动物医学院教师简历挂新网站-Jung

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1 姓名 :Yong Sam Jung 性别 : 男毕业院校 : 韩国培材大学最高学位 : 博士办公地址 : 教学楼 B419-1 办公电话 : 电子邮箱 :ysjung@njau.edu.cn 研究方向 : 病毒 - 宿主互作和比较医学研究动物疫病诊断和防制技术和产品研发个人简介 : 韩国培材大学基因工程专业,1998 年获学士学位,2001 年获硕士学位,2005 年获博士学位年, 韩国忠南国立大学生物技术研究所从事研究工作, 期间获韩国博士后研究基金项目资助 ; 年, 美国加州大学戴维斯分校兽医学院比较肿瘤学研究中心博士后, 承担和参与了 4 项 NIH 基金项目研究 ;2013 年 6 月作为引进高层次人才到南京农业大学动物医学院工作从蛋白降解基因转录和转录后调节等方面研究蛋白内稳态调控在肿瘤和病毒感染中的作用机制在 PNAS JID MCB 和 JBC 等国际知名刊物共发表 SCI 论文 30 余篇 ; 获得中国日本美国加拿大澳大利亚和韩国等国专利 12 项任 J Biol Chem, Oncogene, J Cell Sci 等期刊论文评审人目前主要从以下几方面开展工作 : 研究蛋白内稳态调控在在疱疹病毒冠状病毒流感病毒等病毒致病过程中的作用机理, 发现新的诊断标志物和抗病毒新靶点 ; 重要新发突发动物疫病诊断防制技术和产品研发科研项目 : 1. 海外青年科学家研究基金项目 ( 主持, 项目编号 KYHW201702, 年,50 万 ) 2. 中央高校基本业务费 ( 主持, 项目编号 Y , 年 50 万 ) 3. 南京农业大学引进人才启动经费 4. 江苏省优势学科人才引进启动经费荣誉奖项 : 生泰尔奖教金 (2014 年 ) 发明专利 : 1. Jung YS, Kim E, Kim NJ, Lee YS, Suh JH, Suh Kim HY, Yi KY, and Yoo SE. Aminopyrazole ischemic diseases containing the same. 2012, China, Jung YS, Kim E, Kim NJ, Lee YS, Suh JH, Suh Kim HY, Yi KY, and Yoo SE. Aminopyrazole ischemic diseases containing the same. 2012, Japan, Jung YS, Kim E, Kim NJ, Lee YS, Suh JH, Suh Kim HY, Yi KY, and Yoo SE. Aminopyrazole ischemic diseases containing the same. 2011, USA, Jung YS, Kim E, Kim NJ, Lee YS, Suh JH, Suh Kim HY, Yi KY, and Yoo SE. Aminopyrazole ischemic diseases containing the same. 2011, Canada,

2 5. Jung YS, Kim E, Kim NJ, Lee YS, Suh JH, Suh Kim HY, Yi KY, and Yoo SE. Aminopyrazole ischemic diseases containing the same. 2011, Australia, Seo JH, Yoo SE, Yi KY, Kim N, Kim E, Jung YS, Lee YS, Suh Kim HY. Benzofuran and Benzothiophene derivatives substituted by amide, process for the preparation thereof, and p harmaceutical compositions containing the same. 2010, Korea patent no Seo JH, Yoo SE, Yi KY, Kim N, Kim E, Jung YS, Lee YS, Suh Kim HY. Composition for preventing or treating an ischemic disease containing aminothiophene derivatives. 2008, Korea patent no Seo JH, Yoo SE, Yi KY, Kim N, Kim E, Jung YS, Lee, YS, Suh Kim HY. N-phenylamide derivatives and preparation method thereof. 2008, Korea patent no Seo JH, Yoo SE, Kim N, Kim E, Jung YS, Lee YS, Suh Kim HY. Composition for preventing or treating an ischemic disease containing N-phenylamide derivatives. 2008, Korea patent no Jung YS, Kim E, Kim N, Lee YS, Seo JH, Suh Kim HY, Yi KY and Yoo SE. Aminopyrazole ischemic diseases containing the same. 2008, Korea patent no Kim E, Lee YS, Jung YS, Yoo SE, Seo JH, Chae SK, and Lee KJ. Composition for treating an ischemic disease comprising a human FAF1 protein inhibitor as an active ingredient. 2008, Korea patent no Jung YS, Lee DH, Kim E, and Lim H. Human Daxx protein and a fragment thereof as bin ding agents of human NHE1 ion channel protein. 2006, Korea patent no 近年代表性论著 : 第一 / 通讯作者论文 1. Liu XD, Qian Y, Jung YS* and Chen PY. Isolation and immunomodulatory activity of bursal peptide, a novel bursal peptide from the chicken bursa of Fabricius. J Vet Sci (4): (*Co-corresponding author) 2. Jung YS, Qian Y, Yan W, and Chen X. Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p J. Investi. Dermatol., 133(5): (*Top 1 in the dermatology field; Featured on MDlinx.com). 3. Qian Y*, Jung YS*, and Chen X. DEC1 controls the response of p53-dependent cell survival versus cell death to a stress signal through macrophage inhibitory cytokine-1. Proc Natl Acad Sci USA 2012; 109, (*These authors contributed equally to the work). 4. Jung YS, Qian Y, and Chen X. DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation. DNA Repair (Amst) 2012; 11(2), Jung YS, Qian Y, and Chen X. The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation. J Biol Chem 2011; 286, Jung YS, Hakem A, Hakem R, and Chen X. Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. Mol Cell Biol 2011; 31,

3 7. Jung YS, Liu G, and Chen X. Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation. Mol Cell Biol 2010; 30, Jung YS, Kim HY, Lee MG, Pouyssegur J, and Kim E. Physical interaction and functional coupling between Daxx and sodium hydrogen exchanger isoform 1, an implication regarding Daxx role in ischemic stress-induced cell death. J Biol Chem 2008; 283, Jung YS, Kim HY, Lee YJ, and Kim E. Subcellular localization of Daxx determines its opposing functions in ischemic cell death. FEBS Lett 2007; 581, Jung YS, Lee DH, Lim H, Yi KY, Yoo SE, and Kim E. KR protects cardiac H9c2 cells from chemical hypoxia-induced cell death via inhibition of JNK/p38 MAPK activation. Jpn J physiol 2004; 54, Jung YS, Jung YS, Kim MY, and Kim E. Identification of caspase-independent PKCε-JNK/p38 MAPK signaling module in response to metabolic inhibition in H9c2 cells. Jpn J physiol 2004; 54, Jung YS, Kim, KS, Kim, KD, Lim, JS, Kim, JW, and Kim, E. Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells. Biochem Biophys Res Commun 2001; 288, 合作论文 1. Zhang Y, Qian Y, Zhang J, Yan W, Jung YS, Chen M, Lloyd K, Duan Y, Wang J, Liu G, and Chen X. Ferredoxin Reductase Is Critical for p53-dependent Tumor Suppression via Iron Regulatory Protein Genes&Dev. Published online July 26. doi: /gad Liu K, Zhou B, Wang F, Huan B, Shao D, Wei J, Qiu Y, Li B, Qian Y, Jung YS, Miao D, Tong G, and Ma Z. A conjugate protein containing HIV TAT, ISG20, and a PRRSV polymerase binding inhibits PRRSV replication and may be a novel therapeutic platform Res Vet Sci. 113: Liu K, Qian Y, Jung YS, Zhou B, Cao R, Shen T, Shao D, Wei J, Ma Z, Chen P, Zhu H, and Qiu Y. mosgctl-7, a C-type lectin protein, mediates Japanese encephalitis virus infection in mosquitoes. J Virol 2017 Mar 1 (Epub ahead of print) 4. Yan W, Scoumanne A, Jung YS, Xu E, Zhang J, Zhang Y, Ren C, Sun P and Chen X. Mice deficient in poly(c)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation. Genes Dev (5): Cho SJ, Teng IF, Zhang M, Yin T, Jung YS, Zhang J and Chen X. Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNA-binding protein and a p53 family target, via mrna translation. Oncotarget (1): Ren C,Cho SJ, Jung YS and Chen X. DNA polymerase η is regulated by poly(rc)-binding protein 1 via mrna stability. Biochem J (3): Yan W, Jung YS, Zhang Y and Chen X. Arsenic trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligase. PLoS One (8):e Qian Y, Zhang J, Jung YS, Chen X. DEC1 coordinates with HDAC8 to differentially regulate TAp73 and ΔNp73 expression. PLoS One Jan 3;9(1):e Cho SJ, Rossi A, Jung YS, Yan W, Liu G, Zhang J, Zhang M, Chen X. Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced

4 mortality. Proc Natl Acad Sci USA. 2013;110(23): Cho SJ, Jung YS, Chen X. Poly (C)-binding protein 1 regulates p63 expression through mrna stability. PLoS One Aug 7;8(8):e Yan W, Chen X, Zhang Y, Zhang J, Jung YS, Chen X. Arsenic suppresses cell survival via Pirh2-mediated proteasomal degradation of ΔNp63 protein. J Biol Chem. 2013; 288(5): Yan W, Zhang J, Zhang Y, Jung YS, Chen X. P73 expression is regulated by RNPC1, a target of the p53 family, via mrna stability. Mol Cell Biol. 2012; 32, Cho SJ, Jung YS, Zhang J, Chen X. The RNA-binding Protein RNPC1 Stabilizes the mrna Encoding the RNA-binding Protein HuR and Cooperates with HuR to Suppress Cell Proliferation. J Biol Chem 2012; 287(18), Zhang Y, Yan W, Jung YS, Chen X. Mammary epithelial cell polarity is differentially regulated by p73 isoforms via epithelial-to-mesenchymal transition. J Biol Chem 2012; 287(21), Seo Kw, Holt R, Jung YS, Rodriguez CO Jr, Chen X, Rebhun RB. Fluoroquinolone-mediated inhibition of cell growth, S-G2/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines. PLoS One. 2012;7(8):e Hakem A, Bohgaki M, Lemmers B, Tai E, Salmena L, Matysiak-Zablocki E, Jung YS, Karaskova J, Kaustov L, Duan S, Madore J, Boutros P, Sheng Y, Chesi M, Bergsagel PL, Perez-Ordonez B, Mes-Masson AM, Penn L, Squire J, Chen X, Jurisica I, Arrowsmith C, Sanchez O, Benchimol S, and Hakem R. Role of Pirh2 in Mediating the Regulation of p53 and c-myc. PLoS Genet 2011; 11, e Qian Y, Jung YS, and Chen X. DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. J Biol Chem 2011; 286, Hwang IS, Jung YS, and Kim E. Interaction of ALG-2 with ASK1 influences ASK1 localization and subsequent JNK activation. FEBS Lett 2002; 529, Kim ES, Yoo SE, Yi KY, Lee S, Noh JS, Jung YS, Kim E, and Jeong N. Design, Syntheses and Biological Evaluations of Nonpeptidic Caspase 3 Inhibitors. Bull Korean Chem Soc 2002; 23, Cho SJ, Lee NS, Jung YS, Lee H, Lee KJ, Kim E, and Chae SK. Identification of structural domains affecting transactivation potential of Nm23. Biochem Biophys Res Commun 2001; 289, 综述 1. Ming X, Jung YS, Babiuk LA, Qian Y. The Host Signaling Pathways Hijacked by On-cogenic Viruses. SM Vaccine Vaccin. 2017; 3(1): Jung YS, Qian Y, and Chen X. Pirh2 RING-finger E3 ubiquitin ligase: Its role in tumorigenesis and cancer therapy. FEBS Lett 2012; 586, Jung YS, Qian Y, and Chen X. Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal 2010; 22, Qian Y, Jung YS, Chen X. DEC1 and MIC-1: new players of p53-dependent cell fate decision. Cell Cycle. 2012;11(19):

5 中文核心期刊论文 1. 李雪琪, 陈鸿军, 连雪, 鲍晨沂, 孙海伟, JUNG Yong-Sam *, 钱莺娟 *. 鸡源性 p53 单克隆抗体的制备和鉴定中国动物传染病学报 ( 已接收 ) 2. 李雪琪, 连雪, 鲍晨沂, 孙海伟, 陈鸿军,JUNG Yong-Sam *, 钱莺娟 *. 细胞周期蛋白依赖性激酶抑制蛋白 p21 单克隆抗体制备. 2017, 中国兽医科学 17(06): 郇文彬, 明鑫, 鲍晨沂, 洪涛,JUNG Yong-Sam, 钱莺娟 *. 四环素调控 DEC1 表达的 Vero 细胞系的构建及鉴定. 2017, 畜牧与兽医 49(5): 高俊娜, 连雪, 孙海伟, 李泽君, 张训海,JUNG Yong-Sam, 陈鸿军, 钱莺娟 *. 鸡细胞周期检验点激酶 2 单克隆抗体制备和鉴定. 2016, 细胞与分子免疫学杂志, 32(9): 高俊娜, 张幸星, 连雪, 孙海伟, 郇文彬, 张训海,JUNG Yong-Sam, 陈鸿军, 钱莺娟 *, 马立克氏病病毒 Meq 单克隆抗体的制备. 2016, 中国兽医科学,46(9):

淺談保健食材與阿茲海默氏症之預防食營系詹吟菁特聘教授由於醫療的進步及人民生活品質的改善, 平均壽命得以延長, 罹患退化性疾病的人口也隨之增多而退化性疾病的患

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