cefditoren Pivoxil (6R,7R)-7-[(Z)-2-(2- 氨基 -4- 噻唑基 )-2-( 甲氧亚氨基 ) 乙酰氨基 ]-3-[(1Z)-2-(4- 甲基噻唑 -5- 基 ) 乙烯基 ]-8- 氧代 -5- 硫杂 -1- 氮杂双环 [4.2.0] 辛 -2- 烯 -2- 甲酸新戊酰氧甲酯 2,2-Dimethylpropanoyloxymethyl (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)- 2-methoxyiminoacetylamino]-3-[(Z)-2-(4-methylthiazol-5-yl]ethenyl-8- oxo-5-thia-1-azabicylo[4.2.0]oct-2-ene-2-carboxylate 5 盐酸头孢卡品匹酯 Cefcapene Pivoxil ydrochloride ydrate (6R,7R)-7-[[(Z)-(2- 氨基噻唑 -4- 基 )-2- 戊烯酰 ] 氨基 ]-3- 氨甲酰氧甲基 -8- 氧代 -5- 硫杂 -1- 氮杂双环 [4.2.0] 辛 -2- 烯 -2- 甲酸新戊酰氧甲酯盐酸盐一水合物 (6R,7R)-3-[[(Aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)- 1-oxo-2-pentenyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy)methyl ester hydrochloride monohydrate C C Cl Cl. 2 JP15 JP15 3 头孢布烯 Ceftibuten (6R,7R)-7-[(Z)-2-(2- 氨基 -4- 噻唑基 )-4- 羧基 -2- 丁烯 -1- 氧代氨基 ]-8- 氧代 -5- 硫杂 -1- 氮杂双环 [4.2.0] 辛 -2- 烯 -2- 甲酸二水合物 (6R,7R)-7-[2-(2-Amino-1,3-thiazol-4-yl)-4-carboxy-2-butenamide]-8- oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrate C JP15 二单环 β- 内酰胺类 (Monobactams) 原料药序号药品名称 CA 登记号执行标准 1 氨曲南 Aztreonam UP32 [2-[2α,3β(Z)] ]- 2-[[[1-(2- 氨基 -4- 噻唑基 )-2-[(2- 甲基 -4- 氧代 -1- 磺基 -3- JP15 氮杂环丁烷基 ) 氨基 ]-2- 氧代亚乙基 ] 氨基 ] 氧 ]-2- 甲基丙酸 C02010 [2-[2a,3β(z)]]-2-[[[1-(2-amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo- 2 3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropionic acid C

9 PEICILLI G CLEMIZLE 三抗真菌类 (Antifungal) 原料序号药品名称 CA 登记号执行标准 1 托萘酯 Tolnaftate UP32 - 甲基 --(3- 甲基苯基 ) 硫代氨基甲酸 -2- 萘酯 JP15 -aphthalen-2-yl -methyl--(3-methylphenyl)thiocarbamate EP6.0 C 四抗组胺类 (Antihistaminics) 原料药序号药品名称 CA 登记号执行标准 1 盐酸西替利嗪 Cetirizine Dihydrochloride 2-[2-[(4- 氯苯基 ) 苯甲基 ]-1- 哌嗪基 ] 乙氧基 ] 乙酸盐酸盐 2-[2-[ ( 4-chlorophenyl ) phenylmethyl]-1-piperazinyl]ethoxyl]acetic acid dihydrochloride 盐酸左西替利嗪 Levocetirizine Dihydrochloride (-)-2-[2-[(4- 氯苯基 ) 苯甲基 ]-1- 哌嗪基 ] 乙氧基 ] 乙酸盐酸盐 (-)-2-[2-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxyl] acetic acid dihydrochloride Cl. 2Cl C 21 25Cl 2 3 2Cl Cl. 2Cl C 21 25Cl 2 3 2Cl EP6.0 UP32 JP15 E. β- 内酰胺类抗生素中间体 β-lactam antibiotic intermediates main nucleus precursor 序号产品名称 Product name CA 登记号用途 Application 1 头孢丙烯母核 7-APRA 7-APCA 用于头孢丙烯的合成 (6R,7R)-7- 氨基 -8- 氧代 -3-(1- 丙烯基 )-5- 硫杂 -1- 氮杂双环 [4.2.0] 辛 -2-2 For cefprozil 烯 -2- 羧酸 (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicylo[4.2.0]oct- 2-ene-2-carboxylic acid C 头孢布烯母核 7-ACAB 用于头孢布烯的合成 2 (6R,7R)-7- 氨基 -8- 氧代 -5- 硫杂 -1- 氮杂双环 [4.2.0] 辛 -2- 烯 -2- 羧酸二 For ceftibuten 苯甲酯 (6R,7R)-7-Amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carbox ylic acid diphenylmethyl ester 3 头孢妥仑母核 7-ATCA (6R,7R)-7- 氨基 -3-[(Z)-2-(4- 甲基噻唑 -5- 基 ] 乙烯基 -8- 氧代 -5- 硫杂 -1- 氮杂双环 [4.2.0] 辛 -2- 烯 -2- 羧酸 (6R,7R)-7-Amino-3-[(Z)-2-(4-methylthiazol-5-yl]ethenyl-8-oxo-5-thia- 1-azabicylo[4.2.0]oct-2-ene-2-carboxylic acid 4 头孢卡品母核 BC BPCM (6R,7R)-7-[[(Z)-2-(2- 叔丁氧羰基氨基噻唑 -4- 基 )-2- 戊烯酰 ] 氨基 ]-3- 氨基甲酰氧甲基 -8- 氧代 -5- 硫杂 -1- 氮杂双环 [4.2.0] 辛 -2- 烯 -2- 羧酸二异丙胺盐 (6R,7R)-7-[[(Z)-2-(2-t-Butoxycarbonylaminothiazol-4-yl)-2- pentenoyl]amino]-3-aminocarbonyl-oxymethyl-8-oxo-5-thia-1- azabicylo[4.2.0]oct-2-ene-2-carboxylic acid diisopropylamine salt C C C 用于头孢妥仑匹酯的合成 For cefditoren pivoxil 用于头孢卡品酯的合成 For cefcapene pivoxil hydrochloride 16 17

10 PEICILLI G CLEMIZLE 5 叔丁氧羰基头孢卡品酯 PIVA BPC (6R,7R)-7-[[(Z)-2-(2- 叔丁氧羰基氨基噻唑 -4- 基 )-2- 戊烯酰 ] 氨基 ]-3- 氨基甲酰氧甲基 -8- 氧代 -5- 硫杂 -1- 氮杂双环 [4.2.0] 辛 -2- 烯 -2- 羧酸新戊酰氧甲酯 2,2-Dimethylpropanoyloxymethyl (6R,7R)-7-[(Z)-2-(2-t-Butoxycarbonylamino-thiazol-4-yl)pent-2-enoylamino]-8-oxo-3-aminocarb-on yloxymethyl-5-thia-1-azabicylo[4.2.0]oct-2-ene-2-carboxylate 6 7-ACA 7-ACA (6R,7R)-7- 氨基 -8- 氧代 -5- 硫杂 -1- 氮杂双环 [4.2.0] 辛 -2- 烯 -2- 羧酸 7-Amino-3-nor-3-cephem-4-carboxylic acid C 用于头孢卡品酯的合成 For cefcapene pivoxil hydrochloride 用于头孢唑肟钠的合成 For ceftizoxime 9 a 晶型氨曲南 a-form aztreonam [2-[2α,3β(Z)] ]- 2-[[[1-(2- 氨基 -4- 噻唑基 )-2-[(2- 甲基 -4- 氧代 -1- 磺基 -3- 氮杂环丁烷基 ) 氨基 ]-2- 氧代亚乙基 ] 氨基 ] 氧 ]-2- 甲基丙酸 [2-[2a,3β(z)]]-2-[[[1-(2-amino-4-thiazolyl)-2-[(2-methyl-4- oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2- methylpropionic acid C 用于氨曲南的合成 For aztreonam 7 头孢唑肟酸 ceftizoxime (6R,7R)-7-[(Z)-2-(2- 氨基 -4- 噻唑基 )-2-( 甲氧亚氨基 ) 乙酰氨基 ]-8- 氧代 -5- 硫杂 -1- 氮杂双环 [4.2.0] 辛 -2- 烯 -2- 甲酸 (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetylamino]-8- oxo-5-thia-1-azabicylo[4.2.0]oct-2-ene-2-carboxylic acid 8 氨曲南母核 AMA, main nucleus of aztreonam (2,3)-3- 氨基 -2- 甲基 -4- 氧代 -1- 氮杂环丁基磺酸 ( 2,3 )-3-Amino-2-methyl-4-oxo-1-azetidinesulfonic acid C C C 用于头孢唑肟钠的合成 For ceftizoxime sodium 用于氨曲南的合成 For aztreonam 头孢菌素类抗生素侧链 ide Chains of cephalosporin 序号产品名称 Product name CA 登记号用途 Application 1 PE 用于头孢布烯的合成 2-(2- 苄氧羰基氨基噻唑 -4- 基 )-4-(3- 甲基 -2- 丁烯氧羰基 )-2- For ceftibuten 丁烯酸 2-Pentenedioic acid, 2-[2-[[(phenylmethoxy)carbonyl]- amino]-4-thiazolyl]-, 5-(3-methyl-2-buten-1-yl) ester 2 MFTA 4- 甲基 -5- 甲酰基噻唑 4-Methyl-5-formylthiazole C 用于头孢妥仑酯的合成 For ceftitoren pivoxil C

11 3 BTPA BAPA PEICILLI G CLEMIZLE ( Z )-2-(2- 叔丁氧羰基氨基噻唑 -4- 基 )-2- 戊烯酸 (Z )-2-(2-t-Butoxycarbonylaminothiazol-4-yl)-2-pentenoic acid 用于头孢卡品酯的合成 For cefcapene pivoxil 8 MBTA 2-(2- 苄氧羰基氨基噻唑 -4- 基 ) 乙酸甲酯 Methyl 2-(2-benzyloxycarbonylaminothiazol-4-yl) acetate 用于头孢替安和头孢布烯的合成 For cefotiam or ceftibuten 4 ATA 酯 EATA 2-(2- 氨基噻唑 -4- 基 ) 乙酸乙酯 Ethyl 2-(2-aminothiazol-4-yl) acetate 5 ATA 酸 ATAA 2-(2- 氨基噻唑 -4- 基 ) 乙酸 2-(2-Aminothiazol-4-yl) acetic acid 6 ATA 盐酸盐 ATA 2-(2- 氨基噻唑 -4- 基 ) 乙酸盐酸盐 2-(2-Aminothiazol-4-yl) acetic acid hydrochloride 7 EBTA 2-(2- 苄氧羰基氨基噻唑 -4- 基 ) 乙酸乙酯 Ethyl 2-(2-benzyloxycarbonylaminothiazol-4-yl) acetate C C C Cl C Cl C 用于头孢替安的合成 For cefotiam 用于头孢替安的合成 For cefotiam 用于头孢替安的合成 For cefotiam 用于头孢替安和头孢布烯的合成 For cefotiam or ceftibuten C EFTG 10 IBA 2-(2- 甲酰氨基噻唑 -4- 基 ) 乙醛酸乙酯 Ethyl 2-(2-formylaminothiazol-4-yl) glyoxylate 2- 氨基氧基 -2- 甲基丙酸盐酸盐 2-Aminooxy-2-methylpropanoic acid hydrochloride 11 TAEM 12 ATDA ( Z )-2-(2- 氨基噻唑 -4- 基 )-2-(1- 叔丁氧羰基 -1- 甲基 ) 乙氧亚氨基硫代乙酸 (-2- 苯并噻唑 ) 酯 -2-Benzothiazolyl ( Z )-2-(2-aminothiazol-4-yl)-2- (1-t-butoxycarbonyl-1-methyl)ethoxyiminothioacetate ( Z )-2-(5- 氨基 -1,2,4- 噻二唑 -3- 基 )-2- 甲氧亚氨基乙酸 ( Z )-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetic acid C C Cl Cl C C 用于头孢他啶氨曲南等的合成 For ceftazidime etc. 用于头孢他啶氨曲南等的合成 For ceftazidime, aztreonam 用于头孢他啶氨曲南等的合成 For ceftazidime, aztreonam 用于头孢唑兰的合成 For cefozopran

12 PEICILLI 13 ZAEM G CLEMIZLE ( Z )-2-(5- 氨基 -1,2,4- 噻二唑 -3- 基 )-2- 甲氧亚氨基硫代乙酸 (-2- 苯并噻唑 ) 酯 -2-Benzothiazolyl ( Z )-2-(5-amino-1,2,4-thiadiazol-3-yl)- 2-methoxyiminothioacetate 15 ATDE ( Z )-2-(5- 氨基 -1,2,4- 噻二唑 -3- 基 )-2- 乙氧亚氨基乙酸 (Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetic acid C 用于头孢唑兰的合成 For cefozopran 用于 ceftaroline 等的合成 For ceftaroline 20 异噻唑三钠盐 MIT 3- 羟基 -5- 巯基 -4- 异噻唑羧酸三钠盐 3-ydroxy-5-mercapto-4-isothiazolecarboxylic acid trisodium salt 21 BAEM ( Z )-2-(2- 氨基噻唑 -4- 基 )-2- 三苯甲氧亚氨基硫代乙酸 (-2- 苯并噻唑 ) 酯 -2-Benzothiazolyl ( Z )-2-(2-aminothiazol-4-yl)-2-trityloxyiminothioacet ate a a a C 4a 用于头孢替坦的合成 For cefotetan 用于头孢地尼等的合成 For cefdinir etc. 17 MTD 2- 巯基 -1,3,4- 噻二唑 2-Mercapto-1,3,4-thiadiazole 18 MMT 2- 巯基 -4- 甲基 -5- 噻唑乙酸 2-Mercapto-4-methyl-5-thiazoleacetic acid 19 异噻唑单钠盐 MIM 3- 羟基 -5- 巯基 -4- 异噻唑羧酸单钠盐 3-ydroxy-5-mercapto-4-isothiazolecarboxylic acid monosodium salt C C C a C 4 2a 用于头孢替唑的合成 For ceftezole 用于头孢地嗪的合成 For cefodizime 用于头孢替坦的合成 For cefotetan 22 ATAIA ( Z )-2-(2- 氨基噻唑 -4- 基 )-2- 乙酰氧亚氨基乙酸 ( Z )-2-(2-Aminothiazol-4-yl)-2-acetyloxyiminoacetic acid 23 CAEM ( Z )-2-(2- 氨基噻唑 -4- 基 )-2- 乙酰氧亚氨基硫代乙酸 (-2- 苯并噻唑 ) 酯 -2-Benzothiazolyl ( Z )-2-(2-aminothiazol-4-yl)-2-acetyloxyiminothioacetate C C C 用于头孢地尼等的合成 For cefdinir etc. 用于头孢地尼等的合成 For cefdinir etc

13 P.. Box 5183 Via Pioda, 12 C-6901 Lugano witzerland

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untitled NICPBP 1. 2008 NICPBP 2003 /NICPBP 2. 1 2 3 NICPBP 4 NICPBP 5 NICPBP 3. 1 (2) - 1 - 3 4. 1 2 2008 1 1-2 - 2 chlorophenyl)diphenylmethanol - 3 - - 4 - - 5 - - 6 - - 7 - - 8 - - 9 - - 10 - - 11 - - 12 -