1
2
1924 1948 1931 1938 1956 3
4
5 15 2 3 3 4 7 10 4 7 5
TOGAVIRIDAE Alphavirus FLAVIVIRIDAE Flavivirus Chikungunya Dengue 1, 2, 3 and 4 Japanese encephalitis West Nile Yellow fever BUNYAVIRUS Phlebovirus Rift Valley fever? 6
Flaviviridae flavivirus 7
8
9
( ) 10
11
( ) 2-20 12
5 15 2 5 13
14
IgM IgM IgG IgM IgM IgG 4 15
1 16
17
18
19
-, 1970-1998 1998 3-5 Source: Tsai et al., Vaccines 3rd edition, 1999;672-710. 20
- 21
500 400 300 200 100 0 1998-2007 405 410 23 24 387 400 13 33 310 309 319 306 19 25 32 35 251 264 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 29 37 22
5 10 6 7 70 60 50 40 30 20 10 0 23
1966 80-89 88.3 0 9 15.5 1% 0-9 60-69 70-79 10 19 1% 4% 4% 50-59 1998 20 17% 93% ]- 40-49 23% 10-19 6% 30-39 23% 20-29 21% 24
- - 25
15 2 2 3 5 9 26
-1 (inactivated vaccine) (efficacy): * 2 80% (Taiwan,1965) 91% (Thailand,1985) * 55%~80% 27
-2 28
-3 Immunogenicity of vaccine in Subjects after Two or Three Doses Study Group Seroconversion Rate (%) Two-Dose Series Three-Dose Series United States (1984-1987) 77 % 98 % United Kingdom (1983) 33 % 88 % 29
-4 (~20%),, (10~30%) 2~3 ADEM(acute disseminated encephalomyelitis) 1/50000~1/75000 (Japan,Korea) 30
2004 Ref 93 31
15-90 71% 24-40 (1961-1977 ) (47-61%) 4 Doses 3 Doses 2 Doses Ref 93 ( ) 32
( ) 33
34
24 1 4 7 2 1 3 10 35
(1) 36
2 3mL 7 14 40 2 3mL 37
(1) 24????? 38
2006 5 2008 5 02-23959825 3956 39
40