2
22 (Epidermis) (Dermis) (Subcutaneous) 2-1 2-1
CHAPTER 2 23 (Epidermis) 20 30% 5 7% 0.lmm 0.7mm 1. (Keratinocyte) 5 10 4 7 10 4 2. (Melanocyte) 3. (Langerhans cell) Paul Langerhans 1868 1973 4. (Merkel s cell) 2-2
24 2-2 (1) (Base cell layer Stratum germinatium) 95% 5% (Germinal layer) (Melanin) 2-3 36 (Melanosomes)
CHAPTER 2 25 (2) Stratum spinosum
26 2-3 (3) (Stratum granulosum) 1~2 (Keratohyaline granules) (Histidine)
CHAPTER 2 27 (Glucosaminoglycan) (Phospholipid) (Autophagosomes) (Cholesterol) (Ceramides) (Glycolipids) (4) (Stratum lucidum) 15% (5) (Stratum corneum) (Keratin)
28 (Intercellular lipid) (Sphingolipids) 16.9 11.9 14 4 28 28 14 14 2-2
CHAPTER 2 29 (Ceramide) (Cholesterol) (Free fatty acid) (Amino acid) 15% 65% 5% (Natural Moisturizing Factor, NMF) 15~20% 40.0% (Free amino acid) 12.0%2- -5- (Sodium 2-pyrrolidone-5-carboxylate, PCA.Na) 12.0% (Lactate) 7.0% (Urea) 6.0% (Chloride) 5.0%
30 (Na + ) 4.0% (K + ) 1.5% (Mg ++ ) 1.5% (Ca ++ ) 1.5% (NH 3 ) (Uric acid) (Glucosamine) (Creatinine) 0.5% (Phosphate) 0.5% (Citrate) (Formate) 8.5% (Dermis) 0.6mm 3mm 77% (GAGS) (Hyaluronic acid) (Dermatan sulfate) 2-1
CHAPTER 2 31 1. (1) (Fibers) (Elastic fibers) (Collagen) (Reticulum fibers) (2) (Glycoproteins) (Acid mucopolysaccharides) (Neutral mucopolysaccharides) (3) (Fibroblast) (Mast cell) (Macrophage) (4) 2. (1)
32 (2) (Subcutaneous) (Cystine) (S-S)
CHAPTER 2 33 1. 95% 2-4 (Anagen) (Catagen) (Telogen) 70 120 2-4 1996
34 2-5 (1) (Dermal papilla) (2) (Hair bulb) (3) (Hair root) (4) (Hair shaft) (5) (Hair follicle) 2-5 1996
CHAPTER 2 35 2-5 (1) (Medulla) (2) (Cortex) 85% (3) (Cuticle) 7 8 1 2 18 2-1 2-2 25 C 65%
36 12% 3% 2-1 (%) 1 e 6.0 2 2.8-3 5.5 4.2 4 6.4 8.3 5 4.8 6.8 6 2.4 3.6 2.8 7 4.3 3.2 8 7.4 10.6 16.5 9 7.0 8.5 3.4 10 2.2 3.0 3.4 5.7 11 3.9 7.7 6.4 8.1 12 13.6 14.2 9.1 15.4 13 8.9 10.8 5.9 11.7 14 1.9 3.1 3.1 6.9 15 0.6 1.2 0.6 1.8 16 0.4 1.3 0.5 1.8 17 16.6 18.0 2.3 3.8 18 0.7 1.0 1.0 2.5 (H. P. Lundgren,W. WH. Ward: Ultrastructure of Protein fiber, Academic Press N.Y., p39, 1963)
CHAPTER 2 37 2-2 Koch Zahn (%) (%) (%) 1 9.3 11.2-2 19.9 6.4 1.3 3 3.9 7.7-4 1.8 5.6 0.3 5 1.8 13.3 0.3 6 45.2 50.2 20.7 7 1.8 5.6 0.8 8 - - 76.6 (J. Koch, K. Aitzetmullet et al.: J. Soc. Cosmet. Chem., 33, 317, 1982) (H. Zahn, S. Hiltehaus-bong: Int. J. Cos. Sic., 11, 167, 1789) Koch Zahn 2-6 -NH + 3 -OOC- ph4.5 5.5 35% (-CO-NH-) -CH 2 S-SCH 2 - (C=O HN)
38 2-6 (S. D. Gershon et al.: Cosmetics-Science and Technology, p. 178, Wiley-Interscience, 1972) 2.
CHAPTER 2 39 3. (1) (Sebbaceous gland) 2-3 15 17 C 34 C 15 20 2-3 (Wt%) 1 (Triglycerides) 50~60 2 (Wax esters) 26 3 (Squalene) 12~14 4 (Free fatty acids) 14 5 (Mono and Diglycerides) 5~6 6 (Sterol esters) 1~3 7 (Sterols) 2 8 (Fatty alcohols) 2 1998 (2) (Sweat gland) 2-7
40 (Eccrine sweat gland) 300 400 ph 3.8 5.6 30ml 2-7 (Apocrine sweat gland) ph 6.2 6.9