. 5 : 81-91 2014 Ann. Rept. Food Drug Res. 5 : 81-91 2014 81 102 1 1 1 1 1 1 1 7 2 3 4 8 5 6 9 1 1 2 3 4 5 6 7 8 9 102211 861 呋 Quinolone beta- 呋 Chloramphenicol 861 35 6425 Azaperone(Lincomycin) (Trimethoprim)Tilmicosin(Nicarbazin) (Doxycycline)(Thiamphenicol) 呋 SC () 21
82 - (5) ㈢102961021950329 () (6) ㈣102961021950329 - (7) ㈤1001171001903947 呋 (8) ㈥102961021950329 (9) ㈦10047 1001900952 (10) ㈧102961021950329 (11) ㈨102961021950329 β- (12) ㈩102961021950329 (1,2) (3) (3) () 861 ㈠102961021950329 - (4) ㈡102961021950329 (20) 102961021950329 17α- 4--3,17- (21) 102961021950329 Zeranol17α-17β- (22) 102961021950329 Hexestrol (23) 101223
102 83 102 呋 & Quino lone b- Hexestrol Zeranol17a- 17b- 17α-4- -3,17-3 4 20 2 7 50 7 3 8 16 2 3 4 26 26-57 26 26 - - 31 31 - - - 7 7-7 7 7 - - - - - - - 8 8-8 8 8 - - - - - - - 9 9-9 9 9 - - - - - - - 5 5-5 5 5 - - - - - - - 12 12-12 12 12 - - - - - - - 20 20-20 20 20 - - - - - - - 20 20-20 20 20 - - - - - - - 9 9-9 9 9 - - - - - - - 21 21-21 21 21 - - - - - - - 7 7-7 7 7 - - - - - - - 18 18-18 18 18 - - - - - - - 26 26-26 26 26 - - - - - - - 16 16-16 16 16 - - - - - - - 5 5-5 5 5 - - - - - - - 14 14-14 14 14 - - - - - - - 5 5-5 5 5 - - - - - - - 15 15-15 15 15 - - - - - - - () 10 10-10 10 10 - - - - - - - 25 25-25 25 25 - - - - - - - 9 9-9 9 9 - - - - - - - 5 5-5 5 5 - - - - - - - 22 22 - - - 22 - - 22 22 - - -
84 102() 呋 & Quino lone b- Hexestrol Zeranol17a- 17b- 17α-4- -3,17-11 11 - - - 11 - - 11 11 - - - 10 10 10 - - 10-10 10 10 - - - 10 10 10 - - 10-10 10 10 - - - 88 88 88 - - 88-88 88 88 88 88-10 10 10 - - 10-10 10 10 10 - - 121 121 121 - - 121-121 121 121 - - - 10 10 10 - - 10 - - 10 10 10 10-30 30 30 - - 30 - - 30 30 30 30 30 66 66 66 - - 66 66 - - 66 66 66-25 25 25 - - 25 25 - - 25 25 25-20 20 20 - - 20 20 - - 20 20 - - 20 20 20 - - 20 20 - - 20 20 20-15 15 15 - - 15 15 - - 15 15 15-45 45 - - 45 45 45 - - 45 - - - 3 3 - - 3 3 3 - - 3 - - - 4 4 - - 4 4 4 - - 4 - - - 4 4 - - 4 4 4 - - 4 - - - 5 5 - - 5 5 5 - - 5 - - - 4 4 - - 4 4 4 - - 4 - - - 15 15 - - 15 15 15 - - 15 - - - 830 830 425 323 372 830 226 239 343 569 284 254 30 2,490 3,320 8,500 646 2,604 41,500 1,582 717 2,744 9,104 568 762 120
102 85 (chloramphenicol) (ppb) 1 (Thiamphenicol) 1021950329 (4) 0.3 (Florfenicol) 2 7 1021950329 (5) 1-2.5 3 Quinolone1520 1021950329 (6) 4 7 1021950329 (7) 2-10 AH 0.2 5 呋 AMOZ 0.1 1001903947 (8) AOZ 0.1 SC 0.3 6 1021950329 (9) 0.5 7 (β-agonists) 1001900952 (10) (24) 0.3 8 1021950329 (11) 1-3 9 β-8 1021950329 (12) 1-20 10 1021950329 (20) 1-10 11 17α-4- -3,17-() 1021950329 (21) 10 12 Zeranol17α-17β- 1021950329 (22) 7.5 13 Hexestrol 1021950329 (23) 10 1-5 (20) (24) 102861 354 2564.1% ( )312 310.1332 ppm1(benzylpenicillin) 0.32 ppm1azaperone 0.07 ppm1 0.012 ppm () 1994 (29 (26) β- (27) β- (13) 10211 0.15 ppm (25) Azaperone butyrophenone (28) 0.06 ppm (25,30) 226 25 6(Trimethprim) 0.16-0.48 ppm1 (Tilmicosin) 0.110 ppm4 0.0010-0.00499 ppm1
86 102 % % 66 66 100.0 0 0.0 25 19 76.0 6 24.0 20 20 100.0 0 0.0 20 15 75.0 5 25.0 15 15 100.0 0 0.0 45 36 80.0 9 20.0 20 17 85.0 3 15.0 15 13 86.7 2 13.3 226 201 88.9 25 11.1 30 30 100.0 0 0.0 10 10 100.0 0 0.0 88 88 100.0 0 0.0 10 10 100.0 0 0.0 22 22 100.0 0 0.0 121 118 97.5 3 2.5 10 10 100.0 0 0.0 10 10 100.0 0 0.0 11 10 90.9 1 9.1 312 308 98.7 3 1.3 21 21 100.0 0 0.0 5 3 60.0 2 40.0 14 12 85.7 2 14.3 7 7 100.0 0 0.0 12 11 91.7 1 8.3 9 8 88.9 1 11.1 57 57 100.0 0 0.0 26 26 100.0 0 0.0 20 20 100.0 0 0.0 15 15 100.0 0 0.0 8 8 100.0 0 0.0 20 20 100.0 0 0.0 7 7 100.0 0 0.0 9 9 100.0 0 0.0 9 9 100.0 0 0.0 16 16 100.0 0 0.0 18 18 100.0 0 0.0 5 5 100.0 0 0.0 10 10 100.0 0 0.0 25 25 100.0 0 0.0 5 5 100.0 0 0.0 5 5 100.0 0 0.0 323 317 98.1 6 1.9 861 826 95.9 35 4.1 102 // / (ppm) 1 22 0-2 11 1 1// 0.012 ( ) a 3 10 0-4 10 0-5 88 0-6 10 0-7 121 3 1// 0.32 / (0.05) 1/Azaperone/ 0.07 / (0.06) 1// 0.1332 / ( ) 8 10 0-9 30 0-312 4 a. 1023 102.3.131021300534 (Thiamphenicol) 0.00993 ppm4 (Sulfamethoxazole) 0.36-2.87 ppm3 0.04-0.48 ppm2 (Sulfamonomethoxine) 0.02-2.20 ppm1 (Nicarbazin) 0.13 ppm 10.029 ppm 0.05 ppm30.02-0.44 ppm1 0.08 ppm0.64 ppm1 0.00063 ppm1 (Sulfachlopyridazine) 0.17 ppm 1 0.001 ppm 0.25 ppm 0.19 ppm 10.03 ppm1 0.12 ppm1 0.0004 ppm0.0116 ppm 20.00210.023 ppm 10.0267 ppm
102 87 102 1 66 0-2 25 6 3 20 0-4 20 5 5 15 0 - /// (ppm) 5/ /0.16-0.35/ (0.05) 1/ / 0.48/ (0.05)/ 0.110/ (0.075) 4/ /0.001-0.00499 /() 1/ /0.00993/ () 6 45 9 1/ / 0.67/ (0.1) 1/ / 0.08/ ()/ 0.64 /(0.1) / 0.02 /() 1/ /0.44 / ()/ 0.00063/ () 1/ / 0.17/ (0.1) 1/ / 0.36 /(0.1)/ 0.04 /() 1/ / 0.03 /() 7 3 1 1/ / 0.03 /() 8 4 0-1/ / 0.029 /()/ 0.05/ () / 0.32/ () /2.87, /0.02 Sulfa drugs2.9 /(0.1) 1/ /0.13/ ()/ 0.48 /() / 1.14/ 2.20 Sulfa drugs3.3 /(0.1) 1/ / 0.001 /()/ 0.25 /() / 0.19/ () 9 4 1 1/ / 0.12 /() 10 5 0-11 4 1 1/ / 0.0004/ ()/ 0.0116/ () 12 15 2 226 25 1/ / 0.0021/ ()/ 0.0267/ () 1/ / 0.023/ () 5 (16) () 0.2 ppm (14) (13) 0.05 ppm (14)
88 0.02 ppm (14) 0.1 ppm (14) (Tylosin) Tylosin (13) () 0.075 ppm 1 ppm0.25 ppm (14) (13) 0.1 ppm () 0.2 ppm2.5 ppm0.75 ppm (14) 2-4 (13) 103413 0.2 ppm (14) 3066 1 呋 SC 0.002 ppm2 102 1 57 0-2 7 0-3 8 0-4 9 0-5 5 0 - /// (ppm) 6 12 1 1/ 呋 / SC 0.002/ () 7 20 0-8 20 0-9 9 0-10 21 0-11 7 0-12 18 0-13 26 0-14 16 0-15 5 0-16 14 2 2/ / 0.00210.0083/ () 17 5 2 1/ / 0.11/ () 噻 / 0.07/ () 18 15 0-19 () 10 0-20 25 0-1/ /0.03/ () 21 9 1 1/ / 0.11/ () 22 5 0-323 6
102 89 0.00210.0083 ppm2 0.0030.11 ppm1 噻 0.07 ppm1 0.11 ppm () (17,18) 呋 (15) (15,17,18) (19) () 861 82635 4256 CAS 1. 2000 2. 2002 30(2): 21-26 3. 2011 2: 145-153 4. 2013-102.09.06 1021950329 5. 2013-102.09.061021950329 6. 2013 ()102.09.06 1021950329 7. 2013-102.09.061021950329 8. 2011 呋 100.11.171001903947 9. 2013 102.09.061021950329 10. 2011 100.04.071001900952 11. 2013 102.09.061021950329 12. 2013 β- 102.09.061021950329 13. 2006[http://www.
90 baphiq.gov.tw/public/data /741117495471. doc. ] 14. 2014 103.04.011031300872 15. 2008 呋 26: 306-321 16. 2001 90.01.02891553026 17. 2008 26: 286-294 18. 2006 (Malachite Green)303: 1-2 19. 2007 96.08.290961473107 20. 2013 102.09.061021950329 21. 2013 17α- 4--3,17-102.09.061021950329 22. 2013 Zeranol17α- 17β-102.09.06 1021950329 23. 2013 Hexestrol 102.09.061021950329 24. 2012 (20)[http://www.fda.gov. tw/tc/sitelist.aspx?pn=6&sid=1574&classi fyid=170] 25. 2013 102.11.141021351217 26. 2002 (ortho-dichlorbenzene) (Food-producing animals) (Chloramphenicol)91.12.26 0911473046 27. Goto, T., Ito, Y., Yamada and S., Matsumoto, H. and et. al. 2005. High-throughput analysis of tetracycline and Penicillin antibiotics in animal tissues using electrospray tandem mass spectrometry with selected reaction monitoring transition. J. Chromatogr. A 1100: 193-199. 28. European Medicines Agency. 1997. Committee for veterinary medicinal products Azaperone summary report (2). 29. Stolker, A. A., and U.A. Brinkman, 2005. Analytical strategies for residue analysis of veterinary drugs and growth-promoting agents in food-producing animals - a review. J Chromatogr. A 1067:15-53. 30. 2013 102.3.131021300534
102 91 2013 Post-Market Survey on Veterinary Drug Residues in Livestock and Aquatic Products HSIAO-PING FU 1, HSIAO-WEN KUO 1, CHUN-CHIEH SHIH 1, HUANG-CHUN LIN 1, KAO-HSIEN LIN 1,YI-RONG LIN 1, HSIU-KUAN CHOU 1, JIIN-FUNG SHYU 1, JYH-QUAN PAN 1, CHAO-KAI HSU 7, LI-WU LIU 2, CHUNG-KUEN CHIANG 3, CHIH-CHENG KU 4, LI-CHEN SHIH 8, CHIN-TE HSU 5, SU-O CHEN 6, CHUI-SHIANG CHANG 9, AND HWEI-FANG CHENG 1 1 Central Center for Regional Administration, FDA, 2 Public Health Bureau, Taoyuan County Government, 3 Hualien County Health Bureau, 4 Miaoli County Public Health Bureau, 5 Chiayi County Health Burea, 6 Kaohsiung City Health Bureau, 7 Department of Health, Taipei City Government, 8 Changhua County Public Health Bureau, 9 Public Health Bureau, Pingtung County Government ABSTRACT Residual veterinary drugs in food present a risk to human health. From Feb to Nov, 2013, samples of various animal origins were collected from retail markets or supermarkets and tested for residual drugs, including tetracyclines, sulphonamides, quinolones, nicarbazin, nitrofuran metabolites, malachite green, amphenicol, β-agonist, antiprotozoal drugs and β-lactams. Out of a total of 861 samples, 826 samples were in compliance. Thirty-five cases including 6 aquatic products, 4 livestock products and 25 poultry products contained prohibited or above legal limit of veterinary drug residues such as lincomycin, benzylpenicillin, azaperone, chloramphenicol, trimethoprim, tilmicosin, florfenicol, sulfadrugs, thiamphenicol, nitrofuran metabolites SC, nicarbazin, doxycycline, leucomalachite green. The results had been reported to the local enforcement authorities and the penalties had been enforced to the suppliers who provided the non-compliant products. Key words: veterinary drug residues, livestock products, poultry products, aquatic products