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http //www.cninfo.com.cn 211,355 Active Pharmaceutical Ingredients, 1-2-2
Intermediates FDA U.S. Food and Drug Administration COS Certificate of Suitability 1 2005 100 26 FDA COS 2003-2005 35.95%42.53%48.73%48.67%2006 1-6 41,635.17 2,893.79 2005 23.80%25.37% 4-AA 2 8,000 2,700 10,700 36 1-2-3
12 25% 6 3 2006 7 6 4 1 FDA COS 2 3 1 50.54% 3 1 25.75% 3 4 3 1 43.93% 2006 6 30 15.02 959.15 2006 6 30 1-2-4
47.00 269.60 5 3 1 2005 2004 1,000 1.81% 6 2006 11 17 6,406.60 2006 6 30 31.99% 1 A 2 1.00 3 2,700 25.23% 4 5 0.46 / 2005 6 25.13 7 2.50 / 2006 6 30 8 4.62 / 2006 6 30 9 10 11 3 12 13 31,212 14 29,453.52 1-2-5
Zhejiang Hisoar Pharmaceutical Co.,Ltd. 8,000 2004 5 13 100 318000 05768828065 05768828096 http://www.hisoar.com stock@hisoar.sina.net 1966 97,337 1979 2 1980 12 1981 12 17.90 1989 5 115.99 1992 3 414.90 1995 4 1997 7 1998 5 359.72 2001 8 3,000 2003 2004 5 200416 8,000 2004 6 1 8,000 2,700 10,700 36 1-2-6
12 25% 6 2 1 2 % 1 3,677.9245 45.9741 2 1,600 20.00 3 365 4.5625 4 320 4.00 5 320 4.00 6 320 4.00 7 320 4.00 8 320 4.00 9 242.0755 3.0259 10 SLS 240 3.00 7,725 96.5625 []SLS State-own Legal-person Shareholder 3 % 1 3,677.9245 45.9741 2 320 4.00 3 320 4.00 1-2-7
4 320 4.00 5 320 4.00 6 320 4.00 7 242.0755 3.0259 8 80 1.00 9 365 4.5625-10 35 0.4375-6,000 75.00 [] 3 1 2 90% 56.89% 1 2- BIT 4AA 2 1 2 3 4 1-2-8
5 2-6 7 2 8 9 Sustiva22 10 11 12 BIT 13 14 4-AA 4-AA 3 LONZA 4 DL- 3-5 2005 100 26 BIT COS 1-2-9
FDA COS 9 SFDA GMP ISO 9001 6 2000 3,000 95% ISO 14001 OHSAS 18001 99 2004 5 13 1998 1 2 1 A 2006 1-6 2005 2004 2003-17.88 2.78 66.92 50.30 84.81 53.08 - - 0.25% 0.11% - - - - 0.20% 0.08% - - - 1-2-10
B 2006 1-6 2005 2004 2003 [1] 1,155.56 2,136.00 2,919.30 2,588.00 [2] 230.34 1,003.48 737.11-1,385.89 3,139.48 4,152.70 2,584.00 - - 3.33% 4.54% 8.21% 6.91% - - 3.33% 4.54% 8.21% 6.91% - [1] [2]1,2,3- AIPHA-N- -N- -3-2 A 2004 5 12% 120 100% 2005 6 B 2003 12 31 2,760 2004 C 2,905 ( ) 2006 2 10 2007 2 10 1,000 3 1 1 0.18% 3 1 5.75% 1-2-11
3 1-2-12
2005 1945 1976 1967 1965 1973 1954 1952 1973 1961 2004 4 1970 25.00 45.9741% 1984 2004 4 1996 15.00 4% 1989 2004 4 15.00 4% 2004 4 1988 QC 15.00 4% 2005 4 1996 ( ) - - 1984 1987 1989 2004 4 1994 - - 2004 11 3.00-2004 11 3.00-2004 11 3.00-1-2-13
1960 1971 1951 1965 1971 2004 4 2.10-2004 4 1995 15.00 4% 2004 4-2004 4 1988 QA 15.00 4% 2004 2002 10 15.00 1% 1962-1989 10.00 3.0259% 1969-1966 - 1996 8.00-1989 8.00-1-2-14
1 3 1 2006 1-6 2005 2004 2003 416,351,668.84 690,764,236.66 506,100,523.85 373,747,756.68 342,161,406.17 552,743,398.27 412,073,103.56 306,681,825.09 533,996.68 1,816,840.39 52,836.14 17,511.47 73,656,265.99 136,203,998.00 93,974,584.15 67,048,420.12 673,303.69 1,360,035.62 470,268.86 714,987.87 5,018,333.57 7,653,604.22 6,940,437.17 5,280,677.86 18,661,435.91 40,660,648.84 26,952,340.84 25,265,149.98 8,309,787.68 12,630,371.56 10,132,761.55 6,464,993.23 42,340,012.52 76,619,409.00 50,419,313.45 30,752,586.92 199,273.42 709,565.86 1,168,266.78 1,910,887.35 1,011,715.00 468,536.28 467,662.04 1,060,506.00 3,920.70 74,604.36 246,641.80 897,119.20 766,658.64 4,309,169.38 2,441,358.53 1,581,646.66 42,788,263.00 73,562,946.12 49,860,525.54 33,039,452.81 13,378,290.30 23,199,422.87 14,163,228.89 10,174,560.18 472,102.69 767,507.61 563,196.29 443,882.51 28,937,870.01 49,596,015.64 35,134,100.36 22,421,010.12 2 3 1 2006 6 30 2005 12 31 2004 12 31 2003 12 31 122,706,093.49 63,708,249.01 54,932,864.55 41,511,628.85-800,000.00 576,316.54 4,671,426.87 1-2-15
560,000.00 953,000.00 650,000.00 2,006,500.00 120,342,183.90 104,501,949.14 67,641,729.71 70,757,931.40 1,645,108.97 4,160,835.78 2,345,418.91 30,973,750.12 7,163,704.42 43,854,070.13 20,975,789.07 15,399,476.42 1,903,197.55 1,474,613.74 4,229,682.38 14,671,260.19 169,233,220.93 166,327,353.23 85,193,326.06 48,009,028.93 1,103,483.69 323,197.74 243,123.43 159,354.16 424,656,992.95 386,103,268.77 236,788,250.65 228,160,356.94 10,975,781.83 10,890,755.26 11,627,209.55 10,933,212.55 10,975,781.83 10,890,755.26 11,627,209.55 10,933,212.55 237,812,714.78 213,414,542.00 167,310,250.35 138,246,140.25 63,396,168.90 53,550,940.61 39,254,094.56 26,450,795.92 174,416,545.88 159,863,601.39 128,056,155.79 111,795,344.33 510,743.05 568,194.81 376,688.93 401,085.82 173,905,802.83 159,295,406.58 127,679,466.86 111,394,258.51 1,799,217.60 852,892.26 572,930.03 3,094,443.69 40,448,938.97 19,350,032.76 6,260,993.08 3,855,570.09 216,153,959.40 179,498,331.60 134,513,389.97 118,344,272.29 20,084,802.55-3,876,737.01 4,945,941.93 143,882.22 225,127.19 570,000.00-20,228,684.77 225,127.19 4,446,737.01 4,945,941.93 672,015,418.95 576,717,482.82 387,375,587.18 362,383,783.71 192,256,137.60 192,165,090.04 127,356,664.00 99,300,000.00 81,000,000.00 53,000,000.00 9,000,000.00 14,924,200.00 52,531,117.32 84,219,695.71 33,708,796.62 43,364,317.22 783,693.43 900,732.52 1,155,359.47 685,195.37 3,895,630.37 5,092,423.31 2,897,614.12 1,618,482.07 7,816,927.99 6,841,019.40 5,070,350.13 4,088,515.66 4,551,370.43 2,051,370.43 2,051,370.43 2,051,370.43 141,726.78-5,904,647.52 12,257.85 4,545,604.67 149,577.86 101,826.56 59,444.17 85,378.31 12,711,123.52 10,352,629.56 12,990,296.03 20,750,748.97 289,193.99 331,490.56 282,197.41 335,593.19 2,983,333.00 2,983,333.00 1,763,333.00 1,632,443.00 25,035,222.50 34,054,584.75 21,000,000.00 12,250,000.00 384,145,054.79 386,189,548.32 217,347,683.23 205,631,848.89 84,737,360.00 6,877,595.50 38,000,000.00 59,000,000.00 1-2-16
- - - 12,725,042.31 490,000.00 690,000.00 - - 85,227,360.00 7,567,595.50 38,000,000.00 71,725,042.31 469,372,414.79 393,757,143.82 255,347,683.23 277,356,891.20 2,386,871.36 1,911,617.92 3,264,415.87 3,111,824.64 80,000,000.00 80,000,000.00 80,000,000.00 30,000,000.00 14,673,078.92 14,403,537.21 11,714,319.85 534,074.08 12,969,671.56 12,969,671.56 5,434,790.01 12,363,014.45 4,323,223.85 4,323,223.85 1,811,596.67 4,121,004.82 92,613,382.32 73,675,512.31 31,614,378.22 39,017,979.34-10,000,000.00 - - 200,256,132.80 181,048,721.08 128,763,488.08 81,915,067.87 672,015,418.95 576,717,482.82 387,375,587.18 362,383,783.71 3 1 1 2006 1-6 2005 2004 2003 40,466,256.77 36,071,823.06 42,360,661.88-5,454,935.90-38,794,302.59-75,025,226.22-33,788,692.44-46,532,433.93 53,325,890.30 35,228,787.62 4,849,266.26 54,281,039.63 54,997,870.01-3,724,615.54 13,421,235.70 2,145,684.78 4 2006 1-6 2005 2004 2003 1.11 1.00 1.09 1.11 0.64 0.45 0.70 0.88 % 65.93 63.61 65.56 76.44 3.70 8.03 7.31 5.44 2.04 4.40 6.19 6.45 6,136.47 10,308.98 7,357.22 4,912.41 6.46 7.72 5.55 5.34 / 0.51 0.45 0.53-0.18 / 0.69 0.05 0.17 0.07-0.04 0.13 % / 2.50 2.26 1.61 2.73 1-2-17
5 2006 2 6 1 2 10% 3 4 2006 2 7 25% 1998 11 13 95 000777 241.64 94.41% 5.59% 2006 6 30 12,656.24 4,269.90 2005 21,398.01 983.69 2006 1-6 14,113.12 844.55 1-2-18
1 % 1 2 3 4-AA 13,673.60 16,800.00 3,574.58 20.81 6.32 2005879 8,929.70 18,900.00 4,869.48 43.06 5.08 2005880 5,795.30 7,000.00 3,318.68 44.86 5.16 2005883-28,398.60 42,700.00 11,762.74 - - 2 14-AA 4-AA 5 4-AA 300 10 4-AA 4-AA 2 1-2-19
, 2 4 1990 1993 1995 30 2 FDA 1996 2,000 10 60%, 3-4 DMF 3 1-2-20
- 1994 Basen 1997 1999 Pioglitazone WHO IDF ADA 13 2.5 5,000 2025 3 2002 65 2010 80 400 30% 2000 0.69% 2001 1.22% 86.77% 300 / 3 100% 1-2-21
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2 1 2005 9 2 HX5C0541 BASF S.A US$7,946,400 2 2006 1 12 GHTO60101007 4,075,000 3 2006 1 6 4500261818/116 LONZA US$2,880,360 4 2006 3 6 2006IPC10236 11,375,000 5 2006 4 4 0604031/0604032/06040 33/0604034 OFICHEM US$1,155,700 6 2006 5 11 2006IPC10263 2,080,000 7 2006 6 22 236774 FISCHER CHEMICALS AG US$111,780 8 2006 7 3 746383 WELDING GMBH US$117,600 9 2006 7 10 HX6C0444 OFICHEM US$146,400 10 2006 7 10 HX6C0445 OFICHEM US$295,200 3 1 2005 12 1 HX6P0001 23,700,000 2 2006 1 5 23,000,000 3 2006 1 3 3,851,000 4 2006 1 27 20060127 2,596,000 5 2006 6 13 HX6P0335 3,600,000 6 2006 7 1 HX6P0372 4,600,000 7 2006 7 3 HX6P0385 4,858,500 4 1 66350012302003006 2 66350012302005000156 2,100 2003 10 30-2006 4.1175 10 29 2005 8 29-2006 1,500 5.115 8 28 1-2-23
2006 3 31-2010 3 2006 0229 8,000 3 25 4 2006 3,000 4.05% 092 2006 6 1-2007 5 31 5 81012006280201 2006 6 13-2007 1,200 5.11875 6 13 5 330804101 3,000 1,000 2006 7 28-2007 1 2 2005 13100 2006 212-1 7 15 1,000 2005 12 7-2006 11 25 1,500 1,500 2006 9 26-2007 9 25 3 2006 200 200 2006 8 22-2007 0124 8 10 4 2005 0175 700 700 2005 12 14-2006 12 10 2006 900 700 2006 8 23-2007 5 01189 8 20 200 2006 10 23-2007 10 20 TP 06106 1,500 450 2006 5 29-2007 6 5 29 600 2006 4 30-2007 4 30 7 TP 06291 1,000 56.60 2006 9 5-2007 3 5 8,800 6,406.60 6 1-2-24
1 663500925020030 800 1,180 800 2003 10 30 04-2006 10 29 2 2005 3,900 5,605 600 2005 8 26-2006 0128 8 25 500 2005 10 14-2006 10 12 1000 2005 10 12-2006 10 10 900 2006 6 28-2007 6 20 3 2006 8,200 11,729 8,000 2006 3 31-2010 0030 3 25 7 1 2006 2,000 10,000 067003 2006 1 11-2006 7 11 2 330804101 2006 13031 1,000 5,000 2006 4 25-2006 10 24 3 330804101 2006 13037 1,000 5,000 2006 5 17-2006 11 16 8 2006 2 26 2006 8,000 6,000 9 2006 3 PQZA200633100300000030 239,291,411.60 2006 4 0206331012000104000005 1-2-25
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2006 12 7 1-2-27