CIP /. 2004. / ISBN 7 5366 5543 6....R512.6 CIP 2001 079309 205 880 mm 1 230 mm 1/32 8 4 195 2004 10 1 2004 10 1 1 1 4 000 ISBN 7 5366 5543 6 R 195 16.00
2 156 1 1 0 1 0 1 3.5 1.2 3 000 3 000 10% 20% 1% 5% 90% 25%
2004 9
2002 3.5 1.2 3 000 3 000 10% 20% 1% 5% 50 80 1.7 4 000 50% 85% 1988 31 56 746 15.16%
( 2002 )
I 1. 1 1.1 1 1.2 2 1.2.1 2 1.2.2 3 1.2.3 3 1.2.4 4 1.2.5 4 1.2.6 5 1.2.7 5 1.2.8 6 1.3 7 1.3.1 7 1.3.2 8 1.3.3 8 1.3.4 8 1.3.5 9 1.3.6 9 1.3.7 9 1.4 10 1.4.1 10 1.4.2 11 1.4.3 12
II 1.4.4 12 1.4.5 12 1.4.6 13 1.5 13 1.5.1 14 1.5.2 15 1.5.3 33 1.6 B 35 1.6.1 B 35 1.6.2 B 35 1.6.3 B 36 1.6.4 B 38 1.6.5 B 38 1.6.6 B 39 1.7 39 1.7.1 40 1.7.2 41 1.8 41 1.9 42 1.10 43 1.11 44 1.11.1 44 1.11.2 44 1.11.3 45 1.11.4 45 1.11.5 46 1.11.6 46 1.12 47 1.12.1 47
III 1.12.2 48 1.12.3 52 1.12.4 52 1.12.5 53 1.12.6 54 1.12.7 55 1.12.8 56 1.12.9 57 1.12.10 HBV M 58 1.12.11 60 1.12.12 HBV DNA 60 1.12.13 HBV DNA HBsAg/ HBs 61 1.12.14 HBV DNA HBeAg/ HBe 61 1.12.15 HBsAg HBV 62 1.12.16 63 1.13 65 1.13.1 65 1.13.2 66 1.13.3 67 1.13.4 67 1.13.5 68 1.13.6 69 1.13.7 70 1.14 71 1.14.1 71 1.14.2 72 1.14.3 72 1.14.4 73 1.14.5 74
IV 1.14.6 75 1.15 75 1.15.1 75 1.15.2 76 1.15.3 76 1.15.4 77 1.15.5 78 1.15.6 79 1.16 79 1.16.1 79 1.16.2 80 1.16.3 81 1.17 TTV 81 1.18 82 1.19 84 1.20 84 1.21 86 1.22 87 1.23 87 1.23.1 87 1.23.2 89 1.23.3 89 1.24 90 1.24.1 91 1.24.2 91 1.24.3 91 1.24.4 91 1.24.5 92 1.24.6 92
V 1.24.7 92 1.24.8 92 1.24.9 93 1.24.10 93 1.25 93 1.25.1 93 1.25.2 94 1.26 96 1.26.1 96 1.26.2 97 1.26.3 98 1.26.4 98 2. 100 2.1 100 2.2 100 2.2.1 100 2.2.2 101 2.2.3 101 2.2.4 101 2.2.5 102 2.2.6 HBsAg 102 2.2.7 HCV 102 2.3 102 2.3.1 102 2.3.2 103 2.3.3 103 2.3.4 103 2.3.5 104
VI 2.3.6 104 2.3.7 104 2.4 ( 2.1) 105 2.5 106 2.5.1 106 2.5.2 106 2.5.3 107 2.6 108 2.6.1 108 2.6.2 109 2.7 110 2.7.1 110 2.7.2 110 2.8 111 2.8.1 111 2.8.2 112 2.8.3 112 2.9 113 2.9.1 113 2.9.2 113 2.9.3 HBV 114 2.9.4 HBsAg 115 2.9.5 HBsAg 116 2.9.6 HBV 117 2.9.7 HBsAg 117 2.9.8 117
VII 2.9.9 118 2.9.10 118 2.9.11 119 2.10 120 2.10.1 120 2.10.2 121 2.11 121 2.12 121 2.13 122 2.13.1 123 2.13.2 125 2.13.3 127 2.13.4 128 2.13.5 129 3. 131 3.1 131 3.2 132 3.3 CHB 133 3.3.1 133 3.3.2 133 3.3.3 134 3.3.4 134 3.3.5 135 3.3.6 135 3.3.7 136 3.3.8 137 3.3.9 Adefovir ADV 142 3.3.10 Entecavir 143
VIII 3.3.11 143 3.3.12 143 3.4 144 3.4.1 144 3.4.2 144 3.4.3 144 3.4.4 145 3.4.5 145 3.4.6 Peg IFN 146 3.4.7 147 3.5 147 3.5.1 (Thymosin) 147 3.5.2 148 3.5.3 2 IL 2 148 3.5.4 (Levamisole) 149 3.5.5 (irna) 149 3.5.6 149 3.5.7 151 3.6 152 3.6.1 ( ) 152 3.6.2 (EPL ) 154 3.6.3 ( ) 155 3.6.4 155 3.6.5 Tiopronin 156 3.6.6 156 3.6.7 157 3.6.8 (UDCA) 157 3.6.9 (HGF) 158
IX 3.6.10 E1 158 3.7 158 3.7.1 159 3.7.2 162 3.8 165 3.8.1 166 3.8.2 167 3.9 167 3.9.1 167 3.9.2 168 3.10 168 3.10.1 169 3.10.2 177 3.10.3 180 3.10.4 188 3.11 204 3.11.1 204 3.11.2 205 3.11.3 205 3.12 206 3.12.1 206 3.12.2 207 3.12.3 208 3.12.4 209 3.12.5 211 3.12.6 212 3.12.7 213 3.12.8 214 3.12.9 214
X 3.12.10 216 3.12.11 217 3.12.12 217 3.12.13 219 3.12.14 220 3.12.15 221 3.13 223 3.13.1 223 3.13.2 223 3.13.3 224 3.14 225 3.14.1 225 3.14.2 226 3.14.3 228 3.14.4 229 3.14.5 232 3.14.6 233 3.15 234 3.15.1 234 3.15.2 234 3.15.3 235 3.15.4 235 3.15.5 237 3.15.6 238
1 1.1 1 400 1 600 g 1 200 1 400 g 5 2 4 cm 3 2 4 cm 7 2.5 10 11 80% Herring
2 1.2 1.2.1
3 1.2.2 1.2.3
4 1.2.4 300 700 ml 1.009 1.032 1.2.5 A D E K B B
5 1.2.6 1.2.7 (hotransformation) ( ) ( ) ( )
6 (UDP GA) (3 5 PAPS) 1.2.8 HMWK
7 1.3 1.3.1 1 EB 2
8 3 4 1.3.2 1 2 3 4 5 6 1.3.3 Reyc 1.3.4
9 1.3.5 1 2 1.3.6 1 2 3 1.3.7 1 Cruveilhier Baumgarten 2 Budd chiari 3 4 5
10 6 1.4 1.4.1 (>17.1 mol/l) 80% 85% 1% 5 000 ml 140 g/l 7 g 1 g 36.2 mg 280 mg 3
11 1.4.2
12 1.4.3 1.4.4 1.4.5
13 B 50% 1.4.6 B X CT 1 cm 3 cm 1/3 9 12 cm 1.5
14 700 1.5.1
15 1.5.2 1 40 1 2 17 21 1 60 80 g/l 20 30 g/l / A/G 1.5 2.5 1
16 60 g L 5 20% 60 g/l 5 54.8% 40 g/l 2 1 0.12 0.20 g 40% 60% 40 60 g/l 20 g L 30% 50%
17 30 g/l 20 g/l 2 99.5 0.5 61 10 3 10 40 mg L 1.9 17 21 2 3 T3 T4 30 50 (3) 1 2 2 2 3 2 A/G 3
18 32.2% 17.5% 49.5% 66.4% A/G 4 AFP 24 12 1 70% 33.3% 37.5% 10%
19 2 500 g L ALT 2 ALT ALT 500 g/l 500 g/l 4 200 g/l 8 AFP AFP 3 1/3 2 3 2 20 g/l 4
20 1 4 2 300 g L 400 g/l (5) 27 81 mol/l 5.87 35.22 mol/l AMMONIA checker II IM 52.57 13.44 mol/l 120 mol/l 587 mol L H +
21 6 PT 2 4 g L 80% 120 12 14 3 PT 2 (1) 1 3.9 5.9 mmol/l Folin 4.5 6.7 mmol/l 3.9 5.6 mmol/l 8.96 10.l mmol/l 3.92 mmol/l
22 2 10% 50% 3.4 mmol/l 2.5 3.4 mmol L 3 12% 32% Shewin 2 5 4 30% 2 GTT
23 GTT 3.9 5.6 mmol L 6.7 mmol L 1 8.9 mmol L 2 3 PGTT 2 20 mg GTT GTT GTT GTT PGTT GTT PGTT 1 2 PGTT GTT 4 40 g 1 1 5
24 350 mg/ 20 10 1 5 3 g 14.5 3.5 g 21.9 16.5 12 16 Dubin Johnson 10 3 3/4 1 Chol 2.83 6.00 mmol/l 1
25 2 2 1 3 60% 80% 2.34 3.38 mmol/l 1 ; 2 4 (1) 1 2
26 3 (2) DB 0.51 3.42 mol/l (3) TB 17.1 mol/l 1.71 13.68 mol/l 1 85.5 mol/l 2 / 3 (4) 1 1 20 24 3.5 mg 2
27 5 TBA TBA TBA 0 10 mol L 7 10 TBA 10 mol/l TBA ALT TBA TBA 20 mol/l TBA TBA TBA
28 TBA TBA TBA TBA TBA TBA TBA TBA TBA TBA TBA TBA TBA 100 TBA 40% TBA TBA
29 TBA 5 (1) 20 ALT AST Reitinan AST 4 50 U ALT 2 40 U King AST 44 103 U ALT 20 118 U King AST 15 95 U 55 103 U ALT 10 80 U 25 90 U AST ph ALT 104 1
30 1 80% 100% 3 100 200 U 200 U 3 4 ALT 3 000 4 000 U 2 1 3 3 5 5 000 10 000 U
31 3 ALT 4 5 1 2 6 ALT 7 2 AKP AKP 1.5 4 5 12 60 AKP 2 3 1 3 AKP 9 3 4 AKP 1 2
32 AKP 80% AKP AKP AKP AKP AKP AKP AKP AKP AKP AKP AKP AKP (3) GT GGT Orlouski 0 40 U 50 U 1 GT GT GT 350 U GT 100 GT GT GT GT 2 GT
33 GT GT GT 3 GT GT GT GPT 80 U GT GT 1 2 GT 4 GT GT 5 GT 5 7 GT 10 6 GT GT 2 4 1.5.3
34 1 ALT A/G 2 ALT AKP 3 AFP GT AKP 4 ALT GPT 5 ALT A/G 6
35 1.6 B 1.6.1 B 1 2 3 0.6 cm 1.6.2 B 1 (1)
36 (2) 1.5 cm 1.3 cm 4.5 cm 1.0 cm 0.3cm 1.0 cm 0.5 cm l.0 cm 10% 30% 0.3cm 1.0 cm 0.7 cm 89% 100% 2 CDFI 98 98% 1.6.3 B
37 l (1) 0.5 10.0 cm (2) 1.5 cm 4.5cm 1.0 cm 80 2 20 80
38 65 cm/s 100 cm/s >3.0 khz >5.0 khz 1.6.4 B <5% 30% 40% 50% 5% 10% 1/2 2/3 1.6.5 B 1
39 2 1.6.6 B 1.7
40 1.7.1 1 2 15 3 3 4 5 6 7 8 9
41 1.7.2 1 <60% <60 10 9 /L 2 3 <90 g L 4 5 6 7 8 1.8 EB ECHO 5 A B C D E G TTV
42 1.9
43 1.10 DHBV DHBV DHBV DNA RNA HBV DNA HBsAg
44 1.11 1.11.1 HAV HAV RNA 27 28 nm 32 20 RNA 7 478 HAV 1 1 HAV 98 1 HAV 12 3.2% 0.1% 25 3 0.1% 2% 12 24 5 >10% 20% 25 7 14 30 14% 4.6% 0.4% 1.11.2 HAV 1 3 2 3 HAV 1988 30 HAV
45 1.11.3 1979 3 HAV 10 15 20 25 HAV 74.60% 86.63% 40 HAV 90% 40 90% HAV 30 31.2% 1988 20 39 89.5% 1.11.4 2 6 4 1 (1) 38 5 7 (2) 2 6 (3) 2 4 2
46 3 3 1.11.5 ALT ALT IgM HAVIgM 2 4 HAVIgG HAV 1.11.6 45 3 1
47 0.1% 0.2% 1.12 1.12.1 HBV HBV DNA 42nm HBsAg HBcAg DNA HBV DNA DNA HBcAg e
48 HBeAg 22 nm 22 nm 220 nm HBsAg HBV 20 20 37 7 56 6 20 40 0.5% 3% 0.2% 60 Co 10 15 10 4 Gy 100 10 HBV HBV 1.12.2 HBV HBV AsC
49 AsC AsC HbsAg HBsAg HBV 1 HBV HBV 2% 3% HBsAg( ) AsC HBsAg( ) HBV 10% HCV 2 HBV HBV 1 2 HBsAg 15.4% 11.6% 2 1 2 HBsAg 3.3% 2.1% HBV
50 3 HBV HBsAg + HBsAg 30% 40% HBsAg 10% AsC 20% AsC 1/4 HBV (1) (2) HBsAg(+) 95% 3 HBsAg HBV HBV (3) 1 HBsAg 3% 4% 1 4 HBsAg 8% 12% HBV HBV HBsAg(+) HBeAg(+) HBV HBsAg HBsAg( ) HBsAg(+) 4 HBV HBV HBsAg HBV DNA HBeAg + 62 % HBV DNA 1/1 250 1/250 000 2 4
51 HBsAg HBV 5 HBV HBV HBV HBsAg HBV HBV HBV AsC HBsAg HBsAg 73%
52 1.12.3 HBV HBV HBV 58.4% HBsAg 10.3% HBsAg 8 3 35 45 HBsAg + HBsAg + 1.12.4 45 160 90
53 2 1 2 1 6 2% 3% 1 2 1 2 3 2 4 1.12.5 6 HBV 5% 10% HBeAg + 80% 90% 6 30% HBV 5%
54 HBV 1.12.6 HBsAg(+)
55 1.12.7 1 HBsAg(+) ALT ALT 2 ALT 50 300 U/L 3
56 ALT 1.12.8 HBsAg AsC 2001 HBsAg HBV HBV HBV HBV HBV AsC AsC HBsAg 6 HBV AsC AsC AsC AsC
57 AsC HBV AsC HBV AsC AsC HBV 20%AsC e HBe HBV HBe 10% AsC e HBsAg 2% AsC HBsAg 1 12 AsC HBsAg 0.6% 1.12.9 HBV 1971 HBsAg HBs HBcAg HBc HBcAg HBc e HBeAg e HBe
58 M HBcIgM 5 6 HBc M G A HBc HBc IgM HBcIgG HBV M 1.12.10 HBV M HBsAg HBsAg 100 g/ml HBeAg HBsAg HBsAg HBV HBsAg HBs HBeAg HBV HBeAg + HBV HBV HBeAg HBeAg HBV HBeAg HBeAg + ALT HBe HBeAg + HBe + HBV HBV 15% HBeAg + HBe +
59 HBV HBeAg HBe HBeAg / HBe HBV HBe HBeAg C HBeAg HBV 30%HBeAg + HBeAg + 80% HBeAg 10% HBeAg + 10% HBeAg HBV HBeAg + HBeAg HBcAg HBsAg HBc HBs HBc HBsAg HBc HBs HBc HBc HBc IgM HBc IgM HBV 1.1 HBsAg HBV HBeAg HBV HBs HBe ALT HBV HBsAg + ALT
60 HBc HBc IgM 1.12.11 HBsAg HBeAg HBc HBsAg HBe HBc HBV HBV C HBeAg HBc + HBV ALT ALT HBV DNA HBV 1.12.12 HBV DNA 1 HBV DNA HBV 2 3 4 5 6
7 61 1.12.13 HBV DNA HBsAg/ HBs HBsAg HBsAg HBV DNA DNA HBsAg DNA PCR HBsAg HBV DNA HBsAg HBV DNA 6 15 HBsAg HBsAg HBcAg HbsAg S HBsAg HBV DNA HBsAg a d/y w/r HBsAg adr adw ayr ayw 4 adr adr ayw Abbott adr adw HBsAg 5% HBV HBV HBs HBs DNA HBs HBV DNA HBV DNA 1.12.14 HBV DNA HBeAg/ HBe HBV HBeAg HBV
62 HBe HBeAg HBe HBV HBeAg C 83 G A 28 HBeAg HBe C HBV 40% 80% C HBV HBV HBeAg HBV 75% HBV 25% C HBeAg C HBV HBeAg HBV HBeAg HBV HBc HBeAg 1.12.15 HBsAg HBV HBsAg HBV HBsAg HBV HBc HBV HBc + PCR HBV DNA 30% 35% 6 48 71% 93%HBV DNA ALT HBsAg HBV HBsAg HBV HBV + 615 HBsAg HBs + HBV DNA 6.2% HBsAg HBc + HBV DNA 29% HBsAg HBs
63 + HBc + HBV 3.9% HBsAg HBe + HBc + HBV DNA 66.7% HBsAg HBs + HBe + HBc + HBV DNA 26.7% HBsAg HBs HBeAg HBc HBV DNA 1.6% HBsAg HBV HBV AsC HBsAg + HBsAg HBsAg HBV HBsAg PCR HBV DNA HBsAg + HBV HBsAg HBV 1.2 1.12.16 HBeAg + HBe + HBV DNA HBe + HBV DNA + HBeAg + 5 10 HBe 3 HBe + ALT 42.5% 18.4% ALT
65 HBeAg ALT 10 5.1% HBeAg + 10 7.1% 183 16.78% 11.56% 5 10 15 97.27% 91.62% 84.47% 0 3.19% 11.56% 4.5 1.13 1.13.1 HCV HCV RNA HCV 6 50 HCV 1a 1b 2a 2b 3a 1b 2a 70% 80% HCV HCV 2 2 HCV RNA HCV HCV 10% 10 4
66 100 5 60 10 1 1 000 37 6 HCV 80 72 1.13.2 HCV 1 80% HCV 3 HCV 2 6 HCV ALT HCV 2 HCV HCV HCV RNA HCV 3 HCV 10% HCV RNA HCV 4 HCV
67 HBV HCV HCV RNA HCV HCV 12% HCV 38% 1.13.3 1992 30 1 59 HCV 3.2% 0.9% 5.1% 3.2% 14 3.6% 2.9% HCV HCV HCV 36.5 HCV 1.13.4 70% ALT 10% HCV 10% 10% / 2 20 8
68 ALT 3 5 HCV RNA 2 1.13.5 ALT HCV ALT 3 ALT HCV ALT ALT HCV ALT HCV 3 HCV ALT ALT ALT ALT 6
69 ALT ALT 1.13.6 1 HCV HCV HCV 2 3 (1) HCV HCV C 22 C 22 NS3 C 33 C 33 C 22 C 100 ELISA 5 1 1 C 100 C 100 ELISA C 22 C 33 C 22 NS5 HCV ELISA NS5 ALT 2 HCV HCV HCV HCV HCV RNA HCV HCV HCV
70 (2) HCV RNA HCV ALT HCV HCV RNA HCV RNA HCV HCV 1.13.7 HCV 80% 15% 20% ALT HCV RNA 60% 20 20% 30% 20 30 HCV 20 1% 5% 1% 4% HCV 5 91% 10 79% 50% 2001 10 HCV 24% 46% 3 752 ALT 9 50 1.9% 0.3% 17% 20 25 35% HCV 1.3
71 HCV RNA 1b 1.14 1.14.1 HDV HBV DNA HDV DNA HBV HDV HBsAg HDV RNA HDV HDV HBV HDV HBsAg HDV HBV HDV HBV HBV HDV HBV HDV HBV HDV HBsAg HBV DNA
72 1.14.2 HDV HBV HDV HDV HBV HDV 1.14.3 HDV HDV HDV HBsAg HDV 40% 50% HDV HDV HBsAg HDV HBsAg 5% HBsAg HDV HBsAg HDV 0% 32% HDV HBsAg HDV HDV/HBV HBV HDV/HBV HBV HBV HBsAg HBV HBsAg HDV HDV HDV
73 1.14.4 1 HDV HBV HDV HBV 6 12 HDV HBV HDV HBV 2 HDV HBV HBV HDV 3 1 HBsAg HDV HDV HBsAg HBV DNA HBsAg 2 HBsAg HDV HBsAg HDV 2 60% HDV 11% 12% 3 HBsAg HDV HDV 21%
74 60% HDV HDV HDV HDV 1.14.5 HDV HBV HDV HDV HDV HBV HBsAg HDV HDAg HDV RNA HD HDAg HDAg 87% 100% HDV RNA HDV RT PCR 100% HD HD HDIgM HDIgG HDIgM HDV 2 20 HDV HDIgM HDV
75 HDIgM HDV HDV HDIgM HDIgG HDV 3 8 HDIgG HDV HDV HDIgG HD IgG 1.14.6 HBV HDV HDV HBV HDV HDV HDV HBV HDV 1.15 1.15.1 HEV 27 38 nm 32.2 nm RNA HEV 3 HEV HEV 70 8
76 1.15.2 1 4 HEV 100% 1 70% 4 6 40% 7 9 25% 10 20 14.5% 3 HEV HEV HEV HEV HEV HEV HEV HEV RNA HEV HEV 10 275 HEV IgG 37% HEV 97.3% HEV 30 20 50 HEV IgG HEV IgG 26.7% 15% 8% HEV 44% 90% 1.15.3 1995 20
77 1980 1986 9 20 12 3.0% HEV 18.2% 10% 16% 1 4 75% 16 35 HEV 12% 4 9 5 4 2 Qatar 91 75% HEV 1986 1988 100 2 1.15.4 2 9 6 HEV 4 1 5 1 HEV 75% 80%
78 1 13 15 HEV 1% 1 10 15 40 6 4 6 20% 10% 20% HBsAg HEV 80.7% 75.5% HBsAg HEV 0.1% 0.2% 1% 4% 12% 1.15.5 HAV HBV HCV HEV HEV HAV
79 HEV 1 HEV HEV 2 HEV RNA PCR PCR HEV RNA HEV RNA 3 HEV HEV IgM 26 73% 1 4 50% 6 7 6% 8 HEV IgM HEV IgG 1 92.5% 2 6 100% 12 94.7% 24 48.6% HEV IgG HEV 1.15.6 1%~2% 12% 10%~20% 39% 1.16 1.16.1 10% 20%
80 1966 G B GB 1995 GB GBV A GBV B GBV A GBV B GBV C GBV C GBV A B C HCV HGV GBV C HGV HGV RNA 20 30 nm 25% 50% 56 1.16.2 HGV HCV HBV HGV 12.9% 9% 15.8% 49% 55% 18% 18% 5.2% HGV RNA 0.5% 2.5% HCV HGV RNA 1.4% 1.7% HCV 5 HGV RNA
81 0.67% 2% HCV HGV RNA HGV HGV E2 E2 3.0% 8.1% HGV HGV RNA 1.16.3 HGV HGV HGV HGV HCV HBV HGV HGV HGV HGV HGV HGV HGV 10 7 10 8 HGV 2 75 2 ALT HGV 1.17 TTV 1997 12 1
82 Transfusion transmitted virus TTV TTV TTV 2 4 G1a G1b G2a G2b G1a G2b G2c 1 TTV TTV 95% TTV TTV 47% 46% TTV 46% 12% TTV 43% 2.9% ALT TTV TTV HBV TTV TTV TTV TTV 2% 11% TTV 0 20% TTV TTV 40% TTV TTV 20% 40% 1.18
83 (1) 40% (2) 15 24 40% 17.1 mol/l 10 (3) HBsAg / HBsAg 40% 10 3 (1) 10 40% 30% (2)
84 30% 20% (3) 20% 1.19 60% K 1 60% 1.20 1 2
85 41.6% 66.7% 3 MOF 1.4 90% 2% 4% 5% 10.3% 8% 17% 35% 50%
86 1.21 1.5 70% 10% 15%
87 1.22 1.23 1.23.1 5 1
88 2 3 ; 4 5
89 1.23.2 1.23.3
90 1.24
91 1.24.1 1.24.2 1.24.3 1.24.4
92 1.24.5 1.24.6 1.24.7 1.24.8
93 1.24.9 1.24.10 1.25 1.25.1
94 1.25.2 2 6 F1a 6 Keto PGF1a T3 5 (5 HT) 5 HT T3 T4 rt3 TSH TNF C4 LTC4 E2 PGE2,TNF LTC4 PGE2 P B2 TXB2 F2a PGF2a PGE2 6
95 F1a 6 Keto PGF1a TXB2/6 Keto PGF1a 69.8% TXB2 6 Keto PGF1a TXB2/6 Keto PGF1a AVP II AII, T3 (4) TXB2 6 Keto PGF1a P (1) (2) TNF 2 (3)
96 (4) T3 T4 TSH (5) TXB2 PGE2 6 Keto PGF1a PGF2a/PGE2 (6) NO NO 1.26 1.26.1
97 ALT HBe Ag HBV DNA 61.5% HBsAg 69.2% ALT C 3 IgA HBeAg 61.5% 100% HBV ALT IgA HBeAg 62.5% IgG CIC HBeAg 85.7% HBsAg HBeAg HBc IgM 3 HBV C PCR SSCP HBV C HBV C 1.26.2 CD3+ CD4+ CD4+/CD8+ CD8+ 2 SIL 2R CD3+ CD4+ CD4+/CD8+ CD8+ SIL 2R
98 1.26.3 ALT ALT C 3 CD8+ ALT ALT 1.26.4
99 PCR DNA RNA ( )
100 2.1 3 3 2.2 2.2.1
101 1 1 2.2.2 3 HBsAg HBsAg 2.2.3 2.2.4 45 60
102 1 2.2.5 ALT HBsAg HCV ALT / HBsAg HCV 2.2.6 HBsAg HBsAg HBsAg HBsAg 2.2.7 HCV 2.3 2.3.1
103 2.3.2 0.3mg/L 2.3.3 2.3.4
104 2.3.5 2.3.6 HBsAg / HCV HBsAg HCV HBsAg / HCV HBsAg HBsAg HBeAg HBIG 115 24 2.3.7 82 35 HBsAg HCV
105 2.4 ( 2.1) 0.5% 0.5 g 100 3% 2% ml: 3 g 100 ml 2 ml 100 ml 1 10% 20% 2 1/5 2 2% 2 ml 100 3% 1 ml 3 g 100 ml 0.5% 3% 2% 2% 3% 1 10 20 10 20 0.2% 2 0.2% 0.4 kg/m 3
106 100 ml/m 3 12 24 15 15 30 8 ml 160 1 20 25% 0.3% 100 ml ph 2% 7.7 8.3 1 2 0.3 1.0 mg/l 2.5 2.5.1 2.5.2
107 6 84 30 10 1 2 2.5.3
108 HBsAg 2.6 2.6.1 100 1
109 2.6.2 110 130 150 200
110 1 2 1 5 10 1 2.7 2.7.1 2.7.2
111 2.8 2.8.1 HAV 1 3 HAV 2 HAV
112 2.8.2 40 90% 1988 20 39 89.5% 0.02 0.0 5mL 2 2.8.3 1987 12 20 12 H 2 2 000 95% 100% 1 1 1 ml
113 2.9 2.9.1 AsC AsC HBV DNA 1.12.2 85% 50 10% 1% 2.9.2 HBV HBV HBsAg 37.5% HBsAg 20.0% 31.7% 6 10 22.2% 10
114 35.7% 25.0% 96.4% HBsAg HBV HBsAg 2.9.3 HBV HBV HBsAg HBeAg 1999 3 3 0 1 6 30 g 3 HBIG 1 200 IU HBIG 0 1 1 3 20 mg/ 2 3 5 HBV 85.65% 91.98% 97.13% HBsAg 12 86.93% 91.98% 97.13% 2 3 3 0 1 6 10 g
115 3 0 1 6 20 g 3 1 2 7 20 g HBIG 1 ml 200 IU 2 HBsAg 10.5% 11.1% 2.4% HBIG HBsAg (1) HBsAg 10 10 10 g 0 1 6 (2) HBsAg HBeAg HBsAg HBeAg 24 0 1 1mL HBIG 200 IU/mL 2 3 5 10 g HBsAg (3) HBsAg HBeAg HBsAg (4) HBsAg 0 1 6 20 g 10 g 10 g 1/3 HBsAg 2/3 2.9.4 HBsAg HBsAg 10% HBV DNA
116 HBV HBV DNA HBsAg 2.9.5 HBsAg
117 2.9.6 HBV HBV HBV HBV HBV HBV 2.9.7 HBsAg HBsAg HBsAg HBV 58% HBV HBV 2.9.8 1985 10 1991 1992 1 1 3 85% 40% 1997 HBV HBsAg
118 0 1 6 10 g 3 2.9.9 HBsAg HBsAg 4 2 3 0 1 6 2.9.10 HBs HBs 7 1 5 7 HBs 98.6% 87.9% 80% HBs 5 7 1 HBs HBs HBV HBs 10 HBsAg 12 1
119 2.9.11 0 1 6 90% 5% 10% 1 2 (1) HBs HCV HIV (2) HBsAg HLA HLA DR3+ HLA DR7+ 3 HBs a HBsAg 4 HBsAg HBsAg
120 HBsAg Th1 Th1 HBsAg MHC 5 HBV HBV HBV HBV T HBsAg IL 2 IL 2 HBs HBs HBsAg 10 3 1 90% HBsAg 1 10 g HBs 2.10 2.10.1 HCV
121 2.10.2 2 HCV HCV 2.11 HDV DNA HBV HDV HBV 2.12
122 2.13 126 134 1 2 3 4 5
123 2.13.1 1 15g 15g 20g 10 150g 10g 150g 1.5~2 2 60g 30g 10g 60g 5g 100g 10g 10 2 2.5 100g 6
124 10g 10g 10g 10g 30g 30g 6g 30 500g
125 12g 10g 30g 10 15g 1 000 g 400 ml 30 ml 20 ml 400 g 1 20 g 2.13.2 12g 30g 30g 15g 100g 5g 10g 10
126 2.5 3 30g 10g 10g 12g 50 10g 10 1.5 2 20g 40g 50g 40g 60g 15g 30g 100g 30
127 250g 1 000 ml 1 500 g 120 g 6 g 2.13.3 10g 6g 10g 150g 9g 10 1.5~2 10g 10g 30g 15g 6g 150g 8g 10g 10
128 1.5 2 10 15g 100g 200g 4 1~2 2.13.4 30g 30g 15g 150g 10 10g 6g 1.5 2
129 15g 15g 10g 10g 150g 10g 10g 10 2.5~3 30g 15g 50g 500 ml 15 5g 10g 2.13.5 III 12g 30g 6g 150g 10g 15g 10 3 5~6
130
131 3.1 1 40% 1 2 2 3 1 000 2 000 ml C B 6 B 1 C B
132 4 3.2 (1) (2) (3) (4) (5)
133 3.3 CHB HBV HBV 3.3.1 HBV HBV 3.3.2
134 ALT 2 HBV DNA <10 5 /ml 3 <140 mg/l d <140 mg/l d <130 mg/ L d 3.3.3 (1) ALT 10 (2) (3) (4) (5) (6) 3.3.4 (1) HBsAg (2)HBV DNA ALT (3)HBV C HBsAg (4)
135 3.3.5 500 U 1 3 1 2 8 1 16 24 36 48 35% 45% HBV DNA 35% 50% HBeAg/ HBe 30% 40% ALT 50% 65% 60% HBsAg 5% 10% 3% 7% 5% 15% HBeAg( ) HBe(+) HBV DNA(+) 20% 3.3.6 1 2 8 2
136 3 1 2 4 17 5 6 1 2 7 8 3.3.7 HBV
137 Lobucavir Adeforir Entecavir L dt DNA DNA DNA DNA HBV DNA HBV DNA ALT 3.3.8 2 3 HBV 227 260 5 HBV DNA 52 104 156 208 260 HBeAg 19% 45% 52% 54% 54% HBeAg HBe 16% 28% 40% 54% 50% 1 ALT ALT 2 ULN ALT 1 6 ATL 3 6 ALT 1 2 ULN ( )
138 2 1 1 100 mg, 1 HBeAg 6 12 3 ALT HBV DNA HBeAg/ HBe 2 HBeAg 1 6 12 3 ALT HBV DNA HBeAg/ HBe 3 HBeAg 1 4 HBeAg HBV DNA 2 1 3 1 3 3 1 HBeAg HBV DNA 3 HBsAg HBeAg HBe HBV DNA 1
139 3 1 3 6 1 HBV HBV DNA 6 12 4 ALT ALT 5 ALT ALT ALT ALT ALT 1 EB ( ) HBeAg 6 YMDD HBV DNA YMDD 2 ALT ALT<5 ULN HBV DNA 6 ALT<5 ULN HBV DNA ALT ALT 5 ULN HBV DNA
140 ALT 5 ULN >85.5 mol/l 5 mg / L <35 g/l <60% 4s 6 YMDD YMDD 6 1 14% 32% 67% 208 HBV YMDD 500 /ml ALT 73% 260 ALT YMDD YMDD YMDD YMDD HBV DNA ALT YMDD 7 YMDD HBV DNA 4 A B C D YMDD C YMDD Y M D D YMDD
141 DNA HBV 6 YMDD YMDD 2 YMDD HBV DNA C 522 M V M522V YVDD HBV DNA B 528 L L528M YMDD HBV DNA C 522 I M522I YIDD YMDD YMDD DNA HBV HBV DNA ALT YMDD 8 1 2 3 HBV DNA (HBV DNA>10 5 /ml ALT >2 ULN) 2 ( )
142 3 1 3 4 12 12 16 9 HBeAg 19% 18% 29% HBeAg 35% 19% YMDD (Adefovir) (Entecavir) 2 3.3.9 Adefovir ADV DNA DNA DNA HIV HBV Adefovir dipivoxil ADV ADV 10 mg/d
143 3.3.10 Entecavir 3.3.11 1 98% 6 36.5% 88.5% 1/3 HBeAg 25% HBeAg HBe 40% HBV DNA 2 600 mg/100 ml 5% 500 ml 1 2 3 200 mg/ 2 3 3 6 3 3.3.12 1 ALT HBV DNA HBeAg / Hbe 2 3 4 6 12 5 6 12 ALT
144 HBV DNA 3.4 ALT 3.4.1 (1) (2) (3) (4) 3.4.2 HCV HCV RNA ALT 1.5 ALT HCV RNA 3.4.3 ALT HCV RNA
145 6 ALT HCV RNA 6 (1) ALT (2) HCV RNA (3) ALT HCV RNA (4) (5) 6 3.4.4 1 HCV RNA HCV RNA <1 10 6 /ml HCV RNA>1 10 6 /ml 2 HCV HCV 2 3 HCV 1 4 HCV 1 3 4 3 HCV RNA HCV RNA 100 3.4.5 1998 24 48
146 100 24 HCV RNA ALT 2b 48 24 2b 48 HCV RNA 41% 33% 16% ALT 43% 36% 20% 2 48 24 2b 173 2b 172 24 24 HCV RNA ALT 47% 5% 9 10 2b HCV 2 HCV 3 600 800 mg/d HCV 1 <75 kg 750 900 mg/d 75kg 1 000 1 200 mg/d 3.4.6 Peg IFN Pegsys 1 Peg IFN
147 Peg IFN 56% 2b 44% HCV 1 Peg IFN 46% 36% HCV HCV RNA 2 10 6 /ml Peg IFN 1 HCV HCV RNA 2 10 6 /ml Peg IFN 3.4.7 3.5 3.5.1 (Thymosin) Tal Mutchnick 2 7 6 HBV DNA (86%) 5 l (20%) 5
148 4 7 T l 1 HBV 26 3 HBV DNA HBeAg ALT ( 48.4% 33.0% 24%) IFN ( 42.8% 31.0% 32.3%) 3 IFN ALT 6 HBV DNA ALT 64.8% 51% 65.5% 53.3% HBeAg T l (70.3% 46.3%) 3.5.2 <10kD 20 70 3.5.3 2 IL 2 1L 2 T Th NK LAK CTL
149 IL 2 15fg 28 HBV DNA Kiknchi IL 2 HBeAg HBe CD4 IL 2 IL 2 HBV HBV 3.5.4 (Levamisole) 60% (150mg 3 ) 3.5.5 (irna) HBsAg Liuss 50 irna l 2 6 20% HBsAg 80% ALT 40% 3.5.6 DNA 1
150 HBV T CTL HBV CTL HBV Brechot 32 ( HBsAg Pre S2) HBV DNA 50 3 ( 20 g) HBV DNA 10 (31%) 4 HBV DNA 13% 6 9 IFN 500 U IFN 2b 3 4 IFN 21 IFN 14 8 17 HBV 18 13 IFN 3 HBV 2 (SMAA) DHBs DHBsAg SMAA DHBV 3 3 60% 80% DHBV DNA 50% 60% DHBsAg DHBs Randall SMAA DHBsAg HBS DHBV 50% DHBV DNA DHBsAg 9 64.3% HBV DNA 6 HBeAg HBe HBsAg
151 9 3 DNA (Nucleycacidvaccine) (Genevaccine) (DNA RNA) DNA DNA (DNAVaccine) DNA Davis HBVPreS S DNA 6 17 CTL HBsAg DNA 2 HBs 8 12 HBs IgM IgG2 IgGl HBsAg 20 HBV mrna DNA HBs CTL DNA DNA 3.5.7 HBeAg (NA) (GO)
152 N13 DNA E.coil DNA PHIX l74 DNA DHBV DNA N13 DNA 25A N13 DNA DNA DNA B DNA NK T B IL 6 IL 12 IFN 7 TH 0 TH 1 DNA CpG CpG 3.6 3.6.1 ( ) ( ) ( ) Ca 2+
153 (LPO) LPO T T B T (NK) 10% 40% T l(il 1) 6(IL 6) (TNF ) (R0I) TAD 105 79.1% 42.9% 87% FDP 0.6 1.2g 5 500mL 1
154 3.6.2 (EPL ) EPL ADCC( ) MILT( ) EPL 600 mg 3 300 mg 3
155 3.6.3 ( ) (0.25) (0.1%) (20%) HBeAg 67 68% 46/67 25.7%(17/66) 100 80% (ALT) AST GT 67% 50% 32% 6% HBeAg 61% 73% HBeAb 39% 33% 7% 80 120 ml 3 6 ALT 3.6.4 D D 150 mg 30 ml 10% 250 ml
156 1 100 mg 3 3.6.5 Tiopronin ATP ATP 91.1% 75.0% 66.3% 49.6% 90.1% 73.1% 0.2 g 1 2 4 3 1 2 12 3.6.6 420 mg 3 280 mg 2
157 3.6.7 4 3 15 20 2 3 3.6.8 (UDCA) (UDCA) ( 4%) 20 80 Leuschner UDCA ALT Podda 24 ( ) 2 UDCA AST ALT 7 GT 35% 33% 41% UDCA UDCA (HLA) ( HLA T ) (1L 2 IL 4 IFN )
158 3.6.9 (HGF) HGF 18 15 HGF (ALT) 80 mg/d 120 mg/d 3.6.10 E1 E1 PGE1 PEG1 TNF PEG1 1 PEG1 camp PEG1 3.7 7
159 3.7.1 1 IFN mrna
160 2 IFN mrna 1995 1 I mrna G 9 11.24 5.34 8.67 4.16 12.78 5.19 6.57 2.95 100 U 1 3 1 6 9 3 Tet Tet 3T 6 Tet 50 mg 3 6 2 6 36 93 14 15.1% 54 58.1% 19 20.4% 4
161 5 c myb E E E 6 TGF 5 C 6 HSC HSC HSC TGF 1 10 7 HGF HGF 1 TGF 1 HSC ECM HGF 8 C
162 1 3.7.2 1 1 2 3 4 2 1 + HSC HSC
163 mrna HSC TGF 1 mrna 2 1 TGF 1 2 HSC bb PDGF bb HSC HSC mrna 3 PDGF TGF 1 HSC HSC 4 5 HSC (1) 11 4 0.85g 3 5 0.93g 3 6 2 52 29 71.1% 27.6% (2)
164 202 108 (3) 861 10 49 67% P P ALT 73% 33% 52% 1 8g 3 6 12 18.25 2.07 8.5 2.7 10.0 9.92 2.98 2.07 SMA (4) 1985 21 21 6 / 1 P P AO P P 5 3 4
165 (5) 319 6 0.3g 3 5 LM HA 3 4 CD + CD + CD + 4 /CD + 8 NK C3 IgG IgM 3.8
166 3.8.1 3 /, 20 90
167 3.8.2 3.9 1 3 87.0% 77.4% 10 60% 1977 3.9.1 1
168 3.9.2 1 2 18 3 24.3% HBV HCV HDV 3 23.5% 3.10
169 3.10.1 1
170 10g 10g 15g 15g 15g 15g 2g 12g 9g 6g 9g 5g 9g 4 2
171 20g 5g 3g 10g 10g 6g 3g 10g 3
172 15g 9g 9g 6g 6g 6g 15g 9g 300g 60g 90g 60g 60g 120g 300g 32g 60g 60g 60g 30g
173 4 30g 15g 9g 10g 15g 9g 9g 9g 6g
174 5 30g 10g 10g 5g 5g 10g 6
175 10g 10g 10g 30g 12g 5g 7
176 6g 9g 5g 6g 6g 15g 30g 30g 30g 30g 30g 10g 15g
177 3.10.2 1 HBV DNA HBV HepG.2.2.15 HBV HB S Ag HBeAg DHBV DHBV DNA HBV HBsAg HBV DNA HBsAg AFP 2
178 1 2 3 4 3
179 ALT AST 1 ALT AST ALT AST 2 3 4 TGF 1
180 861 3.10.3 1 (1) 30g 10g 5 10g 5g 10g 10g 15g 20g 15g 10g 10g 10g (2)
181 15g 10g 10g 10g 10g 10g 10g 10g 15g 10g 5g 15g (3) 10g 10g 10g 10g 10g 10g 5g 15g 20g 15g 10g 15g 15g 10g 2
182 (1) 15g 10g 5g 10g 10g 10g 10g 10g 15g 15g 15g 15g 25g 10g (2) 10g 15g 10g 10g 15g 15g 10g 10g 10g 15g 10g 15g
183 10g 10g 10g 10g (3) 10g 10g 10g 10g 10g 10g 10g 15g 10g 15g 10g 15g 10g 15g 10g (4) 10g 10g 10g 10g 10g 10g 20g 10g 15g 15g 5g 10g 15g 15g
184 5g 5g 15g 20g 5g (5) 20g 15g 15g 10g 10g 15g 15g 20g 15g 10g 10g 10g 10g 5g 10g 30g (6) 30g 10g 5g 5g 10g 10g 10g 15g 15g 10g 10g
185 15g 15g 15g 30g 3 15g 10g 15g 30g 10g 15g 10g 15g 15g 15g 10g 10g 10g 4 (1)
186 30g 15g 10g 10g 10g 20g 10g 15g 30g 15g (2) 10g 10g 10g 10g 15g 10g 10g 10g 10g 10g 30g 5
187 30g 15g 10g 15g 15g 15g 10g 10g 20g 15g 20g 10g 6 (1) 50g 15g 10g 10g 10g 15g 10g 20g 30g 15g 30g 15g
188 (2) 15g 10g 20g 50g 15g 15g 10g 15g 15g 20g 30g 15g 30g 15g 30g 15g 15g 30g 15g 7 3.10.4 1 (1)
189 D ALT AKP Y Z CCl 4 ALT AST CCl 4 ALT
190 A CCl 4 ALT CCl 4 D ALT 2 4 ALT HBsAg HbeAg P450
191 CCl 4 D ALT HbsAg HbsAg Oddis CCl 4 ALT 6 ALT 1972 CCl 4 ALT
192 600 30 10 1982 Thyagarajan HBV 6 CCl 4 CCl 4 ALT AST HBV HbsAg HbeAg (2) 6 7 CCl 4 D ALT AST P450
193 CCl 4 CCl 4 D ALT HBs CCl 4 ALT (3) ( )
194 d CCl 4 CCl 4 II(NADPH), CCl 4 CCl 4 D ALT CCl 4 P450 3 3 A HMGR 72 (4)
195 A B C CCl 4 ALT CCl 4 LPO MDA D ALT A B
196 CCl 4 ALT Ca 2+ BSP ALT AST MDA CCl 4 ALT (5)
197 CCl 4 D ALT MDA GSH P450 MDA GSH CCl 4 ALT
198 CCl 4 ALT AST A 2 Ca 2+ A B 12 E CCl 4 D ALT P450 C CCl 4 GSH Px SOD ALT
199 A E CCl 4 ALT P450 ALT 2 (1) 30g 30g 30g 10g 10g 10g 10g 15g 15g 12g 9g 24g 5g 9g 9g 12g 9g 15g 1 3
200 1 3 30g 1 30g 30g 10g 15g 15g 15g 10g 10g 10g 10g 30g 15g 15g 15g 1 3 (2) 10g 60g 30g 30g 30g 15g 15g 1 30g 30g 10g 10g 10g 10g 10g 10g 15g 6g 6 2 1 3 1
201 30g 30 60g 15 30g 15 30g 15 30g 10 15g 10 15g 10 15g 10 15g 10 12g 10 12g 1 3 10g 30g 15g 12g 10g 12g 10g 15g 15g 10g 10g 1 10g 10g 10g 10g 10g 15g 30g 15g 10g 15g 15g 10g 1 3 10g 10g 10g 10g 10g 10g 10g 15g 6g 6g 6g 6g 1
202 30g 10g 15g 10g 6g 6g 10g 10g 10g 15g 10g 10g 10g 1 (3) 15g 15g 30g 10g 30g 20g 12g 1 30g 10g 10g 20g 10g 10g 30g 10g 1 10g 60g 30g 30g 30g 15g 1 (4)
203 (5) 30g 30g 20g 15g 15g 12g 10g 10g 10g 9g 3g 1 3 30g 15g 10g 10g 10g 5g 1 3 (6) I 60 120g 30 60g 20g 15g 30 50g 10 15g 10 15g 10 15g 10g 1 4g 60g 20g 20g 10g 10g 10g 30g 3
204 (7) 30g 30g 10g 10g 10g 10g 10g 10g 1 30g 30g 60 80g 20g 1 3.11 3.11.1 10 10 0.5% 84 30 0.12 ml/m 3
205 3.11.2 3.11.3 CCl 4 CCl 4 CCl 4 CCl 4 CCl 4 CCl 3 CCl 4 CCl 4 2 4 CCl 4 CCl 4 CCl 4 CCl 4
206 3.12 3.12.1
207 3.12.2 70g 1 90 100g 8
208 400g 3.12.3
209 3.12.4 C C 100 g C C 30 mg 2 mg 6 mg 4 mg 1 2 mg 100 mg ( ) 500g
210 18 30 B l A D 1 3
211 3.12.5 B C 6 7 C C
212 3.12.6 5 6
213 3.12.7 ( )
214 3.12.8 500 g 17.5 g 45 g 0.04 0.06 g 154 210 270 3.12.9 ( ) ( ) ( ) 1 500
215 10% 6% 8% 30 50 20 40 100 g 49.8g 36.3 g 2 3 3 5 8 12.1% ( ) 5% 6% 30.4 mg/100g 185mg/100g 6 B 1 B 2 A
216 3.12.10 5 ph 100 A
217 3.12.11 90% 40g 5 HBV 40% HBV (27%) (3%) 75% 3.12.12
218 1 2 6g 3 4 2 1/2 1/3 3 4
219 5 3.12.13 3 1 2.5% ( ) ( ) ( ) 2 3 2.5% 3 4
220 ( ) ( ) 1 2 50 3 3.12.14 1 2 3 4 5
221 3.12.15 15g 10g 100g ( ) ( 10 30 g 6 8 2 )
222 ( ) C 500 g 1
223 3.13 3.13.1 1 2 10 0.2% 2 0.2% 0.2% 0.5% 0.5% 3.13.2 2 3
224 3.13.3 19 1 mg
225 3.14 3.14.1 40% 65% 80% 20% 35% 7 10 1 500 / 25 40 1 350 ml/min 800 25% 60% 25%
226 3.14.2 88.3
227,,,,,,, 1 2 (1)
228 (2) 2 (3) 3 5 3.14.3 3 6
229 1.5 25 30 50 30 50 3.14.4
230 1 6
231 10%~15% 1 2 100 1 2 1 2
232 3.14.5 ( )
233 3.14.6 10
234 3.15 3.15.1 3.15.2
235 3.15.3 3.15.4!
236
237 3.15.5
238 3.15.6 30 1 5% 55 40
239
HBc HBsAg HBs HBeAg HBe HBc HBV DNA IgM HBc + + + + + + + + + + + + +/ + + + + /+ + + + C + + + + + + + + HBsAg HBV HBIG