Chikungunya...1...3 RNAi...5...8 2...8...9...9...10...11...11...12...13
1 Chikungunya Chikungunya Alphaviruses 1952 1953 3 7 1. 39 7 2 5 3 20 50 60 1965 200 30 1987 1 2006 2 10 WHO 8 151 125 75 26 2. La Réunion 4078.5 700 2005 3 7 12 2006 1 4.7
2 1 250 0.1 1.6 2006 12 2006 2007 3. PubMed chikungunya 2004 5 2007 70 4,000 Aedes albopictus 100 PLoS Pathogens 150 chloroquine USAMRIID 20 80
3 Health and Human Services HHS Institute of Medicine IOM
4 1
5 RNAi RNA RNA interference RNAi mrna RNA double strand RNA dsrna mrna RNAi RNA Science Citation Index Expanded SCI-E RNAi 1. RNAi 1998 2007 SCI-E 2008 1 6 2007 1,393 20 90 RNAi 1 1 1998~2007 SCI-E RNAi 2. RNAi 2002 HIV-1 sirna Lee NS et al, 2002 RNAi 2
6 1 HIV-1 rev sirna sirna HIV-1 HIV-1 RNA HIV RNA RNAi HIV-1 sirna RNA sirnas HIV TRBP RNA shrnas HIV sirnas HIV-lhNef HIV-1 sirna 2002 2003-2004 2005 2006 2007 2 RNAi sirna HIV-1 RNAi Xia HB et al, 2002 HIV-1 RNA Boden D et al, 2003 Das AT et al, 2004 RNAi HIV-1 RNA RNAi Westerhout EM et al, 2005 sirnas Sabariegos R et al, 2006 sirna HIV shrna (anti-hiv shrna) CCR5 anti-ccr5 ribozyme nucleolar-localizing TAR decoy HIV Li MJ et al, 2005 shrnas HIV RNAi ter Brake O et al, 2006 RNA short hairpin RNAs shrnas) RNA long hairpin RNAs lhrnas) RNAs sirnas HIV-1 sirnas lhrnas Nef 3' HIV-1 HIV-1 Konstantinova P et al, 2007 HIV HIV-1 RNAi HIV-1 sirna HIV-1 Tat
7 Dicer RNA (SRS)Bennasser Y et al, 2005 Dicer TRBP HIV-1 TAR RNA Dicer RNA TRBP PKR dsrna RNA PKR Haase AD et al, 2005 sirnas Morris KV and Rossi JJ, 2006 RNAi sirnas RNAi sirna sirna RNAi Mescalchin A et al, 2007 3. 1.2 HIV-1 RNAi RNAi (1) HIV-1 sirna shrnas sirna TAR (2) sirna RNAi (3) sirna sirna HIV-1 RNAi RNAi
8 1 University of Haifa Glucose Tolerance Factor GTF GTF GTF 5 10 50 GTF LDL HDL GTF GTF GTF GTF http://media.haifa.ac.il/index.php?option=com_content&task=view&id=3046&itemid=60 2 3 2 20 30 2007 12 31 Proceedings of the National Academy of Science Esra Tasali
9 40 80 100 60 20 2 2 http://www.eurekalert.org/pub_releases/2007-12/uocm-lod122707.php 1,500 DNA 3 2008 1 Reproductive Sciences Genes in Glucose Metabolism and Association with Spina Bifida Hope Northrup DNA 3 Spina Bifida Association 1 7 Northrup 1 2 400 http://www.eurekalert.org/pub_releases/2007-12/uocm-lod122707.php 2 5 2 the U.S. National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK Robert G Nelson
10 1 15 2 10 65 Nelson Journal of the American Medical Association 1,800 40 20 2 25 55 25 34 8 45 54 4 University of Nebraska Medical Center's Department of Pediatrics Pascale H Lane 2 Lane Nelson 2 http://www.nlm.nih.gov/medlineplus/news/fullstory_59477.html gastric inhibitory polypeptide GIP American Journal of Physiology - Endocrinology and Metabolism GIP GIP Receptor Antagonism Reverses Obesity, Insulin Resistance, and Associated Metabolic Disturbances Induced in Mice by Prolonged Consumption of High-Fat Dietpro3 GIP GIP 160 50 pro3 GIP pro3 GIP http://www.eurekalert.org/pub_releases/2008-01/aps-hhb010308.php
11 Weill Cornell Medical College Pbx-1 Prep-1-10 IL-10 1 2007 12 Immunity IL-10 IL-10 IL-10 T CD36 CD36 IL-10 CD36 IL-10 CD36 IL-10 Pbx-1 Prep-1 Pbx-1 Prep-1 IL-10 http://news.med.cornell.edu/wcmc/wcmc_2007/12_28c_07.shtml Wafik S. El-Deiry TRAIL TRAIL Deiry TRAIL TRAIL 2007 12 13 Journal of Clinical Investigation TRAIL TRAIL B
12 1 TRAIL TRAIL 5 TRAIL TRAIL TRAIL http://www.eurekalert.org/pub_releases/2007-12/uops-crl122707.php National Institute of Environmental Health Sciences The American Thoracic Society ATS American Journal of Respiratory and Critical Care Medicine 2008 1 2.5 50 40 parathion 3 Malathion 60 permethrin
13 http://www.eurekalert.org/pub_releases/2007-12/ats-hpa122107.php 2007 12 27 Current Biology Polytechnic University of Marche Roberto Danovaro 65 Danovaro 116 90 http://www.eurekalert.org/pub_releases/2007-12/cp-dsl122007.php