Journal of Chinese Medicinal Materials Coixspirolactam A Coixspirolactam B Coixspirolactam C Coixspirolact

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1 Hu Haobin Zheng Xudong Hu Huaisheng et al. Acylated Stilbene Glucosides and Further Constituents from Acanthopanax brachypus J. Helv Chim Acta J J D J * R284 /R285 A Coix lacroyma-jobi L. var. ma-yuen Stapf 2 3 GC-MS Semen Coicis Benzoxazinone Benzoxazalinone Coixenolide α- α-monolinolein BS Tel springyoyo@ live. cn * Tel rendom@ sdu. edu. cn

2 Journal of Chinese Medicinal Materials Coixspirolactam A Coixspirolactam B Coixspirolactam C Coixspirolactam D Coixspirolactam E Coixlactam Methyl dioxindole-3-acetate Methyl dioxindole-3-acetate Coniferyl alcohol Syringic acid Ferulic acid Threo-l-C-syringylglycerol Erythro-l-C-syringylglycerol dimethoxy-p-hydroquinone-l-O-β-D-glucopyranoside Zhepiresionol Ficusal Syringaresinol Ketopinoresinol Mayuenolide Benzoxazinone 3S 3aR 6aS -3 6-di benzo d 1 3 dioxol-5-yl tetrabydrofuro 3 4-c furan-l 3H -one Benzoxazinone Benzoxazinone Benzoxazinone Benzoxazinone Benzoxazinone 5 19 Benzoxazalinone 34 Coixol Isoindol-1-one Dimethoxy-1H-inden-1-one Eriodictyol 16

3 ' 6-Dihydroxy-4'-methoxydihydroauronol Dihydroxychromone Hydroxy-7-methoxychromone Davidigenin Isoliquiritigenin Naringenin Homoeriodictyol Hesperetin Liquiritigenin Chrysoeriol ' 5 7 -Tetramethoxyflavone ' 4' 5 7-Pentamethoxyflavone Tangeretin ' 4' Heptamethoxyflavone Formononetin Coixspiroenone α β τ Feruliyl phytosterol Friedlin Isoarborinol A Coixan A B Coixan B C Coixan C CA CA ~ 75 1 ~ Adenosine

4 Journal of Chinese Medicinal Materials cdna PaTu p21 28 p27 CDK2 cyclins bcl-2 bax ATM RAD50 p PaTu-8988 Hoechst TUNEL Ehrlich HeLa HeLa Fas FasL Ehrlich Ukita CNE-2Z 1984 ICR S Numata 6 S180 Lee 14 Adlay bran ABM- EtOAc A549 HT-29 COLO205 GC 5 coixspirolactam A coixspirolactam B coixspirolactam S180 C coixlactam methyl dioxindole-3-acetate MTT 5 3 α-monolinolein IC ~ μg /ml Tokuta 13 TPA F ICR ACF F344 AOM 5 G2 /M ACF ABE-EtOAc 1 2- DMH 30 F PaTu-8988 SW1990 mg RAS Ets2

5 1310 Weel COX-2 ABE-EtOAc HPLC ABE-EtOAc CA-1 CA-2 CA-1 38 ABE-EtOAc Benzoxanzinoid CA-2 A E CA-2 CA-1 7 glucan O α-d- 26 Adlay testa 40 ATE-EtOAc Coixol Adlay hull RAW RBL-2H3 AHE 50μg /ml ATE-EtOAc AHE A23187 RBL-2H3 ATE- inos EtOAc IL-4 IL-6 TNF- COX-2 NO α PGE2 p-erk ATE-EtOAc inos COX-2 RBL-2H3 p-erk ATE-EtOAc MAPK 2. 3 OVA ECLJ AMP OVA-IgE OVA-IgG AMPK Th1 /Th2 Th2 T3-L1 AMPK Th1 46 AMPK 2 ECLJ 2. 6 AMPK AMPK AMPK EOFJ A B ABM C alloxan ABM 25 ABM-BuOH StAR P Wistar P450scc mrna Ishiguro Dimethoxy-1H-inden-1-one COX-2 48 ERK

6 Journal of Chinese Medicinal Materials Ukita T Tanimura A. Studies on the anti-tumor component in the seed of Coix lachryma-jobi L. var. ma-yuen Roman. Stapf Ⅰ. Isolation and anti-tumor activity of coix DPPH Adlay enolide J. Planta Medica hull DPPH 12 Tanimura A. Studies on the anti-tumor component in the seed of Coix lachryma-jobi L. var. ma-yuen Roman. StapfⅡ. The structrue of coixenolide J. Planta Medica Tokuda H Matsumoto T Konoshima T et al. Inhibitory 3 effects on Epstein-Barr virus actibation and anti-tumor promoting actibities of Coix seed J. Planta Medica Lee MY Lin HY Cheng F et al. Isolation and characterization of new lactam compounds that inhibit lung and co- lon cancer cells from adlay Coix lachryma-jobi L. var. mayuen Stapf bran J. Food and Chemical FDA Toxicology Chung CP Hsu CY Lin JH et al. Antiproliferative lactams and spiroenone from adlay bran in human breast cancer cell lines J. Journal of Agricultural and Food Chemistry M J Apirattananusorn S Tongta S Cui SW et al. Chemical molecular and structural characterization of alkali extractable nonstarch polysaccharides from Job' s tears J. Journal of Agricultural and Food Chemsitry Otsuka H Takeuchi M Inoshiri S et al. Phenolic com- 4. J. pounds from Coix lachryma-jobi var. ma-yuen J. Phyto M Numata M Yamamoto A Moribayashi A et al. Antitumor components isolated from the Chinese herbal medicine Coix lachryma-jobi J. Planta Medica Biotechnol Biochem J J GS-MS J Satoshi K Naolki I Takamasa S et al. Studies on the J Huang DW Chung CP Kuo YH et al. Identification of compounds in adlay Coix lachryma-jobi L. var. ma-yuen Stapf seed hull extracts that inhibit lipopolysaccharideinduced inflammation in RAW264. 7Macrophages J. Journal of Agricultural and Food Chemistry Kuo CC Chiang W Liu GP et al. 2 2'-Diphenyl-l-picrylhydrazyl radical-scavenging active components fiom adlay Clix lachryma-jobi L. var. ma-yuen Stapf hulls J. Journal of Agricultural Food Chemsitry chemistry Nagao T Otsuka H Kohda H et al. Benzoxazinones from Cotx lachryma-jobi var. ma-yuen J. Phytochemistry Ishiguro Y Okamoto K Ojima F et al. A novel antimicrobial substance in etiolated seedlings of adlay J. Biosci 21 Chen HJ Chung CP Chiang W et al. Anti-inflammato- 8. ry effects and chemical study of a flavonoid-enriched fraction from adiay bran J. Food Chemistry J constituents of seed of Coix lacryma-jobi L. J. Nippon Kagakkai Koen Yokoshu J

7 櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠櫠 Takahashi M Konno C Hikino H. Isolation and hypoglycemic activity of coixan A B C glycans of Coix lachryma-jobi var. ma-yuen seeds J. Planta Medica Yamada H Yanahira S Kiyohara H et al. Characterization of anti-complementary acidic beteroglycans from the seed of Coix lacryma-jobi var. ma-yuen J. Phytochemistry Yamada H Yanahira S Kiyohara H et al. Water-soluble glucans from the seed of Coix lacryma-jobi var. mayuen J. Phytochemistry M J J. β J Bao Y Yuan Y Xia LU et al. Neutral lipid isolated from cndosperm of Job's tears inhibits the growth of pancreatic cancer cells vin apoptosis G2 /M arrest and regulation of gene expression J. Journal of Gastroenterology and Hepatology Phytomedicine J Chen HJ Shih CK Hsu HY et al. Mast cell-dependent allergic responses are inhibited by ethanolic extract of ad- 33. lay Coix lachryma-jobi L. var. ma-yuen Stapf testa J. HcLa J Hsu HY Lin BF Lin JY et al. Suppression of allergic J of Th1 /Th2 cell responses J. Journal of Agricultural J. and Food Chemistry Li SC Chen CM Lin SH et al. Effects of adlay bran and is ethanolic extract and residue on preneoplastic lesions of the colon in rats J. Journal of the Science of Food and Agriculture Epub ahead of print Shih CK Chiang W Kuo ML. Effects of adlay on azoxymethane-induced colon carcinogenesis in rats J. Food and Chemical Toxicology Chung CP Hsu HY Huang DW et al. Ethyl acetate fraction of adlay bran ethanolic extract inhibits oncogene expression and suppresses DMH-induced preneoplastic lesions of the colon in F344 rats through an anti-inflammatory pathway J. Journal of Agricultural and Food Chemistry Otsuka H Hirai Y Nagao T et al. Anti-infiammatory activity activity of Benzoxazinoids from roots of Coix Lachryma-jobi var. ma-yuen J. Journal of Natural Products J Ha DT Nam Trung T Bich Thu N et al. Adlay seed extract Coix lachryma-jobi L. decreased adipocyte differentiation and increased glucose uptake in 3T3-L1 cells J Journal of Medicinal Food J Huang BW Chiang MT Yao HT et al. The effect of adlay oil on plasma lipids insulin and leptin in rat J. Journal of Agricultural and Food Chemistry reactions by dehulled adlay in association with the balance 47 Haia SM Chiang W Kuo YH et al. Downregulation of progesterone biosynthesis in rat granulosa cells by adlay Coix lachryma-jobi L. var. ma-yuen Stapf bran extracts J. Int J Impot Res Tzeng HP Chiang W Ueng TH et al. The abortifacient effects from the seeds of Coix lachryma-jobi L. var. mayuen Stapf J. Journal of Toxicology and Environmental Health Part A Current Issues Normile D. The new face of traditional Chinese medicine J. Scixnce 櫠櫠

Drug Evaluation Research 第 37 卷第 2 期 2014 年 4 月 - 179 - 比较, 血浆和肝胆固醇水平肝三酰甘油水平显著降低, 粪便中三酰甘油肝和粪便中磷脂水平显著升高, 而血浆

- 178 - Drug Evaluation Research 第 37 卷第 2 期 2014 年 4 月薏苡仁抗代谢综合征的药理作用研究进展张明发, 沈雅琴上海美优制药有限公司, 上海 201422 摘要 : 薏苡仁提取物及其有效成分对多种高血糖模型动物和高血脂肥胖模