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1 7 10 Vol. 7 No Journal of Food Safety and Quality Oct., 2016 * 常燕飞, 李爱珍 (, ) 摘要 :,,,,,,,, 关键词 : ; ; ; ; ; Research progress of natural active ingredient for diabetes control and its related gene CHANG Yan-Fei, LI Ai-Zhen * (Inner Mongolia Medical College Affiliated Hospital, Hohhot , China) ABSTRACT: Diabetes is a common endocrine and metabolic diseases. At present, the natural active substances of new pharmacology and mechanisms have been in the continuous exploration, mainly reflected in the antiviral, antitumor, antiox-idant, antibacterial, reducing bloodsugar, reducing blood pressure, prevention of atherosclerosis and coronary heart disease and so on. Genes can be targets of diabetes treatment. This article mainly summarized the relevant regulation of nucleoside, alkaloids, polysaccharide and flavonoids on diabetes, at the same time the genes related with diabetes were simply introduced. The development of modern clinical medicine adopted drugs, antibodies, biological or physical factors to affect on the network of important nodes of the diabetes genes, making it crack or change, which could achieve good results in the treatment of diabetes. With the development of molecular biological and pharmaceutical engineering, further study of specific natural active substances of the pharmacological, toxicological effects and the mechanism can be carried out, so as to excavate its business and clinical valueimmensely. KEY WORDS: natural active ingredients; diabetes mellitus; regulating effect; gene; hpyerglycemic; insulin * 通讯作者 :,,, xiayue061622@sohu.com *Corresponding author: LI Ai-Zhen, Master, Associate Chief Physician, Inner Mongolia Medical College Affiliated Hospital, Hohhot , China. xiayue061622@sohu.com

2 10, : 引言 (diabetes mellitus, DM),, ( ) [1] 1 T1DM 2 T2DM ( β ) GDM,, [2] T2DM [3] T2DM, T2DM, 2 天然活性成分分类及对糖尿病的调控 2.1 苷类, β,, α-, β, [4] Murotomi [5], 4 Ⅱ,,, Sangi [6], 3 mg/kg 5 mg/kg 56 d, 4,, (Anemarrhena asphodeloides) α-,, ALX, β [7] 2.2 生物碱类, ; β ; ; ; α-,, ; [8], -γ(ppa γ) 4(GLUT4) (activated protein kinase, AMPK),,,,,, (streptozocin, STZ) [9] (ephedrae herba) STZ, STZ,, [10] (Stephania) 7-O- 2 -N- 2-N-, [11] T2DM,, 2, (mitogen-activated protein kinase, MAPK) B(protein kinase B, PKB), D 1 [12-14] 2.3 多糖类 (polysaccharide) 4,

3 CSP-1 [15,16], β, β, [16],, : (1) ; (2) ; (3) ; (4) ; (5) ; (6), ; (7), STZ, STZ β β, [17,18] C, β [19] 2.4 生物酮类 β- [20] (total cholesterol, TC) (LQ)-a B(A pob), A I(A poa I) (high-density lipoprotein, HDL-C),,, [21] α-,, [22],, α-, β-, [23] 3 对糖尿病相关基因的研究 3.1 相关基因介绍 1 2,,, (Down Turner ) [24] 1, HLA HLA, 2, 9 CDKN2A CDKN2B 3 IGF2BP2 CDKALl TCF7L2 SLC30A8 HHEX PPARG KCNJl1 SREBF2 FTO [25] 9p CDKN2A/2B β CDK4, CDK4,,, T2DM [26,27], ( ), [28-30] 3.2 天然活性物质对基因的调控,,,, 2, [31,32], PTP1B [33], α- -3-O-β-D- 19(R) β- -6,23- -3β, O-β-D β,22,23,24, O-3-β-D- -(1 6)- D- ( A, momordicoside A) PTP1B Yue [34] (Murraya koenigii L. Spreng) PTP1B mahanine (mahanimbine) 8,8 -biskoenigine, IC μmol/l [35] PTP1B 2, PTP1B, IC 50 (63.43±1.07) μmol/l PTP, PTP1B, PTP1B (activated protein kinase, AMPK), AMPK AMPK-LKB1,, [36] [37], AMPK Gao [38], PPAR Re 3T3-L1, PPARγ2-1(IRS-1) (Ap2 ), TNF-α GLUT4 [39]

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填表说明 1. 本表所填数据截至时间为 2011 年 9 月底 2. 本表请用 A4 纸双面打印, 加盖学校公章后上报 3. 表内所填数据请学校认真核实, 确保准确无误 4. 建设完成情况对照填表说明 1. 本表所填数据截至时间为 2011 年 9 月底 2. 本表请用 A4 纸双面打印, 加盖学校公章后上报 3. 表内所填数据请学校认真核实, 确保准确无误 4. 建设完成情况对照表等相关表格栏高不够请自行增加 5. 表格中填写的相关量