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7 NOAEL

8 4--2- F344/DuCrlCrlj ppm w/w ppm 4000 ppm 7000 ppm 4000 ppm 7000 ppm 4000 ppm F344/DuCrlCrlj NOAEL 280 ppm13 mg/kg / 160 ppm9 mg/kg / -1-

9 4--2- (ppm) Peto Cochran- Armitage * ** C * 12 6 * ** C C-+ C * (ppm) Peto Cochran- Armitage ** C * * : p0.05 ** : p0.01 Fisher : p0.05 : p0.01 Peto, Cochran-Armitage : p0.05 : p0.01 Cochran-Armitage -2-

10 chloro-2-nitroaniline amino-4-chloro-2-nitrobenzene CAS No NH 2 NO 2 Cl LUTFB () EP 99.9%() -3-

11 3 31 () M-80B () FTIR-8200PC APPENDIX () LC-10 APPENDIX () 795 F344/DuCrlCrlj SPF g90108 g F344/DuCrlCrlj SPF -4-

12 ppm ppm w/w OECD F344/DuCrlCrlj ppmw/w ppm -5-

13 7000 ppm 91%10000 ppm 85% 4000 ppm 4000 ppm 91%7000 ppm 88%10000 ppm 87% 4000 ppm 1600 ppm 7000 ppm 4000 ppm ppm 7000 ppm ppm 4000 ppm ppm 4000 ppm ppm 640 ppm 7000 ppm 1400 ppm 280 ppm ppm 800 ppm 160 ppm 5 16 CRF-1 () SS-251CS-20 HP-20M ppm ppm ppm ppmw/w () LC % -6-

14 APPENDIX 2-1 APPENDIX ppm ppm 8 8 () LC-10 APPENDIX kg 1 mg/kg / () () 50 ( ) 50 ( ) 280 ppm 50 ( ) 160 ppm 50 ( ) 1400 ppm 50 ( ) 800 ppm 50 ( ) 7000 ppm 50 ( ) 4000 ppm 50 ( ) -7-

15 % % % 12 8:0020: :008: (W)294(D)176(H) mm 2 () 8-2 CRF-130kGy- CRF-1 CRF-1 CRF-1 () -8-

16 3 () EDTA-2 APPENDIX 3 (MCV) (MCH)(MCHC) -9-

17 35 APPENDIX 3 A/G ASTALTLDHALP-GTPCK ph % -10-

18 4 41 g 1 g kg 1 mg/kg / 1 1 g APPENDIX 3 42 Bartlett Dunnett Kruskal-Wallis Dunnett Peto 9Cochran-Armitage Fisher Peto -11-

19 () %Peto Fisher 5% 1% Peto

20 1 TABLE A 1, 2 FIGURE 1, %280 ppm 36 72%1400 ppm 41 82%7000 ppm 33 66% 4000 ppm ppm 800 ppm %160 ppm 39 78%800 ppm 42 84%4000 ppm 3 6% 2 TABLE B 1, ppm ppm 4000 ppm 3 TABLE C 14 FIGURE 3, ppm 1400 ppm 280 ppm ppm 101% 1400 ppm 96%7000 ppm 68% -13-

21 4000 ppm 800 ppm 160 ppm ppm 101% 800 ppm 98%4000 ppm 53% 4 TABLE D 14 FIGURE 5, ppm 1400 ppm 280 ppm 15.7g 280 ppm 15.8g101%1400 ppm 15.7g100%7000 ppm 14.0g89% 4000 ppm 800 ppm 160 ppm 11.4g 160 ppm 11.5g101%800 ppm 11.6g102%4000 ppm 10.4g91% 5 TABLE E 1, 2 mg/kg /280 ppm ppm ppm mg/kg /280 ppm ppm ppm ppm 1400 ppm ppm mg/kg /160 ppm ppm ppm mg/kg /160 ppm 9800 ppm

22 ppm ppm 800 ppm ppm TABLE F 1, ppm MCHC 7000 ppm MCHC MCV 4000 ppm 800 ppm 4000 ppm 7 TABLE G 1, 2 A/G 1400 ppm ALT-GTP 7000 ppm ASTALTLDHCK 4000 ppm 160 ppm 800 ppm 800 ppm 8 TABLE H 1, ppm ph 1400 ppm -15-

23 1400 ppm ppm ppm ppm ppm ppm ppm ppm ppm ppm ppm ppm ph 160 ppm 4000 ppm 800 ppm ppm ppm ppm ppm ppm ppm ppm 9 91 TABLE I ppm ppm ppm ppm ppm ppm ppm ppm ppm ppm ppm ppm ppm ppm ppm ppm ppm 160 ppm 800 ppm ppm 5-16-

24 92 TABLE J 1, 2 TABLE K 1, ppm 1400 ppm 1400 ppm 1400 ppm 7000 ppm 1400 ppm 7000 ppm 4000 ppm 800 ppm 4000 ppm 4000 ppm 93 TABLE L 16 TABLE M 1, 2 TABLE N 1, 2 Peto Cochran-Armitage Fisher TABLE O 1, 2 TABLE P 1, 2 %%% TABLE Q 16 1 : 0, 0%280 ppm : 1, 2%1400 ppm : 0, 0%7000 ppm : 3, 6% Peto Cochran-Armitage : 0, 0%280 ppm : 0, 0%1400 ppm : 1, 2% 7000 ppm : 0, 0% : 0, 0%280 ppm : 1, 2%1400 ppm : 1, 2%7000 ppm : 3, 6% Peto 0 8,

25 : 41, 82%280 ppm : 35, 70%1400 ppm : 43, 86% 7000 ppm : 47, 94% Peto Cochran-Armitage 56 98, 82.3 Fisher 7000 ppm C Fisher 280 ppm 7000 ppm Fisher 7000 ppm Cochran-Armitage ppm 1400 ppm 7000 ppm 7000 ppm 1400 ppm 7000 ppm 1400 ppm 7000 ppm 280 ppm 280 ppm 1400 ppm 1 C Fisher 4000 ppm Cochran-Armitage -18-

26 2 800 ppm 4000 ppm 4000 ppm 4000 ppm 4000 ppm 4000 ppm 4000 ppm 4000 ppm 800 ppm 800 ppm C 4000 ppm 94 TABLE R 1, ppm ppm

27 ppm ppm ppm 7000 ppm 7000 ppm 4000 ppm 7000 ppm 68% 4000 ppm 53% 7000 ppm 4000 ppm ppm 800 ppm F344 10, 11, ppm 7000 ppm 4000 ppm -20-

28 4000 ppm 13, u ppm 4000 ppm 7000 ppm ppm 4000 ppm MCHCMCV 1400 ppm 800 ppm 7000 ppm 4000 ppm 7000 ppm 4000ppm 15, ppm 4000 ppm 4000 ppm ppm 7000 ppm ppm

29 4 OECD 6 10% ppm 68% 4000 ppm 53% ppm ppm 5 NOAEL 1400 ppm 800 ppm NOAEL 280 ppm13 mg/kg / 160 ppm9 mg/kg / -22-

30 in vitro BALB/c-3T mm mm mm in vitro TA98TA100 2 S9TA98 S9 18) TA98TA100TA1535 TA S9 S9 TA98 TA100 S9 TA98 S9 19) CHO-W-B μg/ml 20) CHO-W-B1 302 μg/ml μg/ml 20) L5178Y TK +/ μg/ml 1-4 μg/ml 21) in vivo NMRI 2200 mg/kg

31 F344/DuCrlCrlj

32 :, () McLafferty FW, ed Wiley Registry of Mass Spectral Data. 6th ed. New York, NY: John Wiley and Sons. 4. () , , OECD OECD Guideline for Testing of Chemicals 451: Carcinogenicity Studies, Paris: Organisation for Economic Co-operation and Development : : Peto R, Pike MC, Day NE, Gray RG, Lee PN, Parish S, et al Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments. In: Long-Term and Short-Term Screening Assays for Carcinogens: A Critical Appraisal. Lyon: IARC. IARC Monographs Suppl 2: (2), C... :, Montgomery CA Jr, Seely JC Kidney. In: Pathology. of the Fischer Rat. (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). San Diego, CA: Academic press,

33 12. Alden CL, Frith CH Urinary system. In: Handbook of Toxicologic Pathology. (Haschek WM, Rousseaux CG, eds). San Diego, CA: Academic press, Short BG, Goldstein RS Nonneoplastic lesions in the kidney. In: Pathology of the aging rat, Vol 1 (Mohr U, Dungworth DL, Capn CC, eds). Washington, DC: ILSI press, Montgomery CA, Seely JC Kidney. In: Pathology of the Fischer rat reference and atlas. (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF eds). San Diego: Academic Press, Bingham E and McGowan WJ, Aromatic Nitro and Amino Compounds. In: Patty s Toxicology, 6th ed (Bingham E and Cohrssen B eds.) Hoboken NJ: John Wiley & Sons, Vol. 2, , ( 3 ).. : Matthews EJ, Spalding JW, Tennant RW Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure. Environ Health Perspect. 101 (Suppl 2): ,,, : Haworth S, Lawlor T, Mortelmans K, Spec W, Zeiger E Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 5 (Supple 1): Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, et al Chromosome aberrations and sister chromatid exchanges in chinese hamster ovary cells: Evaluations of 108 chemicals. Environ Mol Mutagen 10 (Suppl 10): National Toxicology Program, Database Search Application: 4-Chloro-2-nitroaniline. Chemical&cas_no= [accessed 22 July 2014]. -26-

34 22. GDCh-Advisory Committee on Existing Chemicals Chloro-2-nitroaniline. BUA Report 235. Stuttgart: Hirzel Verlag. -27-

35 4000 ppm -28-

关于推介发布秸秆“五料化”利用技术的通知

关于推介发布秸秆“五料化”利用技术的通知附件秸秆五料化利用技术一秸秆肥料化利用技术 1.1 秸秆直接还田技术 1.1.1 秸秆机械混埋还田技术秸秆机械化混埋还田技术, 就是用秸秆切碎机械将摘穗后的玉米小麦水稻等农作物秸秆就地粉碎, 均匀地抛撒在地表, 随即采用旋耕