SHANGHAI JUNSHI BIOSCIENCES CO., LTD. * 1877 2018 12 31 2018 12 31 2017 12 31 2018 12 31 0.9 PD-12017 12 31 275.3538.2 2018 2018 12 31 20.3 714.6 2017 12 31 326.9 JS001 2018 12 313,432.6 2,713.2 * 1
421.0 2018 12 (GMP) IIIII NSCLC TNBCII III JS003PD-L1JS101 CDK 2018 810 NMPAIND 2018 12 17JS001PD-1 NMPA JS001 2019 1 7 (JS001) 7,200240mg 2019 2 26 2012 12 2
(first-in-class) (best-in-class) ADC JS001PD-1 JS001 2018 3JS001 PD-1 NDA NMPA2018 12 17 NMPA 128127 FAS 1 CR 21 PR 51 SD ORR 17.3% (22/127) DCR 57.5% (73/127)OS 23.18 69.3% JS001 NDA 3
JS003PD-L1 2018 8JS003 IND NMPA JS003 PD-L1 CDR PD-L1 PD-L1 PD-L1 PD-L1 JS003 PD-L1 PD-1 T JS101 CDK JS101CDKCDK JS101 2018 10 NMPA IND JS101 JS101 JS104 CDK JS105 PI3K- 2019 2 JS104 JS105 JS104 CDK-1 CDK-2 CDK-4 CDK-6 CDK-9 CDK JS105 PI3K PIK3CA PI3K 50% 2019 2 19 UBP1213BLyS UBP1213 BLyS B NMPA IND 4
JS001PD-1 Ib/II JS001EGFR II (EGFR-) III III 2018 1 9JS001 FDA I Ia JS001 III CM082(Vorolanib) 5
JS002PCSK9 JS002PCSK9FDA 2018 12 11 201779.3 2022 95.9 3.9% JS002 JS002 NMPA PCSK9IND 2018 I UBP1211TNF- UBP1211 2017 2017189UBP1211 III 2018 1,500L 3*500L JS001 2018 89 2018 12 GMP2018 10 2018 10 SFE 240 2019 1 7 7,200240mg 2019 2 26 6
1 JS001 PCT 2 JS002PCT 3 JS003PCT 4 UBP1213 2032 2033 PCT 22 6 10 6 7
10 16 69 123 22 20 101 159 32.48% 26.50% 538,182,847.98 275,303,382.16 18,383.24% 505.15% 1 JS001 4.03 7.35 2 UBP1211 0.38 0.91 3 JS005 0.32 0.34 4 JS002 0.23 0.45 5 JS004 0.17 0.21 5.13 9.26 800 8
UBP1211 2019NMPANDA JS001PD-1 Ib/II2019 II JS002PCSK9II JS003PD-L1 2019 3 22FDA(FIH) IgG4TAB004/JS004 IND B T (BTLA) TAB004/JS004 T BTLA TAB004/ JS004 FIH PD-1 JS001 TAB004/JS004 2019 3 25 2019JS005IL-17AIND 1,500L 3*500L2018 1,500L 3*500L2019 9
30,000L 15*2,000L2019 2019 JS001PD-1 2019 ISS RWS 1. 12 31 2018 2017 3,756 2,308 a 4,631 2,614 b 47,420 8,387 52,342 (a) (b) (i) (ii) (iii) 2017 2 28 cgmp 2017 2017 10.8 10
2. 2017 8 28 UBP1211 UBP1211 UBP1211 36.6 UBP1211 2017 12 31 20172018 12 31 275.3 538.2(i) (ii) 3. 2018 12 31 20.3 JS001 4. 20172018 12 3173.8 124.8 (i)(ii) (iii) 5. 2018 12 31 2017 12 31 266.3 2,763.6 11
6. 2018 4 2.0 2018 6 29 2018 12 310.1 7. 12 12 31 2018 2017 (714,593) (326,915) 24,741 6,097 21,700 14,275 (647,780) (326,915)
8. 2018 12 24H 19.38 17.07158,910,000H 3,079.7 2,713.2 2019 1 4 23,836,500 H 462.0 2018 12 11 65% 40% 1,365.1 JS001JS001(i) (ii) III(iii) (iv)i JS001 16% 546.0 (i) UBP1211 I III (ii) JS002 I II III(iii) UBP1213 I II III (iv) 9% 307.1 25% 853.2 10% 341.3 2018 12 31 13
2018 12 24 H 2018 12 31 2019 1 4H 19.3823,836,500 H H158,910,000 182,746,500 2019 1 4 (JS001) Vorolanib(CM082) 2018 7 18NMPA2019 1 NMPA 2019 1 18 2019 2 (JS001) (CM4307) 2019 2 14 2019 2 19 CDKPI3K 50%150 2019 2 19 14
2018 12 31 2019 5 15 (www.junshipharma.com)(www. hkexnews.hk) 2019 5 15 HH2019 4 15 2019 5 15H H 2019 4 12 HH 183 22 15
2018 12 31 12 31 2018 2017 4 934 1,148 (267) (446) 667 702 8,387 52,342 (32,641) (24,599) (638) (165) (538,183) (275,303) (20,304) (124,837) (73,752) (4) 31 (6,097) (4,063) 5 (717,713) (320,744) 1,213 (58) (716,500) (320,802) 147 (269) (716,353) (321,071) (9,367) 10,638 (5,480) 227 (364) 262 1,760 (5,844) (714,593) (326,915) 16
12 31 2018 2017 (716,503) (320,683) 89 (161) (716,414) (320,844) 3 (119) 58 (108) 61 (227) (716,353) (321,071) (714,654) (326,688) 61 (227) (714,593) (326,915) 3 (1.19) (0.55) (1.19) (1.19) (0.55) (1.19) 17
2018 12 31 12 31 2018 2017 939,341 359,626 74,408 69,553 1,519 1,455 266 1,027 1,031 1,288 139 311,607 272,246 7 18,000 4,323 1,347,126 708,703 48,468 30,603 8 220 92,630 39,490 7 5,516 147,434 26,961 2,763,570 266,298 2,910,184 511,006 9 291,322 41,499 1,111 646 10 178,632 381 7 16,034 471,065 58,560 2,439,119 452,446 3,786,245 1,161,149 18
12 31 2018 2017 10 150,000 28,302 11 241,763 45,047 41,815 465,112 41,815 3,321,133 1,119,334 12 760,310 584,750 2,561,936 535,758 3,322,246 1,120,508 (1,113) (1,174) 3,321,133 1,119,334 19
1. 2012 12 27 2015 52015 8 833330 2018 12 24H 781 602 183 54 2. 20182017 12 31 2018 1 1 20182017 12 31 2019 1 1 9 16 1 17 3 23 1 3 4 10 28 2 1 5 8 19 1 28 1 2015 2017 1 1 2019 1 1 2 3 2021 1 1 4 2020 1 1 5 2020 1 1 20
3. (a) 12 31 2018 2017 (716,414) (320,844) 12 31 2018 2017 601,917,890 579,608,904 12 31 2018 2017 (716,414) (320,844) 89 (161) (716,503) (320,683) 2018 12 31 0.01 2017 0.032018 12 31 89,000 2017 161,000 21
(b) 11 2018 5 14 2018 12 31 2017 12 31 2017 12 31 4. 20172018 12 31 20172018 12 31 2017 2018 12 31 1.1 0.9 5. 20172018 25% 2017 12 3115% 35% 2017 12 222018 1 1 21% 2018 12 31TopAlliance Biosciences Inc. 8.84% 20178.84%TopAlliance Biosciences Inc. 12 31 2018 2017 418 (64) (64) 418 (1,149) (360) (1,213) 58 6. 20182017 12 31 22
7. 12 31 2018 2017 a 5,500 45,000 b 16 102,434 5,516 147,434 c 18,000 d 4,323 e 16,034 (a) (b) (c) (d) (e) 721 2018 12 31 3.95% 20172.74% 3.13% 2018 12 31 2018 4 15,000,000 5% 2018 9 3,000,000 15% 2013 8 2018 3 2017 12 31 15,000,000 2018 5 15 1 7.0092 2,000,000 2018 5 15 1 7.0092 18,000,000 2018 5 16 1 7.0213 2018 12 31 23
8. 2018 12 312018 1 1 220,000 12 31 2018 2017 0 30 31 90 91 180 1811 1 2 106 31 33 24 26 220 9. 12 31 2018 2017 3,620 3,685 36,558 12,621 80,025 777 81,049 4,195 7,867 13,394 50,901 16,160 2,126 323 14,415 32 1,367 3,706 291,322 41,499 24
12 31 2018 2017 0 30 33,372 15,289 31 60 198 207 61 180 81 209 180 6,527 601 40,178 16,306 10. 12 31 2018 2017 150,225 18,132 168,357 160,275 328,632 178,632 150,000 328,632 (178,632) 150,000 25
11. 2018 2 9 500,000,000 2018 2 23 200,000,000 2018 2 23 200,000 32,396 9,367 12. 2018 12 31 241,763 1.0 2017 1 31 550,000,000 550,000 2017 2 24 a 34,750,000 34,750 2017 12 31 584,750,000 584,750 2018 3 7 b 16,650,000 16,650 Hc 158,910,000 158,910 2018 12 31 760,310,000 760,310 26
(a) (b) (c) 2017 2 24 34,750,000 66,000319,634,000 34,750,000 284,884,000 2018 3 7 16,650,000 1,745,000297,955,000 16,650,000 281,305,000 2018 12 2419.38 17.07158,910,000H 3,079,676,000 2,713,194,000 158,910,000 2,554,284,000 H 27
2018 12 31 1 2 NMPA FDA 28
3 GMP 4 2018 12 17 NMPA 5 4+7 29
6 1 NMPA FDA 30
2 GMP 3 31
2018 32 2,763,570,176.83 293,259,373.25 16,402.95 106,756,911.89 6,635,819.82 973,582.93 44,654,789.45 28,721,316.77 6,242,443.73 9,061,729.76 48,467,546.06 30,601,576.03 953,265.70 40,596,756.49 45,000,000.00 2,910,183,935.33 515,327,756.33 1,027,261.40 1,030,943.07 18,000,000.00 259,654,365.00 235,962,271.14 669,870,253.79 123,071,176.90 75,863,697.85 69,818,553.34 1,518,979.51 2,825,984.02 807,048.66 1,287,876.31 139,412.34 311,607,478.72 272,031,944.58 1,340,136,917.09 704,380,329.54 4,250,320,852.42 1,219,708,085.87
18,132,121.03 16,034,072.32 217,395,035.17 21,277,732.58 1,111,152.00 646,207.57 50,901,300.80 16,160,104.14 2,126,240.45 704,208.95 181,401,160.76 3,737,370.00 471,067,010.21 58,559,695.56 150,000,000.00 241,763,000.00 45,046,569.33 41,814,860.37 28,301,886.78 465,111,456.11 41,814,860.37 936,178,466.32 100,374,555.93 33
760,310,000.00 584,750,000.00 3,797,238,509.95 1,056,407,351.21-9,517.84-1,281,398.32-1,242,283,592.26-519,368,145.10 3,315,255,399.85 1,120,507,807.79-1,113,013.75-1,174,277.85 3,314,142,386.10 1,119,333,529.94 4,250,320,852.42 1,219,708,085.87 34
2,630,582,406.18 117,656,921.86 106,717,231.89 11,135,318.83 9,847,170.88 8,303,061.04 4,224,336.20 15,847,383.90 464,927.82 22,085,161.44 2,687,953,331.39 238,910,588.65 1,237,911,814.18 534,221,935.65 18,000,000.00 20,648,776.63 19,814,879.21 334,378.66 863,370.59 164,794,827.94 502,415,421.65 1,442,553,168.00 1,056,452,236.51 4,130,506,499.39 1,295,362,825.16 35
18,132,121.03 16,034,072.32 88,879,389.72 7,333,564.78 22,526,781.25 3,716,285.81 1,610,350.80 83,652.99 181,018,426.24 1,485,905.30 312,167,069.04 28,653,481.20 241,763,000.00 12,374,586.75 8,348,575.21 28,301,886.78 282,439,473.53 8,348,575.21 594,606,542.57 37,002,056.41 760,310,000.00 584,750,000.00 3,784,419,306.04 1,043,588,147.30-9,367,000.00-999,462,349.22-369,977,378.55 3,535,899,956.82 1,258,360,768.75 4,130,506,499.39 1,295,362,825.16 36
2,927,573.86 54,499,848.63 2,927,573.86 54,499,848.63 710,292,306.98 353,558,654.57 1,952,996.83 5,158,451.79 2,243,708.99 967,983.42 20,493,967.88 543,502.53 132,028,850.53 73,658,668.46 538,182,847.98 275,303,382.16 14,738,554.33-2,224,360.30 3,755,992.59 2,308,189.27 151,026.51 651,380.44 4,599,930.24 2,599,109.69 - -26,803,083.15 5,888,332.86-3,681.67 31,324.24 - - 10,270,189.60-26,955,985.55-102.84 - - -719,297,593.59-317,527,348.94 32,160.49 14,793.13 4,802,041.57 50.00 - -724,067,474.67-317,512,605.81-1,213,291.61 58,189.75 37
- -722,854,183.06-317,570,795.56 1. - -723,293,622.07-317,570,795.56 2. - 439,439.01 1. 61,264.10-227,257.16 2. -722,915,447.16-317,343,538.40 1,271,880.48-9,344,269.04 1,271,880.48-9,344,269.04 1. 2. 3. 4. 1,271,880.48-9,344,269.04 1. 2. -9,367,000.00 3. -3,864,034.71 4. 5. 6. 7. 10,638,880.48-5,480,234.33 8. -721,582,302.58-326,915,064.60-721,643,566.68-326,687,807.44 61,264.10-227,257.16-1.21-0.55-1.21-0.55 38
89,622.64 12,594,718.70 60,000.00 1,121,745.90 389,133.40 20,303,927.76 57,508,921.17 14,090,250.97 272,185,443.35 164,039,202.91 16,317,242.34-1,767,849.78 2,090,574.40 1,802,761.10 241,339,980.30 149,194,023.44 523,560.83 1,107,250.49 1,548,904.79 - -27,446,878.85 10,424,233.50-3,681.67 31,324.24 - - 10,269,586.65-25,380,965.41 - - - -625,341,240.72-326,757,869.36 32,160.00 5,673.13 4,175,889.95 - -629,484,970.67-326,752,196.23 - -629,484,970.67-326,752,196.23-629,484,970.67-326,752,196.23 39
-9,367,000.00-3,864,034.71 1. 2. 3. 4. -9,367,000.00-3,864,034.71 1. 2. -9,367,000.00 3. -3,864,034.71 4. 5. 6. 7. 8. -638,851,970.67-330,616,230.94 40
28,861,135.72 59,445,538.46 49,123,938.44 7,863,799.69 14,958,171.50 85,848,873.85 74,403,709.96-8,266,286.57 58,708,234.24 102,980,389.09 52,989,008.87 952,967.92 1,104,330.22 507,133,083.01 272,902,143.07 602,800,153.45 385,703,716.40-516,951,279.60-311,300,006.44 41
539,007,841.24 1,604,830,000.00-24,895,715.13 5,857,008.62 775.86 1,253,767.70 30,717,670.40 51,174,773.83 546,084,340.07 1,661,861,782.45 557,372,243.51 333,926,196.87 403,500,000.00 1,176,000,000.00 960,872,243.51 1,509,926,196.87-414,787,903.44 151,935,585.58 3,212,894,379.80 319,700,000.00 434,132,121.03 3,647,026,500.83 319,700,000.00 106,000,000.00 2,656,145.77 105,768,083.88 66,037.73 214,424,229.65 66,037.73 3,432,602,271.18 319,633,962.27-3,590,606.75-5,358,923.94 2,497,272,481.39 154,910,617.47 266,297,695.44 111,387,077.97 2,763,570,176.83 266,297,695.44 42
30,095,738.21 14,788,979.75 11,351,288.48 5,510,984.15 9,903,153.13 46,958,010.84 24,692,132.88-46,424,953.19 4,817,223.26 37,419,091.04 13,274,057.46-404,951.91 373,061.04 707,472,232.95 347,842,544.55 698,061,418.89 366,306,886.31-651,103,408.05-341,614,753.43 463,981,822.36 1,604,830,000.00-25,097,932.94 10,392,909.26 29,052,252.21 2,201,083.29 467,936,141.63 1,617,423,992.55 47,192,426.03 9,007,487.29 498,929,200.00 1,508,546,000.00 546,121,626.03 1,517,553,487.29-78,185,484.40 99,870,505.26 43
3,212,894,379.80 319,700,000.00 284,132,121.03 3,497,026,500.83 319,700,000.00 106,000,000.00 1,807,277.11 105,768,083.88 66,037.73 213,575,360.99 66,037.73 3,283,451,139.84 319,633,962.27-14,275,085.26 2,539,887,162.13 77,889,714.10 90,695,244.05 12,805,529.95 2,630,582,406.18 90,695,244.05 44
584,750,000.00 1,056,407,351.21-1,281,398.32-519,368,145.10-1,174,277.85 1,119,333,529.94 584,750,000.00 1,056,407,351.21-1,281,398.32-519,368,145.10-1,174,277.85 1,119,333,529.94-175,560,000.00 2,740,831,158.74 1,271,880.48-722,915,447.16 61,264,10 2,194,808,856.16 1,271,880.48-722,915,447.16 61,264,10-721,582,302.58 175,560,000.00 2,740,831,158.74 2,916,391,158.74 1. 175,560,000.00 2,719,131,222.12 2,894,691,222.12 2. 3. 4. 21,699,936.62 21,699,936.62 1. 2. 3. 4. 1. 2. 3. 4. 5. 6. 1. 2. 760,310,000.00 3,797,238,509.95-9,517.84-1,242,283,592.26-1,113,013.75 3,314,142,386.10 45
550,000,000.00 771,523,388.94 8,062,870.72-202,024,606.70-947,020.69 1,126,614,632.27 550,000,000.00 771,523,388.94 8,062,870.72-202,024,606.70-947,020.69 1,126,614,632.27-34,750,000.00 284,883,962.27-9,344,269.04-317,343,538.40-227,257.16-7,281,102.33-9,344,269.04-317,343,538.40-227,257.16-326,915,064.60 34,750,000.00 284,883,962.27 319,633,962.27 1. 34,750,000.00 284,883,962.27 319,633,962.27 2. 3. 4. 1. 2. 3. 4. 1. 2. 3. 4. 5. 6. 1. 2. 584,750,000.00 1,056,407,351.21-1,281,398.32-519,368,145.10-1,174,277.85 1,119,333,529.94 46
584,750,000.00 1,043,588,147.30-369,977,378.55 1,258,360,768.75 584,750,000.00 1,043,588,147.30-369,977,378.55 1,258,360,768.75-175,560,000.00 2,740,831,158.74-9,367,000.00-629,484,970.67 2,277,539,188.07-9,367,000.00-629,484,970.67-638,851,970.67 175,560,000.00 2,740,831,158.74 2,916,391,158.74 1. 175,560,000.00 2,719,131,222.12 2,894,691,222.12 2. 3. 21,699,936.62 21,699,936.62 4. 1. 2. 3. 4. 1. 2. 3. 4. 5. 6. 1. 2. 760,310,000.00 3,784,419,306.04-9,367,000.00-999,462,349.22 3,535,899,956.82 47
550,000,000.00 758,704,185.03 3,864,034.71-43,225,182.32 1,126,614,632.27 550,000,000.00 758,704,185.03 3,864,034.71-43,225,182.32 1,126,614,632.27-34,750,000.00 284,883,962.27-3,864,034.71-326,752,196.23-10,982,268.67-3,864,034.71-326,752,196.23-330,616,230.94 34,750,000.00 284,883,962.27 319,633,962.27 1. 34,750,000.00 284,883,962.27 319,633,962.27 2. 3. 4. 1. 2. 3. 4. 1. 2. 3. 4. 5. 6. 1. 2. 584,750,000.00 1,043,588,147.30-369,977,378.55 1,258,360,768.75 48
2018 (www.junshipharma.com) (www.hkexnews.hk) (www.neeq.com.cn) 2018 2019 3 29 Roy Steven Herbst * 49