绎 1 援 401331 2. 400030 3. 400020 4. 400080 5. 400012 88 44 44 猿 孕 约 0.05 ESR 悦 CRP RF 孕 约 0.05 doi: 10.11842/wst.2014.04.018 R593.22 A Rheumatoid Arthritis RA 44 19 25 32 耀 75 47.71 依 8.53 5 耀 28 4.39 依 3.31 玉 18 域 20 芋 6 44 20 24 31 耀 76 46.59 依 8.66 6 耀 29 4.57 依 3.44 玉 19 域 19 芋 6 1 1 1.2 1.1 88 88 1987 RA [1] 淤 1h 于 3 盂 2013-07-11 2013-08-12 1 榆 元 2010-2-66 DNA 元 元 784
2014 绎 Vol.16 No.4 1 / / 46.59 依 8.66 4.57 依 3.44 / / 玉 域 芋 20 24 19 19 6 47.71 依 8.53 4.39 依 3.31 19 25 18 20 6 虞 愚 Rheumatoid Factor RF 5% 舆 X 7 4 RA 4 6 [2] RA 1.3 郁 1.4 75 mg 员 10 mg 员 0.25 g 猿 0.25 g/ 0.50 g 猿 15 g 10 g 10 g 9g 5g 10 g 15 g 10 g 10 g 10 g 6g 15 g 30 g 15 g 1 1 1 100 ml 28~30 30 min 1 1 1 3 1.5 1 3 [6] 1 3 Erythrocyte Sedimentation Rate ESR C C-reactionprotein CRP RF ALT AST 员 猿 BUN CR 1.5.1 0 1 2 3 4 1.5.2 0 1 2 3 1.5.3 0 1 2 3 1.5.4 0 1 2 3 1.6 785
绎 [2] 逸 95 豫 ESR CRP RF 逸 70 豫 逸 30 豫 约 30 豫 1.7 SPSS 16.0 字 2 依 x 依 s 贼 P< 0.05 P 约 0.01 2 2.1 44 14 10 16 4 90.91% 44 7 9 15 13 70.45% P<0.05 2 2.2 愿 孕 约 0.05 孕 约 0.01 孕 约 0.05 孕 约 0.01 远 3 2.3 CRP ESR RF P 约 0.05 P 约 0.01 P 约 0.05 P 约 0.01 员 猿 ALT AST BUN CR 4 5 3 2 n=44 / / / / /% 7 9 15 13 70.45 14 10 16 4 90.91 * * P<0.05 3 曾 依 泽 n=44 / / / / / /min / mmhg / 3.98 依 0.23 6.54 依 0.79 1.87 依 0.12 10.21 依 0.59 1.79 依 0.14 99.86 依 10.46 24.32 依 1.82 1.97 依 0.37 1 2.51 依 0.23 2.96 依 0.83 1.28 依 0.11 4.58 依 0.23 1.35 依 0.20 40.62 依 2.30 29.36 依 1.70 1.39 依 0.23 3 1.81 依 0.26 1.88 依 0.80 0.68 依 0.10 2.88 依 0.23 0.95 依 0.22 25.61 依 2.32 35.56 依 1.75 1.09 依 0.23 3.38 依 0.27 6.90 依 0.85 1.92 依 0.11 10.87 依 0.75 1.84 依 0.15 108.1 依 10.54 22.41 依 1.77 1.99 依 0.36 1 1.93 依 0.24 2.20 依 0.81 1.01 依 0.08 3.91 依 0.27 1.26 依 0.22 39.23 依 2.23 40.33 依 1.81 * 0.95 依 0.212 * 3 1.03 依 0.22 1.21 依 0.86 0.50 依 0.09 2.11 依 0.26 0.86 依 0.25 20.23 依 2.13 55.34 依 1.80 ** 0.35 依 0.21 ** 孕 约 0.05 孕 约 0.01 * 孕 约 0.05 ** 孕 约 0.01 786
2014 绎 Vol.16 No.4 4 CRP ESR RF 曾 依 泽 n=44 CRP/mg ml -1 ESR/mm h -1 RF/U L -1 17.98 依 4.24 119.12 依 23.71 52.16 依 6.11 1 13.04 依 1.11 91.30 依 20.15 38.30 依 1.21 3 8.64 依 1.15 75.32 依 20.13 26.32 依 1.23 17.66 依 4.13 128.37 依 24.36 51.25 依 6.42 1 10.30 依 1.15 * 66.25 依 21.06 * 18.20 依 1.13 * 3 4.13 依 1.12 ** 45.21 依 21.26 ** 11.29 依 1.11 ** 孕 约 0.05 孕 约 0.01 * 孕 约 0.05 ** 孕 约 0.01 5 ALT AST BUN CR 曾 依 泽 n=44 ALT/U L -1 AST/U L -1 BUN/mmol L -1 CR/mmol L -1 16.77 依 13.78 18.21 依 7.59 5.12 依 1.23 53.33 依 10.71 员 19.22 依 16.20 20.36 依 11.48 5.61 依 1.40 58.41 依 12.23 猿 14.10 依 5.82 17.06 依 5060 4.82 依 1.20 50.31 依 15.10 14.35 依 5.82 19.24 依 6.30 4.86 依 1.73 58.22 依 15.49 员 16.33 依 6.55 21.31 依 8.20 5.53 依 1.84 60.91 依 17.51 猿 15.55 依 4.57 19.66 依 5.06 5.01 依 1.14 54.52 依 13.49 RA RA [3] [4 5] [6] [7] RA 1 颐 2 RA [8] [9] 787
绎 [10] 300 mg kg -1 [11] [12] RA [13] 57 72.4% 93.1 豫 [14] CRP ESR RF RA CRP ESR RF RA RA 员 猿 ALT AST BUN CR RA 1,. 援 :,2008 颐 848~855. 2. ( ) 援 :,2002 颐 115~118 援 3,..,2011,40(11) 颐 1093~1097. 4,,,..,2012,28(2) 颐 118~121. 5..,2012,18(15) 颐 290~292. 6,,..,2010,23(8) 颐 163~164. 7,..,2011,17(1) 颐 202~204. 8..,2011,23(2) 颐 94 ~ 95. 9..,2012,20(6) 颐 1059~1060. 10..,2010,23(4) 颐 599~ 600. 11,,,..,2011,27(6) 颐 58~60. 12,,..,2011,22(12) 颐 3045~3046. 13. 57.,2010,22(3) 颐 244~245. 14. 32.,2011,3(14) 颐 180. Clinical Research on Treatment of Rheumatoid Arthritis of Cold-dampness Syndromes by Combination of Wen-Jing San-Han Tong-Luo Decoction and Acupuncture Zhou Ping 1,ChenOuna 2,SuYongmei 1, Xiang Yanghong 3,WuYumei 4,HuHong 5,ZhouYing 1 (1. College of Chinese Medicine, Chongqing Medical University, Chongqing 401331, China; 2. Chongqing Cancer Hospital, Chongqing 400030, China; 3. Chongqing A cademy of Traditional Chinese Medicine, Chongqing 400020, China; 4. General Hospital of Chongqing Iron and Steel Group, Chongqing 400080, China; 788
2014 绎 Vol.16 No.4 5. Chongqing Osteology and Traumatology Hospital of Traditional Chinese Medicine, Chongqing 400012, China) Abstract: This study was aimed to explore clinical effect on treatment of rheumatoid arthritis (RA) of cold-dampness syndrome by the combination of Wen-Jing San-Han Tong-Luo (WJSHTL) decoction and acupuncture. A total of 88 RA patients were selected and randomly divided into the control group and the treatment group. All 44 cases in the control group were orally administrated with diclofenac sodium, sulphasalazine (SASP) and methotrexate (MTX). All 44 cases in the treatment group were treated with the combination of WJSHTL decoction and acupuncture on the ba 鄄 sis of western medication the same as the control group. Each group was treated for three months. Improvements of clinical symptoms, body signs and laboratory indexes were observed. The results showed that clinical symptoms, body signs and laboratory indexes were greatly improved in the comparison before and after treatment in both groups with statistical significance (P < 0.05). Compared to the control group, the treatment group had no statistical significance in the improvement of rest pain, swelling numbers and index, tenderness numbers and index, morning stiffness time, liver and kidney function. Compared with the control group, the treatment group had more obvious advantages in the improvement of joint function, hand grip strength, erythrocyte sedimentation rate (ESR) decreasing, C-reactive protein (CRP) and rheumatoid factor (P < 0.05). It was concluded that compared with single western medication, the combi 鄄 nation of WJSHTL decoction and acupuncture with western medication had certain advantages in the improvement of joint function of RA and management of patient's disease condition. Keywords: Rheumatoid arthritis, Wen-Jing San-Han Tong-Luo decoction, acupuncture, combination of traditional Chinese medicine and western medicine, clinical effect 789