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1 1) : GERD. : , :. : :. : :. : : Mallory-Weiss. : :. : : B. : :. : : : :. : : 21. : :. : :. : Annual Review : 29. : 1

2 : Barrett. : :. : EBM : CGRP) : :. : MOOK : 27 : : 28 : : : : Part1 GERD. : Helicobacter pylori Q&A :. : UPDETA : GERD. : 96 GERD :. : :. : :. : : Mallory-Weiss. :

3 1 Hamamoto S, Fukuda R, Ishimura N, Rumi MAK, Kazumori H, Uchida Y, Kadowaki Y, Ishihara S, Kinoshita Y. 9-cis retinoic acid enhances the anti-viral effect of interferon on hepatitis C virus replication through increased expression of type-i interferon receptor. Journal of Laboratory and Clinical Medicine 141 (1): 58-66, Hiroshi Sato, Kousaku Kawashima, Mika Yuki, Hideaki Kazumori, Rumi MAK, Ortega-Cava CF, Shunji Ishihara, Yoshikazu Kinoshita. Lafutidine, a novel histamine H2-receptor antagonist, increases serum calcitonin gene-related peptide in rats after water immersion-restraint stress. Journal of Laboratory and Clinical Medicine 141 (2): , ) Kyoichi Adachi, Hirofumi Fujishiro, Takafumi Mihara, Yoshinori Komazawa, Yoshikazu Kinoshita. Influence of lansoprazole, famotidine, roxatidine and rebamipide administration on the urea breath test for the diagnosis of Helicobacter pylori infection. Journal of Gastroenterology and Hepatology 18 (2): , ) Yoshinori Komazawa, Kyoichi Adachi, Takafumi Mihara, Masahiro Ono, Akira Kawamura, Hirofumi Fujishiro and Yoshikazu Kinoshita. Tolerance to famotidine and ranitidine treatment after 14 days of administration in healthy subject without Helicobacter pylori infection. Journal of Gastroenterology and Hepatology 18 (6): , ) Fujishiro H, Adachi K, Imaoka T, Kohge N, Kawamura A, Komazawa Y, Ono M, Yuki M, Sato H, Amano Y, Ishihara S, Kinoshita Y. Analysis of urgent colonoscopy for acute lower intestinal bleeding. Digestive Endoscopy 15 (2): , ) Adachi K, Hashimoto T, Hamamoto N, Hirakawa K, Niigaki M, Miyaoka T, Taniura N, Ono M, Kaji T, Suetsugu H, Yagi J, Komazawa Y, Mihara T, Katsube T, Fujishiro H, Shizuku T, Hattori S, Yamamoto S, Kinoshita Y. Symptom relief in patients with reflux esophagitis: comparative study of omeprazole, lansoprazole and rabeprazole. Journal of Gastroenterology and Hepatology 18: , ) Adachi K, Arima N, Takashima T, Miyaoka Y, Yuki M, Ono M, Komazawa Y, Kawamura A, Fujishiro H, Ishihara S, Kinoshita Y. Pulse wave velocity and cardiovascular risk factors in subjects with Helicobacter pylori infection. Journal of Gastroenterology and Hepatology 18 (7): , ) Kinoshita Y, Adachi K, Fujishiro H. Review article: Therapeutic approaches to reflux diseases, focusing on acid secretion. Journal of Gastroenterology 38 (suppl 15): 13-19, ) Yuji Amano, Yoshinori Komazawa, Norihisa Ishimura, Hirofumi Fujishiro, Shunji Ishihara, Kyoichi Adachi and Yoshikazu Kinoshita. Prevalence of reflux esophagitis in patients with 3

4 duodenal ulcer and gastric ulcer. Journal of Gastroenterology 38 (5): , ) Kyoichi Adachi, Yoshinori Komazawa, Hirofumi Fujishiro, Takafumi Mihara, Masahiro Ono, Mika Yuki, Akira Kawamura, Mohammad Azharul Karim Rumi, Yuji Amano and Yoshikazu Kinoshita. Nocturnal gastric acid breakthrough during the administration of rabeprazole and ranitidine in Helicobacter pylori-negative cases: effects of different regimens. Journal of Gastroenterology 38 (9): , ). GERD GERD. 669: 37-40, ),,,,,,.. 18 (2): , ) Kyoichi Adachi, Tomoyuki Hashimoto, Shunji Ishihara, Hirofumi Fujishiro, Shuichi Sato, Hiroshi Sato, Yuji Amano, Shuzo Hattori, Yoshikazu Kinoshita. Comparison of five day Helicobacter pylori eradication regimens: rabeprazole-based and omeprazole-based with and without omeprazole pretreatment -open, prospective, randomized, multicenter study. Current Therapeutic Research 64: , ) Norihisa Ishimura, Kunihiro Yamasawa, Mohammad Azharul Karim Rumi, Yasunori Kadowaki, Shunji Ishihara, Yuji Amano, Yoshinori Nio, Tetsuya Higami, Yoshikazu Kinoshita. BRAF and K-ras gene mutations in human pancreatic cancers Cancer letters 199: , ),,,,,,,,,,.. 18 (4): , ),.. G. I. Research 11 (2): , ),,.. 33 (4): , ),,. Quiz 109. Clinician 49 (517): , ),,,,,,.. 6 (2): , ),,,,. PPI H2 H2RA PPI H2RA PPI. Therapeutic Research 24 (5): , ) Masahiro Ono, Hiroshi Sato, Hideaki Kazumori, Mika Yuki, Mohammad Azharul Karim 4

5 Rumi, Cesar Francisco Ortega-Cava, Yasunobu Ishihara, Shunji Ishihara, Kyoichi Adachi, Yoshikazu Kinoshita. Effect of a gastrin/cck-b receptor antagonist, S-0509, on the omeprazole-induced proliferation of gastric mucosa in rats. The Journal of Laboratory and Clinical Medicine 142: , ) Yuki T, Ishihara S, Rumi M, Ortega-Cava CF, Kadowaki Y, Kazumori H, Yuki M, Wada T, Miyaoka Y, Yoshino N, Kinoshita Y. Expression of midkine and receptor-like protein tyrosine phosphatase (RPTP)- genes in the rat stomach and the influence of rebamipide. Alimentary Pharmacology and Therapeutics 18 (suppl2): , ) Ortega-Cava CF, Ishihara S, Rumi MK, Kawashima K, Ishimura N, Kazumori H, Udagawa J, Kadowaki Y, Kinoshita Y. Strategic compartmentalization of tall-like receptor 4 in the mouse gut. The Journal of Immunology 170 (8): , ). NUD. Medical Academy News 850: 12, ),. Colitic Cancer. 23: , ),,,,,,,,,,. Boerhaave. 18: , ),. NUD. 18: , ),,,.. 37: , ),,,,,,,,,,. OPZ H. pylori HP OPZ. 35: 1-4, ),. H2. Medicine and Pharma 4: 2-5, ),,,. PPI. Medical Tribune 36 (26): 38-39, ),.. Care Net 61 (7): 4, ),,. H. pylori. 23 (6): , ),.. 23: , ),,. H2. Medical Tribune 36 (30,31): 11-14,

6 36) : 1239, ),,.. 6: , ) , ),,.. Medicina 40: , ),,. AGA 2002 in. 1: , ),,,,,,,. Barrett's surveillance. 30 (Suppl): 7-10, ),. GERD,. 54 : , ),.. 5 (2): 1-5, ).. MEDICAMENT NEWS 1780: 5-6, ),. NAB- nocturnal gastric acid breakthrough-. Current Review of Gastroenterology 8: 8-10, ),.. 80: , ). PPI QOL H2RA. CLINICIAN 50: , ),,. Helicobacter pylori Q&A No75 GERD Helicobacter Research 7: , ),,,,,. GERD Nocturnal gastric acid breakthrough. 15: , ).. 9: 1, ),,,,,,,,,,,.. 9: 91-95, ) Adachi K, Komazawa Y, Mihara T, Fujishiro H, Ishihara S, Amano Y, Kinoshita Y. Administration of H2 receptor antagonist with proton pump inhibitor is effective for 6

7 long-term control of refractory reflux esophagitis. Journal of Clinical Gastroenterology 38 (3): , ) Amano Y, Moriyama N, Suetsugu H, Ishimura N, Imaoka T, Komazawa Y, Fujishiro H, Ishihara S, Adachi K, Kinoshita Y. Which types of non-bleeding visible vessels in gastric peptic ulcers should be treated by endoscopic hemostasis? Journal of Gastroenterology and Hepatology 19 (1): 13-17, ) Youichi Miyaoka, Yasunori Kadowaki, Shunji Ishihara, Takayuki Ose, Hiroyuki Fukuhara, Hideaki Kazumori, Shin Takasawa, Hiroshi Okamoto, Tsutomu Chiba, Yoshikazu Kinoshita. Transgenic overexpression of Reg protein caused gastric cell proliferation and differentiation along parietal cell and chief cell lineages. Oncogene 23 (20): , ) Shuchin Tei, Naoto Kitajima, Shunji Ohara, Yoshifumi Inoue, Masaharu Miki, Toshiyuki Yamatani, Hiroshi Yamabe, Shunji Mishiro, Yoshikazu Kinoshita. Consumption of uncooked deer meat as a risk factor for hepatitis E virus infection: an age-and sex-matched case-control study. Journal of Medical Virology 74: 67-70, ) Kinoshita Y, Ishihara S. Is an intravenous histamine H2 receptor antagonist superior to an intravenous proton pump inhibitor in acid suppression? Journal of Gastroenterology 39 (1): 92-93, ) Amano Y, Komazawa Y, Ishimura N, Ohara S, Aimi M, Fujishiro H, Ishihara S, Adachi K, Kinoshita Y. Two cases of superficial cancer in Barrett's esophagus detected by chromoendoscopy with crystal violet. Gastrointestinal Endoscopy 59 (1): , ) Kinoshita Y, Ishihara S. Role of growth factors in the repair of gastric mucosal injury. Journal of Gastroenterology 39 (2): , ) Dhar DK, Udagawa J, Ishihara S, Otani H, Kinoshita Y, Takasawa S, Okamoto H, Kubota H, Fujii T, Tachibana M, Nagasue N. Expression of Regenerating Gene I in gastric adenocarcinomas: correlation with tumor differentiation status and patient survival. Cancer 100 (6): , ) Kinoshita Y, Ishihara S, Kadowaki Y, Fukui H, Chiba T. Review article: Reg protein is a unique growth factor of gastric mucosal cells. Journal of Gastroenterology 39 (6): , ) Adachi K, Furuta K, Katsube T, Fujisawa T, Azumi T, Fujishiro H, Ishihara S, Amano Y, Kinoshita Y. Nizatidine and cisapride increase salivary secretion in rats. Digestive Disease of Science 49 (3): , ) Amano Y, Kushiyama Y, Takahashi Y, Ishihara S, Adachi K, Kinoshita Y. Prevalence of ileo-colonic ulcerative lesions in chronic NSAIDs users. American Journal of 7

8 Gastroenterology 99 (6): 1193, ) Kinoshita Y. Treatment of GORD: Lifestyle advice and medication. Alimentary Pharmacology and Therapeutics 20 (suppl 8): 19-23, ) Ishihara S, Rumi MAK, Okuyama T, Kinoshita Y. Effect of prostaglandins on the regulation of tumor growth. Current Medicinal Chemistry-Anti-Cancer Agents 4: , ) Ishihara S, Rumi MAK, Kadowaki Y, Ortega-Cava CF, Yuki T, Yoshino N, Miyaoka Y, Kazumori H, Ishimura N, Amano Y, Kinoshita Y. Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis. The Journal of Immunology 173: , ) Ortega-Cava CF, Ishihara S, Kinoshita Y. Epithelial TLR5 is constitutively focalized to the mouse cecum and exhibit a distinctive down-regulation during experimental colitis. Gastroenterology 126 (suppl 2): A150, ) Fujisawa T, Adachi K, Komazawa Y, Mihara T, Katsube T, Azumi T, Furuta K, Rumi MAK, Ishihara S, Amano Y, Kinoshita Y. Helicobacter pylori infection prevents the tolerance of gastric acid suppressing effect of continuous H2 receptor antagonist therapy. Gastroenterology 126 (suppl 2): A535, ) Fujisawa T, Adachi K, Komazawa Y, Mihara T, Azumi T, Katsube T, Furuta K, Kazumori H, Kinoshita Y. Helicobacter pylori infection prevents the occurrence of the tolerance phenomenon of histamine H2 receptor antagonists. Alimentary Pharmacology and Therapeutics 20: , ) Amano Y, Ishihara S, Kushiyama Y, Yuki T, Takahashi Y, Chinuki D, Miyake T, Miyaoka Y, Rumi MAK, Ishimura N, Adachi K, Kinoshita Y. Barrett's esophagus with predominant intestinal metaplasia correlates with superficial cyclo-oxygemase-2 expression, increased proliferation and reduced apoptosis: changes that are partially reversed by non-steroidal anti-inflammatory drugs usage. Alimentary Pharmacology and Therapeutics 20 (7): , ) Rumi MAK, Ishihara S, Kadowaki Y, Ortega-Cava CF, Kazumori H, Kawashima K, Yoshino N, Yuki T, Ishimura N, Kinoshita Y. Peroxisome proliferator-activated receptor -dependent and -independent growth inhibition of gastrointestinal tumor cells. Genes to Cells 9 (11): , ) Ponchon T, Makuuchi H, Morita Y, Fukuda M, Mitani T, Shirasaka D, Aoyama N, Amano Y, Moriyama I, Oose T, Kinoshita Y. Images of early cancer: esophageal squamous-cell carcinoma. Endoscopy 36: , ) Rumi MAK, Ishihara S, Kazumori H, Kadowaki Y, Kinoshita Y. Can PPAR ligands be 8

9 used in cancer therapy? Current Medical Chemistry-Anti-Cancer Agents 4 (6): , ) Kazumori H, Ishihara S, Rumi MAK, Ortega-Cava CF, Kadowaki Y, Kinoshita Y. Transforming growth factor directly augments histidine decarboxylase and vesicular monoamine transporter 2 production in rat enterochromaffin-like cells. American journal of physiology. Gastrointestinal and liver physiology 286: G508-G514, ),.. 101: 7-14, ). world wide topics Mod2 MDP. Nod1. 1: 77-79, ), ),.. G. I. Reseach 12: , ). FD. 6: 20-21, ),.. Medicina 41: , ),,,,,,. Barrett's surveillance crystal violet methylene blue. Therapeutic Research 25: , ) : 507, ). Functional Dyspepsia. 38: 10, ),. IBD. 24: , ),,.. JOHNS 20: , ),,,,, (3): , ),,,. Helicobacter pylori H2 H2RA tolerance. 36: 65-68, ),,,. Current Review of Gastroenterology 9: 2-7, ),,. Helicobacter pylori. Arterial Stiffness 6: 28-29, ). 9

10 . 1: 193, ),.. 1: , ),.. 81: , ),,,,. 2 nocturnal gastric acid break through NAB). 19: , ). Medical Tribune. 3: 6-7, ),,,. GERD. 66: 1-9, ),. Q&A. 101: , ). AGA Report. 31: 41-51, ),,.. G. I. Research 12: , ). 1.. Nikkei Medical 445: , ),.. 16: 31-34, ),,,,,,. H. pylori Toll-like receptor (6): , ),,,,,,,. COX-2 Barrett Barrett COX (suppl): 21-24, ),.. 11 (5): 12-17, 2004 Hideaki Kazumori, Shunji Ishihara, Yoshikazu Kinoshita: Transforming growth factor- directly augments histidine decarboxylase and vesicular monoamine transporter 2 production in rat enterochromaffin-like cells. 104th Annual Meeting of the American Gastroenterological Association. Orlando, USA, May ) Norihisa Ishimura, Ryo Fukuda, Tomoko Wada, Sachiko Hamamoto, Mohammad Azharul 10

11 Karim Rumi, Cesar Ortega, Yasunori Kadowaki, Shunji Ishihara, Yoshikazu Kinoshita: Ribavirin increases the expression of type I interferon receptor in human hepatoma cell lines. 104th Annual Meeting of the American Gastroenterological Association. Orlando, USA, May ) Kyoichi Adachi, Tomoyuki Hashimoto, Shunji Ishihara, Hirofumi Fujishiro, Shuichi Sato, Yuji Amano, Shuzo Hattori, Yoshikazu Kinoshita: Comparison of five day Helicobacter pylori eradication regimens: Rabeprazole-based and omeprazole-based with and without omeprazole pretreatment. 104th Annual Meeting of the American Gastroenterological Association. Orlando, USA, May ) Takafumi Yuki, Shunji Ishihara, Cesar F. Ortega-Cava, MAK Rumi, Tomoko Wada, Youichi Miyaoka, Nagisa Yoshino, Nobuyuki Moriyama, Norihisa Ishimura, Yasunori Kadowaki, Yuji Amano, Kyoichi Adachi, Yoshikazu Kinoshita: Role of midkine and receptor-like protein tyrosine phosphatase-x during epithelial regeneration in dextran sodium sulfate-induced colitis. 104th Annual Meeting of the American Gastroenterological Association. Orlando, USA, May ) Misa Niigaki, Syuichi Sato, Tomoko Wada, Youichi Miyaoka, Masatoshi Niigaki, Sachiko Hamamoto, MAK Rumi, Yoshikazu Kinoshita: Relationship between steatosis and hepatocarcinogenesis in chronic liver disease patients with hepatitis C virus. 104th Annual Meeting of the American Gastroenterological Association. Orlando, USA, May ) Cesar F. Ortega-Cava, Shunji Ishihara, Yoshikazu Kinoshita: Epithelial TLR5 is constitutively focalized to the mouse cecum and exhibit a distinctive down-regulation during experimental colitis. DIGESTIVE DISEASE WEEK New Orleans, USA, May ) Tomoo Fujisawa, Kyoichi Adachi, Yoshinori Komazawa, Takafumi Mihara, Tomoko Katsube, Takane Azumi, Kenji Furuta, Mohammad A. K. Rumi, Shunji Ishihara, Yuji Amano, Yoshikazu Kinoshita: Helicobacter pylori infection prevents the tolerance of gastric acid suppressing effect of continuous H2 receptor antagonist therapy. DIGESTIVE DISEASE WEEK New Orleans, USA, May ) Naoto Kitajima, Syuchin Tei, Syunji Ohhara, Yoshifumi Inoue, Masaharu Miki, Toshiyuki Yamatani, Yoshikazu Kinoshita, Kazuaki Takahashi, Shunji Mishiro: Zoonotic transmission of hepatitis E virus from deer to human beings. DIGESTIVE DISEASE WEEK New Orleans, USA, May ),,,,,, :..,

12 10),, : Nocturnal gastric acid breakthrough NAB.., ),,,,,,,,,, : Regenerating gene REG.., ),,,,,,,,,, : DSS Midkine RPTA-beta.., ),,,,,,,,,,,,,, : HP.., ),, : Toll dextran sodium sulfate DSS.., ),,,,,,,,,,,,,,,,,, : 3 PPI.., ),,, : Peroxisome proliferator-activated receptor PPAR.., ),,,,,, : ERCP.., ),,,,,,,,, : Barrett surveillance.., ),,,,,,,,,,, : CT.., ),,,,,,, 12

13 ,,, :.., ),,,,,,,,,,,,,,, :.., ),,,,,,, : E HEV.., ),,,,,,,,,,,, :. 90., ),,,,, : late parenchymal phase.., ),, : Functional dyspepsia Functional dyspepsia 45., ),, : Toll-like receptor-4 MD-2 H. pylori. 45., ),,,,,,,,, : PPI H2RA. 45., ),, : 400 retrospective study.., ),, : Barrett Barrett's surveillance., 45., ),,,,,,,,,, : Barrett..,

14 31),, : C IFN 2b ribavirin.., ),,,,,,,,,,,,, :. 80., ),,,,,,,,,,,,, : EUS-FNAB MALT. 91., ),,,,,,,,,,,, : EUS-FNAB malignant lymphoma.., ),,,,,,,,,,,, :. 91., ),,,,,,,,,,, :.., ),,,,,,,,,,,,,, :. 80., ),,,,,,,,,,, :. 80., ),,,,,,,,,, : , ),,,,,,,,,,, :..,

15 41), :.., ),, : E zoonosis. 90., ),,,,,,,,,,, :. 90., ),, : Barrett Barrett COX2. 90., ),,,,,,,,,,, : H. pylori H2. 90., ),,,,,,,,, : Body composition analyzer In body , ),,,,,, :. 90., ),, : REG regeneration gene. 90., ),,,,,,,,, : H. pylori IL-8 REG. 90., ),, Mohammad A. K. umi, esar F. Ortega-Cava,, : histidine decarboxylas vesicular monoamina transporter , ),,,,,,, 15

16 ,,,,,, : Barrett pit pattern. 67., ),,,,,,,,,, :. 67., ),,,,,,,,, : NSAIDs ulcer. 67., ),,,,,,, :. 90., ),,,,,,,,, :. 81., ),,,,,,,,,,, :. 81., ),, : 24 ph GERD.., ),,,,,,,,,,, : 1.., ),,,,,,,,,,,,,, : EUS-FNAB.., ),,,,,,, :. 17., ),,,,,,,,, : H2-receptor antagonist PPI crossover. 46.,

17 10 62),, : GERD GERD. 46, 68., ),,,,,,,,,,,,,,,,,, : DSS. 46., ),, : Barrett Barrett Barrett. 46, 68., ),,,, :. 68., ),,,,,,,,, : Barrett. 68., ),,,,,,,,, : X , ),,,,,,,,,,,,,,, : , ),,,,,,,,,,,,,, : Solitary fibrous tumor. 82.,