98 4 98 12

14 85 97 85 1996 27,961 11,273 13,944 7,525 12,422 3,200 4,610 3,547 1,847 2,656 86 1997 29,011 10,754 12,885 7,500 11,297 3,619 4,767 3,504 2,172 2,611 87 1998 29,260 11,030 12,705 7,532 10,973 4,447 4,940 3,435 2,177 2,273 88 1999 29,784 11,299 12,631 9,023 12,960 4,006 5,180 3,474 2,281 1,856 89 2000 31,554 10,552 13,332 9,450 10,515 3,302 5,174 3,872 2,471 1,602 90 2001 32,993 11,003 13,141 9,113 9,513 3,746 5,239 4,056 2,781 1,766 91 2002 34,342 11,441 12,009 8,818 8,489 4,530 4,795 4,168 3,053 1,947 92 2003 35,201 11,785 12,404 10,013 8,191 5,099 5,185 4,306 3,195 1,844 93 2004 36,357 12,861 12,339 9,191 8,452 5,536 5,351 4,680 3,468 1,806 94 2005 37,222 12,970 13,139 10,501 8,365 5,687 5,621 4,822 4,282 1,891 95 2006 37,998 12,283 12,596 9,690 8,011 5,396 5,049 4,712 4,406 1,816 96 2007 40,306 13,003 12,875 10,231 7,130 5,895 5,160 5,099 3,933 1,977 1

97 2008 38,913 15,726 10,663 8,661 8,036 7,077 5,374 4,917 4,128 4,012 35.0 % 33.0 31.0 29.0 27.0 25.0 23.0 21.0 19.0 19.2 18.7 22.8 21.9 20.5 24.8 24.0 22.7 28.2 27.3 27.1 26.6 25.3 25.4 28.5 27.3 25.5 17.0 15.0 18.2 17.8 16.6 16.4 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 4 10 2

96 % % 25,819 222.6 100.0 14,487 128.0 100.0 1 5,650 48.7 21.9 2,535 22.4 17.5 2 5,458 47.1 21.1 2,159 19.1 14.9 3 2,558 22.1 9.9 1,912 16.9 13.2 4 2,152 18.6 8.3 1,552 13.7 10.7 5 1,631 14.1 6.3 843 7.4 5.8 6 1,343 11.6 5.2 833 7.4 5.7 7 1,003 8.6 3.9 578 5.1 4.0 8 801 6.9 3.1 541 4.8 3.7 9 776 6.7 3.0 497 4.4 3.4 10 604 5.2 2.3 405 3.6 2.8 3,843 33.1 14.9 2,632 23.3 18.2 3

4

5 1. 2. 3. TNM TNM N M 2006 2015 2% 10 8400 800 70%

11 10 5 10 10 5 10 96 % 40,306 175.9 100.0 1 7,993 34.9 19.8 2 7,809 34.1 19.4 3 4,470 19.5 11.1 4 1,552 13.7 3.9 5 2,474 10.8 6.1 6 2,312 10.1 5.7 7 1,003 8.6 2.5 8 833 7.4 2.1 9 1,438 6.3 3.6 10 1,354 5.9 3.4 9,068 39.6 22.5 6

1 2 3 4 5 6 ( ) 37092 7165 915 7040 4901 17071 67221 14033 1866 8316 14530 28476 30285 6167 1253 6078 3132 13655 52316 13886 4205 7079 8058 19088 55640 11609 3070 7862 13862 19237 90013 26950 6061 10213 11829 34960 61045 9947 4716 9625 17015 19742 58595 16448 4902 5265 12564 19416 58288 13122 5024 7655 12420 20067 94067 29909 5491 8635 20831 29201 43089 8291 2025 4231 13808 14734 63766 15045 2635 5505 14850 25731 7

7 31755 4629 1710 4197 11121 10098 34010 8610 649 8797 4734 11220 8 9 40073 8697 2725 5842 9544 13265 44739 10321 2268 4340 8212 19598 41300 7200 3074 5413 13156 12457 82342 11680 1269 4818 18309 46266 10 22355 5216 1632 5292 2565 7650 149498 68373 6392 15679 20962 38092 11 37325 7350 1958 6790 5467 15760 141939 45605 9912 15175 29203 42044 12 41887 9403 3263 6588 6708 15925 196832 48075 16822 25076 41051 65808 13 18878 4613 2658 3626 1995 5986 146649 101583 4373 12006 3248 25439 100 8

4,000 5,000 4,000 4,000 1,500~3,000 3,000~5,000 2,000 1,500 6,000 1.5 ~7 4000/ 16=64000 4000/ 18=72000 2500/ 30=75000 2000/ 30=60000 3000/ 30=90000 9

/ Herceptin ( ) 70~80 48,400 MahThera ( ) 6 29 17 Avastin ( ) 100 15~20 Erbitux ( ) 240 2,100 Iressa ( ) 90 3,000 Tarceva ( ) 130 Nexavar 18~20 Sutent 120 7 Mylotarg ( ) 6 42 2000 10

11 5 1 1 1985 1990 (direct 21,763 35,256 62% cost) (mortality cost) 41,151 56,788 38% (morbidity 8,620 11,896 38% cost) (total 71,534 103,940 45% cost) 11

(direct health care costs) ( ) (indirect health care costs) (direct non-health care costs) 12

~ ~ 13

参 7,500 5,000 1.2 11,250 5 2.5 7.5 6 1,2001~90 1,80091~ 1,500 1,0001~90 2,00091~ 600 250 1,000 3,000 2.5 1.5 2.5 1,000 1,500 250 5001 120 500 500 1,000 1,000 1,200 1,000 1,000 5 5 2.5 2 14

2.5 2 1 1 100-100 - / 10 1~6 100-110 90 60 90 100 100 200 30 20 30,552 30,728 6,600 NDDBR 1. 2. 15

1. 2. 1520 ( ) 20AWL 100 20NDDBR 100 45,600 ( 20AWL 16,900 ) 1. 3. 20NDDBR 20AWL 100 2. 16

10 7 10 3 1. 2. 143 365 31 () 3. 250 4. 30 2~5 1. 365 17

18 2. ; 90 3. ; 90 4. 1 2 3 4 5 6 A. B. C. D. E. F. G. H. I. J. K. 10 L. 10 5. 6. 60%

7. 30% 110 220 330 8,800 66 5,500 1,650 1 3160 2 6190 3 91180 4 181365 5 2 30 365 143 3 65% 1. ( ) 30 19

2. 1 3. 1 4. ( ) 5. 0~65 75 6. 5 0~23 23 1~3 30 4 25 5 20 6 15 * + 6,000 10,000 * 7. 8. 9. 1 LTCR 20

1. 2. 1. 2. 36 3. 30 20 ( 20 ) 3 45,480 90 1. 91 18 18 2. 3. 20 108 5 1. 2. 21

3. 35 90 91 1. 2. 1. 2. 3. 22

23

" " 25 SDW HSRN NHSD PCC 25-25 - 25-25 / (01) 20SDW 100 41,800 ( 20 ) (01) 75@HSRN B 4,337 NHSD 10 4,010 95@PCC 4,210 2 ( 95 ) 54,357 28,271 14,242 4,780 NHSD HSRN PCC 24

14 200 * 25-25 - 25-25 (01) ( 100 20 )(20SDW) / 1 25 41,800 1,000,000 1,000,000 1,000,000 2 26 83,600 1,000,000 1,000,000 1,000,000 3 27 125,400 1,000,000 1,000,000 1,000,000 4 28 167,200 1,000,000 1,000,000 1,000,000 5 29 209,000 1,000,000 1,000,000 1,000,000 6 30 250,800 1,000,000 1,000,000 1,000,000 4 31 292,600 1,000,000 1,000,000 1,000,000 8 32 334,400 1,000,000 1,000,000 1,000,000 9 33 376,200 1,000,000 1,000,000 1,000,000 10 34 418,000 1,000,000 1,000,000 1,000,000 11 35 459,800 1,000,000 1,000,000 1,000,000 12 36 501,600 1,000,000 1,000,000 1,000,000 13 37 543,400 1,000,000 1,000,000 1,000,000 14 38 585,200 1,000,000 1,000,000 1,000,000 15 39 627,000 1,000,000 1,000,000 1,000,000 16 40 668,800 1,000,000 1,000,000 1,000,000 17 41 710,600 1,000,000 1,000,000 1,000,000 18 42 752,400 1,000,000 1,000,000 1,000,000 19 43 594,200 1,000,000 1,000,000 1,000,000 20 44 836,000 1,000,000 1,000,000 1,000,000 25 49 836,000 1,000,000 1,000,000 1,000,000 25

30 54 836,000 1,000,000 1,000,000 1,000,000 35 59 836,000 1,000,000 1,000,000 1,000,000 40 64 836,000 1,000,000 1,000,000 1,000,000 45 69 836,000 1,000,000 1,000,000 1,000,000 50 74 836,000 1,000,000 1,000,000 1,000,000 55 79 836,000 1,000,000 1,000,000 1,000,000 60 84 836,000 1,000,000 1,000,000 1,000,000 65 89 836,000 1,000,000 1,000,000 1,000,000 70 94 836,000 1,000,000 1,000,000 1,000,000 71 95 836,000 1,000,000 1,000,000 1,000,000 1,000,000 70 14 200 HSRN 25-25 - 25-25 20SDW 26 25- A. ---------------------------------------------HSRN B. ---------------------------------------75 C. --------------------------------------- B D. ---------------------------------365 E. 1. ------------------1,500 2. --------------------------------41,250 3. ------------84,000

F. 1. 7 )-------2,250 2. -----------------------41,250 3. -----------------------------412,500 -----------------206,250 G. ------------------------- * NHSD 25-25 - 25-25 20SDW 25- A. ------------------------------------------------ B. ------------------------------------------------10 C. ------------------------------------------2,000 D. ------------------------------------------365 E. 1. X------------------------2,000 2. 30 ( 150 )X---------------500 3. X------2,500 4. 1-----------------------------------------3,500 2-----------------------------------------7,500 3-----------------------------------------15,000 4-----------------------------------------20,000 5-----------------------------------------30,000 27

6-----------------------------------------45,000 7-----------------------------------------60,000 8-----------------------------------------75,000 5. 6 ( 90 )X--------------500 6. ---------------- ( ) 1 * PCC 25-25 - 25-25 20SDW 25- A. -------------------------------------------95 B. --------------------------------------------2 C. 1. 1~20 --------------------------------------100,000 21 ()-----------------------------150,000 1~20 --------------------------------------15,000 21 ()------------------------------22,500 2. 1~90 -- X---------------2,400 91 -- X---------------3,600 3. X---------------1,200 4. X-----------------30,000 28

* X--------------4,500 5. X---------------1,000 6. X---------------1,000 7. X-------------------------1,600 8. X------------------------40,000 / / 5,900 / 2,000 / ( 84,000 / 2,000 )/ / 1,700 / 1,500 49,25014,6250 / 5,000 / / 4,000 / 4,000 / 4,000 / 1,000 / 1,000 /22 40,000~12,0000 22 300,450~397,450 22 260,000~380,000 22 110 29

30

1. / / 2. / 3. 4. / 5. vol.1448, Wed, 04 Jan, 2006 6.money+ / 7.SMART 110 /5 / 8. ( ) 9. 2007.07.09/ / 10. /2009/10/01 11. / 12. 31