ues and FA values of the nucleus pulposus. MR DWI and DTI can provide the imaging evidence of the intervertebral disc prophase degenerationand

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1 33 4 Vol. 33 No Journal of Jinan UniversityMedicine Edition Aug DWI DTI DWI DTI 40 1 L 1 ~ 1 S 1 DWI DTI ADC FA 1 /2 L 1 /2 ~ 5 / 1 L 5 /S 1 5 ROI ADC FA ADC FA ADC FA P < ADC 4 /5 L 4 /5 L 5 /S 1 ADC P < FA L 5 /S 1 FA P < ADC FA DWI DTI R A The application study of MR DWI and DTI in lumbar intervertebral disc prophase degeneration SHEN Si 1 WANG Hao 2 WANG Fei 1 QIU Lin 1 LIU Si-run 1 1. Department of Medical Imaging2. Department of Anesthesiology the First Affiliated HospitalJinan UniversityGuangzhou China AbstractAimTo approach the feasibility of the application in lumbar intervertebral disc prophase degeneration by using MR DWI and DTI. MethodsForty young volunteers were subjects and all cases had no history of lumbago and lumbar operation or injury. Magnetic resonance DWIand DTI examination of the lumbar spine disc were performed in the L 1 - S 1 region of the volunteers. ADC and FA values at the five regions of interest ROIplaced in the nucleus pulposus differences. ResultsThere were significant statistical differences among the ADC values and FA values at each lumbar intervertebral disc from L 1 /2 to L 5 /S 1 were measured and statistically analyzed the various ROI in the same lumbar intervertebral disc or at the corresponding ROI in the different anatomic site P < the mean ADC values of intervertebral discs were positively correlated with anatomic location the ADC value of the L 4 /5 and L 5 /S 1 intervertebral disc increased obviously P < the FA values at the corresponding ROI in the different intervertebral disc level increased as the anatomic site stepping down the changes of the FA values at the L 5 /S 1 intervertebral disc could the most obviously further step upp < ConclusionThe ADC values and FA values can reflect the change of water diffuse in lumbar intervertebral discand the transmutation of biochemistry in the prophase degenerative intervertebral disc may be imaged by the ADC val Tel cjr. liusirun@ vip cn

2 ues and FA values of the nucleus pulposus. MR DWI and DTI can provide the imaging evidence of the intervertebral disc prophase degenerationand it is helpful to comprehend the pathogenesy. Key wordsmagnetic resonance DWI DTI lumbar intervertebral disc prophase degeneration 1 T 2 WI DWI 70% 1 50% DTI GE-ADW % Functool ADC FA ADC ~ 5 L 1 ~ L 5 T 2 WI 5 5 ROI ADC 3 1 FA ADC 2 apparent diffusion coefficientadc fractional anisotropyfa DWI DTI T 2 WI ~ ~ 80 kg kg 1 18 MRI 45 ~ 85 kg 1. 2 GE Signa 1. 5T HD 3 DWI SE EPI TR ms TE ms NEX mm 1 mm FOV 34 cm 37s DTI SE-EPI TR ms TE ms NEX mm 1 mm FOV 34 cm b min 15s 1. 3 ADC FA T 2 WI 2 MRI 2 A T 2 WIL 1 /2 ~ L 5 /S 1 B ROI ADC C ADC A ROI FA B FA MRI DTI

3 4 DWI DTI SPSS ± x 珋 ± s one-wayanova ROI ADC FA P < T 2 WI DWI DTI ADC FA P < ADC 3 FA 4 ADC FA P < ADC P < FA L 4 /5 L 5 /S 1 FA L 5 /S 1 FA P < L 5 /S 1 5 ROI FA L 1 /2 ~ L 5 /S 1 ADC 3 L 3 /4 5 ROI ADC 6 L 1 /2 ~ L 5 /S 1 FA 1 40 ADC x 珔 ± s 10-3 mm 2 /s L 1 / ± ± ± ± ± L 2 / ± ± ± ± ± L 3 / ± ± ± ± ± L 4 / ± ± ± ± ± L 5 /S ± ± ± ± ± FA x 珔 ± s L 1 / ± ± ± ± ± L 2 / ± ± ± ± ± L 3 / ± ± ± ± ± L 4 / ± ± ± ± ± L 5 /S ± ± ± ± ± 0. 12

4 ADC 1-2 FA 16 ~ 20 ADC FA 4 ADC FA DWI DTI magnetic resonance imagingmri 5 MRI MRI Kealey 13 DWI ADC FA 11 ADC 9% ADC ADC ADC ADC Kealey Kealey 7 8 Kealey Brownian 14 motion ADC ADC DWI ROI ADC MR ADC ADC ADC DWI ADC FA FA DTI FA FA ADC FA FA FA 9 10 FA FA DWI DTI FA DWI DTI 11

5 4 DWI DTI SWI DTI ADC FA J. DWI DTI MRI ADC FA J. CT MRI SIBELL D MKIRSCH J R. The 5-Minute Pain Management ConsultM J MATSUMURA YKASAI YOBATA Het al. Changes in water content of intervertebral discs and paravertebral muscles before and after bed restj. J Orthop Sci SAMARTZIS DKARPPINEN JCHAN Det al. The association of lumbar intervertebral disc degeneration on MRI in overweight and obese adultsa population-based study J. Arthritis Rheum FA ADC 5. MRI J FA ADC ZUO JSAADAT EROMERO Aet al. Assessment of intervertebral disc degeneration with magnetic resonance single-voxel spectroscopy J. Magn Reson Med URBAN J PSMITH SFAIRBANK J C. Nutrition of the FA L 4 /5 L 5 /S 1 FA intervertebral discj. Spine L 1 /2 L 2 /3 L 3 /4 L 4 /5 L 5 /S ADC 8MAJUMDAR S. Magnetic resonance imaging and spectroscopy of the intervertebral discj. NMR Biomed L 5 /S 1 ADC ADC FA 9SHANMUGANATHAN KGULLAPALLI R PZHUO J 15 et al. Diffusion tensor MR imaging in cervical spine trau- ma J. AJNR Am J Neuroradiol CARBALLIDO-GAMIO JXU DNEWITT Det al. Single-shot fast spin-echo diffusion tensor imaging of the lumbar spine at 1. 5 and 3 T J. Magn Reson Imaging KEALEY S MAHO TDELONG Det al. Assessment of apparent diffusion coefficient in normal and degenerated intervertebral lumbar disksinitial experience J. Radiology URBAN J P GROBERTS S. Degeneration of the intervertebral disc J. Arthritis Research&Therapy J

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