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1 7 10 Vol. 7 No Journal of Food Safety and Quality Oct., 2016 张倩茹 1, 李安平 (1., ; 2., ) 2* 摘要 : (Semen Ziziphi Spinosae),,,,,,, 关键词 : ; ; ; Function of Semen Ziziphi Spinosae pieces and its risk assessment analysis in the production processing ZHANG Qian-Ru 1, LI An-Ping 2* (1. Shanxi University of Traditional Chinese Medicine, Taiyuan , China; 2. Shanxi Zhendong Pharmaceutical Co., Ltd., Taiyuan , China) ABSTRACT: Semen Ziziphi Spinosae is the ripe fruit of rhamnaceae jujube trees after removing the flesh and core shell, collecting the seeds and drying. Semen Ziziphi Spinosae contains a variety of functional ingredients, such as jujuboside, flavonoids, alkaloids, etc., which has the functions of sedative hypnosis, anticonvulsants, anti-myocardial ischemia, hypolipidemic, anti-tumor and enhancing the role of the immune system. In the production processing of Semen Ziziphi Spinosae pieces, the processing technology is not standardized, standards are not uniform, and quality regulatory is oversight, so the quality of Semen Ziziphi Spinosae pieces have some problems. Establishment of the quality assessment of risk system in the production processing, on the one hand it can effectively control the quality and safety problems of Semen Ziziphi Spinosae pieces in the production processing, on the other hand it can lay the basis for study of Semen Ziziphi Spinosae pieces processing technology standardization. This review summarized the functional ingredients and healthy functions of Semen Ziziphi Spinosae pieces, and the risk assessment analysis in the production processing. KEY WORDS: Semen Ziziphi Spinosae, functional ingredient, healthy function, risk assessment 1 引言 (Semen Ziziphi Spinosae),,,, [1], [2] * 通讯作者 :,, ( ) xiayue061622@sohu.com *Corresponding author: LI An-Ping, Master, Shanxi Zhendong Pharmaceutical Co., Ltd., Zhendong Science and Technology Park, Handian Town, Changzhi County, Changzhi City, Shanxi , China. xiayue061622@sohu.com

2 10, : 3907,, [3],, [4] [5], ;, ; ; ;, [6,7],,,, 2 酸枣仁饮片的功能性成分,, 32%, 8,, C A B B1 [8] 2.1 皂苷类,, A B, [9], [10] [11] [12] O- -25-, G H A A1 B, B1 C [13] 2.2 黄酮类 ,, [14-16] 2.3 脂肪酸类 32% 1.6%,,, [17,18], : 6,, 49.1% 26.0% 4.1%, [19] 2.4 其他类, A(sanjoinine A,, frangufoline) B D E [20] C 7 [21], [22] 3 酸枣仁饮片的保健功能作用 3.1 镇静催眠作用, [23],,, [24] 0.5 g/kg,,,, [25,26], ( 50% 100%), ( ) [27,28] 3.2 对心血管系统的作用 [29],, - [30] SOD [31] [31] A, A 3.3 抗焦虑作用, [32,33], 5

3 3908 7, [34] 3.4 增强免疫作用,, 0.1 g/kg, 1 d,, 60 Co [35],, 0.1 g/kg, 16 d,,,, 3.5 其他作用, [36], 1.45 ml/kg 0.35 ml/kg, (MAD), SOD,,, PGL2 [37,38] 4 酸枣仁饮片在生产过程中的风险评估分析,,,, [39], [40],, [41] 4.1 严格控制原料选种与种植环节,,,,,,,,,, [42],, [40], ;,, [43] 4.2 规范酸枣仁饮片生产过程中的各个环节,,,,, [44],,, ;,, ;,,,,, [45],,, [46],,, [47],,,,, [48],,, [49] 4.3 完善产品追溯体系, 建立统一信息平台,,

4 10, : 3909,,,,,,,,, [50] 5 结论,,,,,,,,, 参考文献 [1],,,. [J]., 2008, 19(5): Huang W, Jin BQ, Cheng GY, et al. Zizyphus jujube kernel function testing and health care function to improve sleep research [J]. Lishizhen Med Mater Med Res, 2008, 19(5): [2],,,. [J]., 2012, 32(12): Zeng BY, Li JY, Li XC, et al. Chinese medicine research status of Semen Ziziphi Spinosae (zs) [J]. J Hunan Univ Chin Med, 2012, 32(12): [3],. [J]., 1987, 12(8): 499. Hong GX, Cao B. Research progress of Semen Ziziphi Spinosae (zs) [J]. Traditional Chinese medicine (TCM) Bull, 1987, 12(8): 499. [4],,. [J]., 2006, 28(1): Zheng Y, Qian SY, You ZL, et al. Advances in study onpharmaco logical effects of Semen Zizphi Spinosae [J]. Sichuan J Physiol Sci, 2006, 28(1): [5] Chung KF, Lee CK. Over the counter sleeping Pills: a survey of use in Hongkong and a review of their constituents [J]. Gen Hosp Psy, 2002, 24(6): [6],,. [J]., 1999, 21(3): Li HJ, Li P, Yu GD. Advance of research and prospect of development of Zizyphus jujuba var.spinosa(bunge) Huex H F Chow [J]. Chin Wild Plant Res, 1999, 21(3): [7] Cheng G, Bai YJ, Zhao YY, et al. Flavonoids from Ziziphus jujuba Mill var. Spinosa [J]. Tetrahedron, 2000, 56(2): [8],. [J]., 2001, 12(1): Peng ZS, Zhu JJ. Chemical constituents and pharmacological research progress of Semen Ziziphi Spinosae (zs) [J]. Lishizhen Med Mater Med Res, 2001, 12(1): [9],. [J]., 2008, 11(11): Gao JF, Xu WY. Zizyphus jujube RenZao glycosides research review [J]. J Chin Med, 2008, 11(11): [10],,. [J]., 2006, 27(4): Wang XF, He JG, Chen Y. The extraction of zizyphus jujube RenZao glycosides and improve sleep efficacy study [J]. Food Sci, 2006, 27(4): [11],,. [J]., 1987, 13(2): Zeng L, Zhang RY, Wang X. The chemical composition of Semen Ziziphi Spinosae (zs) [J]. J Integrat Plant Biol, 1987, 13(2): [12],. [J]., 2008, 28(1): Wang JZ, Yang JS. Triterpenoid saponins in zizyphus jujube kernel separation and structural study [J]. J Organ Chem, 2008, 28(1): [13] Matsuda H, Murakami T, Ikebata A, et al. Bioactive saponins and glycosides Structure elucidation and immunologi-cal adjuvant activity of novel protojujubogenin type triterpene bisdesmosides, protojujubosides A, B, and B1, from the seeds of Zizyphus jujuba var. Spinosa(Semen Zizyphi Spinosae)[J]. Chem Pharm Bull, 1999, 47(12): [14] Niu CY, Wu CS, Sheng YX, et al. Identification and characterization of flavonoids from semen zizyphi spinosae by high -performance liquid chromatography/linear ion trap FTICR hybrid mass spectrometry [J]. J Asian Nat Prod Res, 2010, 12 (4): 300. [15] Xie YY, Xu ZL, Wang H, et al. A novel spinosin derivative from Semen Ziziphi Spmosae[J]. J Asian Nat Prod Res, 2011, 13 (12): [16] Han RH, Park MH, Han YN. Cyclic peptide and peptide alka-loids from seeds of Zizyphus vulgaris[j]. Phytochemistry, 1990, 29(10): [17],,. [J]., 2011, 8(3): Ma JJ, Liu P, Ma BP. Chemical composition and its sedative hypnotic effect research progress of Semen Ziziphi Spinosae (zs) [J]. Int J Pharm Res, 2011, 8(3): [18],,. [J]., 2009, 11(3): Zhang X, Ding CH, Li HP. Chemical composition and pharmacological activity research progress of zizyphus jujube kernel [J]. J Food Ind Sci Technol, 2009, 11(3): [19] Zhang L, Xu ZL, Wu CF. Two new flavonoid glycosides from Semen Ziziphi Spinosae [J]. J Asian Nat Prod Res, 2012, 14 (2): 121. [20]. [J]., 2006, 31(8): Lu K. Zizyphus jujube kernel oil physical and chemical properties and composition analysis [J]. China Oils Fats, 2006, 31(8): [21]. [J]., 2009, 7(4):

5 Peng SX. Zizyphus jujube benevolence of the chemical constituents and pharmacological activities of the results of the study [J]. Chin Med Guid, 2009, 7(4): [22],,. [J]., 1995, 10(1): Guo SM, Fan XW, Song SG. Zizyphus jujube benevolence ferulic acid extraction, isolation and identification [J]. Pharm J Northwest, 1995, 10(1): [23],,. [J]., 2002, 25(6): Chen BQ, Du GJ, Xu QT. Zizyphus jujube RenZao of sedative hypnotic effect [J]. J Chin Med Mater, 2002, 25(6): [24] Wang LE, Cui XY, Cui SY, et al. Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT 1A, receptors [J]. Phytomed Int J Phytother Phytopharmacol, 2010, 17(6): [25] Jin-Jie MA, Liu P, Bai-Ping MA. The chemical constituents of Semen Zizyphi Spinosae and pharmacologic mechanism of its sedative and hypnotic effects: research advances [J]. J Int Pharm Res, 2011, 32(8): [26],,. [J]., 2010, 27(5): Yang B, Dong W, Wang XJ. Zizyphus jujube kernel soup sedative hypnotic effect [J]. Inf Tradit Chin Med, 2010, 27(5): [27],. [J]., 2011, 22(7): Chen W, Huang SJ. Chemical components and pharmacological effects of Semen Ziziphi Spinosae (zs) research progress[j]. Lishizhen Med Mater Med Res, 2011, 22(7): [28],,. [J]., 2007, 19(1): 4 5. Zhao LH, Qiao W, Xu L. Experimental study on anti-convulsion effect of alkaloids from Semen Zizyphi Spinosae [J]. Tianjin Pharm, 2007, 19(1): 4 5. [29]. [J]., 1996, 27(2): 103. Wan HY. Total saponins of semen ziziphi spinosae (zs) anti lipid peroxidation [J]. Chin Herb Med, 1996, 27(2): 103. [30],,. [J]., 2001, 15(1): Ren FZ, Luan XH, Zhao YM. The research progress of pharmacological action and chemical composition of Semen Ziziphi Spinosae (zs) [J]. J Mod Chin Med Res Pract, 2001, 15(1): [31],,,. A L- [J]. ( ), 2009, 30(3): Deng W, Tang QZ, Li X, et al. Zizyphus jujube RenZao glycosides A ventricular muscle cells of rat L - type calcium channel influence [J]. J Wuhan Univ (Med Ed), 2009, 30(3): [32]. [D]. :, Wang SY. Zizyphus jujube kernel soup components compatibility of anti-anxiety effect and its mechanism [D]. Beijing: Beijing university of Chinese Medicine, [33],,,. [J]. ( ), 2009, 18(5): Zhu TL, Hu ZS, Li L, et al. Study on the antidepressant effect of active fraction from Semen Zizyphi Spinosae [J]. Acta Acad Med Cpaf, 2009, 18(5): [34] Zhang SB, You QY, Wu LL. Effects of total saponins in Semen Zizyphi Spinosae(SZS) on cerebral contents of glutamic acid,gamma-aminobutyric in aged rat models of insomnia with yin and blood deficiency syndrome[j]. J Hubei Univ Chin Med, 2009, 11(2): [35] Lang X, Li M, Jia B, et al. Experimental research of the effect of polysaccharides in Semen Ziziphis Spinosae and Ziziphis Spinosae on enhancing the immune function of mice injured by radiation [J]. China J Chin Mater Med, 1991, 16(6): [36]. [J]., 1995, 16(3): 259. Wang QL. Zizyphus jujube kernel oil of airy ascites carcinoma in mice survival and quality of body [J]. J Xi'an Med Univ, 1995, 16(3): 259. [37] Bai X, Huang Z, Mo Z, et al. Effects of total saponins of semen Ziziphi Spinosae on brain damages and brain biochemical parameters under cerebral ischemia of rats [J]. China J Chin Mater Med, 1996, 21(2): [38]. [M]. :, Shen YJ. Chinese medicine pharmacology [M]. Shanghai: Shanghai Science and Technology Publishing House, [39],,. [J]., 2015, 40(16): Liu Y, Nie Q, Chen J. Suggestions to strengthen quality management of traditional Chinese medicine yinpian, based on Chinese medicine yinpian production chain analysis [J]. Chin J Trad Chin Med, 2015, 40(16): [40] Qiao XH. The important factors that affects the quality of Chinese materia medica [J]. China Health Nutr, 2012, 22(10): [41],,,. [J]. :, 2011, 13(3): Cai H, Qing KM, Liu X, et al. Research status quo of Chinese medicine yinpian quality standards and relevant thinking[j]. Sci Technol World: Mod Trad Chin Med, 2011, 13(3): [42],. [J]., 2006, 20(9): Deng SW, He Q. The research progress of traditional Chinese medicine quality standard test methods and suggestions [J]. J China Pharm Aff, 2006, 20(9): [43],. [C]., He H, Sun CK. Standard management in the application of Chinese medicine yinpian quality control [C]. Drug testing Quality Management Academic Seminar of China Medicine Institute, [44]. [J]., 2011, 20(18): 2 4. Xia W. Chinese medicine yinpian quality present situation and the improvement strategy in China [J]. China Pharm Ind, 2011, 20(18): 2 4. [45]. [J]., 2009, 23(3):

6 10, : 3911 Li W. Analyses the influencing factors on the quality of the Chinese medicine yinpian and countermeasures [J]. J China Pharm Aff, 2009, 23(3): [46],,,., [J]., 2012, 37(14): Xiao YQ, Zhang C, Li L, et al. Build slices quality guarantee system, ensure the clinical curative effect of traditional Chinese medicine (TCM) [J]. Chin J Tradit Chin Med, 2012, 37(14): [47],. [J]. -, 2014, 8(3): Zhan ZB, Wu CJ. Chinese medicine yinpian quality evaluation and process quality control of new technology [J]. Sci Technol World - Mod Tradit Chin Med, 2014, 8(3): [48],,. [J]., 2011, 9(7): Sun J, Yang L, Cheng R. Chinese medicine yinpian quality problems and management countermeasures [J]. J China Mod Distance Ed Chin Med, 2011, 9(7): [49],. [J]., 2011, 8(35): Peng Q, Xiu Y. Chinese medicine yinpian quality problems and countermeasures [J]. China Med Herald, 2011, 8(35): [50],,,. [J]., 2015, 50(4): Wei F, Liu W, Yan H, et al. Quality of Chinese herbal medicine yinpian and situation and related problem analysis [J]. J Chin Pharm, 2015, 50(4): 作者简介 ( 责任编辑 : 白洪健 ) 张倩茹, 硕士研究生, 主要研究方向为中药学 ( 药事管理 ) dunyun975987@sohu.com 李安平, 研究生, 主要研究方向为中药学 ( 药事管理 ) xiayue061622@sohu.com

第 33 卷第 2 期 2010 年 4 月 - 149 - 脱蛋白较好的方法是 Sevag 法, 它是根据蛋白质在氯仿等有机溶剂中变性的特点, 使蛋白质变性成胶状, 此法条件温和, 可避免多糖的降解

第 33 卷第 2 期 2010 年 4 月 - 149 - 脱蛋白较好的方法是 Sevag 法, 它是根据蛋白质在氯仿等有机溶剂中变性的特点, 使蛋白质变性成胶状, 此法条件温和, 可避免多糖的降解 - 148 - Drug Evaluation Research Vol.33 No.2 April 2010 植物多糖的研究进展陶遵威 1, 郑夺 1, 邸明磊 2, 单晓菊 1 天津市医药科学研究所, 天津 300020; 2 天津中医药大学, 天津 300073 2 摘要多糖是由单糖连接而成的多聚物,