Probiotics Prebiotics prebiotics synbiotics B.. () ()ph (). K 4. Obradovic 996 7 005 9
00 ml.5 mmol/l 0 L. para. subsp. paracasei NTU 0 6.4. 4. A - 88 8 7 4 7 4 68 4 4 9 7 0 4 9 synbiotic (prebiotic) ( ) + 0 005
synbiotics Lactobacillus sporogenes (Bacillus coagulans) 8908-89 AB (prebiotic) 900-9006 ( ) Lactobacillus bulgaricus Bifidobacterium bifidum Streptococcus thermophilus 9007-90 90-906 ABC / (Daidzein 907-9 nystose) 90-906 908-9 - 90-906 907-9 940-9406 9407-940 TCELL- LGG (synbiotic) (synbiotic) (synbiotic) 4 ABC / AB TCELL- LGG 005
LGG ABC / AB TCELL- (Lactobacillus) (Bifidobacterium) Lactobacillus casei Lactobacillus delbrueckii Lactobacillus paracasei Lactobacillus casei sp. Rhamnosus Lactobacillus rhamnosus Lactobacillus bulgaricus Lactobacillus fermentum Bifidobacte-rium longum Bifidobacterium lactis Bb- Bifidobacterium bifidum Enterococcus faecium Streptococcus thermophilus AB La-5 Bifidobacterium lactis Bb- BB56 + Bifidus Bifidobacterium lactis HN09 5 Bifidobacterium lactis Bb- Enterococcus faecium Streptococcus thermophillus Lactobacillus delbrueckii DR0TM Streptococcus thermophillus Lactobacillus delbrueckii 005
/ ABC 5 Streptococcus thermophillus Lactobacillus delbrueckii Lactobacillus paracasei Bifidobacterium lactis 4 Bifidobacterium lactis Enterococcus faecium Lactobacillus paracasei sp. rhamnosus GG Bifidobacterium lactis Shirota Bifidobacterium lactis Bifidus TCELL- Lactobacillus rhamnosus Tcell- Lactobacillus sporogenes (Bacillus coagulans) powder 5 Lactobacillus bulgaricus Bifidobacterium bifidum Streptococcus thermophilus LGG 7 Lactobacillus bulgaricus Streptococcus thermophilus Lactobacillus rhamnosus GG Lactobacillus bulgaricus Bifidobacterium bifidum (Daidzein Lactobacillus fermentum nystose) 005
46 5 T-cell 8 Lactobacillus rhamnosus Tcell- 4 8 4 (GOT GPT) (RBC HGB HCT MCV MCH MCHC PLT WBC) 8 (8-day feeding toxicity study)spf60 0 6 8 66 L. rhamnosus Tcell- 8 Wistar 0 g/kg (7x0 CFU) 0.5 g/kg (.5x0 ) 0. g/kg (7x0 0 CFU) 4 L. rhamnosus Tcell- L. rhamnosus Tcell- HPRT (S9) 6(S9).5, 6.5,.5, 5, 50, 00 µl/ml 0. µl/ml methanesulfonic acid, ethyl ester 8~4 (S9).565,.5, 6.5,.5, 5, 50 µl/ ml 00 µg/ml N- nitroso-dimethylamine 8~4 HPRT ICR5 5 5 50 00 0 ml/kg mitomycin C mg/kg 6~48 ICR S9 S9 0 5 -S9, +S9, -S9, 0 4 005
5 (µl/ml) 6.5,.5, 5, 50, 00-S9 mitomycin C µm +S9 cyclophosphamide 40 µm SD 4865 0 0 ml/kg (0 ml/kg) 4 SD 4 8 SD 80 0.5 5 5 ml/kg/day (5 ml/kg/day) 8 400 () 97-974 Streptococcus type Lactobacillus type () 987-99 99 004 () (L. reuteri) Co-culture/overlayer (RPLR) 0-76 00L. GG Caco- 00 Clostridium difficile Caco- (4) 987 9 L. acidophilus L. bulga- 005 5
ricus Streptococcus lactis SK 99L. plantarum L. plantarum Escherichia coli, Pseudomonas aeruginosa Bacillus cereus (5) 995 Bifidobacterium -D- ~ B. longum B. bifidum (6) 995 Bacillus coagulans Leuconostoc mensenteroides Pediococcus cerevisiae L. brevis L. plantarum (7) L. plantarum Pediococcus acidilacici Pediococcus pentosaceus (8) 995 L. bulgaricus L. acidophilus Streptococcus thermophilus Lactococcus lactis -8 C -l C 5 7 log CFU/mL (9) 995 glutathione 00 000 00 Lactobacillus paracasei subsp. paracasei NTU 0 BCRC 847 : 575 0 5 0.44 0.4 5 4 C 4 0 9 CFU/mL L. para. subsp. paracasei NTU 0L. plantarum NTU 0 L. para. subsp. paracasei NTU 0 L. plantarum NTU 0 L. para. subsp. paracasei NTU 0 6.4 L. plantarum NTU 0.5 LDL HDL L. plantarum NTU 0 L. para. subsp. paracasei NTU 0 (0) 986 6 005
994 (probiotics) 000 5 () 994 5 C 0 ppm 0 ppm ethyl carbamate 7 ppb 5 ppb 0 ppb () 995 L. acidophilus B. bifidum () 989 Streptococcus lactis 67 Bacillus subtilis 566 4 nisin 986 Leuconostoc sp. TMB4440.5 Ca-alginate gel 99 998 00 00 004 pnlp p0 00 (4) 995 Streptococcus faecium 00 () (Helicobacter pylori) (rotavirus diarrhoea) (gastritis) () 005 7