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涤经
7 years ago
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1 FP7...3 mirnas let-7 mirnas aliskiren Bt

2 Nature O-linked N-acetylglucosamine (O-GlcNAc) O-GlcNAc O-GlcNAc OGT 3,4,5, trisphsophate OGT OGT OGT O-GlcNAc ( TZD) IR4-5 ACEI

3 RNAi 2. / / ( ) 1 Generex Rapid Mist TM 2 Nektar/ Exubera Nektar Therapeutics SanofiAventis Pfizer 60%MMAD 3µm FDA 3 AERx NovoNordisk Aradigm 2 3µm 4 Alkermes Air Air Aerogen aerodose 6 Eligen N-[8-(2-hydroxyl benzoyl) amino] caprylate ( SNAC) Caco-2

SanofiAventis Pfizer 60%MMAD 3µm 5 10 2006 1 27 FDA 3 AERx NovoNordisk

4 FP the Seventh Framework Programme FP7 FP7 Cooperation Ideas People Capacities FP FP Food, Agriculture And Fisheries, And Biotechnology FP FP7 FP7-KBBE FP7-KBBE A FP7-KBBE B omics 1.2 / CDM 1.3

35 6.0 2007 1 1 2007 FP7 FP7-KBBE-2007-1 2006.12.22 2007.05.02 1.9209 FP7-KBBE-2007-2A 2007.06.15 2007.

6 5 mirnas let-7 mirnas WHO ,000 1,200 RNA micrornas mirnas RNA mrna mirnas mirnas mirnas mirnas RNA RNAi Science Citation Index Expanded SCI-E mirna let-7 1. let-7 mirnas let-7 Caenorhabditis elegan 21 nt RNA strna small temporal RNA cdna C. elegans C. briggsae Drosophila melanogaster HeLa Danio rerio Arabidopsis thaliana Oryza sativa RNA mirna ~2007 Web of Science let-7 mirnas let-7

let-7 mirnas let-7 Caenorhabditis elegan 21 nt RNA strna small temporal RNA cdna C. elegans C.

7 mirna SCI-E let-7 mirnas 248 let-7 mirnas let-7 mirnas 2 let-7 mirnas 2000 mirnas RNA let-7 mirnas RNAi MicroRN A let-7 mirnas mrna let-7 C. elegans let-7 mirnas mirna mirna let-7 mirnas let-7 let-7 Drosha let-7 mirna mirna RAS let-7 MiRNA let-7 MiR-430 Hmga2 let-7 mrna HMGA2 let / 2 let-7 mirnas let-7 mirnas Science RNA Lau NC et al, 2001 mirnas Lagos-Quintana et al, 2001 RNA Lee RC et al, 2001 RNA let-7 mirnas RNAi Hutvagner G et al, let-7 mirnas mrna let-7 lin-4 mirnas mrna Bagga S et al, 2005 MiR-430 mrna Giraldez AJ et al, 2006 let-7 Hmga2 Mayr C et al, 2007 MiRNA let-7 HMGA2 Lee YS et al, 2007let-7 HMGA2 E-cadherin vimentin Snail let-7

2001 3 let-7 mirnas Science RNA Lau NC et al, 2001 mirnas Lagos-Quintana et al, 2001 RNA Lee RC et al, 2001 RNA let-7 mirnas RNAi Hutvagner G et al, 2002 2 2002 let-7 mirnas mrna let-7

8 7 Shell S et al, 2007 mirnas MicroRNAs let-7 lin-4 Aboobaker AA et al, 2005 mirna let-7 3 let-7 C. elegans Grosshans H et al, 2005 mirna let-7 mirna mir-48 mir-84 mir-241 C. elegans Abbott AL et al, 2005 C. elegans mirna let-7 Lall S et al, 2006 RAS let-7 mirna Johnson SM et al, 2005 let-7 mirna Pillai RS et al, 2005 let-7 lin-4 micrornas Schulman BRM et al, 2005 RAS let-7 let-7 mirna Johnson CD et al, 2007 mirna 2006 let-7 mirna Drosha Drosha mirna Thomson JM et al, 2006 mirna mirna let-7 BT-IC Yu F et al, mirna mirna mirna mirna mirna mirna let-7 mirnas Ras let-7 mirnas

elegans mirna let-7 Lall S et al, 2006 RAS let-7 mirna Johnson SM et al, 2005 let-7 mirna Pillai RS et al, 2005 let-7 lin-4 micrornas Schulman BRM

9 University of Leeds David Keeling David Keeling aliskiren University of Kentucky Lisa Cassis Alan Daugherty aliskiren Alan Daugherty 3 Journal of Clinical Investigation Aliskiren Novartis Tekturna FDA Aliskiren

htm aliskiren University of Kentucky Lisa Cassis Alan Daugherty

10 9 ACEARBs % statins Tufts University Mark Estes III Universitaire Trousseau 3, European Heart Journal Imperial College London mmhg 7.4 mmhg

Universitaire Trousseau 3,600 61 http://www.eurekalert.

11 mmhg 5 10dB /90mmHg 500ml Acute blood pressure lowering, vasoprotective and anti-platelet properties of dietary nitrate via bioconversion to nitrite Hypertension

htm 500ml Acute blood pressure lowering, vasoprotective and anti-platelet properties

12 11 Harvard Stem Cell Institute HSCI Massachusetts General Hospital MGH Cell Stem Cell induced pluripotent ips cells ips Proceedings of the National Academy of Sciences University of New Brunswick Canadian Rivers Institute Karen Kidd

sciencedaily.com/releases/2008/02/080215130617.

13 normal hormonal processes Bt (Bacillus thuringiensis Bt) Helicoverpa zea Bt Bt Bt Bt Bt University of Arizona Bruce Tabashnik Bt Bt Tabashnik Insect resistance to Bt crops: evidence versus theory Nature Biotechnology Bt Bt

php Bt 2003 2006 (Bacillus thuringiensis Bt) Helicoverpa zea Bt Bt Bt Bt Bt

14 13 Bt Cry1Ac Cry1Ac Bt Cry2Ab Tabashnik Cry2Ab Cry1Ac Marc Hauser humaniqueness 4 Hauser 4 4 Hauser

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