80%-90%30% 40%4-615% 8 HIV
41% 34% 31% *Fleming DT N Engl J Med 1997; 337:1105-1111 1997 754
HSVHSV-2HSV-12 HSV HSVG HSV HSV HSV Tzanck HSV-PCR DNAHSVDNA
ß
4 sil-2ril-2 sil-2r 5 mil-2rcd8 + T sil-2rmil-2r IL-2TIL-2 IL-2 6 RGH CD56 + NKCD56 + CD69 + NKNK
7 RGH CD11c + DC CD123 + DC CDla CDla CD80 CD83 DC DCCDla CD80 CD80 B7-1CD86 B7-2DC CD83 RGH RGH CD11c + DC CD8 + TCTL
( )
1
2
1 IFN IFN-a r 2 IL-22 IL-2 Th1NK LAK CTLIFN-r
1 2GH 3 4
5 6
HSV HSV HSV HSV HSV HSV 50 50HSV-1 HSV-2 HSV-220 HSV HSV-2 1
HSV HSV HSV HSV HSV HSV HSV HSV 2
HSV ( ) ( ) HSV
1 2 3
n=134 n=266 n=269 Reitano etc J Infect Dis 1998 sep:178:603-10
Baker DA etc. Obstet Gynecol 1999 Jul;94(1):103-6
P<0.005 Lawrence C etc., New England Journal of Medicine 2004 Jan :350: 11-20
P<0.001 n=39 0.5g QD8 n=50 Lawrence C etc., New England Journal of Medicine 2004 Jan :350: 11-20
Lawrence C etc., New England Journal of Medicine 2004 Jan :350: 11-20
Lawrence C etc., New England Journal of Medicine 2004 Jan :350: 11-20
2. Lawrence C etc., New England Journal of Medicine 2004 Jan :350: 11-20 3. Reitano etc J Infect Dis 1998 sep:178:603-10
6