2013 4 专论与综述 PPCPs * ( 浅水湖泊综合治理与资源开发教育部重点实验室, 河海大学环境学院, 江苏南京 210098) PPCPs PPCPs PPCPs PPCPs X171. 5 A 1006-2009 2013 02-0010 - 06 Bioaccumulation and Metabolism of PPCPs in Aquatic Organisms of Different Trophic Levels DING Jian-nan LU Guang-hua * LIU Jian-chao YAN Zhen-hua Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education College of Environment Hohai University Nanjing Jiangsu 210098 China Abstract Based on summarizing the distribution characteristics of PPCPs in water environment the bioaccumulative effects of PPCPs on aquatic organisms of different trophic levels phytoplankton benthos and fish were analyzed and compared. Furthermore the metabolic pathways and mechanisms of typical PPCPs in fish were illustrated. Finally the future research directions including a study of bioaccumulation of PPCPs transfer process of PPCPs along the food chain and metabolism of PPCPs in aquatic environment were suggested. Key words PPCPs Aquatic organisms Bioaccumulation Biological metabolism Pharmaceutical and Personal Care Products PPCPs 1 β - PPCPs Atlasi 5 PPCPs 34 354 ng /L 1 6 815 ng /L 804 ng /L Yang Gwinnett 16 PPCPs 2 PPCPs 120 μg /L 3 2012-08 - 15 2013-02 - 21 51079049 51279061 20 90 PPCPs 4 10 PPCPs 1988 * E-mail ghlu@ hhu. edu. cn
. PPCPs 2013 4 130 μg /L 6 Valcárcel 7 PPCPs 25 PPCPs PPCPs 677 μg /L 60 μg /L 132 μg /L ph 5 2. 1 在浮游植物体内的累积 75 ng /L 34 ng /L 100 ng /L PPCPs Babu 8 Kaveri 28. 3 ng /L Tamiraparani 944 ng /L PPCPs PPCPs 9 9 Melinda 23 Cladophora spp. 1 340 ng /L 50 ng /g ~ 6 400 ng /g 50 ng /L ~ 10 ng /L ~ 100 ng /L 200 ng /L 3 Gabrielle 24 Pseudokirchneriella subcapitata 10 PPCPs 24 h ng /L μg /L 321. 7 mg /L BAF 2. 2 Raphael PPCPs 11 25 Fontinalis antipyretica 12 3 13-14 3 PPCPs BAF 250 ~ 450 75 ~ 140 100 ~ 200 2. 2 在底栖生物体内的累积 2 PPCPs PPCPs 15 PPCPs 16 17-19 0. 18 μg /g 0. 16 μg /g 10 000 μg /L 82 μg /g 20-21 360 μg /g BAF 10 ~ 180 Valeska 27 Dreissena polymorpha 22 PPCPs PPCPs 150 mg /L Hanna 26 1 μg /L BCF 11
. PPCPs 2013 4 BCF 92 ng /g 24 ng /g 0. 534 μg /L BCF 20 534 μg /L BCF 2 28 PPCPs Liu 33 BCF 100 4 BCF > > 141 d 21 Melanie 29 Gammarus pulex 6 BCF Xu 30 4. 6 ~ 185 900 BCF < 5 Oreochromis niloticus - < < < < 50 mg /kg 7 d Xu 30 Penaeus > > chinensis 50 mg /kg Gomez 34 7 d 1. 68 μg /g 2. 3 在鱼体内的累积 PPCPs 2 BCF < 1 Rigos PPCPs 30 mg /kg Sparus aurata Alejandro 31 Diplodus puntazzo 4 d 5 2 660 ng /g > 2 370 μg /L PPCPs > 2 350 ng /g > 1 330 ng /g > 2 100 ng /g 290 ng /g Babu 32 BCF 17 ~ 59 22 PPCPs Oncorhynchus mykiss Ictalurus punctatus BCF 83. 5 76. 2 880 μg /L 35 PPCPs Manila 20 1 1 Table 1 PPCPs Bioaccumulation effects of typical PPCPs in fish PPCPs ρ / μg L - 1 t /d BAF /BCF 20 11 mg /kg 1 724. 4 36 0. 64 49. 4 μg /kg 7 74 37 0. 3 132. 9 μg /L 7 416 38 6. 7 3 171. 3 μg /L 7 481 38 102. 7 8 519. 4 μg /L 7 83 38 2. 9 0. 7 μg /L 7 0. 26 38 24. 7 2. 2 μg /L 7 0. 09 38 175. 3 10. 3 μg /L 7 0. 06 38 43 25 μg /L 10 0. 3 39 100 156. 8 μg /kg 2 1. 57 40 250 167. 1 μg /kg 28 1. 09 41 250 104. 8 μg /kg 28 0. 69 41 250 105. 4 μg /kg 28 0. 69 41 250 98. 6 μg /kg 7 0. 44 41 250 18. 7 μg /kg 7 0. 08 41 250 114. 2 μg /kg 7 0. 51 41 250 142. 3 μg /kg 7 0. 63 41 250 314. 9 μg /L 7 1. 4 41 12
. PPCPs 2013 4 PPCPs ρ / μg L - 1 t /d BAF /BCF 25 82 μg /L 10 3. 3 39 1. 5 170 μg /L 14 113 42 1 500 78 000 μg /L 14 52 42 1 2 882. 4 μg /kg 28 2 732 43 1 1 024. 8 μg /kg 28 971 43 1 804. 6 μg /kg 28 763 43 1 72. 8 μg /kg 28 69 43 43 210 μg /L 10 4. 9 39 1. 2 0. 05 μg /L 14 0. 042 44 7. 2 0. 19 μg /L 14 0. 028 44 90. 5 0. 62 μg /L 14 0. 007 44 1. 6 810 μg /L ~ 3 690 μg /L 10 500 ~ 2 300 45 40 55 μg /L 10 1. 4 39 49 1. 0 μg /L 10 0. 02 39 6 - PPCPs Gabrielle 24 150 mg /L Pseudokirchneriella subcapitata 24 h BAF 2. 2 10 ml Thamnocephalus platyurus 24 h BAF 12. 6 Hydra attenuata Marja 39 5 On- corhynchus mykiss PPCPs 3 3 3 PPCPs PPCPs 30 46 Jenny 45 Xu 30 Oreochromis niloticus Penaeus chinensis 2 Emily 47 4 3 - - 2-2 ~ 4 P450 CYP Nils 36 20 μg /L CYP2D6 3-24 h 2' - 3' - 13
. PPCPs 2013 4 water of the Madrid Region Spain and potential ecotoxicologi- CYP2D6 cal risk J 4 and parabens in Indian rivers J. Journal of Hazardous Materi- 1 als 2011 186 1586-1593. PPCPs 9 J 10 2 PPCPs - 20. 11 J. Compara- PPCPs zebra mussel Dreissena polymorpha hemocytes J PPCPs tive Biochemistry and Physiology Part C 2009 13 COLLEEN M F PPCPs Daphnia survival growth and reproduction J 2005 61 200-207. 14 BRIAN Q FRAN OIS G 3 PPCPs J PPCPs - 739. 1 ELLIS J B. Pharmaceutical and personal care products PPCPs in urban receiving waters J. Environmental Pollution 2006 144 184-189. 2 TERNES T A JOSS A SIEGRIST H. Scrutinizing pharmaceuticals and personal care products in wastewater treatment J. Environmental Science and Technology 2004 38 392-399. 3 MARTA C FRANCISCO O JUAN M L. Removal of cosmetic ingredients and pharmaceuticals in sewage primary treatment J. Water Research 2005 39 4790-4796. 4 DAUGHTON C G TERNES T A. Pharmaceuticals and personal care products in the environment agents of subtle change J. Environmental Health Perspectives 1999 107 907-938. 5 ATLASI D KHADIJA A LIZA V et al. Evaluating pharmaceuticals and caffeine as indicators of fecal contamination in drinking water sources of the Greater Montreal region J. Chemosphere 2012 88 131-139. 6 XIN Y RILEY C F HOWARD S W et al. Occurrence and removal of pharmaceuticals and personal care products PPCPs in an advanced wastewater reclamation plant J. Water Research 2011 45 5218-5228. 7 VALC RCEL Y ALONSO S G RODR GUEZ J L et al. Detection of pharmaceutically active compounds in the rivers and tap 14. Chemosphere 2011 84 1336-1348. 8 BABU R R GOVINDARAJ S GEETHA V et al. GC-MS analysis and ecotoxicological risk assessment of triclosan carbamazepine.. 2007 16 384-388.. J. 2012 24 4 14.. 2008 20 5 38-39. 12 BINELLI A COGNI D PAROLINI M et al. Cytotoxic and genotoxic effects of in vitro exposure to Triclosan and Trimethoprim on 150 50-56. STANLEY I D. Effects of pharmaceuticals on. Chemosphere CHRISTIAN B. The effects of pharmaceuticals on the regeneration of thecnidarian Hydra attenuate. Science of the Total Environment 2008 402 62-69. 15 HALLING-SOENSEN B. Algal toxicity of antibacterial agents used in intensive farming J. Chemosphere 2000 40 731 16 FERNANDO S C CAMILO D S ALDO R S et al. Biological effects of environmentally relevant concentrations of the pharmaceutical Triclosan in the marine mussel Perna perna Linnaeus 1758 J. Environmental Pollution 2012 168 145-150. 17 GAGN F ANDR C CEJKA P et al. Evidence of neuroendocrine disruption in fresh water mussels exposed to municipal wastewaters J. Science of the Total Environment 2011 409 3711-3718. 18 RAIMONDO L MERCEDES B CINTA P et al. Low environmental levels of fluoxetine induce spawning and changes in endogenous estradiol levels in the zebra mussel Dreissena polymorpha J. Aquatic Toxicology 2012 106-107 123-130. 19 GAGNE F BLAISE C ANDRE C et al. Neuroendocrine disruption and health effects in Elliptio complanata mussels exposed to aeration lagoons for wastewater treatment J. Chemosphere 2007 68 731-743. 20 MART N-D AZ M L GAGN F BLAISE C. The use of biochemical responses to assess ecotoxicological effects of Pharmaceutical and Personal Care Products PPCPs after injection in the mussel Elliptio complanata J. Environmental Toxicology and Pharmacology 2009 28 237-242. 21 VALESKA C J CLAUDIA L STEPHAN P et al. Molecular effects and bioaccumulation of levonorgestrel in the non-target organism Dreissena polymorpha J. Environmental Pollution 2011 159 38-44.
. PPCPs 2013 4 22 LIU J L WANG R M HUANG B et al. Biological effects and bioaccumulation of steroidal and phenolic endocrine disrupting chemicals in high-back crucian carp exposed to wastewater treatment plant effluents J. Environmental Pollution 2012 162 325-331. 23 MELINDA A C REGINA E E THOMAS W L et al. Algal bioaccumulation of triclocarban triclosan and methyl-triclosan in a North Texas wastewater treatment plant receiving stream J. Chemosphere 2007 67 1911-1918. 24 GABRIELLE V PHILIPPE E ANDR L et al. Toxic effects and bioaccumulation of carbamazepine evaluated by biomarkers measured in organisms of different trophic levels J. Chemosphere 2010 80 1062-1068. 25 RAPHAEL D HERVE P HERVE L B. The bryophyte Fontinalis antipyretica Hedw. bioaccumulate soxytetracycline flumequine and oxolinic acid in the freshwater environment J. Science of the Total Environment 2004 322 243-253. 26 HANNA E GUNNAR T LINDA K. Physiological effects of diclofenac ibuprofen and propranolol on Baltic Sea blue mussels J. Aquatic Toxicology 2010 99 223-231. 27 VALESKA C J CLAUDIA L STEPHAN P et al. Exposure to human pharmaceuticals Carbamazepine Ibuprofen and Bezafibrate causes molecular effects in Dreissena polymorpha J. Aquatic Toxicology 2011 105 428-437. 28 VALESKA C J STEPHAN P GUNNAR N et al. The β-receptor blocker metoprolol alter sdetoxification processes in the non-target organism Dreissena polymorpha J. Environmental Pollution 2010 158 2059-2066. 29 MELANIE M W LAURA J C RICHARD F et al. Uptake and depuration of pharmaceuticals in aquatic invertebrates J. Environmental Pollution 2012 165 250-258. 30 XU W H ZHU X B WANG X T et al. Residues of enrofloxacin furazolidone and their metabolites in Nile tilapia Oreochromis niloticus J. Aquaculture 2006 254 1-8. 31 ALEJANDRO J R RICHARD A B SASCHA U et al. Occurrence of pharmaceuticals and personal care products in fish results of a national pilot study in the United States J. Environmental Toxicology and Chemistry 2009 28 2587-2597. 32 BABU R R KIM J W TOMOHIKO I et al. Determination of preservative and antimicrobial compounds in fish from Manila Bay Philippines using ultra high performance liquid chromatography tandem mass spectrometry and assessment of human dietary exposure J. Journal of Hazardous Materials 2011 192 1739-1745. 33 LIU J L WANG R M HUANG B et al. Distribution and bioaccumulation of steroidal and phenolic endocrine disrupting chemicals in wild fish species from Dianchi Lake China J. Environmental Pollution 2011 159 2815-2822. 34 GOMEZ C F CONSTANTINE L HUGGETT D B. The influence of gill and liver metabolism on the predicted bioconcentration of three pharmaceuticals in fish J. Chemosphere 2010 81 1189-1195. 35 GEORGE R IOANNIS N MARIA A et al. Tissue distribution and residue depletion of oxolinic acid in gilthead sea bream Sparus aurata and sharpsnout sea bream Diplodus puntazzo following multiple in-feed dosing J. Aquaculture 2003 224 245-256. 36 NILS H S IDA F TOMOFUMI K et al. Bioconcentration metabolism and excretion of triclocarban in larval Qurt medaka Oryzias latipes J. Aquatic Toxicology 2011 105 448-454. 37 GORDON P CHRIS D M. Uptake and depuration of the anti-depressant fluoxetine by the Japanese medaka Oryzias latipes J. Chemosphere 2008 74 125-130. 38 OLURANTI P T KEN D O MARK R S et al. Determination of pharmaceutical residues in fish bile by solid-phase microextraction couple with liquid chromatography-tandem mass spectrometry LC /MS /MS J. Environmental Science and Technology 2012 46 5302-5309. 39 MARJA L JENNY M B ANTTI J et al. Uptake from water biotransformation and biliary excretion of pharmaceuticals by Rainbow trout J. Environmental Toxicology and Chemistry 2011 30 1403-1411. 40 KHAGESHOR B BARNEY V. Ibuprofen bioconcentration and prostaglandin E2 levels in the bluntnose minnow Pimephales notatus J. Comparative Biochemistry and Physiology Part C 2011 153 251-257. 41 GOPINATH C N PETER M P LISA A C et al. Bioconcentration of ibuprofen in fathead minnow Pimephales promelas and channel catfish Ictalurus punctatus J. Chemosphere 2011 84 1371-1377. 42 GOPINATH C N PETER M J MIAO X S et al. The human lipid regulator gemfibrozil bioconcentrates and reduces testosterone in the goldfish Carassius auratus J. Aquatic Toxicology 2005 73 44-54. 43 SCHWAIGER J FERLING H MALLOW U et al. Toxic effects of the non-steroidal anti-inflammatory drug diclofenac Part I histopathological alterations and bioaccumulation in rainbow trout J. Aquatic Toxicology 2004 68 141-150. 44 FILIP C JERKER F MARIJA C et al. Does ketoprofen or diclofenac pose the lowest risk to fish J. Journal of Hazardous Materials 2012 229-230 100-106. 45 JENNY M B MARJA L AIMO O et al. Detection of naproxen and its metabolites in fish bile following intraperitoneal and aqueous exposure J. Environmental Science Pollution Research 2011 18 811-818. 46 JANER G LEBLANC G A PORTE C. A comparative study on androgen metabolism in three invertebrate species J. General and Comparative Endocrinology 2005 143 211-221. 47 EMILY M S CHU S G GORDON P et al. Cross-species comparison of fluoxetine metabolism with fish liver microsomes J. Chemosphere 2010 79 26-32. 15