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- DNA Francis Crick 1958 Sequence HypothesisDNA RNA Central DogmaDNA, C, A, G DNADNA RNA 4 x 4 x 4 = 64 Francis CrickThe Frozen Accident Hypothesis Crick UGA UAG -(Selenocysteine, Sec) (Pyrrolysine, Pyl) -CRL2 UGA RNAUGA UGA UGA CRL2 CRL2 UGACRL2 -CRL2 CRL2UGA CRL2CRL2 UGA UGA CRL2 CRL2 UGA 2
CRL2 RNAUGA UGA CRL2 CRL2 UGACRL2 CRL2 CRL2substrate receptor CRL2 CRL2CRL2 UGA UGA CRL2 1. Lin, H.C., Ho, S.C., Chen, Y.Y., Khoo, K.H., Hsu, P.H., and Yen, H.C.S. (2015). CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding. Science 349 (6243), 91-95. 2. Lobanov, A.V., Turanov, A.A., Hatfield, D.L., and Gladyshev, V.N. (2010). Dual functions of codons in the genetic code. Crit Rev Biochem Mol Biol 45(4), 257-265. 3. Driscoll, D.M., and Copeland, P.R. (2003). Mechanism and regulation of selenoprotein synthesis. Annu Rev Nutr 23,17-40. 同仁來函 3 314 7 2012 84 15 4 18 4 20 3
4 26 82 8164 2010 7 105 4 1336 4 191050502787 4
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