乳清蛋白與免疫力.pdf

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1 Paul Cribb Director of Research, AST Sports Science, Colorado Carla Sorensen Director, Whey Protein Institute, Minnesota ( g l u t a t h i o n e, G S H ) (Glutamine) GSH 1

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7,14,30,40,55 2 0 % 3 5, 4 6 - - 2 3 2 2 19,62 WPC W P I 2 9, 3 7 W P C 8 0 1 00 8 0% 1.20 g 1.50 g 5.36 g 6.25 g 4.80 g 5.90 g 8.08 g 13.00 g 7.84 g 9.15 g 1.60 g 2.05 g 2.72 g 3.10 g 2.

4 7,14,30,40, % 3 5, ,62 WPC W P I 2 9, 3 7 W P C % 1.20 g 1.50 g 5.36 g 6.25 g 4.80 g 5.90 g 8.08 g g 7.84 g 9.15 g 1.60 g 2.05 g 2.72 g 3.10 g 2.48 g 2.30 g 2.24 g 3.15 g 4.45 g 5.35 g 2.00 g 2.65 g 1.20 g 1.35 g 4.08 g 6.00 g 8.00 g 9.00 g g g 1.36 g 2.35 g 5.12 g 4.80 g 4.08 g 5.00 g % 4 0 W P C ,41 4

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G S H 5 8 3 8 G S H 6,58,65 G S H 3 6 5 G S H 4 3, 5 8 G S H G S S G 6,37,58,65 ( W P C ) ( W P I ) 4 1 6 W P C W P I G S H G S H G S S

6 G S H G S H 6,58,65 G S H G S H 4 3, 5 8 G S H G S S G 6,37,58,65 ( W P C ) ( W P I ) W P C W P I G S H G S H G S S G 8, 9, 3 7, 3 9, 4 3 G S H 7-14,39,40,44 ( B C A A s ) B C A A s 3 2 B C A A s 6 2 WPI W P I G S H 45,

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8 3 3, 3 4, 4 4, 6 4 G S H. W P C 2 0 % W P C G S H 3 7 W P I 6 4 % G S H G S H 3 7 G S H 1 0, 3 3, 3 4, D r. Mickael Murray 2 0 ~ 30 B C A A s 8

( B C A A s ) 26% 6 % 1 6 1 / 3 G H S 1 0 0 4 * ( 40% / 3 0% / 30 % ) % 18.29 16.17 14.89 11.

9 ( B C A A s ) 26% 6 % / 3 G H S * ( 40% / 3 0% / 30 % ) % / * DAV ISCO FOOD S I NTERNA- TIONAL, Inc. 9

10 H I V Patrick Micke M.D., Medical Department Johannes Gutenberg University, Germany H I V H I V 3 H I V H I V H I V [Bounous et al.,1993] H I V H I V H I V % 1 5 G S H 2 2 HIV G S H [Micke et al., 2001] 1 8 H I V G S H H I V T 1 4 G S H H I V G S H [Agin et al., 2001] G S H 6 _ _ [Chlebowski et a l., 1993 ] 4 76 [Williams et al., 2003 ] 1. Agin D, Gallagher D, Wang J, Heymsfield SB, Pierson RN Jr, Kotler DP. Effects of whey protein and resistance exercise on body cell mass, muscle strength, and quality of life in women with HIV. AIDS. 2001,15: Bounous G, Batist G, Gold P. Immunoenhancing property of dietary whey protein in mice: role of glutathione. Clin Invest Med ,12 : Chlebowski RT, Beall G, Grosvenor M, Lillington L, Weintraub N, Ambler C, Richards EW, Abbruzzese BC, McCamish MA, Cope FO. Long-term effects of early nutritional support with new enterotropic peptide-based formula vs. standard enteral formula in HIV- i n f e c t e d patients: randomized prospective trial. Nutrit i o n. 1993, 9: Micke P, Beeh KM, Buhl R. Effects of long-term supplementation with whey proteins on plas ma glutat hione levels of HIV-infected patients. Eur J Nutr. 2002, 41: Micke P, B eeh KM, Schlaak JF, Buhl R. Oral supplementation with whey proteins increases plasma glutathione levels of HIV- i n f e c t e d patients. Eur J Clin Invest. 2001, 31:

1. Allison KC ed. Healthy Eating: A Guide t o the New Nut rition. Harvard Health R eport Harvard Health Publications, 2003. 2. Allison KC ed Living Better, Living Longer. The Secrets of Healthy Aging.

11 1. Allison KC ed. Healthy Eating: A Guide t o the New Nut rition. Harvard Health R eport Harvard Health Publications, Allison KC ed Living Better, Living Longer. The Secrets of Healthy Aging. Harvard Health Report Harvard Health Publi cations, Baladoo A, R eid M, Forrester T, Heird WC, Jahoor F. Cysteine supplement ation improves the eryt hrocyte glutathione synthesis rate in children with severe edematous malnutrition. Am J Cli n Nutr 76:646 52, Barringer TA, Kirk JK, Santaniello AC, et al. Effect of a multivitamin and mineral supplement on infection and quality of life Ann Intern M e d : , Bos C, Gaudichon C, Tomé D. Isotopic studies of protein and amino acid requirements. Curr Opin Clin Nutri and Metab Care 51: , Bounous G, Molson JH. The antioxidant s ystem. Anti cancer Res , Bounous G. Whey protein concentrate (WPC) and glutathione modulation in cancer treatment. Anticancer Res 20: , Bounous G, Batist G, Gold P. Immunoenhancing property of dietary whey protein in mice: role of glutathione. Cl in Invest Med12 ; 3: , Bounous G, Kongshavn PA, Gold P. The immunoenhancing property of dietary whey protein concentrate. Clin Invest Med 11; 4 : , Bounous G, Papenburg R, Kongshavn PA, Gold P, Fleiszer D. Dietary whey protein inhibits the development of dimethylhydrazine induced m a l i g n a n c y. Clin Invest Med 11; 3 :213-7, Bounous G, Kongshavn PA. Differential effect of dietary protein type on t he B-cell and T-cell immune responses in mice. JNutr 115;11: , Bounous G, Letourneau L, Kongshavn PA. Influence of dietary protein type on the immune system of mice. JNutr 113 ;7: , Bounous G, Kongshavn PA. Influence of dietary proteins on the immune s ystem of mice. JNutr 112 ; 9: , Bounous Gand Kongshavn PK. Influence of Protein Type in Nutritionally Adequate Diets on the Development of Immunity. In Absorption and Uti liz ation of Amino Acids., ed. M. F riedman. Boca Raton, FL: CRC Press, Inc Brosche T and Platt D. Nutritional Factors and Age Associated Changes in Cellular Immunity and Phagocytos is: A Mini-Review. Aging: Immunology and Infe ctio us Dise ase 6(1): , Bucci LR & Unlu L. Proteins and amino acids in exercise and sport. In: Energy-Yi e l d i n g Macronutrients and Energy Metabolism in Sports Nutrition. Driskell J, and Wolinsky I. Eds. CRC Press. Boca Raton FL, p , Cheng YJ, Macera CA, Church TS, and Blair SN. Heart rate reserve as a predictor of cardiovascular and all-caus e mortality in men. Med Sci Sports Exerc3 4;12: , Child RB, B ullock M, Palmer K, Physiological and biochemical effects of whey protein and ovalbumin supplementation in healthy males. Med Sci Sports Exerc 35; 5:S270, Clare DA and Swaisgood HE. Bioactive milk peptides: A prospectus. J Dairy Sci8 3: , Cribb PJ, Williams AD, Hayes A and Carey MF. The effect of whey isolat e on strength, body composition and plasma glutamine. Med Sci Sports Exerc 34;5:S299, Cross ML, and Gill HS, Modulation of Immune Function by a Modified Bovine Whey Protein Concentrate. Immunology and C el Biology77: , Cross M L and Gill HS. Immunomodulat ory properties of milk. British J Nutr 8 4 : S81-S89, Dangin M, Guillet C, Garcia-Rodenas C, et al., The rate of protein digestion affects protein gain differently during aging in humans. J. Physiol 549.2: , Deneke SM and Fanburg BL. R egulation of cellular glutathione. Am J Physiol 2 57: L16 3 -L17 3, de Wit JN, Nutrit ional and funct ional characteristics of whey proteins in food product s. J Dairy Sci 81: , Dröge W and Holm E. Role of cyst(e)ine and glut athione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J11: , Enomoto M, Konishi A, Hachimura S, and Kaminogawa S. Milk Whey Protein Fed As a Constituent of t he Diet Induced Both Oral Tolerance and a Systemic Humoral Response, While Heat Denatured Whey Protein Induced Only Oral Tolerance. Clini cal Immunology and I m m u n o p a t h o l o g y 6 6 ; 2: , Farnsworth E, Lus come ND, Noakes M, et al., Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women. Am J Clin N u t r 7 8 :31-39, Field CJ. Us e of T cell function to determine the effect of physiologically active food components Am J Clin Nutr 71: S-1725, Ford JT, Wong CW, Colditz IG. Effects of dietary protein types on immune responses and levels of infection with Eimeria vermiformis in mice. Immunol Cell Biol 7 9;1:23-8, Gleeson M, Neiman DC, Pedersen BK. Exercise, nutrit ion and immune function. JSports Sci 2 2: , Ha E and Zemel MB. Functional properties of w h e y, whey components, and essential amino acids: mechanisms underlying health benefits for active people. Journal of Nutri tional Biochemistry 14; , Hakkak R, Korourian S, Ronis MJ, Johnston JM, Badger TM. Dietary whey protein protects against azoxymethane-induced colon tumors in male rats. Cancer Epidemi ol Biomarkers Prev 10;5: 555-8,

12 3 4. Hakkak R, Korourian S, Shelnutt SR, Lensing S, Ronis MJ, Badger TM. Diets containing whey proteins or soy protein isolate protect against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in female rats. Cancer Epidemiol Biomarkers Prev9;1:113-7, Huffan LM and Harper WJ. Maximiz ing the Value of Milk Through Separation Technologies. JDairy Sci8 2 : , Irwin M, Thompson J, Miller C, Gillin JC and Ziegler M. Effects of sleep and sleep deprivation on catecholamine and interleukin-2 levels in humans: clinical implications. J of Cl in Endo & M e t a b 8 4 ; 6: , Kent KD, Harper WJ, Bomser JA. Effect of whey protein isolate on intracellular glutathione and oxidant-induced cell death in human prostate epithelial cells. Toxicol In Vi t r o 17;1: 27-33, Kinney JM, Allison SP. Clues to ageing from cells, organs and outer space. C urr Opi n Clin Nutr and Metab Care 6;1:3-7, Lands LC, Grey VL, and Smountas AA. Effect of supplementation with a cysteine donor on muscular performance. 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Curr Opin Clin Nutr Metab Care3 : , Peterson B K, Herzenberg LA, Vasquez K, Waltenbaugh C. Glut athione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc Natl Acad Sci9 5 : , Pizza FX. Overtraining and Immunity. Encyclopedia of Sports Medici ne and Science Ravaglia G, Forti P, Maioli F, et al. Effect of micronutrient status on natural killer cell immune function in healthy free-living s ubjects aged >/=90 years. Am J Clin Nutr 71( 2 ) : , Redwine L, Hauger RL, Gillin JC, Irwin M. Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. J Clin Endocrinol Metab 8 5;10 : , Rowbottom DG, Keast D, Morton AR. The emerging role of glutamine as an indicator of exercise stress and overtraining. Sports Med 21(2): 80-97, Seres T, Knickelbein RG, Warshaw JB, and Johnston RJ. The Phagocytosis-Associated Respiratory B urst in Human Monocytes Is A ssociated with Increased Uptake of Glutathione. 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非傳染病直擊2010年12月 - 汽水及兒童的健康

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