...1...2...5...6...8... 11...13...14...15...17...19...21...22...24...25...26...28...29...32 I
...33...34...35...36...38...39...41...41...43...44...45...46...48...48...49...50...52...53...55...57 X...58 II
X...60 X...61 X...61 X...63 X...64 X...66 X...67 X...68 X...69 X...70 X...70 X ( )...71...72...73...74...75...77...78...78...79...81 III
...81...82...83...84 (FDS)...85...86 CT...87...89...90...91...92...93...95...95...96...98... 100... 101... 102... 104... 104... 107 IV
... 110...111... 112... 113... 115... 116... 118... 119... 120... 121... 123... 125... 126... 128... 129... 132... 134... 136... 138... 139... 140... 140 V
... 142... 144... 145... 146... 147... 149... 149... 151... 152... 153... 153... 155... 157... 158... 159... 160... 161... 163... 164... 165... 166 VI
... 167... 169... 171... 172... 172... 174... 175... 179... 182... 183... 186... 187... 188... 190... 191... 193... 195 VII
08 1.5cm 3 4cm 2 6 4 5 1cm 1 2cm 6 1
15 20 10 100 15 20 2
Cooper s 3
4 / 2 6 3 4
60% 2 4 1 2cm 5
6 1 3 (1)
7 (2) 2 3 10 (3)
(1) (estrogen E) 8
(progesterone P) (prolactin PRL) PRL - 9
10 Na+ 5 ( ) (2) (follicle-stimulatinghormone FSH)
(oxytocin) (androgen) 13 15 9 10 2 3 1 2 4 6 11
12 (GnRH) - - (FSH) (LH)
60% 70% 1 2 13
3 4 14
2 3 15
3 16
camp-pk - 17
2 3 18
ACTH 50 19
( ) 20
( ) 21
22
( ) 23
2.0cm 1.5 24
2 6 8 9 5 ( ) ( ) 1% 5% 25
26
27
28
29
30
31
32
33
34
( ) ( ) ) ( ) ) ( ) ( ) ( ) ( ) ( ) ( ) X 35
5 6cm 36
3 4cm 37
38
1 2-39
40 50%
41
- - 3 6 42
43
44
45
Cooper's Cooper's 46
47
48
49 1 2 10kg 8
7 8 50
51
52 10
(1) 53
54 8 45 55 25 (2) 35 35
(3) (4) - 55
(1) (2) (3) (4) (5) (6) 56
(1) (2) (3) 10 (4) (5) (6) 57
Cooper's (7) X 60 X 58
X X X X ( ) X X X (1) (2) X ( ) (3) (4) X (5) X (6) 59
X X X 35 40 X 40 49 50 X (1)35 ( ) (2) (35 ) (3) ( ) 60
(4) (5) (6) ( 55 ) (7) X X 1 2 X X X X X 3 X X X X 61
X 62
X ( ) X X (1) X (2) 1 5mm (3) 1mm (4) 0.5 2.5mm Cooper's 63
(5) X X X 3 5 (6) X ( ) (7) 5mm (8) X X X X WOLFE 64
(1976) 5 (1)N 1 30 41.4% (2)P 1 1mm 3 4mm 1/4 30 26% (3)P 2 P1 1/4 30 26% P1 P2 (4)DY X 30 7% 65
(5)QDY X DY 40 WOLFE (1974) 7 (1990) 4 X X X WOLFE N1 P1 P2 P1 A DY A 66
WOLFE P2 DY 4 50 X X X X X X 67
X X X X 25 X 68
X X X 1 2cm 3cm 69
X X X X X 70
71 X X ( ) X
50 X 412 ( ) 1 1.5cm 60% 72
0.5 3ml 73
74 1.28mm 0.93mm 0.59mm
612 ( 90%) 50 75
70 5 10MHZ X (1) X (2) X 76
X (3) X (4) (5) (6) X 1 1 77
95% 80 78
80 1cm X 79
(1) (2) (3) (4) (5) 80
50 81
82
70 X 83
( 10cm) 80% 84
85 1 2 (FDS) 80 045mm 04mm
( ) FDS 23 19 4 23 7 3 4 FDS FDS FDS (DSA) DSA DSA 86
DSA DSA CT CT 70 X CT 87
CT X CT X 0.2cm CT X CT CT CT CT CT CT X 88
(MRI) 89
X 90
70% 80% 50% 8129 1647 1012 82.2% 91
70 X X B 10 20ml 6 8 45.O 2 3 92
5 10 H.E 85% 98% 2% 93
1cm 5 15 5 1% 30% 94
X X 92.6% X X 95
96 80% X 99% 1% + X + 2cm
1 97
30 - - 98
(E1) 99
100 4 5
101
1 3 102
103
104
105 16
106
15g 15g 1 30g 60 90g 1 30g 30g 30g 1 15g 1 10g 1 5g 2 3 1 3 1 1 3 1 150g 3 5 2 1 107
1 5 20 30 3 3 1 1 3 1 2 1 10 1 20 30 10 1 1 1 2 3 10 20 2 3 1 2 108
3 5 2 1 2 ( 13 ) 2cm 2 4ml 1 1 60oC 10 70oCC 20 2 3 1 109
110 1% 2% 20 40
(1) 20 40 (2) (3) (4) (5) (6) X 3 X (7) 111
(8) (1) X 20 40 40 (2) 112
(3) (1) 1g 03g 045g 113
114 075g 1.5g 2 4 3 6 (2) (3) (4) 1
115 (5) 1978 20 1 30 50
116
/ PRL 117
(1) (2) 118
3 4cm (3) (4) (5) (1) 3 (2) (3) 119
120 (4) X B (1)
121 30 20 25 X (2) X
( ) 6 70% 122
20% a 5% b 5% 75% 100% 5 18 123
( ) (ALA) (ALB) 124
(1) 3 (2) 1/2 (3) 1/2 1/2 (4) 125
10 1 5 15mg 100mg 3 4 25mg 2 7 8 5 10mg 2 5mg 20 40mg 126
(1mg) 3 6 2 3 10mg 1 1.25 5mg 127
3 100mg 1 6 10% (1) (2) 35 (3) 128
(4) X (5) (6) 3 6 129
130 (1) 9g 9g 6g 12g 12g 12g 10g 15g 10g 10g 10g 5g (2) 10g 10g 10g 15g 6g 10g 12g 10g 12g 10g 10g 6g 6g 10g 30g 15g 10g 10g 15g
( ) ( 14 ) 131
(1) 0.4g 0.5g 3 6 30 60g 10 15 2 2ml 2 1 1 1 3 1 132
(2) (3) 20 30 (4) 133
- - 134
135
30 136
20 X 137
18 25 138
1 3cm 139
(1) 18 25 (2) (3) X 35 140
141 (1) 30 30 X (2) 18 25
(3) 1 3cm 5cm 30 35 X 142
(1) (2) (3) 143
20 1cm 35 144
(1) (2) (3) 2 15% 145
146 2cm 1cm 20 1cm
147 3cm 1cm 2cm 35 9g 12g 12g 15g 15g 12g
148 9g 30g 15g 30g 9g 9g 12g 12g 30g 12g 30g 30g 30g 30g 6g 12g
7cm 149
408 49 5cm 150
40 50 151
5% 10% 20% 152
(1) 153
1cm 1cm (2) 154
(1) 155
156 50 (2) 9g 9g 6g 9g 12g 9g 9g 9g 15g 9g 9g 6g
157 15g 9g 9g 9g 12g 12g 9g 6g 9g 6g (1) (2) (3)
(1) 20 40 (2) 7 10 158
(3) (4) X (1) 20 40 159
160 (2) (3) X 1 2
161 (1) (2) (3) (1) 12g 12g 9g 12g 12g 30g 15g 12g 15g 15g 15g 30g 30g 15g 15g 12g 15g 12g 30g
162 15g (2) a b ( )
163 2 3 2 3 - - - - - -
164 - - - (1)Chiari-Frommel - - (FSH) (LH) (2)Argonz-del Castillo ( ) - -
(3)Forbes-Albright (1) (2) (3) - - 165
166 1 (4) (5) - - (1)
167 X (2)
168
() (1) 5 795% 85.5% 5 74% (2) 5 73% 10 149% 4.5% 18% 5 844% 5 169
65.5% (3) 10cm 5 97% 10 93% 20cm 5 10 90% 170
171
(1) 172
X (2) 173
(WBC) (1) (2) ( ) 174
X (3) (4) B4 B6 (1) 112 5 81.7%67.9%(P 0.05) 5 175
50% (2) Fesher Bonadonna 1972 Fesher TSPA 9 176
10 L-PAM L- PAM L-PAM0.15mg/kg/ 5 6 2 10 8%(P 0.06) 5%(P 0.4) ( 49 ) 1 3 ( ) 1973 Bonadonna CMF CTX100mg/m 2 1 14 600mg/m 2 MTX40mg/m 2 1 8 5FU600mg/m 2 1 8 28 6 7326 CMF 3 CMF 26.3% 45.7% 10 LPAM CMF 10 177
(3) 50% 178
(1) 20 179
(2) 5 90% 95% 5 75% 80% 5 30% 40% 5 10% 16% (DNH)1985 9 9 11 180
(3) 50% 1 181
(TAM) Clomiphenecitrate( ) Nafoxidine( ) 30% Toremifene 182
ER Szamel Toremifene (TAM) (1) 5 90% 95% 5 75% 80% 5 30% 40% 5 ER( ) (2) 183
Monridsen 715 844 35% 29% 25% (3) ER( ) ER( ) ER 1/4 3/4 32% 3% 13% 4% ER( ) ER( ) ER ER( ) 11% 5% ER 184
(4) 10 20mg 2 16 2 10 ( 10mg 2 /) 2 5 (5) (10%) 15% 20mg 5 10% 185
( AG) 186
( ) ( AG) (LH-RH) (GN-RH) FSH LN Leuprolide( ) Nafarelin Busereline(Zoladex) 187
250mg/ 2 100mg( 25mg 5 25mg 50mg) 2 250mg 4 25mg 2 30% 50% 50% 55% 31% 33% 11 17 188
ER( ER( ) Nemoto ) 38% ER( ) 11% Nemoto 37% 18% 30% 50% 20% 36% 2 22% 14% 189
7 14 4 5 1000mg 40% 1500mg (ER) ER ER 190
(1) (TAM)+ - - (AG) (2) (TAM) (AG) (3) (TAM)+ ER ( ) ( ) ER 191
( ) 11 192
(1) 1982 WHO 193
194 (2) (3) (4) ( )
195 (5) 1938 Muller 27% WHO (Thylloiues Tumor) (1) (2)
196