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2 2. (1) Preimplantation stages Implantation Placentas Chorioallantoic placenta The yolk sac placenta Postimplantation stages The organogenetic period The maturation period

3 (2) 1) 2) :, 3) 24

5 ( ) (1)

6 8 12

14 (2) g 20 25g 1:1 2:

17 ( ) : A(l5000IU/kg (250mg/kg)

18 (4) 1 2d 19 20d 18 19d (5)

21 ( lmm 2mm) (Bouin) 2

22 : (1) (2) (3) (4) (5) (6)

23 -

25 5 ( Guinea Pigs) SPF

26 1530

27 1495 Paintings such as the last supper have included the guinea pig as main course meal

28 guinea ---- Guinea, Guiana sows,

29 16, 1780 VitC 1770 s

30 : Rodentia : Caviidae (1) (2) : Cavia : Porcellus,

32 .

33 A. a. (3.8 cm) b. Solid colors: c.

34 Hartley, Dunkin-Hartley,

35 Lab stocks-outbred NIH, ; Lab strains-inbred : a. 4 (C4D/N): in 1970 NIH b. Waltzer (Wz) c.

36 B. a. b.

37 C. 15 cm (6 in)

38 . 1. 2N=64 one pair of sex chromosomes 31 pairs of autosomes. 2. Popular as pets Seldom bite or scratch Easily alarmed, injuries of young, abortion when startled,

39 3.

40 4. 5. Preyer reflex: 6., 7. 8.

41 . 1. : Forefeet have 4 digits each, Rear feet have 3 digits each. Upper surface of right manus Upper surface of right pes

42 2. tympanic bullae 3cm 4cm 2cm 2cm

43 58 75

50 3. Thymus

51 4. 5.,.,. MICE

52 6. Adrenal glands In this image, in which the animal's head is to the left, the kidney is obscured by renal fat, but the left adrenal gland is indicated by an arrow.

53 7. 1 cm 125 cm cm 65% 15%

54 6 lobes 7 cm 4 8.

55 9. 1 Dental formulas, one permanent set of teeth., 2(I 1/1 C 0/0 PM 1/1 M 3/3) = 20 MICE

56 : : : / , 32 4,30

57 2 : C7 T13-14 L6 S2-3 Cy4-6 7, 13-14, 6,

58 10. (1) (2) (3) a. (R) is characteristic of the Abyssinian breed b. (l)

59 .

60 11. U

61 Penile styles The os penis, or baculum, is found within the dorsal surface of the entire length of the glans. The intromittent sac, unique to hystricomorph rodents, is in the ventral aspect of the glans. When the penis is erect, the intromittent sac everts, revealing two keratinaceous, horn-like styles attached to its caudal end.

62 ,,,,

63 . 1. White Blood Cells (1) Neutrophils 38% (2) Lymphocytes 55% (3) Monocytes 3% (4) Others 4% : 100 mm Hg.

64 2. 1 Kurloff cells 2 3

65 3. vitamin C, 4.

66 g 7.

67 . 1. (1) Males a b. 3-5 months ( gm) c months (2). Females: a. 4-5 weeks of age b months gm.

68 2. without significant seasonal variations. Estrous cycle 15-17d Has distinct signs of estrus (vaginal membrane opening) lasts 9-11 hours Postpartum estrus: Occurs with a hours : days; mean = 63 days

69 3. (1). : (2) : 3-4 : g

70 d, 68 d g 50 g 5 8.3% g

71 .

72 . 1. (arginine, methionine, and tryptophan) 18-20% 2. : 13.5%

73 3. C a. Vc Vc Vc b.

74 c. : (1) (2) (3) (4)

75 d. : (1) (2) (3) (4)

76 e. : (1) : 0.5 mg/100 g (2) ( 300 g BW): 6 mg (3) : 20 mg f.

77 5. : (1) (2) (3) : (a) ; (b)

78 6. (1). 3-5 days (2). : a. a. b. c. a. b. c. d.

79 (3). : a. : 60 mg 5-7 d b. : mg/kg BID IM c. : 4 ml 12.5% /500 ml 1-2 d. : 10 mg/day

80 Table 8.1 Biologic and reproductive data for guinea pigs Adult body weight: Male Female Life span Body temperature Heart rate Respiratory rate Food consumption Water consumption Breeding onset: Male Female Estrous cycle length Gestation period Postpartum estrus Litter size Weaning age Breeding duration Chromosome number(diploid) g g 4-5 y beats per minute breaths per minute 6 g/100 g/d 10 ml/100 g/d 3-4 m ( g) 2-3 m ( g) d d Fertile d 18-48m 64

81 . A. 23 Vitamin C

82 1905,,

84 :,,

85 B. ß

86 C. > > > > >

87 D s,,, C Vitamin C vitamin C.

88 2 AA,,, 3 LDL

89 E. In 2003,

91 mg kg 30 mg kg

93 1-1.2 mm ( 0.8 mm)

94 1-1.2 mm ( 0.8 mm)

95 4 mm

97 spiral organ Corti

100 F. Safety testing 1999, 18,

101 G. 1882,. Mycobacterium tuberculosis H. 2-3, 350~400 g

102

103 6. Germ-Free vs. Conventional (1) a. Conventional animals' cecum is 15% of body weight, 30% in germ-free. b. Same weights as conventional when corrected for increased cecal size. c. d. 5%.

104 2. WBC: WBC : , : a % b. 4. a. b. c.

105 5. 6. a. b. c. d. 7.

106 . A.

107 B.

108 C..

109 ;

110 D.

111 .

112

113 IV,

114 IV, dorsal penile vein Intravenous access is also possible into the dorsal penile vein; however this is a painful procedure and premedication is necessary.

115 F.,,

116 (0.05 mg/kg SC at 8 hour intervals), (10 mg/kg SC or IM every 4 hours) (20 mg/kg, IM or SC, every twothree hours).

117 ( mg/kg IM) (5 mg/kg IM or IP) (0.05 mg/kg SC).

118 . (25-40 mg/kg) (5-12 mg/kg) IM or IP (25-35 mg/kg, IP) -

119

120 10-15 ml 30

121 G.

122 G. Euthanasia (1 50 mg/kg).

123

124 2 a b mg kg -1 ( R ab ) b b b b b b b b b b b /kg /m a a a a a a a a a a a

125 1 150g 5mg.kg -1? 2 a b R ab =0.162 =D b.r ab = =0.81mg.kg -1

126 2 a b mg kg -1 ( R ab ) b b b b b /kg a a a

127 2 20g 4mg.kg -1 10kg? 2 a b R ab =0.150 =D b.r ab = =0.600mg.kg -1

128 2 a b mg kg -1 ( R ab ) /kg b b b b b /m a

129 3 10kg 0.68mg.kg -1 22g 38g? 1 2 a b R ab = g =D b.r ab = =4.536mg.kg -1 ;

130 2 a b mg kg -1 ( R ab ) b b b /kg a a a

131 3 10kg 0.68mg.kg -1 22g 38g? S a =(W a /W ) 1/3, S b =(W /W a ) 1/3, a b /mg.kg -1 D a D b /mg.kg -1 D a D b R ab S a S b D b =D a.r ab D b =D a.r ab.s b D b =D a.s a.r ab.s b

132 3 Sa,Sb B=W/W S a =B 1/3 S b =1/B 1/

133 3 10kg 0.68mg.kg -1 22g 38g? (2) 22g 20%, 4.536mg.kg -1 Db =Da.Rab.Sb W =20g W b =22g, B=22/20=1.1 3 S b =0.969 =D b.r ab.s b = =4.395 mg.kg -1 3%

134 3 Sa,Sb B=W/W S a =B 1/3 S b =1/B 1/

135 3 10kg 0.68mg.kg -1 22g 38g? (3)38g B=38/20=1.9 3 S b =0.807 =D b.r ab.s b = =3.660mg.kg -1 31~46g

136 b b b b /kg a a a a D b =D a.r ab 20% mg.kg -1 1~ g Da=(130mg 3-6)/60= /60=6.5-13mg/kg;Rab=1.85 D b =D a.r ab =6.5~13mg/kg 1.85=12.025~24.05 mg/kg ~240.5mg 0.12~0.24g/ ; 1/3~2/3 3

幻灯片 1

幻灯片 1 Chapter 6 Rabbits Taxonomy : Mammalia : Lagomorpha : Leporidae : Lepus(Hares) Sylvilagus(cottontails) Oryctolagus (domestic rabbit) : The European rabbit, Oryctolagus cuniculus The European rabbit is the