1

2

3

4

5

6

7

8

9

10

11

12

13

14

2007-06-23 850000 500000 2002 16.93/10 9.96/10 36.1/10 5 90% <10% <1cm 10 >50 1~2cm 10%>2cm 31.4%~50% 5%~9% 9% 40 %~50% 50% 20 %~30% >50 : (familial adenomatous polyposis,fap hereditary nonpolyposis colon cancer,hnpcc 1 50 101 1 51 + 51 1cm (invasive cancer)

2 76% 76%~90% ~90% 2%~5% 2%~5% 58.6% 58.6% 0.1%~0.2% 0.1%~0.2% 5mm 5mm 27 27% 10mm 10mm 6% 3 3 2 23.9% 23.9% 15% 15%~33% ~33% 4 70.3% 70.3% 60% 60%~80% ~80% 3 60 60 5 + 1 75.3% 75.3% 6 6~10mm 10mm 53% 53% >1cm >1cm 48% 48% 83% 83% 95% 95% CT CT 10mm 10mm 55% 55%~100% ~100% 94% 94%~98% ~98% DNA DNA 4 2 1 FAP FAP APC APC + - APC(?) APC(?) (+) ( (+) (-) 10~12 10~12 1 40 40 3~5 3~5 1 7~10 7~10 1 40 40 5 1 10~12 10~12 1

HNPCC 2 44 20~25-10 1~2 1 40 3 40 10 <60 3~5 40 60 5 40 10 <60 5 60 4 P 61 54 29/25 NBI 63 26/37 62 / 36/25 24/38 0.088 54.9015.05 50.6715.40 52.1112.69 53.3213.45 0.423 NBI63 P 1 4 61 3 > 0.05 5 13 18 18 26 4 3 > 0.05 1 7 17 28 22 38 1 4 61 13 18 5 4 54 23 32 5 P < 0.05 > 0.05 4 1 4 17 19 22 28

1 4 61 13 18 4 1 17 22 P min 9.884.18 12.127.1 1 0.04 5 P 2.411.9 8 2.352.0 0 0.888 (RMB) P 461.86102.2 8 435.98110.6 7 0.205 4 62 P > 0.05 1 9 14 8 < 0.01 8 39 55 NBI 14.327.5 3 13.037.0 3 0.00 0 0.00 4 3.002.3 6 2.722.1 5 0.136 0.406 488.73100.8 1 468.64107.4 4 0.147 0.726 NBI 8~10 1~2

2%~30% 2 <1cm 1 5 3~5 3~10 3 14 5 10 3 2~6 1 0.5cm 1. ASGE guidelilne: colorectal cancer screening and surveillance, Gastrointestinal endoscopy2006;63(4)546-5757 2. WGO practice guideline:colorectal cancer screening and surveillance. Summer 2002 3. Winawer SJ et al.guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society.Gastroenterology.. 2006;130(6):1872-85. 85. 4. Winawer SJ, Zauber AG.The advanced adenoma as the primary target of screening. Gastrointest Endosc Clin N Am. 2002 Jan;12(1):1-9, v. 5.. 1998123 298-9

20

21

22

23

24

APCEMRESD

1. 2. 3.

1. 2. 3. 4. 1. X 2. 3.

29

30

31

32

33

34

35

36

37

38

39

40

41

42

43

44

45

46

47

48

49

50

51

52

53

54

55

56

57

58

59

60

61

62

63

64

65

66

67

68

69

70

71

72

73

74

75

76

77

78

79

80

81

82

83

84

85

86

87

2500 2000 1500 1000 500 300 1 2 3 4 730 2500 2000 1500 1000 500 300 1900 bp 1 2 3 2500 2000 1500 1000 500 1 2 bp 2500 2000 1500 1000 500 300 88

89

90

91

92

93

94

95

96

97

98

99

100

101

102

103

104

105

106

107

108

109

110

111

112

113

114

115

116

117

118

119

120

121

122

123

124

125

126

127

128

129

130

131

132

133

134

135

136

137

138

139

/ 20 40 14 140

141

142

143

144

145

146

147

148

149

150

151

152

153

154

155

156

157

158

159

160

161

162

163

164

165

166

167

168

169

170