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1 5 7 Vol. 5 No Journal of Food Safety and Quality Jul., 2014 Meta 李 * 晓, 李雪梅, 张立实 (, ) 摘要 : 目的方法 MEDLINE FMJS(EMCC) OVID (CNKI)(VIP), 结果, 8, [SMD 6.20, 95% CI( 9.72, 2.67)], (P < ), (I 2 = 94%),, (P =0.003), (P=0.72) 结论关键词 : ; ; Meta ; Effect of aloe on the blood glucose of diabetic rats: a Meta-analysis LI Xiao, LI Xue-Mei, ZHANG Li-Shi * (West China School of Public Health, Sichuan University, Chengdu , China) ABSTRACT: Objective To evaluate the effect of aloe on decreasing the levels of blood glucose of model diabetic rats. Methods The Medline, FMJS(EMCC), OVID, CNKI, VIP and WANGFANG databases were searched between Jan and Mar. 2014, and relevant controlled trials diabetic model rats were extracted, reviewed, and validated independently by two reviewers according to the study protocol. Results Totally 8 articles were selected and validated. Compared to the control group, the total effect of aloe on the blood glucose showed as [SMD 6.20, 95% CI( 9.72, 2.67)], with a statistical significance (P< ) by random effect model, implying that aloe could reduce the levels of blood glucose of rats. The result of subgroup analysis found that the blood glucose of diabetic rats with long term aloe intakes were decreased (P=0.003), but the levels with short term aloe intakes showed no obvious change (P=0.72). Conclusion Aloe may have effects of reducing the blood glucose of diabetic rats. KEY WORDS: aloe leaves; diabetes mellitus; Meta-analysis; rats, 11.6% [1],,, 基金项目 : ( ) Fund: Supported by the National Natural Science Foundation of China ( ) * 通讯作者 :,,,. lishizhang_56@ 163.com *Corresponding author: ZHANG Li-Shi, Professor, PhD Supervisor, West China School of Public Health, Sichuan University, Chengdu, , China. lishizhang_56@ 163.com

2 2016 5,, (Aloe),,,,,, Meta 2006, Peters 103 /Meta, [2], Meta Revman,, 1 资料来源 1.1 纳入标准 1, (STZ) ; 2 ; 3,, 4 ; 5,, 1.2 排除标准, ; ; 1.3 文献检索及资料来源 : MEDLINE FMJS(EMCC) OVID (CNKI) (VIP) : +, : aloe AND diabetes mellitus, , 文献质量评价 2, 1.5 资料分析和统计学处理 Cochrane Review Manager 5.1 χ 2, P>0.1, I 2 <50%,, Meta ; P<0.1, I 2 >50%,,, WMD( SMD ) 95%CI 2 结果 2.1 纳入文献 94, 58,, 13, 7, 7, 质量评分 JADAD, Peters,,,,, 1, 2.3 芦荟对血糖的影响结果 8, 3 20, 5 20, ( 20 )( 1) 1 1, [ (SMD) 6.20, 95% CI ( 9.72, 2.67)],

3 第7期李晓, 等: 芦荟对糖尿病大鼠血糖影响的 Meta 分析 2017 效应模型 P< 有统计学意义, 提示基于现有研义; 短期摄取芦荟组(group2)对糖尿病大鼠的效应为究, 芦荟对大鼠具有一定的降血糖作用异质性检验 [SMD 0.56, 95% CI ( 2.43, 3.54)], P=0.72 没有统计 2 I =94%, 提示各研究之间不完全同质, 根据芦荟摄学意义因两实验组异质性检验分别为 I2= 93% I2= 取时间长短(分界点定为 20 天)进行亚组分析后, 长 91%, 且 8 篇文献中有 2 篇实验动物为非 Wistar 大鼠, 期摄取芦荟组(group1)对糖尿病大鼠的效应为[SMD 故再根据受试动物不同进行亚组分析(图 2) 16.50, 95% CI( 27.56, 5.43)], P=0.003 有统计学意图 1 血糖变化的 Meta 分析结果 Fig. 1 Meta-analysis of the effect of GLU 图 2 经动物品系分组的 Meta 分析结果 Fig. 2 Meta-analysis by grouping animal species

4 表 1 纳入研究的一般特征 Table 1 Characteristic of included trials (g) Rajasekaran [3] Wistar 160~200 ipstz55 mg/kg ig 300 mg/kg (21 ) Jain [4] Wistar 150~200 ipstz40 mg/kg (GLU 200 mg/kg) ig 100 mg/kg (20 ) 1 ml/kg (20 ) Al-Awadi [5] Wistar 200~250 ipstz60 mg/kg ig 10 ml/kg (10 ) (10 ) Rajasekaran [6] Wistar 160~200 ipstz55 mg/kg ig 90 mg/kg (30 ) (30 ) Koo [7] SD 180~220 ipalloxan120 mg/kg ig 2 ml/kg (2 / )(10 ) 2 ml/kg (2 / ) Okyar [8] Wistar 150~200 ipstz65 mg/kg (2-3 GLU 250 mg/kg) ig 500 mg/kg (2h) ig PBS 6 ml/kg Ramachandraiahgari [9] Wistar 160~200 ipstz40 mg/kg (4 GLU 250 mg/dl) ig 300 mg/kg (30 ) [10] SD 250~300 ip Alloxan100 mg/kg (7 GLU 11 mmol/l) ig 0.4 ml/ (16 ) ig : ip. ; ig. 2 2,, (I 2 =26%), (P< ); (P=0.67), I 2 =95%, 3 讨论, [11] 1986 Hikino [12], Ajabnoor [13] Okyar [8] Ghannam [14] Fatania [15], Roman-Ramos [16], Chalaprawat [17], Meta,,,,,,, β,,,, I Ⅱ, 1986, Ghannam [13] B ; 2005 Rajasekaran [6] ; 2012 Moniruzzaman [18], ( ),,,

5 7, : Meta 2019,,, Reviewing Animal Trials Systematically (RATS), Meta :, ; [19], Meta,, Meta,, 20 Meta,,,,,, Meta,,,,,,, (>20 ),,, 参考文献 [1] Yu X, Li M Wan, JH, et al. Prevalence and Control of Diabetes in Chinese Adults [J]. J Am Med Assoc, 2013, 310(9): [2] Peters JL, Sutton AJ, et al. A systematic review of systematic reviews and meta-analyses of animal experiments with guidelines for reporting [J]. J Environ Sci Heal B, 2006, 41(7): [3] Rajasekaran S, Ravi K, Sivagnanam K, et al. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes [J]. Clin Exp Pharmacol P, 2006, 33(3): [4] Jain N, Vijayaraghavan R, Pant S C, et al. Aloe vera gel alleviates cardiotoxicity in streptozocin induced diabetes in rats [J]. J Pharm Pharmacol, 2010, 62(1): [5] Al-Awadi FM, Gumaa KA. Studies on the activity of individual plants of an antidiabetic plant mixture [J]. Acta Diabetol Lat, 1987, 24(1): [6] Rajasekaran S, Sivagnanam K, Subramanian S. Mineral contents of Aloe vera leaf gel and their role on streptozotocin-induced diabetic rats[j]. Biol Trace Elem Res, 2005, 108(1-3): [7] Koo MWL. Aloe vera: antiulcer and antidiabetic effects [J]. Phytother Res, 1994, 8(8): [8] Okyar A, Can A, Akev N, et al. Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models [J]. Phytother Res, 2001, 15(2): [9] Ramachandraiahgari MY, Somesula SR, Adi PJ, et al. Protective role of ethanolic extract of Aloe vera antioxidant properties on liver and kidney of streptozotocin-induced diabetic rats [J]. Dig J Nanomater Bios, 2012, 7: [10]. [J]., 2009, 2(11): 3 4. Liu W. Experimental Study on Preventive and Therapeutic Effect of Aloe on complications of diabetes mellitus and kidney in animal study [J]. Chin Comm Doc: Med, 2009, 2(11): 3 4 [11],,,. [J]., 2013, 23(1): Wan JZ, Zhong JS, Wu XF, et al. Status and Trends of Rearches of Aloe Drugs [J]. Today s Pharm, 2013, 23(1): [12] Hikino H, Takahashi M, Murakami M, et al. Isolation and Hypoglycemic Activity of Arborans A and B, Glycans of Aloe arborescens var natalensis Leaves [J]. Pharm Biol, 1986, 24(4): [13] Ajabnoor MA. Effect of aloes on blood glucose levels in normal and alloxan diabetic mice [J]. J Ethnopharmacol, 1990, 28(2): [14] Ghannam N, Kingston M, Al-Meshaal I A, et al. The antidiabetic activity of aloes: preliminary clinical and experimental observations [J]. Horm Res, 1986, 24(4): [15] Al-Awadi F, Fatania H, Shamte U. The effect of a plants mixture extract on liver gluconeogenesis in streptozotocin induced diabetic rats[j]. Diabetes Res, 1991, 18(4): [16] Román-Ramos R, Flores-Sáenz JL. Experimental study of the hypoglycemic effect of some antidiabetic plants [J]. Archivos de

2020 5 Investigacion Medica, 1991, 22(1): 87 93. 作者简介 [17] Chalaprawat M. The hypoglycemic effects of aloe vera in Thai diabetic patients [J]. J Clin Epidemiol, 1997, 50: 3.

com role of these extracts as antidiabetic and antilipidemic agents on streptozotocin-induced type 2 diabetic model rats [J]. Molecules, 2012, 17(11): 12851 12867.

6 Investigacion Medica, 1991, 22(1): 作者简介 [17] Chalaprawat M. The hypoglycemic effects of aloe vera in Thai diabetic patients [J]. J Clin Epidemiol, 1997, 50: 3. [18] Moniruzzaman M, Rokeya B, Ahmed S, et al. In vitro antioxidant effects of Aloe barbadensis Miller extracts and the potential 李晓, 在读硕士研究生, 主要研究方向为食品毒理 larkinleewanzhou@163.com role of these extracts as antidiabetic and antilipidemic agents on streptozotocin-induced type 2 diabetic model rats [J]. Molecules, 2012, 17(11): [19] Pound P, Ebrahim S, Sandercock P, et al. Where is the evidence that animal research benefits humans [J]. BMJ, 2004, 328(7438): 张立实, 教授, 博士生导师, 主要研究方向为营养与食品卫生 lishizhang_56@ 163.com ( 责任编辑 : 张宏梁 ) 酶技术在食品工程中的应用专题征稿 tougao@chinafoodj.com 食品安全质量检测学报编辑部

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中草药 Chinese Traditional and Herbal Drugs 第 45 卷第 15 期 214 年 8 月 2277 稳心颗粒治疗心律失常的 Meta 分析 * 何颖, 刘莹, 邹爱英天津中医药大学第二附属医院, 天津 15 摘要 : 利用 Meta 分析法评价稳心颗粒治疗心律失常的