分子生物学在医学中的应用诞生了分子医学。分子医学从分子水平阐述由分子改变产生的各种疾病的分子基础和机理。转基因和基因打靶技术产生了众多动物模型，为在体内水平研究生命现象和疾病的分子基础提供了前所未有的的机会。先进

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1 The First Guangzhou International Forum on Frontiers of Hypertension Research and The 2 nd Cardiovascular Pharmacology Symposium of Guangdong Pharmacological Society Program Chairs: Tianxin Yang, Yongyuan Guan, and Guoquan Gao Co-Chair: Host: Co-host: Guangju Guan, Jiandong Luo, Xiyong Yu Zhongshan School of Medicine, Sun Yat-sen University Shandong University, Guangdong Pharmacological Society Date: May 8-9 Venue: Research Building, Lecture Hall, Zhongshan School of Medicine, Sun Yat-sen University Background: The incidence of hypertension is increasing, affecting one in three adults in the United States and one in four adults in China. Based on this estimation, China has 200 million patients with hypertension. This disease, often labeled as the silent killer is an independent rick factor of cardiovascular disease stroke and renal failure, costing more than $75 billion annually. The hypertension in nearly half of the patient population is not controlled. This meeting covers advances in hypertension research, particularly with focus on the roles of gastro-renal communications, (pro) renin receptor, and eicosanoids, and sympathetic nerve, in the pathogenesis of hypertension. Hypertension is both a cause and complication of chronic kidney disease (CKD) which is another public health problem in the world. Hypertension together with diabetes account for two-thirds of cases of CKD. Antihypertensive therapies with inhibitors of renin-angiotensin system are used as first-line antiproteinuric treatment for CKD of almost all causes. Accordingly, this meeting will cover extensively the mechanism and therapeutics of CKD. Invited speakers include several world leaders and members of Chinese National Academy of Sciences, and many national leaders in the area of hypertension and kidney diseases.

2 MEETING AGENDA May 8, :30-8:35 Opening remarks Mengfeng Li ( 黎孟枫, 中山大学副校长, 中山医学院院长 ) 8:35-8:40 Welcoming remarks and introduction of guests Tianxin Yang ( 杨天新, 中山医学院高血压研究所所长 ) Session I Plenary talks Autocrine factors in regulation of cardiovascular function Chaoshu Tang ( 唐朝枢, 北京大学生理系教授 ) Nephropathy in China Zhihong Liu( 刘志红, 南京总院肾脏病研究所, 院士 ) Hypertension and kidney injury Xueqing Yu ( 余学清, 中山一院副院长 ; 中山一院肾脏病研究所长 ) Tea break Session II Gastro-renal communication and ion transport in hypertension Gastro-renal communication in salt sensitive hypertension Pedro Jose (Professor of Medicine, University of Maryland) GRK4 and hypertension Chunyu Zeng ( 曾春雨, 第三军医大学大坪医院心血管病专科医院院长 ) Ion transport in the gastrointestinal tract and its relevance to blood pressure control Jingxia Zhu ( 朱进霞, 首都医科大学生理系主任 ) By-pass surgery as a novel antihypertensive therapy Zhiming Zhu ( 祝之明, 重庆高血压研究所所长, 大坪医院内分泌科主任,973 首席 ) The mission of Novo Nordisk (short talk) Fang Zhang (Head of Metabolism Branch, Novo Nordisk)

3 May 8 afternoon Session III (Pro)renin receptor and local RAS in hypertension and cardio-renal disease Biology of (pro) renin receptor and its implication in hypertension and diabetic complications Genevieve Nguyen (Director, Centre for Interdisciplinary Research in Biology, Paris) Renal function of (pro) renin receptor Tianxin Yang ( 杨天新, 中山大学医学院高血压研究所所长, 千人计划教授 ) Session IV Local RAS in the kidney Joe Zhuo (Professor of Pharmacology, University of Mississippi, Jackson, USA) Eicosanoids and hypertension Central prostaglandins and hypertension Gregory Fink (Professor, Michigan state University; Program Chair, AHA Council on High Blood Pressure Research; Hypertension Associate Editor) Prostaglandin EP receptors in hypertension Youfei Guan ( 管又飞, 深圳大学医学部部长,973 首席 ) Vascular prostaglandin F 2 and hypertension Yu Huang (Chinese University of Hong Kong) Rare SNP rs in the mir-590-3p target site of the prostaglandin F 2 receptor gene confers risk for essential hypertension in the Han Chinese population Ying Yu ( 余鹰, 中国科学院上海营养所教授 ) Oobstructive nephropathy: renal inflammation and COX-2 Jorgen Frokiaer (Vice-chair, Institute of Clinical Medicine, Aarhus University) The vascular function of prostaglandins in human Boye Jensen (Professor, University of Southern Denmark, Chair of Department of Pharmacology) Tea break Session V Sympathetic nerve activity and hypertension Adrenergic signing in the cardiovascular system Youyi Zhang ( 张幼怡, 北大三院教授 )

4 Adipose tissue sympathetic nerve activity in hypertension Guoqing Zhu ( 朱国庆, 南京医科大学生理系主任 ) Renal denervation for treatment of resistant hypertension Pinjing ( 高平进, 上海高血压研究所教授, 瑞金医院高血压科主任 ) Summary Guoquan Gao ( 高国全, 中山医学院教授副院长 ) May 9, 2014 Morning Session VI Novel mechanisms of hypertension Renal tubular dysfunction as a cause of night-time hypertension Jiguang Wang ( 王继光, 上海高血压研究所所长, Hypertension Associate Editor) Mitochondrial dysfunction and hypertension Aihua Zhang ( 张爱华, 南京医科大学教授, 杰青 ) Endophilins and endothelium homeostasis. Jiaguo Zhou ( 周家国, 中山医学院教授 ) EPC dysfunction and salt-sensitive hypertension Alex Chen ( 陈丰原, 中南大学药学院院长, 千人计划教授 ) Session VII Diuretics, ion transport in hypertension Novel mechanism of blood pressure-lowering effect of diuretics Daowen Wang ( 汪道文, 武汉同济医院内科主任 ) The discovery of new diuretic targeting urea transport Baoxue Yang ( 杨宝学, 北大药理系主任 ) ENaC inhibitor in hypertension treatment Zhiren Zhang ( 张志仁, 哈尔滨医科大学教授 ) Sessions VI Cardiovasuclar diseases Stem cells for treatment of cardiovascular disease Xi-Yong Yu ( 余细勇, 广东省人民医院心血管研究所主任 )

5 Matrix metabolism and vascular disease Wei Kong ( 孔炜, 北大生理系主任 ) Lipid metabolism and cardiovascular disease Jingsong Ou ( 区景松, 中山一院教授杰青 ) Contribution of epicardial cells in the transient regeneration of neonatal mammalian hearts. Weibin Cai ( 蔡卫斌, 中山医学院教授 ) May 9 Afternoon The Joint Symposium of Cardiovascular Pharmacology, Guangdong Pharmacological Society and Cardiovascular Program, Sun Yat-sen University School of Medicine

Time Estimation of Occurrence of Diabetes-Related Cardiovascular Complications by Ching-Yuan Hu A thesis submitted in partial fulfillment of the requi

Time Estimation of Occurrence of Diabetes-Related Cardiovascular Complications by Ching-Yuan Hu Master of Science 2011 Institute of Chinese Medical Sciences University of Macau Time Estimation of Occurrence