MN M
acetylcholine ACh H3C H 3 C H3C N + CH 2 CH 2 OCOCH 3 Acetylcholine (ACh)
M N 1. M,,,,
N 1 2. N N 2 3. ACh
carbacholine) ACh AChE 0.5%~1.5% 0.5%~1.5% H 3 C H 3 C H 3 C H 3 C H 3 C H 3 C N + CH 2 CH 2 OCOCH 3 Acetylcholine (ACh) N + CH 2 CH 2 OCONH 2 Carbacholine
(muscarine)
(polocarpine, ) pilocarpus alkaloid) HC CH CH 2 C N CH 3 O C O CH 2 HC N CH Pilocarpine
M M
1
1. 1% 2% 2. 3.
AChE
+ (H 3 C ) 3 N O C N C H 3 O C H 3 Neostigmine
ACh AChE AChE ACh ACh M N 1 AChE ACh 2 N 2 3 ACh
1. 2. 3. 4. 5.
M
physostigmine N CH 3 N O C NH O CH 3 CH 3 CH 3 Physostigmine eserine
1. 2. 3.
AchE ACh M N N 2 ACh
DW
7.1
7.2 2.N 3. 1.M [] []
[ ] AChE [ ] ( ) 5min 24h
7.3
7.3 1.M-R :,,, :,0.5~1.0mg,2 ~ 3 / :,1,1 ~ 2mg, 0.5 ~ 2h :,1~3mg, 15~30min : M, N 2, 2.
7.4 - (PAM) N + CH N OH.I N + CH N OH.Cl - CH 3 PAM CH 3 PAM-Cl
1. 1. : 2. 2., 3. 3. (M ), Ach, 4. 4.