人尿可

Size: px

Start display at page:

Download "人尿可"

昔秤夏
7 years ago
Views:

1 ( ) 91 TEL: (04) Ext FAX: (04)

2 g/kg 2.0 g/kg 1) 2) 3) 4 4) 5) 6) 2.0 g/kg/day 2

3 (Anoectochilus formosanus Hayata) (Orchidaceae) (Anoectochilus Blume) glucosyloxy- 4-hydroxybutyric acid 5 6, 7 3

4 Kai C 280 mg/ml C 3 % ml SD C g/kg 2.0 g/kg 0 0 4

5 ( ) (F 0 ) ( ) (F 0 ) (Gestation index) = / X ( 28 ) 4 (Viability index) 28 (Weaning index) = 4 / X 100 = / 4 X 100 (Birth index) = / X 100 ( ) (F 1 ) 7 7 ( ) (F 1 ) 10 6 (Columbux; Opto videomex-one; USA) 30 ( ) (F 1 ) 5

6 10 5 (Muromachi Kikai; Japan) (one-way analysis of variance) Dunnet P 0.05 χ 2 (600 ) g/kg 2.0 g/kg 16.7 g/kg 66.7 g/kg ( ) (F 0 ) ( ) 2.0 g/kg 2.0 g/kg 3 ( ) (F 1 ) ( ) 6

7 ( ) 4 28 ( ) ( ) 7 7 ( ) 6 ( ) g/kg 2.0 g/kg ± ± ± g/kg 2.0 g/kg ± ± ± 21.8 ( ) 5 7

8 (NSC B ) 1. vol 5, pp p Lin JM, Lin CC, Chiu HF, Yang JJ, Lee SG. Evaluation of the anti-inflammatory and liverprotective effects of Anoectochilus formosanus, Ganoderma lucidum and Gynostemma pentaphyllum in rats. Am J Chin Med 21:59-69, Huang DD, Law RCS, Mak OT. Effects of tissue-cultured Anoectochilus formosanus Hay. extracts on the arachidonate metabolism. Bot Bull Academia Sinica 32: , Takeshita T, Tago H, Nakamura M, Muraoka S, Yoshizawa T. Hypoglycemics and lipid metabolism-improving agents containing 3-glucosyloxy-4-hydroxybutyric acid or its derivatives from plant. Jpn Kokai Tokkyo Koho JP 7:76522, (1):pp : Kai S, Kohmura H, Koizumi S, Sakakura K, Ishikawa K, Kawano S, Hattori N, hisada S, Konda H, Chikazawa H, Kadota T, Takahashi N. Effects of sotalol hydrochloride, an antiarrhythmic drug, administered to pregnant and lactating rats on behavioral observations in their offspring. Jpn Pharmacol Ther 26: ,

9 Table 1. Weight changes of pituitary gland in F 0 rats treated with crude aqueous extracts of Anoectochilus formosanus orally during the fetal organogenetic and lactation periods. Dose Absolute weight Relative weight No. (g/kg/day) (mg) (mg / 100 g body weight) of rats Control 14.9 ± ± ± ± ± 0.8** 5.7 ± 0.3** 14 All values are means ± S.E. **p<0.01 compared with control group. 9

10 Table 2. Delivery status in F 0 rats treated with crude aqueous extracts of Anoectochilus formosanus orally during the fetal organogenetic and lactation periods, and postnatal viability in F 1 offspring. Groups Normal A.F.E. (g/kg/day) 0.5g 2.0g No. of pregnant dams No. of dams with live offspring Gestation index (%) Gestation period Mean S. E..day No. of implants Total Mean S. E No. of stillborn pups (%) 0 (0.0) 0 (0.0) 0 (0.0) No. of offspring born alive Total Mean S. E Birth index (%) No. of offspring alive on postnatal day Viability index on postnatal day 4 (%) No. of offspring alive immediately after culling No. of live weanlings Weaning index (%) External malformations: No. of offspring with External malformations (%) 0 (0.0) 0 (0.0) 0 (0.0) 10

11 450 Food consumption (g/day) Body weight (g) Gestation day Postpartum day Fig. 1. Body weight changes and food consumption in pregnant and lactating F 0 rats treated with crude aqueous extracts of Anoectochilus formosanus (AAF) orally during the fetal organogenetic and lactation periods. : control (n=8); : AAF: 0.5 g/kg/day (n=14); : AAF 2.0 g/kg/day (n=14) 11

12 Food consumption (g/day) Body weight (g) Male Postnatal Weeks Postnatal Week Female Fig. 2. Body weight changes and food consumption in male and female F1 rats delivered from F 0 dams treated with crude aqueous extracts of Anoectochilus formosanus (AAF) oralyy during the fetal organogenetic and lactation periods. : control (n=32-31); : AFE 0.5 g/kg/day (n=56-53); : AFE 2.0 g/kg/day (n=53-55) 12

13 EFFECTS OF CRUDE AQUEOUS EXTRACTS OF Anoectochilus formosanus Hayata ADMINISTERED TO PREGENANT AND LACTING RATS ON THEIR OFFSPRING Wen-Chuan Lin 1, Chun-Ching Shih 2 and Yueh-Wern Wu 1 1 Department of Pharmacology, 2 Graduate Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan (Received 16 th September 1999, revised Ms received 13 th October 1999, accepted 21 th October 1999) Crude aqueous extracts of Anoectochilus formosanus (AAF) was administered orally to female rats at daily dose levels of 0, 0.5 and 2.0 g/kg from day 7 of gestation to postpartum day 28. Results obtained were as follows: 1) AAF did not affect the body weight gains, food intake in F 0 dams. 2) Delivery status in F 0 dams as well as number of stillborn pups, number of live pups and birth index were not affected by AAF. 3) AAF did not affect the viability index on postnatal day 4 and weaning index in F 1 rats. 4) Body weight gain and food consumption were not affected in F 1 rats given AAF. 5) AAF did not alter learning, spontaneous motor activity in both male and female F 1 rats. 6) Teratogenicity of AAF could not be detected. The result indicate that no-effect dose level of AAF is 2.0 g/kg/day for dams, fetuses and offspring. Key words: Anoectochilus formosanus, Reproduction study. Correspondence to: Wen-Chuan Lin, Research Institute of Chinese Medicine, China Medical College, Taichung, Taiwan, R.O.C. Tel:(04) ext

<4D6963726F736F667420576F7264202D205F31335FA578C657AAF7BD75B373AABAACE3A873AAF1AA702DAA4CA4E5A474A7F3B773AAA9303732332E646F63>

<4D6963726F736F667420576F7264202D205F31335FA578C657AAF7BD75B373AABAACE3A873AAF1AA702DAA4CA4E5A474A7F3B773AAA9303732332E646F63> 2004 國際藥用植物產業發展研討會專刊 231 台灣金線連的研究近況林文川中國醫藥大學藥理學科教授摘要台灣金線連是台灣有名的草藥, 用於多方面的疾病治療, 其中尤其是糖尿病及肝病過去 10 年, 有一些化學成分及藥理作用的科