Microsoft Word - 常用藥物之安定性與泡製法 docx

Alprostadil /Prostin VR 500mcg/mL/Amp Alprostadil (PGE1) / Promostan 20μg/Vial Amiodarone / Cordarone 150mg/3mL/Amp Atracurium / Genso 25mg/2.5mL/Amp 冷藏 2-8 C 開瓶即棄 : 24 hrs 常用藥物之安定性與泡製法 KMTTH pharmacy 1 Amp + NS 25-250mL 0.01-0.4 mcg/kg/min : 24 hrs 2-3 Vial + NS 500mL qd- bid Over 2 hrs. 冷藏避光 (14 天 ) 開瓶即棄 : 24hrs in polyolefin 容器 DEHP 材質 (2) IV bolus: 1Amp +D5W 100mL over 10min. IVD: 6 Amp + D5W 500mL(1.8mg/mL) D5W only!! VT: 300mg Af: 250mg 34mL/hr for 6h then 17mL for 18h 開瓶即棄 Genso :8 Amp +NS 80mL (2mg/mL) Genso :0.4-0.5mg/kg (IBW) Genso :0.3-0.6mg/kg/hr (60kg 9-18mL/hr) Atropine/Atropine 1mg/mL/Amp Unknown 25 Amp + NS 250mL (0.1mg/mL) 0.5-1 mg 5-10mL/hr Cacium chloride / Vitacal 20mL/Amp Cis-atracurium /Nimbex 10mg/5mL/Amp Desmopressin / DDAVP 4μg/mL/Amp Diazepam 10mg/2mL/Amp Diltiazem / Herbesser 50mg/Amp Dobutamine/Utamine 250mg/20mL/Vial Dopamine/Dopamin 200mg/5mL/Amp 開瓶即棄 1. 5 Amp in 500mL 2. N Amp in NS X ml 冷藏避光 1-3 Amp over 5-10 min 1. Over 24h. 2. Over (N 70 BW) hrs. 開瓶即棄 10 Amp + NS 50 ml (1mg/mL) 0.15 to 0.2 mg/kg IV bolus 1~3μg/kg/min (60kg 3.6~10.8 ml/hr) 冷藏開瓶即棄 4 Amp+ NS 50mL for 30min q6-8h IVD: 1amp +NS 500mL ( 玻璃瓶 ) 開瓶即棄 Step1: 1Amp+NS 5mL(2mL for bolus) Step2: residual 3mL+NS 57mL (0.5mg/mL) 20mg (Step 1 solution 2mL) for 2min 15-50mL/hr :24 hrs 2 Vial + NS 500mL (1mg/mL) 7.5-45mL/hr 開瓶即棄 4 Amp + NS 500mL (1.6mg/mL) 2-40mL/hr Epinephrine/Adrenalin 丟棄 5 Amp + NS 500mL (10μg/mL) 6-60 ml/hr 10-20mL/hr (max: <720mL/day) 1

1mg/mL/Amp 避光 ETT: 1 Amp + NS 9mL ( 分 2 次投予 ) Esmolol 100mg/10mL/Vial Esomeprazole / Nexium 40mg/Vial Furosemide / Rasitol 20mg/2ml/Amp Gabexate / Foy 100mg/Vial Heparin 25,000U/5mL/Vial 5000U/5mL/Vial Hydrocortisone/ Solucortef 100mg/Vial :7 days.. 0.05mL/kg over 1min. 0.3-1.8mL/kg/hr (60kg: 18-108mL/hr) :12hrs in NS 開瓶即棄 ;24 hrs 以原液 continue infusion 時需避光每 1vial + NS 100mL (0.4mg/mL) IV 3mins or IV infusion 10-30 min. Pump: Loading 2vial 30min +following continuous infusion (0.8mg/mL)*3day. 2 vial + NS 100mL (0.8mg/mL) 1-4 amp over 1-2min qd-qid 10mL/hr <24mL/hr (max: 2g) Unknown 20Vial + D5W 500mL (4mg/mL) 15-30mL/hr 未開封 : 可置於下, 不需冷藏已開封 : 需置於 4-8 冰箱, 安定期為二週 :72 hrs 20000 U + NS 500mL Iron sucrose Fe3+: 100mg/5mL/Amp 開瓶即棄 1 Amp + N/S 100mL Over 15~30 mins Isoproterenol /Proternol-L 0.2mg/mL/Amp Labetalol/Trandate 25mg/5mL/Amp Levetiracetam/ Keppra 500mg/5mL/Vial Lidocaine/Xylocaine 100mg/5mL/Amp 開瓶即棄 :24 hrs 10Amp + D5W 500mL (4μg/mL) 15-60mL/hr 開瓶即棄 20 Amp + NS 400mL (1mg/mL) 1-2Amp for 1-2 min, :24 hrs q5-10min repeat 15-120mL/hr :24 hrs 1 Vial + NS or D5W 100 ml IV over 15 mins Lidocaine ( 局麻 ) / Xylocaine :3 天開瓶即棄 20 Amp +D5W 400mL (4 mg/ml) 15-60 ml/hr 2

400mg/20mL/Vial Lidocaine+E / Lidophrine+E 局麻 400mg/20mL/Bot Lorazepam/Anxicam 2mg/mL/Amp Lorazepam/ Neuropam 2mg/mL/Amp Methylprednisolone /Solu-medrol 40mg, 500mg/Vial MgSO4 2gm/20mL/Amp Midazolam / Dormicum 5mg/mL/ Amp Midazolam / Midatin 15mg/3mL/Amp Milrinone / Primacor 10mg/10mL/Vial Nicardipine / Perdipine 10mg/10mL/Amp Nimodipine / Nimotop 10mg/50mL/Vial 冷藏避光 (4 週 ) 冷藏避光 : 開瓶後 3 天內用畢開瓶即棄開瓶即棄 :48 hrs 開瓶即棄 :24 hrs in container (2) 開瓶即棄 :24hrs ( 混合液 ) <5 :3 天 ( 混合液 ) 開瓶即棄 :24 hrs( 混合液 ) <5 :3 天 ( 混合液 ) 5 Amp + NS 45mL (0.2mg/mL) 或以等體積稀釋液稀釋後使用 5 Amp + NS 45mL (0.2mg/mL) 或以等體積稀釋液稀釋後使用以廠商的專用稀釋液 (sterile water, SW) 稀釋 --40mg+1mL SW --500mg+7.8mL SW 如需泡製成大量靜脈輸液時, 可用 D5W, NS 100mL 稀釋 0.5-1 Amp Initial: 5mL/hr, titrate to (BW 0.2-0.4) ml/hr 0.5-1 Amp Initial: 5mL/hr, titrate to (BW 0.2-0.4) ml/hr 5 Amp + D5W 500mL (20mg/mL) 1Amp over 2min 40mL/hr 10Amp +NS 40mL (1mg/mL) 1Amp + NS 12mL or 5Amp + NS 60mL (1mg/mL) 0.05mg/kg 2.5-3mL 0.05mg/kg 2.5-3mL <250mg: over 5 min >250mg: over 30 min 1.5-15 ml/hr 1.5-15 ml/hr :3 天 (in NS) (2) 1Amp + NS 40mL (0.2mg/mL) 50μg/kg 0.375-0.75μg/kg/min (60kg:6.5-13mL/hr)(Max:1.13mg/kg/day) 開瓶即棄 (2) 2Amp + NS 20mL (0.5mg/mL) 0.03-0.36 mg/kg/hr 避光投予時應避光或日光下安定 10 hrs (0.2mg/ml)! 請以 3-way 投予 (via central line) ( 原液 : 溶液 =1:4) PVC Norepinephrine / Levophed 開瓶即棄 2 Amp +D5W 500mL (16μg/mL) 7.5-45mL/hr 15μg/kg/h (60kg: 4.5mL/hr) 2 hrs 30μg/kg/hr (9mL/kg) 3

未開封之稀釋或開封後之貯存條件安定性 4mg/4mL/Amp 避光 NTG / Glyceryl trinitrate 50mg/10mL/Amp NTG / Millisrol 5mg/10mL/Amp Octreotide / Sandostatin 0.1mg/mL/Amp 冷藏 (2 週 ) 開瓶即棄 :24 hrs 冷藏 : 7 天 in glass container 開瓶即棄開瓶即棄 :24 hrs 1 Amp+ D5W 490mL (100μg/mL) PVC 10 Amp+ D5W 150mL (200μg/mL) PVC 6 Amp + NS 120mL (5 μg/ml) or 6 Amp + NS 500mL (1.2μg/mL) 3-180 ml/hr 1.5-90 ml/hr 5-10 ml/hr 5 days Omeprazole / Losec :12 hrs in NS. 每 1vial + NS 100mL (0.4mg/mL) Over 20-30 min. 40mg/Vial 避光 6 hrs in D5W 2vial + NS 200mL (0.4mg/mL) 2 次 20mL/hr 6hrs in NS (1mg/mL) Pamidronate/Aredia :24 hrs 4-6 Vial + NS 250mL 60-120 ml/hr 15mg/5mL/Vial 冷藏 :24hrs L/R (Ca 2+ ) (0.24-0.36mg/mL) Parecoxib / Dynastat 40mg/Vial :12-24hrs IM, IV: 1vial +NS 2mL IV: Over 15 sec. Phenobarbital / Phenobitol 100mg/mL/Amp Phenytoin / Aleviatin 250mg/5mL/Amp Pralidoxime / PAM 500mg/20mL/Amp Propofol / Diprofen 200mg/20mL/Amp NS, D5W only 丟棄 10Amp + NS 40mL (20mg/mL) (2) N/S only * 廠商建議之給藥途徑 :IM, SC, not IV. IV bolus: 1 st :40mL>20min 2 nd :20mL>20 min MD: 0.5Amp q8h IM, SC 0.3-0.4mL/kg/day (max: 20mL) Over 20min Over 20min IVA: 0.5Amp + N/S 20mL Over 3min Unknown (25mg/mL) 2-4 amp for 10-30min 20mL/hr 開瓶即棄 12 小時需更換 set 與丟棄剩餘藥品 :6 hrs( 稀釋液 ) (10mg/mL) 1 Amp + D5W 20mL (5mg/mL) 0.25-1mg/kg (60kg 1.5-6mL) 0.25-1mg/kg (60kg 3-12mL) 0.3-3mg/kg/hr (60kg 1.8-18 ml/hr) 0.3-3mg/kg/hr (60kg 3.6-36mL/hr) 4

RI HM 1000U/10mL/Vial Somatostatin/Somatosan 3mg/Amp Theophylline ethylenediamine / Asiphylline 250mg/10mL/Amp Valproate / Depakine 400mg/Vial Vasopressin / Pitressin 20U/mL/Amp 冷藏避光 (6 週 ) 稀釋後 : 24 hrs (1U/mL) 已開封未稀釋 : (4 週 ) ( 稀釋液 50μg/mL):8 hrs (2) 2.5mL + NS 250mL (1U/mL) As guideline 1 Amp + NS 36mL (83 μg/ml) 2 Amp + NS 500mL (12μg/mL) 開瓶即棄 2 Amp + NS500mL (1mg/mL) 6mg/kg or 1 amp + :5 hrs in plastic NS 50mL for 20min syringes (2) 3mL/ hr 20mL/hr 0.2-0.7mg/kg/hr :24 hrs IV bolus: 2 Vial + 8mL SW ( 廠商 ) 15mg/kg Over 5min Unknown Bleeding: 20Amp + D5W 500mL (0.8 U/mL) IVA: 1vial + NS 50mL Over 20min IVD: 2vial + NS 100mL 1-10mg/kg/hr (60kg: 7.5-75mL/hr) Septic shock: 1amp+ D5W 25mL or 10Amp + D5W 250mL (0.8U/mL) VT/VF: undiluted 2 Amp 15-30mL/hr (max: 67.5mL/hr) 3mL/hr (max: 30mL/hr) 注意事項 : 1. 本資料僅供參考, 實際配製方式與滴速仍需依照醫師之處方如遇特殊個案而需特殊泡製法時, 請與藥師聯絡 2. 禁止使用, 停用 3. 表格內之配製溶液為廠商建議之標準泡製溶液, 但非唯一可相容之溶液 4. 貯存條件中的避光為廠商建議之貯存環境, 而非絕對之貯存條件 5. 藥品若非當次用完, 剩餘藥量欲留待下次再給時, 必須以建議的貯存條件來處理未使用完的藥品 Amp 製劑一律開瓶即棄, 欄位內的安定性時間是指已泡製好的藥品以連續輸注的方式給藥時, 必須在安定時效內給完, 未給完的部分一律丟棄 6. 資料會經常更新, 請密切注意新版本的資料 7. Ref:. 仿單 (2). Micromedex 5