1. 530023 2. 530001 3. 530001 DCP 100 DCP 47 53 3 HOMA -IR HOMA - IR P<0.01 HOMA -IR P<0.01 81.1% 59.6% P<0.05 DCP DCP DCP doi: 10.11842/wst.2014.06.019 R277.7 A Diabetic Cystopathy DCP 25% ~85% 1 DCP [1] DCP 1.1 2 Type 2 Diabetes Mellitus T2DM DCP WHO1999 [2] DCP [3] 淤 T2DM 于 盂 Bladder Residual Urine BRU >50 ml [4] 淤 于 盂 榆 Hcy / UAER 4 2 淤 T2DM 2013-10-14 2013-11-13 DCP 于 盂 元 GZYQJ2011018 元元 元元元 1313
绎 18~70 榆 HbA1c 臆 7.5% 虞 DCP 2 BRU 1.2 100 2008 11 ~2012 10 53 30 23 64.3 依 8.8 174.8 依 55.7 65.7 依 16.7 HbA1c % 6.9 依 0.6 47 27 20 63.9 依 8.3 171.7 依 56.7 62.9 依 13.4 HbA1c % 6.8 依 0.6 字 2 t 2 2.1 500 ug/ 500 ug 3 [ 3g 3g 15 g 薢 15 g 15 g 12 g 12 g 12 g 12 g 9g 9g 9g 9g 6g 6g ] 1 2 3 2.2 BRU HOMA-IR 2.3 [5] 0 1 2 3 伊 1.0 伊 2.0 [ - 衣 ] 伊 100% HOMA-IR 滋 U ml -1 mmol L -1 22.5 [6] BRU 2.4 [5] 逸 75% BRU 臆 10 ml 50%~ 75% BRU 臆 50 ml 25%~50% BRU 50% 25% BRU 2.5 SPSS 16.0 x 依 s t P<0.01 3 3.1 BRU BRU BRU P<0.01 BRU P<0.01 1 3.2 P<0.01 P<0.01 2 1 BRU ml 47 188.4 依 70.3 107.5 依 45.3 ** 53 196.2 依 64.7 80.2 依 39.8 ** 吟吟 2 47 18.9 依 7.3 13.7 依 4.8 ** 53 19.7 依 7.1 10.4 依 4.7 ** 吟吟 1314
3 n / / / / /% 47 0 7 21 19 59.6 53 5 10 28 10 81.1 * * P<0.05 4 /mpa.s /mpa.s /% 47 11.73 依 1.47 6.43 依 1.02 49.21 依 3.72 2.71 依 0.63 11.41 依 1.42 6.21 依 1.09 48.14 依 3.25 2.73 依 0.59 53 11.93 依 1.64 6.44 依 1.17 48.26 依 4.25 2.74 依 0.62 10.12 依 1.26 ** 吟吟 5.42 依 0.98 ** 吟吟 46.13 依 3.15 ** 吟吟 2.37 依 0.45 ** 吟吟 3.3 P<0.05 3 3.4 P<0.01 P<0.01 4 3.5 HOMA-IR HOMA-IR HOMA-IR HOMA-IR P<0.01 HOMA-IR P< 0.01 5 3.6 6.9 依 0.6 %6.8 依 5 HOMA-IR 47 4.1 依 1.8 4.0 依 1.6 53 4.2 依 1.9 3.1 依 1.5 ** 吟吟 0.6 % 6.8 依 0.6 % 6.7 依 0.7 % 3.7 4 DCP Na + -K + -ATP Ca 2+ [7] DCP B 12 DCP [8,9] DCP DCP [10] 1315
绎 [11] / [12] DCP / DCP DCP DCP DCP DCP DCP DCP BRU DCP DCP DCP 薢 薢 DCP DCP DCP DCP DCP 1 Lee W C, Wu H P, Tai T Y, et al. Effects of diabetes on female voiding behavior. JUrol, 2004, 172(3) 颐 989~992. 2 World Health Organization. Definition, diagnosis, and classification of diabetes mellitus and its complications. report of a WHO consul 原 tation. Part 1: diagnosis and classification of diabetes mellitus. Geneva: W H O, 1999. 3.. :, 2002 颐 415~416. 4,,,.., 2010,28(5) 颐 25~27. 5.( ). :,2002 颐 233~237. 6,,,. Bergman., 2000, 16 ( 6 ) 颐 358~362. 7 Chang S, Hypolite J A, Mohanan S, et al. Alteration of the PKC - mediated signaling pathway for smooth muscle contraction in obstruc 原 tion -induced hypertrophy of the urinary bladder. Lab Invest, 2009, 89(7) 颐 823~832. 8.., 1999,38(1) 颐 14~17. 9,..,1997,13(4) 颐 197~200. 10..,2011,52 (S1) 颐 190~192. 11,..,2007,34 (1) 颐 28~29. 12..,2009,26(5) 颐 9~10. Exploration on Curative Effect of Zhuo-Du-Qing Particles on Diabetic Cystopathy Based on Theory of Turbid Toxin Zhao W ei 1,FengXiaotao 2, Li Shuanglei 1,ZhaiLinna 1, Wang Zhengang 1, Huang Rong 1, Chen Wenhui 1, Li Min 1, Luo Feng 1, Tang Chunli 1,QinYan 3 1316
(1. The First A ffiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China; 2. Center of Scientific experiment of Guangxi University of Chinese Medicine, Nanning 530001, China; 3. Graduate School of Guangxi University of Chinese Medicine, Nanning 530001, China) Abstract: This study was aimed to explore the curative effect of Zhuo-Du-Qing (ZDQ) particles on diabetic cystopa 鄄 thy (DCP) based on the theory of turbid toxin. A total of 100 DCP patients were randomly divided into the control group with 47 cases and the treatment group with 53 cases. Mecobalamin tablets was given in the control group. And ZDQ particles were given to the treatment group. The treatment course was 3 months. The observation was made on the bladder residual urine (BRU), clinical manifestation integral, hemodynamic indexes, HOMA-IR and HbA 1 c before and after the treatment. The results showed that compared with pretreatment, the BRU, clinical manifestation integral, hemodynamic indexes, and HOMA-IR were significantly reduced (P < 0.01). Compared with the control group, the BRU, clinical manifestation integral, hemodynamic indexes, and HOMA -IR were also significantly reduced (P < 0.01). The effective rate in the treatment group was 81.1%, which was significantly higher than 59.6% in the control group (P < 0.05). There were no obvious changes on the blood routine examination, urine routine examination, stool routine examination, liver function, renal function, electrocardiogram and so on before and after treatment. It was con 鄄 cluded that the treatment of DCP with ZDQ particles was safe and effective. To remove toxin and descend turbid may be another effective treatment method for DCP. The occurrence and development of DCP were closely related to the turbid toxin. Keywords: Zhuo -Du -Qing, turbid toxin, toxin -removing and turbid -descending, diabetic cystopathy, clinical observation 1317