cm, 10% : 10% 24 h, (30% 50% 70% 80% 90% 100% ), 2 3 h,, (HE) 113, 011 cm 011 cm 011 cm 011 cm, 4 215%, 1%,,,,, JEM EX 96, 92,, (

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1 2005, 28 (4) : Journal of N anjing A gricultural U niversity, 3 (, ) :, 96,, (CEH) ; ;,, CEH,, : ; ; ; ; ; : S : A : (2005) Histopathological m icroscopical and ultram icroscopical studies on changes of uterus and ovary of patients in can ine pyometra Q IAN Cun2zhong, HOU J ia2fa 3 (College of Veterinary Medicine, Nanjing Agricultural University, Nanjing , China) Abstract: M icroscop ical and ultram icroscop ical structure of the uterus and ovary from 96 canine pyometra cases were observed with m icrotomy and light m icroscopy and transm ission electron m icroscopy to discuss the etiology of canine pyometra. The results showed that there were histophathological changes of endometrial glads with various degrees of cystic endometrial hyperp lasia ( CEH ) inflammation and retained or cystoid corpus luteum in ovary in most patients. and Thickness of endometrium was observed in most opened2cervix cases. A trophy of endometrium and very thin wall of uterus were seen in most closed2cervix cases. W hen CEH oc2 cured in the endometrial gland in closed2cervix cases, pathological changes such as spuamous metap lasia and adenomatoid lesion were found in the ep ithelium of endometrium. In addition, the macroscop ical, m icroscop ical and ultram icroscop ical histopathologi2 cal changes of the ovary and uterus in closed2cervix cases was more obvious than those of opened2cervix cases. Key words: dog; pyometra; ovary; uterus; m icroscop ical structure; ultram icroscop ical structure ( canine pyometra),,,,,,,,,,, ;,,,,,, 96,, , 49, cm 115 cm 015 cm : : (1963 ),,,, E2mail: czqian@ njau1edu1cn 3 Corre2 sponding author, E2mail: jfhou@ njau1edu1cn ' China Academic Journal Electronic Publishing House. All rights reserved.

2 cm, 10% : 10% 24 h, (30% 50% 70% 80% 90% 100% ), 2 3 h,, (HE) 113, 011 cm 011 cm 011 cm 011 cm, 4 215%, 1%,,,,, JEM EX 96, 92,, ( 1) 1 20 cm,, 2, 1, 1, 110 cm ;,,,,, ( cm ),,, 2 5 mm,, ( cyst2 ic endometrial hyperp lasia, CEH) ( 2 A ), 500 ml,,, ( cm ),, ;,,, CEH ( ml 212 B ), ml, d,,,, CEH,,, ;, CEH,, ( 2, C) ; CEH, 3 cm,, d,,,, CEH,,,, ( 2 D) ;,, ;,, ( 2 E) ;,, 21213,, ( F) ;, 21311,,,,,, nm, 150 nm ( 3 A ) ;, ;,, ( ) (

3 4 : 115 ),, 21312,,, ; ( 3 B ),, ;,,, 1, nm, 800 nm, ( 3 C), 21313,, ;,,,, 21314,,, ( ), mm, mm,,, nm ( ),, ( 3 D ) 3 F ig13 Photograph ies of tran sm ission electron m icroscopy of uterus and ovary from can ine pyom etra (A. ( 7 400) Opened canine pyometra case: shortened villi of endometrial ep ithelium; B.,, ( 6 000) Closed canine pyometra case: few villi of endometrial ep ithelium, infiltration of inflammatory cells in the chamber and exfoliation of ep ithelium; C. ( ) Bacteria phagocytized by histocyte in the uterus of canine pyometra; D. ( a), ( b) ( c) ( ) Ovoid nucleus ( a) of ovarian cells, many secretive particles ( b) and neuroendocrine ones ( c) ) /96, ( ) ng ml - 1 ( ) pg ml - 1,,, [ 1 ],,

4 116 28,,,,, [ 2 ], ( ),, ( 3 C),,,, [ 3 ] [ 3, 4 ] 312 CEH CEH, Dow [ 5 ] Hardy [ 6 ], CEH, CEH [ 7 9 ], CEH [ 6, 7 ] CEH,, CEH, ; CEH,,, de Bosschere [ 10 ], CEH, CEH,,, Hardy [ 6 ] M iller2l iebl [ 8 ],, ; Cock [ 7 ] CEH, 313 Dow [ 5 ], ( 2 F) Jubb [ 3 ] Hardy [ 6 ] [ 9 ] [ 2, 4 ] : [ 1 ]. [M ]. 5. :, [ 2 ],,,. [ J ]., 1994, 3 (4) : [ 3 ] Jubb K V F, Kennedy P C, Palmer N. Pathology of Domestic Animal [M ]. 2nd ed. London: Harcourt B race Jovanovich Publishers, [ 4 ] B lendinger K, Bostedt H, Hoffmann B. Hormonal state and effects of the use of an antip rogestin in bitches with pyometra [ J ]. Journal of Rep roduction and Fertility Supp lement, 1997, 51: [ 5 ] Dow C. Experimental rep roduction of the cystic hyperp lasia2pyometra comp lex in the bitch [ J ]. J Pathol Bacteriol, 1959, 78: [ 6 ] Hardy R M, O sborne C A. Canine pyometra: pathophysiology, diagnosis and treatment of uterine and extra2uterine lesions [ J ]. JAAHA, 1974, 10: [ 7 ] Cock H D, Vermeirsch H, Ducatelle R, et al. Immunohistochem ical analysis of estrogen recep tors in cystic2endomentritis2pyometra comp lex in the bitch [ J ]. Theriogenology, 1997, 48: [ 8 ] M iller2l iebl D, Fayer2Hosken R, Caudle A, et al. Rep roductive tract diseases that cause infertility in the bitch [ J ]. Vet Med, 1994, 89: [ 9 ]. [M ]. :, [ 10 ] de Bosschere H, Ducatelle R, Vemeirsch P H, et al. Cystic endomentrial hyperp lasia2pyometra complex in the bitch: should the two enti2 tles be disconnected? [ J ]. Theriogenology, 2001, 55: :

5 : Q IAN Cun2zhong et a l: H istopa tholog ica l m icroscop ica l and ultram icroscop ica l stud ies on changes of uterus and ovary of pa tien ts in can ine pyom etra 1 F ig11 The pa tholog ic h istology changes of uterus and ovary from som e pa tien ts (A. U terus of opened canine pyometra; B. U terus of closed canine pyometra; Ovary of canine pyometra) C. 2 F ig12 H istopa tholog ica l changes of uterus and ovary of can ine pyom etra (A. Thickened uterine wall and cystic endometrial hyperp lasia ( CEH ) ; B. cystic hyperp lasia on the affected endometrium; B leeding and C. ( 40) CEH; D., ( a) ( b) ( 20) Thin uterine wall, atrophia of mucous ( a) and muscular ( b) layer; E. ( 100) Spuamous metaplasia of the endometrial ep ithelium from CEH of endometrial glands; F. ( a) ( b),, ( c), ( d) ( 40) Coexist of corpus luteum ( a) and cystic follicle ( b), follicle cell disappear ( c), defluvium of germ inal epithelium ( d) )

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幻灯片 1 二十年目睹之怪现状清吴沃尧 (1866 1910) 著吴氏原字茧人后改趼人广东南海人因居佛山故笔名我佛山人出身世宦之家因家道中落 20 多岁去上海谋生后客居山东又远游日本 1904 年任美国人办的楚报主笔后辞职返沪参加反华工禁约