原著 X 小動物臨床関連部門要約 X MV X.. Gy.... Gy TDF TDF TDF,... Gy time-dose-fractionation factor TDF Gy TDF.. Gy TDF TDF.. Gy.... Gy 症例 MIX FAX yamam

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1 原著 X 小動物臨床関連部門要約 X MV X.. Gy.... Gy TDF TDF TDF,... Gy time-dose-fractionation factortdf Gy TDF.. Gy TDF TDF.. Gy.... Gy 症例 MIX FAX yamamoto@vet.osakafu-u.ac.jp 44 68

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3 生存率生存率生存率生存率全症例癌肉腫癌肉腫篩板構造再照射篩板維持篩板崩壊再照射 - 再照射 MV X.. XiO, Elekta AB, Stockholm, Sweden GTVgross tumor volume.. Gy.. Gy. Gy. Gy FAX Kaplan-Meier Log-rank Cox EZR Veterinary Radiation Therapy Oncology GroupVRTOG 成績 P. Log-rank P

4 A B log-rank P adams. adams.... P adams A log-rank P. B Cox 考.. Gy TDF., Adams 察 444 Score veterinary radiation therapy oncology group VRTOG,. TDF. score score score QOL VRTOG score

5 score score score TDF TDF TDF QOL TDF.. Gy.. TDF 引用文献 Medewell BR, Priester WA, Gillette EL, Snyder SP : Neoplasms of the nasal passages and paranasal sinuses in domesticated animals as reported by veterinary colleges, Am J Vet Res,, () MacEwen EG, Withrow SJ, Patnaik AK : Nasal tumors in the dog: retrospective evaluation of diagnosis, prognosis, and treatment, J Am Vet Med Assoc,, () Mellanby RJ, Stecenson RK, Herrtage ME, White RA, Dobson JM : Long-term outcome of dogs with nasal tumours treated with four doses of radiation at intervals of seven days, Vet Rec,, () Maruo T, Shida T, Fukuyama Y, Hosaka S, Noda M, Ito T, Sugiyama H, Ishikawa T, Madarame H : Retrospectives study of canine nasal tumor treated with hypofractionated radiotherapy, J Vet Med Sci,, () Adams WM, Miller PE, Vail DM, Forrest LJ, MacEwen EG : An accelerated technique for irradiation of malignant canine nasal and paranasal sinus tumors, Vet Radiol Ultrasound,, () Nadeau ME, Kitchell BE, Rooks RL, LaRue SM : Cobalt radiation with or without low-dose cisplatin for treatment of canaine naso-sinus carcinomas, Vet Radiol Ultrasound,, () Adams WM, Bjorling DE, McAnulty JE, Green EM, Forrest LJ, Vail DM : Outcome of accelerated radiotherapy alone or accelerated radiotherapy followed by exenteration of the nasal cavity in dogs with intranasal neoplasia: cases (), J Am Vet Med Assoc,, () McEntee MC, Page RL, Heidner GL, Cline JM : Thrall DE, A retrospective study of dogs with intranasal neoplasms treated with cobalt radiation, Vet Radiol,, () Adams WM, Kleiter MM, Thrall DE, Klauer JM, Forrest LJ, La Due TA, Havighurst TC : Prognostic significance of tumor histology and computed tomographic staging for radiation treatment response of canine nasal tumors, Vet Radiol Ultrasound,, () Theon AP, Madewell BR, Harb MF, Dungworth DL : Megavoltage irradiation of neoplasms of the nasal and paranasal cavities in dogs, J Am Vet Med Assoc,, () Sones E, Smith A, Schleis S, Brawner W, Almond G, Taylor K, Haney S, Wypij J, Keyerleber M, Arthur J, Hamilton T, Lawrence J, Gieger T, Sellon R, Wright Z : Survival times for canine intranasal sarcomas treated with radiation therapy: cases, Vet Radiol Ultrasound,, () Kanda Y : Investigation of the freely-available easy-touse software EZR(Easy R) for medical statistics, Bone Marrow Transplant,, () Ladue T, Klein MK : Toxicity criteria of the veterinary radiation therapy oncology group, Vet Radiol Ultrasound,, () Mason SL, Maddox TW, Lillis SM, Blackwood L : Late presentation of canine nasal tumours in a UK referral hospital and treatment outcomes, J Small Anim Pract,, () Langova V, Mutsaers AJ, Phillips B, Straw R : Treatment of eight dogs with tumours with alternating doses of doxorubicin and carboplatin in conjunction with oral piroxicam, Aust Vet J,, ()

6 The Effectiveness of Megavoltage Radiation Therapy Against Nasal Tumors in Dogs Yusuke WADA ), Ryohei YAMAMOTO ), Norihiko KITAMURA ), Hideo AKIYOSHI ), Takashi HASEGAWA ), Terumasa SHIMADA ), ), Fumihito OHASHI ) and Kihei KUBO ) ) Veterinary Medical Center of Osaka Prefecture University, 58 Rinku-ouraikita, Izumisano, , Japan ) Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 58 Rinku-ouraikita, Izumisano, , Japan SUMMARY We retrospectively investigated a total of dogs with nasal tumors that were treated with megavoltage radiation therapy from to at the Veterinary Medical Center of Osaka Prefecture University. For the radiation therapy, a MV X-ray was used, and the prescribed dose was.-. Gy given in - measures. The dogs received.-. Gy per measure,.-. times a week. The median overall survival time of all dogs was days. The median survival time of dogs with cribriform plate involvement was significantly shorter than that of dogs with an intact cribriform plate. Clinical signs improved in out of dogs after the treatment, and the side effects of the radiation were mild. These findings indicate that our radiation therapy protocol based on TDF for nasal tumor can result in life prolongation, the amelioration of clinical symptoms, and the reduction of radiation side effects. Key words : canine, nasal tumor, radiation therapy, TDF. Correspondence to : Ryohei YAMAMOTO (Graduate School of Life and Environmental Sciences, Osaka Prefecture University) 58 Rinku-ouraikita, Izumisano, , Japan TELFAX yamamoto@vet.osakafu-u.ac.jp J. Jpn. Vet. Med. Assoc.,, ()

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原 著 X 小動物臨床関連部門 要 約 X MV X.. Gy.... Gy TDF TDF TDF,... Gy time-dose-fractionation factor TDF Gy TDF.. Gy TDF TDF.. Gy.... Gy 症例 MIX FAX yamam

原著 X 小動物臨床関連部門要約 X MV X.. Gy.... Gy TDF TDF TDF,... Gy time-dose-fractionation factor TDF Gy TDF.. Gy TDF TDF.. Gy.... Gy 症例 MIX FAX yamam