...1...3 RNAi...5...8 mirna...8 BRCA1 BRCA2...9...10 Cytokinetics Ispinesib...10...11...11...12...13
1 2007 12 22 3 10mg 15mg GMT 1. 2007 1 H5N1 1996 H5N1 WHO 2008 1 6 Nature Biotechnology α2 6 α2 6 2. 2007 FDA FDA 2005 H5N1 90µg/ml 2007 CSL 16 65 30
2 2 H5N1 GSK ViroClinics WHO 3. H5N1 2007 2 4,000 1,200 1,000 5,000 800 2,000 4 2007 12 10 GE Healthcare Novavax GE Healthcare Bioprocess Ready To Process Novavax VLP Novavax I/IIa 12
3 Department of Health Alan Johnson 2008 1 9 Clean, safe care: Reducing infections and saving lives 2 2.7 meticillin-resistant Staphylococcus aureus MRSAClostridium difficile healthcare associated infections HCAIs 1. HCAIs 25 8.2 MRSA 20 90 5 MRSA MRSA 40 MRSA 1,000 MRSA 90 National Health Service NHSMaidstone and Tunbridge Wells NHS BuckinghamshireStoke Mandeville 33 300 HCAIs 3 10 4 1 NHS MRSA 2. NHS
4 2 2010/2011 2.7 NHS NHS 5,700 2008 3 NHS 2008 9 NHS NHS Operating Framework NHS MRSA 2003 4 2011 30 2007 8 MRSA 3. MRSA MRSA 2009 3 MRSA 2009 the Care Quality Commission 4,500 MRSA HCAIs NHS MRSA HCAIs Health Protection Agency HPA MRSA 10 7
5 RNAi 50 1/4 1.2 3,000 RNAi Science Citation Index Expanded SCI-E RNAi 1. RNAi 1998 2007 SCI-E 2008 1 13 2007 251 20 90 RNAi ( 1 1 1998~2007 SCI-E RNAi 2. RNAi 2.1 RNAi HBV 2003 RNAi 2 RNAs(shRNAs) RNAi HBV (McCaffrey A P et al, 2003) RNAi HBV
6 2 shrnas sirna HBV HBV HBV shrna anti-hbx anti-hbx lhrnas shrnas HBV shrnas HBV HBV HBV dsaav2/8 lhrnas sirna shrna HBV HBV anti-hbsag HBV 2003 2004 2005 2006 2007 2 RNAi HBV sirna HBV (Konishi M et al, 2003) HBV (Giladi H et al, 2003) RNAi HBV psuper/hbvs1 HBV shrna A B C HBV (Wu HL et al, 2005) 2 2.2 RNAi RNAi HBV HBx Pol III U6 shrnas HBx U6 shrna 5 U6 shrna 6 HBV (Carmona S et al, 2006) lhrnas sirnaslhrna (Carmona S et al, 2006) shrna HBV Morrissey, DV et al, 2005) anti-hbsag sirnas sirna HBV Morrissey DV et al, 2005) shrna
7 shrna (dsaav2/8) shrna 120 HBV (Chen, CC et al, 2007) RNAi 2.3 HBV RNAi HBV polymerase II shrnas psilencer4.1/hbv HBV HBV(Ren GL et al, 2007) 3 RNAi HBV RNAi (dsaav2/8) RNAi (Suda T et al, 2007) RNAi [1] Carmona S, et al. Molecular Therapy, 2006, 13(2): 411-421 [2] Chen CC. Gene Therapy, 2007, 14(1): 11-119 [3] Giladi H, et al. Molecular Therapy, 2003, 8(6): 769-776 [4] Konishi M, et al. Hepatology, 2003, 38(4): 842-850 [5] Konishi M. Hepatology, 2003, 38(4): 842-850 [6] McCaffrey AP et al. Nature Biotechnology, 2003, 21(6): 639-644 [7] Morrissey DV. Hepatology, 2005, 41(6): 1349-1356 [8] Ren GL, et al. Antiviral Therapy, 2007, 12(6): 865-876 [9] Suda T, et al. Molecular Therapy, 2007, 15(12): 2063-2069 [10] Weinberg MS. Molecular Therapy, 2007, 15(3): 534-541 [11] Wen WH, et al. Hepatology, 2007, 46(1): 84-94 [12] Wu HL. Gastroenterology, 2005, 128(3): 708-716 [13] Ying CX, et al. Biochemical and Biophysical Research Communications, 2003, 309(2): 482-484
8 2 University of Texas Health Science Center lab-on-a-chip 2008 1 10 Cancer Investigation 25 2,500 1,000 X 150 200 30 49 http://www.eurekalert.org/pub_releases/2008-01/uoth-uhs010908.php mirna - MSKCC RNA(miRNA) 2008 1 10 Nature mirna mirna
9 mirna RNAs mirna mir-335 mir-126 mir-206 mir-335 SOX4 tenascin-c mir-126 mir-335 mir-206 http://cancerfocus.net/molecules can block breast cancers ability to spread/735 BRCA1 BRCA2 Journal of the American Medical Association BRCA1 BRCA2 BRCA1 BRCA2 BRCA1 BRCA2 BRCA1 BRCA2 Memorial Sloan-Kettering Cancer Center Colin B. Begg BRCA1 BRCA2 BRCA1 BRCA2 1985 1 2000 12 55 1,394 73 5.2% 42 BRCA1 31 BRCA2 704 108 15.3% 67 BRCA1 41 BRCA2 BRCA1 BRCA2 BRCA1 BARCA2
10 2 BRCA1 BRCA2 http://cancerfocus.net/molecules can block breast cancers ability to spread/735 2008 1 8 Journal of the National Cancer Institute docetaxel (doxorubicin) Peter MacCallum Cancer Centre Prudence Francis III 5 78% 5 74% 5 73% http://www.physorg.com/news119033916.html Cytokinetics Ispinesib Cytokinetics ispinesib IIIB IV I/II ispinesib Cytokinetics E CENP-E I ispinesib MTD 28 1-15 1 MTD II (RECIST) I MTD 1-15 1 Cytokinetics II
11 2007 6 Cytokinetics GSK ispinesib / anthracyclines taxanes II 21 18mg/m 2 ispinesib 1 45 4 7.1-30 http://www.marketwire.com/mw/release.do?id=806443 the Salk Institute for Biological Studies 2007 12 30 Journal of Cell Biology ductal carcinoma in situ DCIS 16 5 DCIS ERK1/2 MAP http://www.biospace.com/news_story.aspx?storyid=81510 boll weevil 2003 3
12 2 Agricultural Research Service ARS Crop Protection and Management Research Unit Patricia Glynn Tillman Fruit and Nut Research Laboratory Ted Cottrell Euschistus servus Nezara viridula 5 45 50 0.12 1.16 http://www.sciencedaily.com/releases/2008/01/080106132757.htm 2008 1 Psychological Science McGovern Institute for Brain Research John Gabrieli functional magnetic resonance imaging fmri 10 10
13 Gabrieli attention machinery http://www.physorg.com/news119269414.html Arizona State University s Biodesign Institute DNA 2008 1 11 Science DNA RNA DNA DNA DNA M13 M13 100 100% RNA DNA RNA DNA-RNA RNA http://www.nanotech-now.com/news.cgi?story_id=27384