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彼卓尹
7 years ago
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1 ...1 iplant Notch Clavis Elacyt II

2 Nautre GRACE

4 3 iplant NSF University of Arizona UA 5,000 iplant iplant Collaborative Cold Spring Harbor Laboratory CSHL Arizona State University ASU University of North Carolina at Wilmington UNCW Purdue University PU Michigan State University Robert Last UA 79CSHL 16 ASU 4 UNCW PU 1 UA iplant BIO5 Eller iplant UA BIO5 BIO5 UA Cyberinfrastructure iplant K-12 NSF BIO5 iplant K iplant UA

5 BIO5 Richard Jorgenson iplant iplant Google Earth iplant Google Earth 3. Richard Jorgenson iplant iplant iplant Richard Jorgenson Science Foundation Arizona William C. Harris iplant BIO5 Vicki Chandler iplant iplant

6 5 singlet oxygen 1 O 2 Photodynamiv therapy PDTPhotoradiation therapy PRT Photochemo therapy PCT PDT Web of Science 3, PDT Web of Science 1,

7 PMB Dougherty 20 PS PDT 2007 FRET PDT Photodynamic molecular beacons PMB Zheng G et al 2007 PMB 1 O 2 (1) PDT 1998 Dougherty Dougherty TJ et al, 1998 (2) PDT Zhang M et al 2003 Sharman WM et al 2004 PDT (3) Hirakawa K et al 2005 Snyder JW et al O 2 cleavable peptide linker PMB (1) molecular beacons MB FRET (2) caspase-3 Thornberry NA et al 1998 (3) Zheng G PMB MMPs MMPs MMPs PMB MMP7 Brooks PC et al 1996

8 7 Shiomi T et al 2003 Overall CM et al PDT PMB PDT MB MMP-2 MT1-MMP MMP7 3 PMB Chen J et al, 2007 (Kashyap M et al) (Stefflova K et al, 2007) 3. PMB PDT PDT PDT PMB

9 Notch University of Pennsylvania School of Medicine Pear Notch Notch Cell Stem Cell Notch Notch Notch Notch Notch Notch Pear Notch T Notch T T Notch National Cancer Institute National Institute of Allergy and Infectious Diseases Leukemia and Lymphoma Society Damon Runyon Damon Runyon Foundation Joslin Joslin Diabetes Center Cell Stem Cell EGR-1

10 9 EGR-1 EGR-1 EGR-1 EGR-1 EGR-1 European Molecular Biology Laboratory,EMBL) Claus Nerlov C/EBPa Cancer Cell Claus Nerlov acute myeloid leukaemia AML) C/EBPa Peggy Kirstetter 10 AML C/EBPa C/EBPa Claus Nerlov AML

11 Clavis Elacyt II Clavis Elacyt II I II II Elacyt late stage acute myeloid leukaemia AML 16 Elacyt cytarabine Elacyt I/II 77 Clavis 2500mg/m² Elacyt 2500mg/m² Elacyt Elacyt AML I MD Anderson MD Anderson Cancer Centre MDACCDuke University Hospital University of Texas Health Science Centre UTHSC Paoli Calmettes II Blood 5,

12 Nature 1991 G G G 2 Or83b UK National Stem Cell

13 Network Science Meeting ES Paul Fairchild Medical Research Council Fairchild Nathan Robertson T ReishiMax Tegreen ReishiMax Tegreen 98%~99% Pharmanex ReishiMax ReishiMax Tegree 28 ReishiMax

14 13 12 ReishiMax ReishiMax Tegree 14 ReishiMax Tegree 45% ReishiMax Children's Cancer Institute Australia for Medical Research ornithine decarboxylase ODC1) ODC1 MYCN ODC1 Michelle Haber MYCN MYCN ODC1 ODC1 209 MYCN difluoromethylornithine DFMO DFMO ODC1 Haber MYCN DFMO DFMO DFMO

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