( )
... 1... 2... 4... 5 -... 7 -... 9 -... 13... 14... 16... 17... 19... 21... 23... 25... 27... 30... 32... 34 I
... 35... 39... 42... 43... 45... 48... 51... 53... 55... 57... 59... 60... 62... 65... 68... 70... 73... 75 -... 77... 80 -... 83... 85 II
... 88... 91... 93... 93... 97... 100... 103... 105... 106... 107...112...115...116... 120... 123... 125... 128... 133... 135... 137... 140... 142 III
... 144... 146... 148... 149... 151... 153... 155... 156... 159... 161... 164... 165... 167 5... 169... 171... 173... 175... 177... 178... 180 50... 182... 184 IV
... 186... 187... 189... 191... 193... 195... 197... 199... 200... 201... 203... 204... 206... 207... 207... 209... 210... 212... 214... 215... 216... 217 V
... 219 C... 221... 222... 224... 226... 227 VI
3 3 1
0.35g 48 * (1996) 012750 EPA-E C22H34O2 2
DHA-EC24H36O2 70% E1% 3 2-4 0.45 EPA-3+DHA-E315 60 3
(1996) 189901 HDL-C 2-3 0.1gx10 4
20.09 0.5 5
72 42.41% 53.01% 95.42% 100mg 2 3 6
50mg 50mg 100mg 20 2 100mg 10 1 50mg 100mg (94) X-203(1) (94) X-203(2) - - Gemfibrozil Capsules CAPSULAE GEMFIBR- OZILI 2 2- -5-2 7-5-
0.3-0.6g, 0.6-1.2g 2 8
0.3g (1998) XF-0128 - - Gemfibrozil capsules 9
( ) 600mg / 30 900mg/ 1500mg/ 1. ( 10
) 2. 1. 10 2. 3. 4. 5. 11
6. 7. 8. AST(SGOT) ALT(SGPT) LDH 300mg 12
- - TG 600mg,2 / 30 900mg 30 300mg,2 / 1. 13
2. 3. / 300mg/ 30 / 200 Gemnpid Cap.Tab. TC TC HDL 2051 5 66.7% 34% 14
600mg 2 / 30 900mg 30 300mg 2 / 1. 2. 3. 300mg*30 / 600mg*10 / 15
( 5000 15000, 8000), 8 16,,, 3, 1 2 15, 2 3, 1 16
1.,,, 2. 21.5/ 1200 /,10 / Lescol 21.06mg 20mg 42.12mg 40mg 17
20-40mg 40mg 2 18
/ 20mg/7 / Norvatis Lovastatin-Livzon lovastatin A 19
20mg/ 10mg/ 4 80mg/ LDL 75mg/100 ml 140mg/100mL 20
Stevens-Johnson 20mg x 10 Lipanthy fenofibrate ( ) 21
/ 200mg qd 100mg tid 300mg qd 100mg bid 200mg qd ( ) 100mg x 25 300mg x 10 200mg x 10 22
LIPIFEN 23
( ) - - - - - - 10 250mg 24
Pravachol 3-3- A (HMC-CoA ) HMC-CoA HMC-CoA HMC-CoA (LDL) LDL LDL - 25
(VLDL) LDL (a b ) 10mg 20mg 1 40mg 1. 2. SGPT SGOP 3. 4. HMG-CoA CPK 10 26
5. HMG-CoA 10mg/ 7 / 28 / Zocor 27
simvastatin â- 3-3 A (HMG-CoA ) HMG-CoA HMG-CoA A 28
B 10mg/ 80mg/ 5mg/ 10mg/ 20mg 29
5mgx10 10mgx10 ( ) 30
2-4 1-2 3-6 / 150ml 3-4, 31
0.5gX50 32
E B6 E â- 2 2-3 3 E17mg 100 33
(1995) 010643 2 2 2 34
(0.06%) (0.12%) 0.3g Probucol Tablets 4.4-[ 1-35
] [2.6-1.1-1 ( ) PTCA 4 24 1000mg/ Bid 2 (PDGF) -1 3 LDL OX-LDL 4 RS 5 ( ) (TC) (TG) (LDL-C) LDL-C/HDL-C 6 ( ) (OX-LDL) 36
(1) A(HMG-COA) (LDL-C) (2) LDL LDL(OX-LDL) (3) HMG-COA PTCA (RS) 37
(1)PTCA 4 24 1000mg bid (2) 500mg 2 2 (1) (2) (3) 125mg/, 8 / 4 /5 38
/20 / (98) X-127-2 ( ) 1. (CM) ( I ) 39
2. (VLDL) VLDL -- ( III V ) 3. (LDL) LDL ( lla llb ) 4. (HDL) HDL LDL Gemfibrozil VLDL LDL VLDL LDL HDL 40
98% 1 2% 70% S.M.Kurty (1983) LD50 3.162g/kg 4.786g/kg 41
DHA=27% EPA=18% =2.0% 3 1 2 / 100 0.5 1998 527 42
1. (TC) (TG) - (LDL-C) B100(ApoB100) - (HDL-C) A1(ApoA1) 2. TC TG LDL-C ApoB100 HDL-C ApoA1 3. 43
3 ( ) 250 3 3. 0.35g 0.35g 48 (1996) 012750 44
( ) Ca2+ 12 45
1. 20% 2. 3. 46
4. 12 (20mg) 20mg/ 10 10 20 47
Adalat GITS 30/60 30/60 (Nifedipine) 48
24 ( ) 1. ( ) 2. 30mg qd 49
(8 ) 30mg x 7 60mg x 7 50
Plendil â 51
24 5mg 5 10mg 2.5mg ( 52
) ( ) 2.5mg x 10 5mg x 10 10 x 24 Astrazeneca 53
12 1-2 12 54
92) X-65 MONO-TILDIEM 200mg E171 E172 55
II III 28 56
EnTong 1,4-57
20-60mg 3 b ( ) 58
( 90 ) 20mg. Herbesser Capsule diltiazem HCl 90 mg bid II 59
I GOT GPT 90 mg x 10 90 mg x 20 90 mg x 200 Herbesser Injection diltiazem HCl 60
10 mg/ 10 mg/ 5-15 ìg/kg / 5-15 ìg/kg / (II III ) I â- 61
10 mg x 10 50 mg x 10 Isoptin SR 240 ( ) 62
30-45 30 5-6 85% 10 90% 1-2 10 15 240-480mg 240mg 360mg 120mg( ) 63
480mg( ) 360mg ( ) (II III ) ( - ) 64
I (50 / ) ( <90mmHg) WPW ( ) ( ) ( 3 ) 10 Lacipil 65
Lacidipine â Lacidipine (>95%) a 1 â â 4mg mg 4mg 4 66
2mg 2mg 4mg 6mg ( ) 67
Glaxo Wellcome Amlodipine Besylate Tablets ( ) 68
( ) ( ) 69
1. 2. 3. Nifedipine sustained-release capsules Nifedipin-ratiopharm 70
20 Ca2+ ( ) ( ) ( 8 ) 2 1 2 2 2 1 71
2 2 ( ) 8 20mg/ 20 / 72
5~10mg 2 73
1 2 3 5mg/ (1999)X-48 74
1 4-75
1. 60 120mg 2. 60mg 3. 60mg 12 4. 60mg 5 3 4 76
â- 60mg 6 2 / (97) X-311 - - 77
(Nimodipine) 1. 2. ( ) 2 0.5mg/h 2 1mg/h 4 2mg/h ( 50ml 10mg )10mg 5% 5% 1ml 25-50ml ( 10ml 2mg )4-6mg 500ml5% 78
8 24mg/ ( ) 50ml 10mg 10ml 2mg 79
X-121 (95) X-121 2 (95) Nimotop nimodipine 80
( 5- ) 30mg tid 5-14 7 2 6 / 81
30mg x 20 10mg x 50mL 82
- - 10 /50 50 /250 96% 400 2 1 ( 5 15 / / ) 2 2 ( 10 83
30 / ) 70 0.5 ( 2.5 / ) ( ) 40 5% 0.9% 40 6% HAES( -2- ) 84
( 90 ) 50 10 250 50 Nimodipine Injection ± -4 3- -2 6- -3 5- -1 4-1 4-85
1. 2. 1 2 24-48 7-14 86
1. â 2. 3. 4. 5. 6. 5ml 10mg 87
Perdipine LA 1 2 24 1. 2. 88
3. 14 2 (1 40mg) 7 7.6 2 40mg 1. 2. 89
3. 4. 40mg/ 30 / (96) J-07 90
Perdipine injection D 1. 5% 0.01-0.02%(1ml 0.1-0.2mg) 2-10ug/kg 91
2. 5% 0.01-0.02%(1ml 0.1-0.2mg) 0.5-6ug/kg 0.5ug/kg 10-30ug/kg 2mg(2ml).10 92
10mg(10ml).10 Extended Release Nifedipine Tablets Tabellae Nifedipini Lente Liberantes 2 6- -4-2- -1 4- -3 5-93
C17H18N2O6 346.34 1.6-4 - (10ng/ml) 12 94
92-98% 54% P-450 70-80% 24 90% 0.1% 1. 2. 60% 3. 12 4. 5. 95
1-2 (10-20mg) 2 1. 2. 3. 4. 5. 6. GOT GPT 1. 96
500 2. 3. 4. 10mg 24 1 [1996] 001901 -(+)-5-[(2- ) ]-2-(4-97
)-3- -2 3-1.5- -4(5H)- 80mg 2 P-R A-H 98
1-2 1. 2.I 3. â 40 100 99
1,4-100
1.5~2 93~95% 1 30~120mg 3 2 40mg 3 12 88% 101
3 40~60mg 3~4 3~4 4 40~60mg 5 3~4 5 40mg 3 0.24g â- 20mg 102
30 (97) X-120 103
5mg~10mg 3 1. 2. 5mg 20 / 104
(1997) 226001 Ca2+ 105
20 / 1-2 ( ) 106
6mgx12 / x1000 / á-322-3 4- -3 4- -á- Verapamil Hydrochloride Tablets IV ( 107
) 90% 20-35% 90%(87-93%) 20-35% 10 T1/2 2.8-7.4 4.5-12 T1/2á 4 T1/2â 2-5 T1/2 9 108
1-2 3-4 6 2 (1-5 ) 2-5 2 3-5 10-20 24 50% 5 70% 3% 9-16% 109
1. 40-80mg 3-4 240-480mg 2. 480mg 3. 2 20mg 2-3 2 40-120mg 2-4 (50 / ) L-G-L 110
1. P-R <30ng/ml >30ng/ QRS Q-T 2. <12kPa(90mmHg) L-G-L 3. 111
>2.67kPa(20mmHg) <20% 4. 30 / (1985) 001948 Almarl 112
Arotinolol HCl á â- 1 8 á â ( - ) ( - ) l 20mg 1 30mg 1 10mg 1 20mg l 113
30mg (II III ) 114
48 hr a- ( ) 100 10 mg x 10 10 mg x Atenolol-Zhulin Antun atenolol 115
50-200mg qd 100mg qd 25-50mg bid II-III 50mg x 100 Zhulin Antun 116
Isosorbide Dinitrate Injection 1 4 3 6- -2 5- C6H8N2O8236.14 117
2-5- 2-7mg 5 5ml 500ml0.9% 5% 50ug/ml 5 10ml 500ml 100ug/ml 30ug/ 0.5 1 118
10 5ml/5mg/ 10ml/5mg/ 119
(96) X-27(1) (96) X-27(2) Adalat GITS 30/60 30/60 (Nifedipine) 120
24 ( ) 1. ( ) 2. 121
30mg qd (8 ) 30mg x 7 122
60mg x 7 Betaloc â1 ( ) 123
â1 10mg 100mg 300mg/ 124
II III 25mgx20 50mgx20 100mgx10 25 x18/ Astrazeneca Plendil 125
â 24 5mg 5 10mg 2.5mg 126
( ) ( ) 127
2.5mg x 10 5mg x 10 10 x 24 Astrazeneca Bisoprolol Fumarate Tablets 1-[4-[[2-1- ] ]- ]-3-[ 1- ]-2-128
â1- â1- â2-11 34 â1 (Atenolol) 4 (24 ) (>90%) (<10%) (t1/2 10 ) 50% 50% 1 2.5mg 10mg 129
â- 1. 2. ( ) ( ) 3. 4. 5. 6. 130
7. ( ) 1. ( ) ( ) (50/ ) 2. ( ) á- 3. 1. 2. 3. 4. 131
0.5 2.0mg 1 5( 10)mg 5. 6. 72 48 72 7. 132
5mg 10 / (97) X-283 1. ATP 2. 3. 133
4. 5. 6. ATP 1. 2. 134
2-4 / 1-2 / / 155mg 10 *2 *100 (98) X-105 5-135
15-20 4.2 40-60mg/ 136
( ) 100 Tablets Isosorbide-5-Mononitrate Sustained Release 137
138
1. 2. 3. 4. 139
60mg 10 140
250ml 12g 16g 5% 12-24g (2 ml X 5-8 100 ml`500 ml ) 3-5 5% 141
1. 2. 3. 5-5- 40mg 142
E171 E172 1. 2. 3. 4. / ( ) 1. 143
2. 3. 4. 5. 40mg 30 144
100-200mg 3, 145
100mg 20 * (91) Z-51 MONO-TILDIEM 200mg E171 E172 146
II III 147
28 ( ) ( ) ( ) 12-24 148
290 TT55 5*7cm/ 2 *3 / ZZ-5587-1995 100009 149
Bufferin Plus / 1-2 8 10 3 acetaminophen 500mg, caffeine 65m 10 150
1 2 3 4 151
5 2 3 1 2 1 2 3 2 3 3 4 2 3 5 6 2 I 2 3 1 2 II 2 3 3 4 III 2 3 5 6 152
1 2 60 60 (1996) 116006 Concor bisoprolol â â1 â2 153
â2 2-4 â ) 5-10mg qd ( 1-2 154
5mg x 10 Merck-Lipha Lizhu Xinle 5- isosorbide 5-mononitrate 155
10-20mg/ 2-3 / 10mg x 50 Isosorbide mononitrate Injection 1 4 3 6- -D- -5-156
157
2-7mg 60ug/ 60-120ug/ 10 158
5ml 20mg 6 / (98) X-235 Amlodipine Besylate Tablets ( ) ( ) 159
( ) 1. 160
2. 3. Nifedipine sustained-release capsules Nifedipin-ratiopharm 161
20 Ca2+ ( ) ( ) ( 8 ) 2 1 2 2 2 1 2 2 ( 162
) 8 20mg/ 20 / 163
Nitrostat nitroglycerin 5 15 3 164
600ìg x 25 Tenormin atenolol â- 165
50-100mg qd II III 166
50mgx28 Astrazeneca -(+)-5-[(2- ) ]-2-(4- )-3- -2 3-1.5- -4(5H)- 80mg 167
2 P-R A-H 1-2 168
1. 2.I 3. â 40 100 5 5 169
/ ( ) 5 170
5 25 10?5 20 171
3 3 30 30 172
1 2 3 4 5 6 173
1 2 3 4 2ml 1 2 10-20ml 5-10% 250 500ml % 10% /10ml 5 1ml 1 174
ZZ-5266-1995 010706 175
5mg~10mg 3 1. 2. 5mg 20 / 176
(1997) 226001, 4-6 2 0.35gX12 X3 / 177
(1996) 430615 Isosorbide-5-Nitrate Tablet 1,4 3,6- -D- -5-178
10-20mg, ( ) ) 1. 2. 3. 179
20mg 50 14 2 (96) X-156-3 180
13% ( 81%) PH 7 30 60mg 181
1. 2. 3. 30mg 60mg Astrazeneca 50 50 182
(?20Elantan?20) 1. ( ) 2. 3. ( ) 183
25 12.7g(=15.0ml) 375 0.05 1.25 400 1. 184
2. 3. 4. 5. (PTCA) 30 1. 2. ( ) ( 95mm ) 3. ( ) 4. 185
Isoketi.v. 2-7 10 186
? ( )???? 0.09 187
1.25 ( ) ( ) 1 3 30 ( <100 mm ) 188
3 90.0% +25 (77 ) ALVENOR 450 50 189
2 2 2 4 6 3 4 2 30 190
20 / 500mg 2 5- ( ) 1. -- ( - ) -- ( ) 191
2. -- -- (CVI) 3. -- -- 4. 5. 2 1-3 5-6, 1-2 / 2-3 4-6 2 2-3 1-2 192
2 20 60 (Doxium-500) 500mg/ Aescuven forte Aescuven forte 150mg (Escin) 30 mg 193
1. ( ) 2. ( ) 3. 4. 5. 194
(150 mg 40 / ) 40 Julirs Redel Cesral Bufferin Caplet 1-2 6 hr 8 /, 195
11-12 16hr 4 / 10 5 3 acetaminophen 500mgx10 196
BINOL 500mg 30mg 1. 2. 3. 197
1. 8 7 12 2. 3. 4. 5. 6. 198
Childrens Bufferin / 10-15 mg/kg / 3 4 / 5 / 10 16 kg 160 mg/ 800 mg/ 17 22 kg 240 mg/ 1.2 g/ 23 27 kg 320 mg/ 1.6 g/ 28 32 kg 400 mg/ 2 g/ 33 44 kg 480 mg/ 2.4 199
5 3 3 acetaminophen 160mg/5mL x 60mL 160mg x 15 200
1-2 50ul 48_+2u1(n=30); 8ml 201
H 1-2 3 1. 2. 1. 202
2. Bufferin Plus / 1-2 8 203
10 3 acetaminophen 500mg, caffeine 65m 10 204
1 2 3 4 5 6 3 10-20ml 205
78.3% 95% 90% 2 ( ) 30-206
(96) X-231-8 10 3 Childrens Bufferin Cold & Cough Relief 207
Liquid 6-11 22-43.9 kg 10 ml/, 2-5 11-21.9 kg 5 ml/4-6 hr 1 24 hr 4 7 3 208
5mL acetaminophen 160 mg pseudoephedrine HCl 15 mg, dextromethorphan HBr 5 mg, chlorpheniramine maleate 1 mg 60 ml ( ) ( ) 1 1 1-2 209
15g/ ( ) (1994) 606093 Bufferin Cold 210
( - ) 12 1-2 6hr 1 8 /, ( - ) 12 1-2 - acetaminophen 500 mg, 211
dextromethorphan hydrobromide 15 mg, pseudoephedrine HCl 30 mg, - acetaminophen 500 mg, dextromethorphan hydrobromide 15 mg, pseudoephedrine HCl 30 mg, chlorphenamine maleate 2 mg - ) 8-4 150mg 1mg 50mg 1mg 212
4 3 213
24 (1994) l29010 214
3 0.8mL acetaminophen 80mg, pseudoephedrine HCl 7.5mg 15 ml 215
0.3g( 0.1g) 10 ZZ-4574- (1998) 4035 216
2-3 3 0.3g( 100mg) 10mg 3mg 250mg 15mg 217
H1 218
1-2 TAC-AU-TAC 100mg, 250mg 10mg ( ) 219
12 1 5 1. 2. 220
3. 400mg 10 C C 3 3 221
, 1.,,,,,, 2., 222
( 1 3 ) 3.,, 4.,,,,,, 3~4, 0.5~1 ;, 1~2 ;, 2~3 ;, 3`4 223
, 24, 2, 6 (98) Z-016 0.125g 0.0015g 0.0075g 0.005g 1. -- E 224
E 2. H1 3. 4. 225
6-9 1 3 1-5 6 ( ) Infant Bufferin Drops acetaminophen 1 /4 hr 24 hr 5, 11-15.9 kg 1.6 ml (160 mg)/, 8-10.9 kg 1.2 ml (120 mg)/, 5.5-7.9 kg 0.8 ml (80 mg)/, 2.5 5.4 kg 0.4 ml (40 mg)/ 226
5 3 2 80mg/0.8mL x 15mL 300mg 10mg 1mg 12.5mg 1. 227
2. 6 1-2 24 12 12 / 300 228