...1...2...8...10... 11...13...15...16...16...17...20...21...22...23 50...24...25...26...27...28 I
II...28...30...31...32...33...34...35...36...38...39...39...40...41...42...44 GLEEVEC...45...46 HLA...48...50...51...52
...52...54 1000...55...56...57...60...61...62...63 Á-...64...65...66...70...72...77...86...92...111... 113... 135 T... 146 III
... 148... 150... 151... 152... 155... 155... 156... 157... 158... 159... 160... 162... 163... 163... 164... 165 A... 165... 167... 168... 169... 170... 171 IV
... 171... 172... 173... 174... 175... 177... 178... 178... 181... 182... 183... 184... 185... 186... 188... 190... 191... 192... 194 V
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
50 24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
Gleevec 45
46
47
HLA 48
49
50
51
52
53
54
1000 55
56
57
58
59
60
61
62
63
- 64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
4 1 2 4 10 12 95
10 10 2 5 1 10 50 1 15% 50% 96
Ph1 ( 4 ) (1 ) 9 3 (11/2 10 ) 97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113 (L1) (L2) (L3) 1 1
HLA-DR CD19 CD10 Cyì SmIg I B + + - - - + + + - - B + + + + - B + + + - + 114
HLA- DR CD7 CD5 CD2 CD3 CD4 CD8 CD1 CyCD3 I - + + + - - - - + - + + + - + + + + - + + + + +/- +/- - + 115
FAB CD19 TdT CD10 CD20 CyIg SmIg B- -ALL + + + - - - L1 L2 B- -ALLt(4 11) B- -ALLt(9 22) 116
CALL -ALL + + + + - - L1 L2 6q- CALL CALLt del(12p) CALLt(9 22) B-ALL + + + + + - L1 B-ALltL(1 19) B-ALLt(9 22) B ALL + - +/- + -/+ + L3 B ALLt(8 14) B ALLt)(2 8) B ALLt(8 22) B ALL6q- FAB CD7 CD2 TdT T- -ALL + - + L1 L2 T- -ALLt del(9p) T- ALL + + + L1 L2 T ALLt(11 14) T- ALL6q RC WBC25 109/L 3 3 117
T-ALL B-ALL CNSL / 5cm1 2.5cm1 X FAB L3 12 3 2 2 1 1 1 1 1 3 1 2 10 1 t(9 22) 3 118
119
120
121
122
123
124
125
126
127
128
( ) 1 1 3 4 9 9 MTX(mg) 6 9 12 15 Ara-C(mg) 12 18 24 30 DXM(mg) 2 2 4 4 129
130
131
132
133
134
135
136
RC FAB M1 M2 M3 M4M5 M6 M7 - - - - - + +/- + + + +/- - - - + + + +/- - - - + + + +/- - - +/- 137
+ + + +/- + + +/- - - - +/- + - +/- RC M1 M2 M3 M4 M5 M6 M7 HLA-DR + + - + + +/- +/- CD34 + +/- - +/- +/- - +/- 138
CD33 + + + + + +/- +/- CD13 +/- + + + + - CD14 - +/- - + + - CD15 - + +/- + + +/- A - - - - - + - Gpb/a/Ib(J15 - - - - - - + AN51 C17) RC B T (Pox) SmIg3) CD5 A2) CD34 ANAE±F1) b/a/ib CyIg4) CD3 CD13 CD34 Spectrin CD19 CD25) CD13 CD20 CD75) CD14 139
(%) FAB 1) MIC t(8 21)(q22 q22) 12 M2 M2/t(8 21) t(15 17)(q22 q12) 10 M3 M3/t(15 17) t/(del(11)(q23) 6 M5a(M5b M4) M5a/t(11q) inv/del(16)(q22) 5 M4Eo M4Eo/inv(16) t(q 22)(q34 q11) 3 M1(M2) M1/t(9 22) t(6 9)(p21 22 q34) 1 M2 M4 M1/t(6 9) 140
inv (3)(q21q26) 1 t(8 16)(p11 p13) 0.1 t/del(12)(p11 13) 0.1 M1(M2 M7) M4 M1/inv (3) M5b M5b/t(8 16) M2 M2Baso/t(12p) +4 0.1 M4(M2) M4/+4 RC (%) 8 8 M /+8-7 4 M /-7 7q- 3 M /7q- 5q- 3 M /5q- -y 1 M /-Y MIC +21 1 M / 21 9q- 0.1 M /9q- i(17q) 0.1 M /i(17q) 20q- 0.1 M /20q- +22 0.1 M /+22 141
142
143
144
145
T 146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
A 165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196