1. (hemostat) 2. (iert) 1
3. (o-toxic) 4. (o-allergic respose) 5. (o-carciogeic) 6. 7. (metals ad alloys) (ceramics) (polymers) 2
(biological materials) ( stailess steel ) (o)-62.5% (r)-30% (Mo)-5% ()-0.5% ( 0.9%) Ti-6Al-4V ( ) (alumia, Al 2 3 ) - (tricalcium phosphate, a 3 (P 4 ) 2 ) (calcium hydroxyaptite, a 10 (P 4 ) 6 () 2 ) ( Si 2 a Na 2 P 2 5 3
) (sythetic polymers) (aturally occurrig polymers) (polymethylmethacrylate, PMMA) (polyethylee, PE) (silicoe rubber or polydimethylsiloxae) (polyester) (polytetrafluoroethylee, PTFE) (polyurethae, PU) (MMA) (free radical, R ) (boe cemet) ( cotact les ) (low desity polyethylee, LDPE) (high desity polyethylee, DPE) (ultra high molecular weight polyethylee, UMWPE) (catheter, ) 4
: 3 Si 3 : ( ) (carboxyl group) (hydroxyl group) polycodesatio (Dacro) (polylactic acid, PLA) (polyglycolic acid, PGA) 1960 1970 ( 10 mm ) (sewig rig, ) 5
3 3 F F F F ( 4 10 6
mm ) (patch) (collage) (gelati) (hyaluroic acid) (chiti) (chitosa) (algiate) (cellulose) 60~70 % collage mucopolysaccharides elasti 70 % 30 % 7
(cross-likig) (deature) (~ 4 ) (biological glue) (woud dressig) (drug carrier) ( ) 2 N 3 3 N 2 2 10 6 ~ 6 10 6 [poly( -1,4- N-acetyl-D-glucosamie)] 8
( ) ( ) ( ) 2 2 2 2 2 N 2 N 3 N 2 N 3 N 3 [ poly( -1,4- glucosamie)] N- N- N- 60% ( ) ( 酶 2 2 2 2 2 N 2 N 2 N 2 N 3 N 2 ( ) l al 2 240,000 9
Na Na ( ) ellophae, urophae cellulose acetate 2 2 (autograft) (homograft) (heterograft) (bypass) (iteral thoracic artery) (sapheous vei) (-196 ) 10
( ) - 11
1976 1976 12