1 RNA Yellow fever virus, YFV Flaviviridaegenus Flavivirus 2 Aedes Haemagogus sppaedes aegypti WHO revised International Health Regulat

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第9章 疫苗 Required 黃熱病疫苗 與流行性腦脊髓膜炎球菌疫苗 (Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine) 仁濟醫院家庭醫學科 作者:洪孜幸 台大醫院家庭醫學部 大綱 作者:詹其峰 一 前言 二 黃熱病與疫苗簡介 三 國際預防接種證明介紹 四 最新黃熱病疫情及各國黃熱病疫苗要 求查詢 五 各國黃熱病疫情 疫苗要求 六 流行性腦脊髓膜炎球菌疫苗簡介 七 結語 前言 目前世界衛生組織實際規定旅遊者必須接種的強制性疫苗 Required or Mandatory Vaccine 只有黃熱病疫苗一項 然而 沙烏地阿拉伯另規定朝聖 者必須接種腦膜炎球菌疫苗 本文謹將介紹上述黃熱病與流行性腦脊髓膜炎球菌疫苗 以及國際預防接 種證明之相關規定 190-255第9章.indd 190 2013/4/2 下午 12:59:55

1 RNA Yellow fever virus, YFV Flaviviridaegenus Flavivirus 2 Aedes Haemagogus sppaedes aegypti 3 1960 5 20 40 WHO revised International Health Regulations infected area a risk of yellow fever transmission is present [1,2,4] 7 10 1 5 2 3 CDC the Yellow Book 2 191

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine 50 / 100,000 10 / 100,000 5 / 100,000 1 / 100,000 4 3 6 1 143 5 15% [1] 5 1. 2. 3. 24 4. 1 2 1 2 192

4IgM 6 Aspirin 7 DEET Type Number of doses 0.5ml Booster Contraindications 6 thymoma CD4 T <200/mm3 <15% Percautions 6 860 CD4 T 200 499/ mm3 15%~24% Indications for use 9 193

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine 1. 9 7-10 30-35 1010 10 6 30 2. International Health RegulationsIHR waiver 3. 10%-30% 5 10 1 2 1.8 Yellow f ever vaccine associated neurologic disease, YEL-ANDGuillain- Barré 3 28 0.8 60 69 70 1.62.3 Yellow fever vaccine associated viscerotropic disease YEL-AVD 194

200150 65%3 1 8 0.460 69 70 1.02.3 4. neomycin thymoma CD4 T <200/mm3 <15% 6 860 CD4 T 200 499/mm3 15% 24% waiver 1969 IHR, International Health Regulations 1973 1981 2005 195

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine 1 2 3 2005 1. 6 10 10 1010 2. [4] 1. 1249 200 150 196

2. www. cdc.gov.tw [1,3] WHO CDC, Centers for Disease Control and Prevention Yellow Book 197

疫苗 Required 黃熱病疫苗與流行性腦脊髓膜炎球菌疫苗 (Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine) Step1 CDC http://www.cdc.gov ->Traveler s Health Step2 Traveler s Health -> Yellow Book 198 190-255第9章.indd 198 2013/4/2 下午 12:59:58

Step3 Yellow Book -> Table of Contents Step4 Yellow Book -> Table of Contents ->Chapter 3 Infectious Diseases Related to Travel 199 190-255第9章.indd 199 2013/4/2 下午 12:59:59

疫苗 Required 黃熱病疫苗與流行性腦脊髓膜炎球菌疫苗 (Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine) 針對黃熱病疫苗接種 經過文獻回顧後 世界衛生組織 WHO 美國 疾病管制局 CDC 與專家學者們共同訂出三種建議模式 黃熱病疫苗建議 原因 建議接種 建議所有9個月以上前往該區者應接種疫苗 意即該 Recommended 區持續或週期性發生黃熱病病毒流行 一般 該區黃熱病病毒傳染風險低 意即迄今並無人類罹患 通常不建議 Generally not recommended 黃熱病病例且活或黃熱病病毒傳播程度低 但部分暴 露風險較高的旅行者 如長期旅遊 大量蚊蟲接觸 或未能有效防蚊者仍應考慮接種 不建議接種 該區不具黃熱病病毒傳染風險 意即迄今並無黃熱病 Not recommended 病毒活動或環境因素不利黃熱病病毒傳播 註 1.資料來源 美國疾病控制中心 2012 Yellow Book Update 2013/03 2.黃熱病疫苗不建議年齡未滿9個月的嬰兒接種 本表所列僅供現況參考 各地區情況 仍可能隨時發生變化 地圖1 2012年非洲黃熱病流行地區疫苗接種建議 Yellow fever vaccine recommendation in Africa 2012 200 190-255第9章.indd 200 2013/4/2 下午 01:00:00

資料來源 美國疾病控制中心 2012 Yellow Book Update 2013/03 圖2 2012年中美洲黃熱病流行地區疫苗接種建議 Yellow fever vaccine recommendation in the America 2012 201 190-255第9章.indd 201 2013/4/2 下午 01:00:00

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine [1,3] AFGHANISTAN Requirement ALBANIA Requirement ALGERIA Requirement >12 2012 5 AMERICAN SAMOAUS Requirement ANDORRA Requirement ANGOLA Requirement 9 202

ANGUILLA U.K. Requirement 2012 5 ANTARCTICA Requirement ANTIQUA AND BARBUDA- Requirement ARGENTINA Requirement 9 <2300Corrientes Berón de Astrada, Capital, General Alvear, General Paz, Itatí, Ituzaingó, Paso de los Libres, San Cosme, San Martín, San Miguel, Santo Tomé Misiones. Iguaçu Falls 2300 Chaco Bermejo Formosa all departments Jujuy Ledesma, San Pedro, Santa Bárbara, Valle Grande Salta Anta, General José de San Martín, Oran, Rivadavia 2300 203

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine ARMENIA Requirement ARUBA Requirement 6 AUSTRALIA Requirement São Tomé and Príncipe, Somalia Tanzania Galápagos Islands in Ecuador Misiones Province in Argentina AUSTRIA Requirement AZERBAIJAN Requirement AZORESPORTUGAL Requirement 204

BAHAMAS Requirement >12 2012 5 BAHRAIN Requirement BANGLADESH Requirement BARBADOS Requirement Guyana,Trinidad Tobago >12 2012 5 BELARUS Requirement BELGIUM Requirement 205

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine BELIZE Requirement BENIN Requirement 9 BERMUDA U.K. Requirement BHUTAN Requirement 2012 5 BOLIVIA Requirement 9 <2300 Beni, Pando, Santa Cruz Chuquisaca, Cochabamba, La Paz, Tarija >2300 La Pazc Sucre 206

BOSNIA AND HERZEGOVINA Requirement BOSTWANA Requirement >12 2012 5 BRAZIL Requirement 9 AcreAmapáAmazonas Distrito Federal Goiás Maranhão Mato GrossoMato Grosso do Sul Minas Gerais Pará RondôniaRoraima TocantinsEspirito Santo PiauiBahiaSão Paulo Paraná Santa Catarina Rio Grande do Sul Iguaçu Falls http://portal.saude.gov.br/portal/arquivos/pdf/base_ dados_acre2010_2011_18_10_2011.pdf Area com recomendação de vacina Area sem recomendação de vacina Fortaleza, Recife, Rio de Janeiro, Salvador, São Paulo 207

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine BRITISH IINDIAN OCEAN TERRITORY ; includes Diego Garcia U.K. Requirement BRUNEI Requirement >12 2012 5 BULGARIA Requirement BURKINA FASO Requirement 9 BURMA see MYANMAR BURUNDI Requirement 9 208

COMBODIA Requirement >12 2012 5 CAMEROON Requirement 9 CANADA Requirement CANARY ISLANDS SPAIN Requirement CAPE VERDE Requirement CAYMAN ISLAND U.K. Requirement 209

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine CENTRAL AFRICAN REPUBLIC Requirement9 9 CHAD Requirement 9 CHILE Requirement CHINA Requirement 9 2012 5 CHRISTMAS ISLAND AUSTRALIA Requirement São Tomé and Príncipe, Somalia, Tanzania, Galápagos Islands in Ecuador Misiones Province in Argentina 210

COCOS ISLANDS AUSTRALIA Requirement São Tomé and Príncipe, Somalia, Tanzania, Galápagos Islands in Ecuador Misiones Province in Argentina COLOMBIA Requirement 9 <2300Corrientes Berón de Astrada, Capital, General Alvear, General Paz, Itatí, Ituzaingó, Paso de los Libr es, San Cosme, San Martín, San Miguel, Santo Tomé Misiones Iguaçu Falls <2300 Chaco Bermejo Formosa all departments Jujuy Ledesma, San Pedro, Santa Bárbara, Valle Grande Salta Anta, General José de San Martín, Oran, Rivadavia 2300 Requirement Magdalena Cordillera OrientalChocoano Antioque Urabá Sierra Nevada de Santa Narta Orinoquia Amazonia COMOROS Requirement 211

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine CONGO, REPUBLIC OF THE Requirement 9 COOK ISLANDS NEW ZEALAND Requirement COSTA RICA Requirement 9 12 2012 5 Argentina, Panama, Trinidad and Tobago CÔTE D IVOIRE IVORY COAST Requirement 9 CROATIA Requirement CUBA Requirement 212

Requirement Requirement CYPRUS CZECH REPUBLIC DEMOCRATIC PEOPLE S REPUBLIC OF KOREA see KOREA, DEMOCRATIC PEOPLE S REPUBLIC OF DEMOCRATIC REPUBLIC OF THE CONGO Requirement 9 Katanga Requirement DENMARK DJIBOUTI Requirement DOMINICA Requirement 12 2012 5 213

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine DOMINICAN REPUBLIC Requirement ECUADOR Requirement 92300 Andes MountainsMorona-Santiago, Napo, Orellana, Pastaza, Sucumbios, and Zamora-Chinchipe 2300 Andes MountainsEsmeraldas, Guayas, Los Rios, Manabi, and designated areas of Azuay, Bolivar, Canar, Carchi, Chimborazo, Cotopaxi, El Oro, Imbabura, Loja, Pichincha, and Tungurahua 2300 Quito Guayaquil Galapagos Islands EAST TIMOR CHILE Requirement EGYPT Requirement 615 214

EL SALVADOR Requirement EQUATORIAL GUINEA Requirement 9 ERITREA Requirement Anseba, Debub, Gash Barka, Mae Kel, and Semenawi Keih Bahri. Dahlak Archipelago ETHIOPIA Requirement 9 Afar Somali FALKLAND ISLANDS MALVINAS Requirement 215

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine FAROE ISLANDS DENMARK Requirement FIJI Requirement 12 2012 5 FINLAND Requirement FRENCE Requirement FRENCH GUIANA Requirement FRENCH POLYNESIA Requirement GABON Requirement 9 216

GAMBIA, The Requirement 9 GEORGIA Requirement GERMANY Requirement GHANA Requirement9 9 GIBRALTAR U.K. Requirement GREECE Requirement GREENLAND DENMARK Requirement 217

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine GRENADA Requirement 12 2012 5 GUADELOUPEFRANCE Requirement GUAMU.S. Requirement GUATEMALA Requirement GUINEA Requirement 9 GUINEA BISSAU Requirement 9 218

GUYANA Requirement Argentina, Paraguay, Suriname, Trinidad and Tobago 9 HAITI Requirement HONDURAS Requirement Panama >12 2012 5 HONG KONG SAR CHINA Requirement HUNGARY Requirement ICELAND Requirement 219

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine INDIA Requirement 9 1 6 2 3 30 WHO 4 WHO 6 Angola, Benin, Burkina Faso, Burundi, Cameroon, Central African Republic, Chad, Congo,Côte d Ivoire, Democratic Republic of the Congo, Equatorial Guinea, Ethiopia, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Kenya, Liberia, Mali, Niger, Nigeria, Rwanda, Senegal, Sierra Leone, Sudan, Togo, Uganda Bolivia, Brazil, Colombia, Ecuador, French Guiana, Guyana, Panama, Peru, Suriname, Trinidad and Tobago, Venezuela. INDONESIA Requirement 9 IRAN, ISLAMIC REPUBLIC OF Requirement 220

IRAQ Requirement IRELAND Requirement ISRAEL Requirement ITALY Requirement JAMAICA Requirement 2012 5 JAPAN Requirement JORDAN Requirement 221

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine KAZAKHSTAN Requirement KENYA Requirement 9 Kilifi, Kwale, Lamu, Malindi Tanariver Nairobi Mombassa KIRIBATI Requirement KOREA, DEMOCRATIC PEOPLE S REPUBLIC OF, Requirement KOREA, REPUBLIC OF Requirement KUWAIT Requirement 222

KYRGYZSTAN Requirement 12 2012 5 LAO PEOPLE S DEMOCRATIC REPUBLIC Requirement LATVIA Requirement LEBANON Requirement 6 LESOTHO Requirement 9 12 2012 5 LIBERIA Requirement 9 223

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine LIBYAN Requirement LIECHTENSTEIN Requirement LITHUANIA Requirement LUXEMBOURG Requirement MACAO SAR CHINA Requirement MACEDONIA, THE FORMER YUGOSLAY REPUBLIC OF, Requirement MADAGASCAR Requirement 224

MADEIRA ISLANDS PORTUGAL Requirement MALAWI Requirement >12 2012 5 MALAYSIA Requirement >12 2012 5 MALDIVES Requirement MALI Requirement 9 MALTA Requirement 2012 5 225

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine MARSHALL ISLANDS Requirement MARTINIQUE FRANCE Requirement MAURITANIA Requirement 9 MAURITIUS Requirement >12 2012 5 MAYOTTE FRENCH TERRITORIAL COLLECTIVITY Requirement MEXICO Requirement 226

MICRONESIA, FEDERATED STATES OF Requirement MOLDOVA, REPUBLIC OF Requirement MONACO Requirement MONGOLIA Requirement MONTENEGRO Requirement MONTSERRAT U.K. Requirement MOROCCO Requirement 227

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine MOZAMBIQUE Requirement MYANMAR FORMERLY BURMA Requirement >12 2012 5 NAMIBIA Requirement NAURU Requirement NEPAL Requirement 228

NETHERLANDS Requirement MONTSERRAT Requirement NEW CALEDONIA FRANCE Requirement NEW ZEALAND Requirement NICARAQUA Requirement NIGER Requirement 9 229

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine NIGERIA Requirement 9 NIUE NEW ZEALAND Requirement 9 NORFOLK ISLAND AUSTRALIA Requirement São Tomé and Príncipe, Somalia, Tanzania, Galápagos Islands in Ecuador Misiones Province in Argentina NORTH KOREA Requirement NORTHERN MARIANA ISLANDS U.S. Requirement NORWAY Requirement 230

OMAN Requirement PAKISTAN Requirement 9 >12 2012 5 PALAU Requirement PANAMA Requirement 9 Emberá Kuna YalaDarié Colón Panamá San Blas, Balboa PAPUA NEW GUINEA Requirement 231

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine PARAQUAY Requirement 9 Asunción PERU Requirement 9 2300 Amazonas, Loreto, Madre de Dios, San Martin, Ucayali Ancash ApurimacAyacucho CajamarcaCusco HuancavelicaHuanuco Junin La LibertadPascoPiura Puno Lambayeque Tumbes Cajamarca Piura 2300Cuzco Lima Machu Picchu Inca Trail PHILIPPINES Requirement 2012 5 PITCAIRN ISLANDS U.K. Requirement 232

POLAND Requirement PORTUGAL Requirement PUERTO RICO Requirement QATAR Requirement REUNION France Requirement ROMANIA Requirement RUSSIAN FEDERATION Requirement 233

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine RWANDA Requirement 9 SAINT HELENA U.K. Requirement SAINT KITTS AND NEVISU.K. Requirement >12 2012 5 SAINT LUCIA Requirement SAINT PIERRE AND MIQUELON France Requirement SAINT VINCENT AND GRENADINES Requirement 234

SAMOA Requirement SAN MARINO Requirement SAO TOME AND PRINCIPE Requirement SAUDI ARABIA Requirement SENEGAL Requirement 9 9 SERBIA Requirement 235

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine SEYCHELLES Requirement SIERRA LEONE Requirement 9 SINGAPORE Requirement 6 SLOVAKIA Requirement SLOVENIA Requirement SOLOMON ISLANDS Requirement 236

SOMALIA Requirement Bakool, Banaadir, Bay, Galguduud, Gedo, Hiiraan, Lower Jubabada, Lower Shabelle, Middle Jubabada, Middle Shabelle SOUTH AFRICA Requirement Eritrea, São Tomé and Príncipe, Somalia, the United Republic of Tanzania, Zambia SOUTH KOREA Requirement SPAIN Requirement SRI LANKA Requirement 237

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine SUDAN Requirement 9 SURINAME Requirement 9 SWAZILAND Requirement SWEDEN Requirement SWITZERLAND Requirement SYRIAN ARAB REPUBLIC Requirement 238

TAJIKISTAN Requirement TANZANIA, UNITED REPUBLIC OF Requirement Tanzania THAILAND Requirement 2012 5 TIMOR-LESTE Requirement TOGO Requirement 9 TOKELAUNEW ZEALAND Requirement 239

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine TONGA Requirement TRINIDAD AND TOBAGO Requirement Trinidad9 Spain Tobago TUNISIA Requirement TURKEY Requirement TURKMENISTAN Requirement TUVALU Requirement 240

UGANDA Requirement 9 Requirement Requirement UKRAINE UNITED ARAB EMIRATES UNITED KINDOM WITH CHANNEL ISLANDS AND ISLE OF MAN Requirement UNITEND REPUBLIC OF TANZANIA see TANZANIA, UNITED PREPUBLIC OF Requirement Requirement UNITED STATES OF AMERICA URUGUAY Requirement 241

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine UZBEKISTAN Requirement VANUATU Requirement VENEZUELA BOLIVARIAN REPUBLIC OF Requirement 9 Aragua, Carabobo, Miranda, Vargas, Yaracuy Falcón Lara,Zulia Paez Municipality Margarita Caracas Valancia VIET NAM Requirement VIRGIN ISLANDS USA Requirement WAKE ISLAND Requirement 242

YEMEN Requirement ZAMBIA Requirement 9 >12 2011 12 ZIMBABWE Requirement 243

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine Type MPSV4 Number of doses >2 3 ~2 : 3 Booster 3 Contraindications Indications for use 2 12 6 the meningitis belt 10 1. Meningococcal disease Neisseria meningitides A B C Y W-135 2-10 8%-15% 2. Meningococcal vaccine meningococcal polysaccharide vaccine-mpsvmeningococcal conjugate vaccine-mcv 90% 244

2012 Yellow Book Update 2013/03 3 2012 Yellow fever vaccine recommendation in Brazil 2012 245

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine bivalent-a&c tetravalent- A, C, Y&W- 135 MPSV4 4 A, C, Y, W-13590% 2 4 C monovalent serogroup C tetravalent- A, C, Y&W-135 3. sub-saharan Meningitis Belt 2 10 32 MPSV4 212 3 Menomune MPSV4 Menactra Menveo MCV4 4. 1-2 5. 246

1936 99% 92001 Yellow fever vaccine associated viscerotropic disease YEL-AVD Yellow fever vaccine associated neurologic disease,yel- AND [1,5] 1. World Health Organization 2012. ITH 2012 Country list.international Travel and Health. Available at http://www.who.int/ith/en/. Accessed December 1, 2007. 2. Arya, S. C. 2002. Travel and Yellow Fever Vaccine. J Travel Med, 9 6,334. 3. Centers for Disease Control and Prevention. 2012. Chapter 3:Infectious diseases related to travel. Health Information for International Travel 2012. Available at http://wwwnc.cdc.gov/travel/yellowbook/2012/table-of-contents.htm. Accessed March 15, 2013. 4. Centers for Disease Control, R.O.C Taiwan 2013 Available at:http://www.cdc.gov.tw/ Accessed March 15, 2013. 5. Monath, T.P., 2007. Dengue and Yellow Fever Challenges for the Development and Use of Vaccines. N Engl J Med 357 2222-5. 6. Centers for Disease Control and Prevention. 2010 Yellow Fever Vaccine recommendations of the Advisory Committee on Immunization Practices ACIP. MMWR 59 RR07 ;1-27 247

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine -2012 Yellow Book Update 2013/03 4 2012 Afghanistan Albania Algeria Angola Anguilla Antigua and Barbuda Argentina Australia * 248

Bahamas Bangladesh Barbados Belize Benin Bhutan Bolivia Botswana Brazil Brunei Darussalam * Burkina Faso Burundi Cambodia Cameroon Cape Verde Central African Republic Chad China Christmas Island Colombia Congo, Democratic Republic Congo, Republic of the Côte d Ivoire Djibouti * * * * 249

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine Dominica Ecuador Egypt El Salvador Equatorial Guinea Eritrea Ethiopia Fiji * * French Guiana French Polynesia Gabon Gambia Ghana Grenada Guadeloupe Guatemala Guinea Guinea-Bissau Guyana Haiti Honduras India Indonesia Iran Iraq Jamaica 250

Jordan Kazakhstan Kenya Kiribati Lao People s Democratic Republic Lebanon Lesotho * Liberia Libyan Arab Jamahiriya Madagascar Malawi Malaysia Maldives Mali * Malta Mauritania Mauritius Montserrat Mozambique Myanmar Namibia Nauru Nepal Netherlands Antilles New Caledonia Nicaragua * 251

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine Niger * Nigeria Niue Oman Pakistan Palau Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Islands Portugal Reunion Rwanda Saint Helena Saint Kitts and Nevis Saint Lucia S a i n t V i n c e n t a n d t h e Grenadines Samoa Sao Tome and Principe Saudi Arabia Senegal Seychelles * * 252

Sierra Leone Singapore Solomon Islands Somalia South Africa Sri Lanka Sudan Suriname Swaziland Syrian Arab Republic Tanzania, United Republic of Thailand Timor Leste Togo Tonga Trinidad and Tobago Tunisia Uganda Uruguay Venezuela Vietnam Yemen Zimbabwe * WHO International Travel and Health publication Annex 1 www.who.int/ith/en/index.htm * * 253

Required Required Vaccines: Yellow Fever Vaccine and Meningococcal Vaccine 02 24292525 5610 5618 2013/3/4 201 47 268 02 25433535 2131 2132 2133 104 49 2 92 02 23123456 67614 100 48 1 10 02 87923311 114 90 325 03 3983456 337 58 15 B1 03 5326151 4006 300 59 442 25 254

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