CHAPTER PATHOLOGY 01 1-1 1-2 PATHOLOGY
Pathology pathology pathos logos (etiology)(pathogenesis) 1-1 (estrogen) ( ) poliovirus Penicillin - - 2 -
( ) (paraquat) Chapter 01 (iatrogenic) ( ) X ( ) (protein-energy malnutrition)(marasmus)(kwashiorkor) (nodular goiter)b 1 2 ( ) (psychosomatic disease) (psychosomatic medicine) - 3 -
Pathology 1. 1 ( a 1 -antitrypsin deficiency) (GAG AAG) α 1 2. (factor VIII) A(hemophilia A) 3. 21 (Down s syndrome)13 (Patau's syndrome) 4. (degenerative osteoarthritis)(senile cataract) 1. (developmental) (cretinism) 2. (inflammatory) (pneumonia) ( i m m u n e c o m p l e x ) (glomerulonephritis) 3. (neoplastic) 4. (degenerative) - 4 -
B B ( ) Chapter 01 (structural disease) (organic disease)(growth hormone) (gigantism)(acromegaly) (lesion) (nevus) (melanoma)abcde (Asymmetry) (Border irregularity)(color variegation)(diameter) ( E l e v a t i o n ) ( h e r e d i t a r y 1-1 nephritis)alport(alport syndrome) 1-1 ( ) (functional disease)(irritable bowel syndrome) - 5 -
Pathology (nocturnal enuresis)(anorexia nervosa) (serotonin) (organic brain syndrome) 1. (symptom) 2. (sign) 39 3. (laboratory abnormality) hematuria B(fulminant hepatitis)b - 6 -
1-2 Chapter 01 (general pathology) (systemic pathology) (anatomical pathology) (autopsy) - 7 -
Pathology ( ) (frozen section) 20 ( ) ( ) (immunohistochemical stain) Alport 1-1 ( ) (autopsy) - 8 -
(1)(2) (3)(4)(5) (6)(7) (clinicopathological conference) Chapter 01 70 (clinical pathology) C C - 9 -
Pathology (gross examination) Paget(Paget s disease) ( ) 10%(neutral formalin)4%(formaldehyde) ( ) (hematoxylin & eosin stain, HE stain)hematoxylin (basic dye) 1-2 (signet ring cell carcinoma) - 10 -
Eosin (acid dye)1-2 (frozen section diagnosis) (permanent section diagnosis) Chapter 01 ( ) (histochemical stain) 1-3 (glycogen) (acid-fast stain, AFS) (amyloidosis) (amyloid)(congo red) (polarized microscope) 1-4 1-3 Oil red-o (Gram s stain) potassium ferrocyanide(iron)gms (Gomori s methenamide silver stain)(fungus) - 11 -
Pathology A B 1-4 AB ( ) 1. 2. B(cytomegalovirus)1-5 A B 1-5 (A)(B) - 12 -
3. (alpha fetal protein, AFP)(hepatocellular carcinoma)(yolk sac tomor)(thyroglobulin) (prostate specific protein, PSA) Chapter 01 4. (estrogen receptor, ER) 5. HER2/neu 1-6 HER2/neu 1-6 HER2/neu ( ) ( i m m u n o f l u o r e s c e n t stain) 1-7 1-7 (membranous glomerulonephritis)igg (air dry)95% (Papanicolaou stain) 1-8 - 13 -
Pathology 1-8 1-9 EB (in situ hybridization)1-9(polymerase chain reaction)(cytogenetic analysis)dnarna (fluorescence in situ hybridization, FISH) DNA - 14 -
References (2005) Kumar, V., Abbas, A. K., & Fausto, N. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). Philadelphia: Elsevier Saunders. Macfarlane, P. S., Callander, R., & Reid, R. (2000). Pathology illustrated (5th ed.). New York: Churchill Livingstone Chapter 01-15 -
Pathology / Review Activities 1. (frozen section biopsy)(a)(b) (C)(D) 2. (A) (B)(C)(D)(toluidine blue) 3. (A)(hematoxylin and eosin)(b)(acid fast)(c)iii (Sudan III)(D) (Congo red) 1. B 2. A 3. B - 16 -
CHAPTER PATHOLOGY 02 2-1 2-2 2-3 2-4 2-5 2-6 PATHOLOGY
Pathology 2-1 宋 明 澤 (nuclear envelope) (nucleus) (organelle)(cytoplasm) 2-1 2-1 Fox2006 (mitosis) DNA(chromatin) (chromosome) (nucleolus)rna (nuclear membrane) ( c y t o p l a s m i c m a t r i x ) ( p h o s p h o l i p i d s ) (cholesterol)(proteins) 1. (mitochondria)atp - 18 -
2. (endoplasmic reticulum) (ribosome)(rough endoplasmic reticulum, RER) (smooth endoplasmic reticulum, SER) 3. (Golgi's apparatus) 4. (endosome) 5. (lysosome) Chapter 02 6. (peroxisome)(oxidative enzyme)(catalase) (free radicals) 7. (cytoskeleton) 2-2 朱 旆 億 (cellular adaptation) (hypertrophy) (phisiological hypertrophy)(pathological hypertrophy) (estrogen) (multiple organ failure) - 19 -
Pathology (atrophy) (physiological atrophy) (pathological atrophy) (atrophy of the heart) (brain edema)(brain tumor) (pressure atrophy of brain)(ventricles)(cerebral cortex) (pressure atrophy of kidney)(renal pelvis) (hyperplasia) (physiological hyperplasia) (pathological hyperplasia) (keloid) (atypical hyperplasia) - 20 -